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장티푸스 치료에서 Chloramphenicol 및 Co-trimoxazole 투여시 해열기간의 비교관찰
김정암,김종국,윤석현,이영일,전기환 대한감염학회 1984 감염 Vol.16 No.2
Typhoid fever is far more prevalent in Korea than in western countries and is on the trend of epidemic disease. So great efforts and interests are taken to the treatment of the disease in Korea. Chloramphenicol and ampicillne have been used in the medical treatment of typhoid fever, but they have accompanied various undesirable side effects. Recently Bactrim (Trimethoprim and Sulfamethoxazole) is known to be safer and more effective drug in the treatment of typhoid fever, especially due to lesser occurrence of side effects and its favorable therapeutic results to Chloramphenicol-resistant organisms. Author reviewed the duration of fever in response to the administration of chloramphenicol and Cotrimoxazole in 68 patients with suspected typhoid fever who were admitted to department of Internal Medicine, Busan Medical Center from February 1, 1983 to January 31, 1984. Patients were divided into two groups; 38 cases of Chloramphenicol-administered group and 30 cases of Bactrim-given group. The results obtained were summarized as follows: 1) The mean duration from initiation of drug administration to defervescence was 4.95 days in chloramphnicol-administered group and 6.07 days in Cotrimoxazole-given group respectively. 2) In all patients of both groups fever subsided in response to the treatment with Chloramphenicol and Cotrimoxazole. 3) Only one patient of Cotrimoxazole-administered group complained of slight degree of indigestion following the use of Bactrim.