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참당귀(Angelica gigas) 뿌리 추출물로부터 (+)-Decursinol의 대량 제조 방법
이지현(Jee-Hyun Lee),최용석(Yong-Seok Choi),김주환(Joo-Hwan Kim),정혜광(Hye-Gwang Jeong),김동희(Dong-Hee Kim),윤미영(Mi-Yong Yun),김진숙(Jin-Sook Kim),이상한(Sang-Han Lee),조수현(Soo-Hyun Cho),신귀남(Gui-Nam Chen),김의검(Eui-Geom Kim 대한약학회 2006 약학회지 Vol.50 No.3
The purpose of this study is to develop a mass preparation method of (+)-decursinol from Angelica gigas roots. Recently, it has been shown that (+)-decursin, (+)-decursinol angelate and its analogues, isolated from Angelica gigas root, exhibit various biological activities such as antitumor, antibacterial and neuroprotective activities. The contents of these compounds, ester form of (+)-decursinol, is very high in the Angelica gigas roots, whereas the content of (+)-decursinol itself is very low. Therefore, (+)-decursinol which can be used as starting material to synthesize various its analogues was easily prepared from decursin analogues in the Angelica gigas roots. In order to achieve such aim, the Ether-Fr, of the ethanol extract of Angelica gigas root was hydrolysed with various alkalis and solvents. As a result, the order of (+)-decursinol preparation was 1) NaOH, KOH, 2) K2CO3, and 3) NaHCO3 as alkali. Also, the yield of (+)-decursinol was higher in diethyl ether than any other solvent conditions. From 1kg of dried Angelica gigas roots, we could obtain 27.4g of (+)-decursinol as a pure white solid.
송규용,배기환,명창선,김문일,박용진,윤미영,김동희,Song Gyu Yong,Bae Ki Whan,Myung Chang-Seon,Jin Wen Yi,Park Yong Jin,Yun Mi Young,Kim Dong Hee 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
Antitumor and anti-metastatic effects of mineral powder(MP) were studied. In the present study, MP did not exhibit the any cytotoxic activity against leukemic cells such as L1210 and U937 tumor cell lines in vitro. Also, MP did not exhibit the any cytotoxic activity against solid cells such as A549 and B16-BL6 tumor cell lines in vitro. However, in vivo, MP exhibit a significant antitumor activity in BDF1 mice bearing Lewis lung carcinoma cells(LLC) with inhibition rates of 46 and $23\%$ at 200 and 100 mg/kg/day, respectively. Furthermore, in pulmonary colonization assay, MP exhibit the inhibitory effect of tumor metastasis. From these results, it was concluded that MP had antitumor and anti-metastatic activity suggesting its application for the prevention and treatment of cancer.
이지현,이재호,김현관,김의검,신귀남,조수현,명창선,김동희,윤미영,최용석,김성훈,송규용,Lee, Jee-Hyun,Lee, Jae-Ho,Kim, Hyun-Kwan,Kim, Eui-Geom,Shen, Gui-nan,Cho, Soo-Hyun,Myung, Chang-Seon,Kim, Dong-Hee,Yun, Mi-Young,Choi, Yong-Seok,Kim, Su 대한약학회 2006 약학회지 Vol.50 No.5
A novel series of 4-senecioyloxymethyl-6,7-dimethoxycoumarin, isolated from Crinum latifolium, was prepared by reacting 4-bromomethyl or 4-bromomethyl-6,7- dimethoxycoumarin with various carboxylic acids and examined for their anti-angiogenic activities in human umbilical vein endothelial cells (HUVECs). Among them, 4e, 4f, 4g and 4i with noncyclic moiety exhibited potent anti-angiogenic activity. However, compounds with cyclic moiety such as phenyl, pyridinyl, thiophenyl and furanyl group did not exhibit any anti-angiogenic activity. Also, compounds 4f and 4g which exhibited strong anti-angiogenic activity in a dose-dependent manner showed antitumor activity.