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요통환자 대상 오적산 엑스산 투여 임상시험 이상반응 연구
윤은혜,장민기,황지후,이승훈,정원제,이재동,이승덕,김경호,김갑성,김은정,Yoon, Eun-Hye,Jang, Min-Gee,Hwang, Ji-Hoo,Lee, Seung-Hoon,Jeong, Won-Je,Lee, Jae-Dong,Lee, Seung-Deok,Kim, Kyung-Ho,Kim, Kap-Sung,Kim, Eun-Jung 대한침구의학회 2010 대한침구의학회지 Vol.27 No.4
Objectives : This study was performed to report adverse events in Ojeok-san extract powders RCT. Methods : 180 patients with LBP were randomized into groups for a double blind, placebo-controlled clinical study. They received Ojeok-san simple Extract, Ojeok-san complex Extract or placebo in powders, orally dissolved 3times a day for 4weeks. During 4weeks, we researched the symptoms and duration of adverse events and Digest ability, Milk hypersensitivity, Starch hypersensitivity, Caramel hypersensitivity, West-med hypersensitivity, Herb-med hypersensitivity in patients who had adverse events. Results : 52patients(28.9%) had adverse events and of them 44patients(28.9%) had lost adverse events naturally. But 5patients(2.8%) were withdrawn from the research because of the adverse events. Most of the symptoms of adverse event was Gastrointestinal symptom(88.3%) and adverse events frequency was not different from Ojeok-san simple Extract, Ojeok-san complex Extract and placebo. Conclusions : Ojeok-san extract powders had adverse events no different from the placebo, which shows that it is a safe drug.
Papanicolaou smear 진단에 있어 원격 영상처리 장치 ( Patho _ Net system ) 의 유용성 : 슬라이드 진단과 영상진단의 비교연구
윤은혜(Eun Hye Yoon),이경순(Kyung Soon Lee),김승철(Sung Chul Kim),우복희(Bok Hee Woo),이민진(Min Jin Lee),성순희(Sun Hee Sung),한운섭(Woon Sup Han) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A objective : To validate the efficacy of Patho_Net system for cervical cytology screening Methods : The results of imaging diagnosis by Patho_Net system were compared to those of 102 cervical smears diagnosed by conventional light microscopy. Results : There was 52.9% concordant results. The image result for the slide were 41 (80.4%) WNL or atrophy, 19 (61.3%) inflammation or benign atypia, 1 (20%) LSIL, 2 (20%) HSIL and 1 (100%) invasive squamous cell carcinoma. Conclusion : Patho_Net system has potential for diagnostic value as a valid alternative to the traditional glass slide screening of Pap smear.
특수학교 학교기업 담당자가 인식하는 성공요인들 간의 상대적 효과 및 요인 간 구조적 관계 분석
윤은혜 ( Yoon Eun Hye ),허유성 ( Heo Yu Sung ) 한국지적장애교육학회(구 한국정신지체아교육학회) 2016 지적장애연구 Vol.18 No.3
본 연구는 특수학교 학교기업을 운영하고 있는 학교에서 관련 업무를 담당하는 교사를 대상으로 특수학교 학업기업 운영 현황을 간단히 분석한 후, 운영 현황에 근거하여 성공적인 학교기업 운영에 영향을 미치는 관리자 역량 및 교직원 참여도, 지역사회 네트워크 구축, 직업훈련실의 적정성, 교육과정과 학교기업 연계의 적절성 요인들 간의 상대적 효과를 분석하였다. 또한 최종적으로 네 요인 간의 구조적 관계를 분석하였다. 이를 위해 16개 학교에 소속된 학교기업 담당교사 94명의 설문조사 자료를 활용하였다. 주요 연구결과를 보면, 첫째, 운영 현황을 물어본 모든 문항의 평균이 3.5이상으로 담당자들은 학교기업 운영을 긍정적으로 인식하고 있는 것으로 나타났다. 둘째, 매출 현황을 보면, 64.5%는 상승하고 있다고 응답하였으며, 감소하고 있다는 비율은 약 10%로 크게 높지 않았다. 셋째, 성공적인 학교기업에 영향을 미치는 요인으로 관리자 역량 및 교직원 참여도, 지역사회 네트워크 구축, 직업훈련실의 적정성, 교육과정과 학교기업 연계의 적절성을 독립변인으로 회귀분석을 실시한 결과, 설명량이 약 55%로 비교적 높게 나타났으며, 지역사회 네트워크 구축이 가장 중요한 요인으로 나타났다. 직업훈련실의 적정성 역시 정적으로 유의미한 변인으로 나타났다. 구조적 관계를 보면, 관리자 역량 및 교직원 참여도는 교육과정 연계 및 직업훈련실의 적정성에, 교육과정 연계는 지역사회 네트워크 구축과 직업훈련실의 적정화에 긍정적인 영향을 미쳤다. 마지막으로 직업훈련실의 적정성은 지역사회 네트워크에 정적인 영향을 미치는 것으로 나타났다. This study was implemented to investigate the current situations of special school-based enterprises and the relative effects of variables influencing on the success of them. A total of 94 teachers from 16 special schools in charge of special school-based enterprises participated in questionnaires. According to the key results, first, teachers perceived current special school-based enterprises positively. In addition, most of teachers thought that special school-based enterprises had positive impacts on their students. 64.5% of teacher reported sales had been up. On the other hand, only 10% of teachers reported sales had been down. Third, according the regression analysis for the variables impacting on special school-based enterprises` success level, the local network was most important variable and the proper vocational training room was also positively significant variable. This model explained about 55% of total variances. According to structural relation analysis, supervisor`s competences and staff participation gave positive impacts on curriculum and vocational training room. The vocational training room impacted positively on local networks.
김은걸,윤은혜,송수철,이성노,황민섭,Kim, Eun-Geol,Yoon, Eun-Hye,Song, Soo-Cheol,Lee, Seong-No,Hwang, Min-Seop 대한한의정보학회 2008 大韓韓醫情報學會誌 Vol.14 No.2
Objectives : The purpose of this case is to report the improvement of a patient with lymphedema due to axillary lymph node dissection after acupuncture therapy and herbal medicine. Methods : We treated the patient with Dong-Qi acupuncture, herbal medication(木通大安湯), lymph absorption massage, compresses, abdominal breathing. We measured the circumference of the patient's elbow and wrist every day at 6pm. Results : Since being hospitalized, the circumference of the patient' elbow and wrist has been decreased and VAS score has gotten lower gradually. Conclusions : We considered Dong-Qi acupuncture, herbal medication had a useful effect on lymphedema due to axillary lymph node dissection with lymph absorption massage, compresses, abdominal breathing.
폐경 전 한국 여성에서의 에스트로겐 수용체의 유전자 아형과 Bone Mineral Density 의 연관성에 관한 연구
허성은(Sung Eun Hur),류호선(Ho Sun Lyoo),박한뫼(Han Moie Park),윤은혜(Eun Hye Yoon),심성신(Sung Shin Shim),이홍수(Hong Soo Lee),김형래(Hyung Rae Kim),정혜원(Hye Won Chung) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
N/A Objective : The goal of this study was to determine the relationship between peak bone density and polymorphism of estrogen receptor gene in Korean premenopausal women. Method : We amplified Estrogen receptor by polymerase chain reaction and its digestion pattern of Pvu II and Xba I was examined from the 172 women who were in premenopause. The genetic subtype was classified by its digestion pattern and its combination genotype, e.g. PP, Pp, pp, XX, Xx, xx, PPXX, PPXx, PPxx, PpXx, Ppxx, xxpp. Bone mineral density of each genetic subtype were compared. Results : The genotype distribution was as follows: PP; 16.3%, Pp; 45.9%, pp; 37.8%, XX; 1.2%, Xx; 25.0%, xx; 73.8%, PPXX; 1.1%, PPXx; 8.7%, PPxx; 6.4%, PpXx; 16.3%, Ppxx; 29.7%, ppxx; 37.8%. ER gene polymorphism was associated with bone mineral density at forearm bone mineral density (p<0.05) with the xx genotype having the less BMD than Xx genotype. Conclusion : Xba I estrogen receptor gene polymorphism is associated with bone mineral density in premenopausal women. Estrogen receptor gene polymorphism may have a modulatory role in bone metabolism in premenopausal women. And it can be used as predictor of forearm peak bone density.
굴곡신연법(屈曲伸延法)으로 시술한 요각통 환자 60례에 대한 임상적 고찰
김은걸,이동건,윤은혜,정원제,김경호,조현석,황민섭,Kim, Eun-Geol,Lee, Dong-Gun,Yoon, Eun-Hye,Jeong, Won-Je,Kim, Kyung-Ho,Cho, Hyun-Seok,Hwang, Min-Seop 척추신경추나의학회 2009 척추신경추나의학회지 Vol.4 No.1
Objectives : The purpose of this report is to estimate Cox flexion distraction treatment by comparing the Improvement of Sciatica treated by Cox flexion distraction treatment with Common treatment. Methods : This study was carried out on 60 patients with Sciatica who were hospitalized in Dongguk University Gyeongju Oriental Hospital from February, 2008 to December, 2008. Group A of 30 patients were taken both common treatment and Cox flexion distraction treatment. And Group B of 30 patients were only taken common treatment. And at treatment conclusion day, we checked and compared VAS(Visual Analogue Scale)and ODI(Oswestry disability index) out of these two group. SPSS(Statistical Program for Social Science) for Windows was used for a statistical analysis and the independent T-test was performed to gauge the improvement of VAS(Visual Analogue Scale)and ODI(Oswestry disability index) out of these two group, in which case, value of P below 0.05 is considered as useful. Results and Conclusions : The results of the VAS(Visual Analogue Scale)and ODI(Oswestry disability index) of comparison analysis between two group at treatment conclusion day, show that the improvement of Sciatica in common treatment with Cox flexion distraction treatment Group is more effective than that in common treatment.
임신성 고혈압 한국인 환자에서 C677T Methylenetetrahydrofolate reductase 유전자 변이 , 호모시스테인 , 지질성분의 감수성 연구
안정자(Jung Ja Ahn),윤은혜(Eun Hye Yoon),서지현(Ji Hyun Suh),김영주(Young Ju Kim),이경순(Kyung Soon Lee),하은희(Eun Hee Ha) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : The purpose was to test the hypothesis that the common missense mutation of 5,10-methylenetetrahydrofolate reductase(MTHFR) is more prevalent among preeclamptic women compared with control and also was to determine whether homocysteine and other lipid profile is changed in pregnant women with preeclampsia. Methods : We measured plasma homocysteine, cholesterol, HDL, LDL, triglyceride, apoprotein B, vitamin B12, and folate in 48 pregnant women without preeclampsia and 22 women with preeclampsia. And the MTHFR genotype was determined with a polymerase chain reaction/restriction fragment length polymorphism method. Results were analyzed with aX2 contingency table and T-test. Results : The prevalence of the MTHFR C677T mutation was not significantly different between the population studied. There was no significant difference in the level of plasma homocysteine, cholesterol, HDL, LDL, triglyceride, apoprotein B, and folate between controls and preeclamptic women. Furthermore, there was a significant difference in the level of plasma vitamin B12 between the population studied. Conclusion : These data suggest that the MTHFR C677T mutation is not a risk factor for preeclampsia in this population. Plasma homocysteine, cholesterol, HDL, LDL, triglyceride, apoprotein B, and folate level are not elevated in preeclamptic women. However, the plasma vitamin B12 level is elevated in preeclamptic women. Further studies are necessary to determine why the plasma vitamin B12 level is elevated in preelamptic women although they did not have vitamin drug.
Nurr1 과발현에 의한 도파민신경세포 기능향상에 미치는 Mash1의 역할
강진선 ( Jin Sun Kang ),고현철 ( Hyun Chul Koh ),윤은혜 ( Eun Hye Yoon ),박장환 ( Chang Hwan Park ) 한국조직공학·재생의학회 2007 조직공학과 재생의학 Vol.4 No.1
In vitro expanded CNS precursors provide a potentially unlimited source of dopamine(DA) neurons for the experimental treatment in Parkinson`s disease. But an efficient DA differentiation from CNS precursors in vitro is limited to mesencephalic precursors isolated from early embryonic ages (embryonic day 11.5~12.5). Recently demonstrated that Nurr1, a steroid-type orphan nuclear receptor, sufficiently derives neural precursor cells, isolated from rat embryonic brains, to differentiate toward DA neurons. Nurr1-induced DA neurons, however, were less mature in their neuronal morphology and pre-synaptic functions in vitro and do not elicit behavioral recovery upon transplantation into a rodent model of Parkinson`s disease. In this study, genetic manipulation of Mash1 in the Nurr1- DA cells contributes to the acquisition of the functions to restore behavioral deficits in Parkinsonian rats, thereby these cells become a potential cell source for Parkinson`s cell therapy.
열전도성 점착제 응용을 위한 고분자 기반 탄소나노소재 복합체 제조 및 특성 평가
이병주(Byeong-Joo Lee),조성일(Sung-Il Jo),윤은혜(Eun-Hye Yoon),이애리(Ae-Ri Lee),이우영(Woo-Young Lee),허성규(Sung-Gyu Heo),황재성(Jae-Sung Hwang),정구환(Goo-Hwan Jeong) 한국표면공학회 2020 한국표면공학회지 Vol.53 No.4
A polymer-based carbon nanomaterial composite was fabricated and characterized for the application of a thermal conductive adhesive. Low-dimensional carbon nanomaterials with excellent thermal conductivity such as carbon nanotube (CNT) and graphene were selected as a filler in the composite. Thermal, electrical and adhesive properties of the composite were investigated with respect to the morphology and content of the low-dimensional carbon nanomaterials. As a result, the composite-based adhesive fabricated by the loading of surface-treated MWCNTs of 0.4 wt% showed uniform dispersion, moderate adhesion and effective heat dissipation properties. Finally, it was confirmed through the thermal image analysis of LED module that the temperature reduction of 10°C was achieved using the fabricated composite adhesive with MWCNT-6A. Expecially, heat dissipation performance of the optimized composite adhesive was evident at the hot spot in the module compared to other samples mixed with graphene or different MWCNT loading ratios.