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        • LC-MS/MS를 이용한 농산물 중 이미다졸리논계 농약의 시험법 개발

          김지영 ( Ji Young Kim ), 김효진 ( Hyochin Kim ), 송지영 ( Ji Young Song ), 한아름 ( A Reum Han ), 성누리 ( Nu Ri Sung ), 윤상순 ( Sang Soon Yoon ), 정용현 ( Yong Hyun Jung ), 오재호 ( Jae Ho Oh ), 김종수 ( Jong Soo Kim ) 한국환경농학회 2019 한국환경농학회 학술대회집 Vol.2019 No.-

          Imidazolinone herbicides (Imazapyr, Imazalil, Imazamox, Imazaquin, Imazapic, Imazamethabenzmethyl and Imazethapyr) control weeds by inhibiting the enzyme acetohydroxyacid synthase(AHAS), also known as acetolactate synthase (ALS). AHAS is critical enzyme for the biosynthesis of branched chain amino acids in plants. Currently, each individual analytical method for Imidazoline herbicides is used as Ministry Food and Drug Safety (MFDS) method. Thus it consumes lots of time and effort to determine residue of Imidazolinone group in food. A Single analytical method for the determination of Imidazolinone residue in foods was developed as Ministry of Food and Drug Safety (MFDS) method. Five agricultural commodities (mandarin, potato, soybean, brown rice, and chilli pepper) were used as group representative to verify. After extracting with 1% formic acid in acetonitrile, samples were partitioned by citrate buffer. To remove the interferences, dispersive-SPE using C18 and PSA was performed before LC-MS/MS (Liquid Chromatography -Tandem Mass Spectrometry). The liner standard calibration curve were confirmed (coefficient of determination with calibration range). Mean average accuracies were shown 72.0~116.6 %. The precision were also shown less than 11.6% for all five samples. Thus, this method is acceptable to CODEX guideline for residue analysis (CAC/GL 40). Is sum, the proposed method for Imidazolinone group residue determination can be suitable for CODEX guidelines and useful as government method.

        • 2019년 농산물 중 펜프로피모르프 등 78종 농약의 잔류허용기준 설정을 위한 위해평가

          장동은 ( Dong Eun Jang ), 윤상순 ( Sang Soon Yoon ), 신혜선 ( Hye-sun Shin ), 조성민 ( Sung Min Cho ), 이한솔 ( Han Sol Lee ), 박지수 ( Ji-su Park ), 이수정 ( Su Jung Lee ), 정용현 ( Yong-hyun Jung ), 오재호 ( Jae-ho Oh ) 한국환경농학회 2019 한국환경농학회 학술대회집 Vol.2019 No.-

          식품의약품안전처(식약처)는 농산물의 생산량 증대 및 식품 중 잔류농약의 안전성 확보를 위하여 식품위생법에 근거하여 식품 중 농약의 잔류허용기준을 설정하여 관리하고 있다. 이를 위해서는 농약의 일일섭취허용량(ADI) 설정 산출과정 및 노출평가 등을 포함한 위해평가가 반드시 선행되어야 한다. 위해평가는 급성독성, 반복투여독성, 만성독성 및 발암성, 유전독성, 생식 및 발달독성 등의 자료를 검토하여 최대무독성용량(NOAEL)을 산출하고 안전계수를 적용하여 ADI를 설정하는 위험성 확인 및 결정단계, 작물잔류시험성적, 국민 1인 1일 평균 식품섭취량과 국민 평균체중 등을 고려하여 농약의 일일노출량을 산출하는 노출평가 단계와 위해도 결정단계로 이루어진다. 위해도 결정은 기준을 설정하고자 하는 농산물로부터 섭취되는 농약의 이론적일일최대섭취량(TMDI)을 환경 및 음용수를 통한 노출량 20%를 사전 고려하여 ADI 80% 이내로 설정하는 것을 기본방침으로 하고 있다. 본 연구에서는 우리나라에 신규 등록된 fenpropimorph, fluthiacet-methyl, pydiflumetofen 및 quinoxyfen 4종 농약의 농산물에 대한 잔류허용기준과 기준이 확대되는 iminoctadine, deltamethrin 및 dichlorvos 등 74종 농약의 농산물에 대한 잔류허용기준 설정을 위하여 위해평가를 수행하였다. 그 결과, 78종 농약의 TMDI는 ADI 대비 0.05∼79.87%로 평가되어 농산물 182품목에 대한 78종 농약의 잔류허용기준이 신설 및 개정되었다. 따라서, 총 78종 농약의 ADI 대비 TMDI 비율은 모두 80% 미만으로 안전성 문제는 없을 것으로 판단된다. 본 연구결과는 농약의 잔류허용기준 설정에 대한 과학적 근거로 활용될 것이다.

        • KCI등재
        • KCI등재

          임신성 고혈압 및 자궁내 태아발육제한에서의 태아심박동 각 변수들의 상관분석

          윤상순,김성희,주명희,정경미,황정혜,정성로,문형,차경준,박영선,박문일 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.1

          목적 : 정상 임신 산모군과 고위험 산모군 (임신성 고혈압, 자궁내 발육제한 등)을 산전 태아 상태를 평가하는 한 방법인 비수축검사를 이용하여, 이들을 선형성에 기초한 상관분석을 통하여 비교분석하였다. 태아의 심박음과 그 제변수 상호간 1차적 관계, 즉 선형성을 두 군사이의 비교를 통하여, 태아의 신경계 및 심혈관계등의 형태적 기능적 발달과 모체적응 등을 간접적으로 분석해 보고자 하였다. 연구 방법 : 1993년 7월부터 1998년 11월까지 수집된 대상 파일 에서 분석 가능한 2,876예 중 정상임신 대조군 500예과 고위험임신군 500예 (자궁내발육지연, 만성고혈압, 경증 및 중증 전자간증)의 5개의 집단으로 분류한 후 FHR와 제변수들 사이의 집단간 선형적 의존관계를 비교하였다. 분석된 상관관계에 기초하여 임신 주수에 따른 FHR 값과 두 변이도, 즉 진폭 (Amplitude, Amp) 및 박동간격 (Mean minute range, MMR)를 종속변수군 (이하 FHR-D)으로 하고, 임신주수 (NSTweeks), 기록손실도 (Signal loss) 그리고 태동횟수 (Fetal movement)를 또 다른 하나의 집단군, 즉 독립변수군 (이하 FHR_I)으로 하여, 정준상관분석 (Canonical correlation analysis)을 실시하였다. 결과 : 고위험임신군의 경우에 24주 이하에서는 선형의존도가 0.6~0.8, 25-29주에서는 0.53~0.68, 30-34주에서는 0.50~0.60, 임신 35-39주에서는 0.38~0.45, 그리고 40주 이상에서는 0.42~0.55였다. 정상임신군에서는 24주 이하에서 0.44~0.52, 임신 25-29주, 임신 30-34주 그리고 임신 35-39주까지 0.38~0.45 정도로 안정된 선형의존도를 보였으며 임신 40주 이상에서도 큰 변화를 보이지 않았다. 임신 32주 이하에서 고위험임신군의 경우 정준변수 FHR_D와 FHR_I는 태동횟수에서 가장 높은 가중치를 보였으며 (각각 0.36, 0.47), 정상군에서는 각각 태동횟수 (0.32)와 기록손실도 (0.48)에서 가장 높게 평가되었다. 임신 33-37주에서는 고위험임신인 경우에 각각 태동횟수 (0.40), 기록손실도 (0.48)과 관계가 컸으며, 정상임신군에서도 각각 태동횟수 (0.34), 기록손실도 (0.49)에서 가장 높아 대조군간 비슷한 양상을 보였다. 반면 임신 38주 이상에서는 고위험 임신의 경우에 정준변수 FHR_D와의 관계는 임신주수가 가장 높았고 (0.52), FHR_I와는 태동횟수 (0.38)가 가장 높게 나타났다. 또한 정상임신군에서는 각각 태동횟수 (0.40)와 기록손실도 (0.52)가 가장 높은 선형의존도를 보였다. 결론 : 임신이 진행되면서 기능적으로 수동적 의존구조에서 자율적이고 능동적인 생체현상으로 진행됨을 간접적으로 관찰할 수 있었다. 특히, 고위험임신군에서는 정상임신군보다 더 선형적이며 덜 복합적인 인자로서 표현되었던 바, 고위험군임신에서의 태아의 기능적 발달 저하는 선형적 의존관계의 증가와 관련되는 것으로 보여진다. Objective : We aim to analyze each variable of FHR in high risk pregnancies, namely intrauterine growth restriction (IUGR) and pregnancy-induced hypertension (PIH) including chronic hypertensive vascular disease (CHVD), mild and severe preeclampsia to build an objective decision basis using correlation analysis. Methods : The patients were divided into two groups (500 normal pregnancies and 500 high risk pregnancies related to IUGR, CHVD, mild and severe preeclampsia), and then subdivided into intrauterine pregnancy before 24 weeks, 25-39 weeks, and after 40 weeks. We compared the canonical correlation between each group using variables of FHR after nonstress test (NST). Results : In high risk pregnancies, the linearity was 0.6-0.8 in intrauterine pregnancy before 24 weeks, 0.53-0.68 in 25-29 weeks, 0.50-0.60 in 30-34 weeks, 0.38-0.45 in 35-39 weeks and 0.42-0.55 in after 40 weeks. In normal pregnancies, the linearity was 0.44-0.52 in intrauterine pregnancy before 24 weeks, 0.38-0.45 in 25-39 weeks which was stable, and there was no specific change in after 40 weeks. Before 32 weeks, canonical variates of FHR_D and FHR_I revealed highest (0.36, 0.47 respectively) in high risk pregnancy and fetal movement and signal loss was the most valuable factors in normal pregnancy. In between 33 to 37 weeks, fetal movement (0.40) and signal loss (0.48)were related most closely in high risk pregnancies and 0.34 and 0.49 respectively in normal pregnancies which show similar pattern. In contrast, FHR_D was most highly related to the duration of pregnancy and FHR_I to fetal movement (0.38) in high risk pregnancy. In normal pregnancies, fetal movement (0.40) and signal loss (0.52) showed the highest linearity. Conclusion : The pregnancy with intrauterine growth restriction and pregnancy induced hypertension has more linear relation and less complexity in each variable of FHR than the normal pregnancy group. The formal, functional underdevelopment of fetus may results in the increasement of the linear depedent relation in each variable of FHR in these type of high risk pregnancies.

        • KCI등재

          제왕절개술 후 발생한 T3 Thyrotoxicosis 1 예

          윤상순,황정혜,성영모,황윤영,문형,박문일,구미경,정성노,이재웅,안유헌 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.10

          Thyroid storm (thyrotoxicosis) is rarely encountered during pregnancy or the puerperium, even in untreated women and characterized by hypertension, hyperthermia, and multiple systems involvement. Much more common is heart failure, apparently caused by the long-term myocardial effects of thyroid hormone and intensified by other pregnancy complications that include severe preeclampsia, infection, anemia, or combinations of these. Prompt diagnosis and treatment of thyroid storm are essential in reducing morbidity and mortality of a patient from this disorder. We experienced a case of triiodothyroxine induced thyroid storm (T3 thyrotoxicosis) developed after Cesarean section. This case highlights both physicians should be aware of the symptoms and risk factors and reversing of heart failure successfully by reducing cardiac workload is important through immediate medical treatment-adequate hydration, thermoregulation, and control of hypertension, infection and anemia et al.

        • 태아심박동 제 변수를 이용한 임신주수 추정알고리즘의 개발

          박영선,차경준,류제선,윤상순,문형,정성로,박문일,황정혜 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

          Objective : The objective of this study is to estimate gestational age by using FHR parameters after linear and nonlinear analysis of FHR data. Linear spectral decomposition has a limit to describe and analyze the nonlinear and complex physiological nature. Random processing and chaotic analysis assist to quantify some patterned energies, interaction of the physiological system in body system, which the constancy is preserved, and complexity of physical cardiovascular system. But there are no great development of new device which notify fetal age. Methods : From March 1995 to December 2000, 2,548 cases who received NST during antenatal visit were included in this study. Among these cases, 1000 cases were sampled randomly. We divided this cases into a study and a control group, 500 cases for model building set and the other 500 cases for validation set. Each FHR parameters such as baseline FHR, variability (AMP, MMR), acceleration & deceleration (15 bpm- 15 seconds), loss of signal, the number of fetal movement were analysed by using our own computerized HYFM-I, II software system. The linear and non-linear analysis of FHR were done after extracting approximate entropy (ApEn) value. Finally, we performed regression analysis and extract an equation for estimation of gestational weeks using bootstrap method. Results : We extract a following equation using above study method: Log(GA)=5.870-0.051(Sloss*)-0.065(Mean FHR*)+0.049(Mean FHR*)²-0.058(FM*)+0.048(AMP*)²+0.121(A1515*)-0.031(A1515*)²+0.036(ApEn*)² Conclusions : Accurate dating of pregnancy, namely gestational week is very important for antenatal diagnosis in the field of perinatal medicine. This study will propose scientific research results which are useful for studying normal and morbid generating physiological fetal condition. We extract an appropriate equation for estimation of gestational weeks only using FHR parameters. We hope to compare our result with other authors` results in the near future.

        • KCI등재
        • KCI등재

          경증태아 빈맥에서의 심박동 각변수의 근사엔트로피 및 정준상관분석

          박영선,차경준,윤상순,황정혜,문형,박문일 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12

          Objective : This study was to determine differences of fetal heart rate (FHR) parameters, approximate entropy, canonical correlation coefficient and perinatal outcome between fetuses with mild baseline tachycardia (FHR range : 161-180 bpm) and fetuses with normal baseline FHR. Methods : Using our own software developed by Hanyang University Hospital in Korea, non-stress tests were performed for 20 minutes and cases were divided into two groups; mild tachycardia group (FHR range; 161-180 bpm, 100 cases) and normal group(FHR ranges;129-160 bpm, 197 cases). And then, we analyzed various FHR paramaters, approximate entropy, adjusted canonical correlation coeffcient and perinatal outcome in each group. Results : Perinatal outcomes between two groups were not significant. However, mean minute range (MMR) was lower and the number of deceleration(15 bom for 15 sec, more than one) was significantly higher in fetuses with mild tachycardia than normal group(p<0.05). The approximate entropy and canonical correlation coefficient showed respectively 0.77±0.02, 0.45±0.06 in mild tachycardia group and 0.80±0.01, 0.43±0.07 in normal group, there were no significant differences. Conclusion : The results showed that mild baseline tachycardia in this range were not associated with an increase in the incidence of adverse perinatal outcome, although decreased MMR and increased number of deceleration in mild tachycardia group may suggest hidden subtle change of FHR parameters. Fetuses with mild tachycardia were not different irregularity of FHR quantified by approximate entropy from normal fetuses and were also similar tendency to correlation with perinatal outcome by adjusted canonical correlation coefficient, which is a multivariate extension of univariate correlation analysis.

        • 농산물 중 잔류 플루피리민과 그 대사체 분석법 개발

          김대원 ( Dae Won Kim ), 김지영 ( Ji Young Kim ), 김효진 ( Hyochin Kim ), 송지영 ( Ji Young Song ), 한아름 ( A Reum Han ), 김종수 ( Jong Soo Kim ), 윤상순 ( Sang Soon Yun ), 정용현 ( Yong Hyun Jung ), 윤혜정 ( Hae Jung Yoon ), 윤은경 ( Eun ) 한국환경농학회 2020 한국환경농학회 학술대회집 Vol.2020 No.-

          Flupyrimin is used for rice plants. Not only it exhibits outstanding pesticidal property, but also it ensures excellent safety for organisms with pollinator by interacting with insectile neurons(nAChR, nicotinic Acetylcholine receptor). In this study, an analytical method for the determination of Flupyrimin and its metabolites residues in foods was developed as Ministry of Food and Drug Safely (MFDS) method. We used five agricultural products (mandarine, potato, soybean, hulled rice, and chilli pepper) as group representative to verify. The sample preparation process was conducted in two steps with QuEChERs method. First, in order to extract the samples, 2% formic acid in acetonitrile was added and shaken for 10 minutes. After that magnesium sulfate and sodium chloride were added, followed by centrifugation (4,700 G) for 10 minutes. Thereafter, to remove the interferences in samples, dispersive-SPE using C18 and magnesium sulfate was performed for 10 minutes before LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) analysis with C18 column. The linear standard calibration curve were confirmed (coefficient of determination with calibration range). Mean average accuracies of Flupyrimin and its metabolites (Flupyrimin-M1) were shown 85.18~110.66% and 72.36~100.06%, respectively. The precision were also shown less than 10.58% for all five samples. These results are suitable for CODEX guideline for residue analysis (CAC/GL 40). In short, the proposed method for determination of Flupyrimin residue in foods could be utilized as governmental method.

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