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증례 : 악성 식도협착에 있어 티타늄 제재의 금속제 확장형 인공식도삽관술 최근 경험 5예
손봉준 ( Bong Jun Son ),유종현 ( Jong Hyeon Yoo ),황기은 ( Ki Eun Hwang ),장남수 ( Nam Soo Chang ),김기택 ( Ki Taek Kim ),전우규 ( Woo Kyu Jeon ),정을순 ( Eul Soon Chung ),이상종 ( Sang Jong Lee ) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.6
Endoscopic esophageal endoprosthesis is a safe and effective procedure for the palliative treatment of obstructive esophagogastric malignancy. However, the placement of conventional plastic esophageal endoprosthesis is difficult in some cases and this procedure is associated with significant complications such as perforation, hemorrhage & dysfunction of the prosthesis in the long term. The self-expanding metallic stents offer an attractive alternative to conventional esophageal stents. Ultraflex(TM) esophageal prosthesis is knitted from a single strand of Elastalloy(TM) wire, and undulates to conform with normal esophageal peristalsis, maintaining patency and promoting patients` comfort. Recently developed EsophaCoil(TM) esophageal prosthesis is unique in that it is a simple coil with close loops made from a single flat wire of nickel titanium alloy. Because the radical force of this material is much stronger than stainless steel, expansion time is therefore faster and the stent is able to dilate even extremely resistant strictures. We report our recent experience in five patients with malignant esophageal obstruction palliated with the new self-expandable titanium stent(Ultraflex(TM) and EsophaCoil(TM)).(Korean J Gastroenterol 1997;29:826-835)
혈액투석증인 만성 신부전 환자에서 C 형 간염바이러스 항체 양성율과 위험인자
김향(Hyang Kim),김기택(Ki Taek Kim),유종현(Jong Hyeon Yoo),김병익(Byung Ik Kim),이상종(Sang Jong Lee),이은주(Eun Joo Lee),박상은(Sang Eun Park),서상열(Sang Yeol Suh),구자룡(Ja Ryong Koo),김선숙(Sun Sook Kim),차대룡(Dae Ryong Cha),권영 대한내과학회 1997 대한내과학회지 Vol.52 No.6
N/A Objectives: The aim of this study was to evaluate the prevalence and risk factors of hepatitis C virus(HCV) infection in patients on chronic hemodialysis. Methods: We measured antibody to HCV using second generation enzyme immunoassay(ELISA) test or radioimmunoassay(RIA) and hepatitis B surface antigen, serum values of AST, ALT in 224 patients of six urban hemodialysis units. We also investigated some clinicai parameters such as age, sex, duration and frequency of hemodialysis, the amount of blood transfusion, and hemodialysis of infected patients on separate machines. Results: 1) 33 of 224 patients(14.7%) were positive for HCV antibody. 2) The prevalence of HCV antibody were most significantly correlated with duration of hemodialysis and less significantly with frequency of hemodialysis, amount of blood transfusion but not correlated with age, sex and level of liver enzyme. 3) The prevalence of HCV antibody was significantly higher in a center which did not separate dialysis machine for HCV antibody positive patients than centers which did. Conclusion: Th prevalence of HCV antibody was most signficantly correlated with duration of hemodialysis. We suggest that environmental factor of hemodialysis unit may play major role in HCV infection of hemodialysis patients. So the importance of separate dialysis machine from HCV antibody positive patients should be emphasized.
Kyu Hyun Yang(양규현),Si Young Park(박시영),Je Hyun Yoo(유제현),Tae Hwan Kim(김태환),Hui Wan Park(박희완),Jong Hyeon Ryu(유종현),Kyo Seok Choo(추교석) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.8
목적: 백서 골다공증 모델에서 파미드로네이트의 장기간 투여가 장관골의 강도와 골절 치유에 미치는 영향을 알아보고자 하였다. 대상 및 방법: 양측성 난소 제거술을 시행하여 골다공증을 유발시킨 생후 3개월된 Sprague-Dawley계 암컷 백서 66마리를 대상으로,3개월 후 무작위로 실험군(n=33)과 대조군(n=33)으로 나누었다. 실험군은 6개월 동안 매달 파미드로네이트(0.5 ㎎/㎏)를 복막내 투여를 하였고, 대조군은 생리 식염수를 투여하였다. 6개월의 투여기간 후에 좌측 대퇴골을 도수 골절 방법으로 골절 시키고 K-wire를 이용하여 골수강내 고정술을 시행하고, 5주 후 양측 대퇴골을 적출하였다. 정상 대퇴골과 골절을 유발시킨 대퇴골사이의 역학적인 특성을 측정하였고, 우측 대퇴골두의 골밀도를 측정하였다. 파미드로네이트의 골내 농도는 high performance liquid chromatography를 이용하여 측정하였다. 결과: 정상 대퇴골에서 최대강도는 실험군에서 154.4±17.5 N, 대조군에서는 129.7±28.0 N였으며(p=0.0002), 강성은 실험군에서 452.5±122.8 N/㎜, 대조군에서는 378.6±126.2 N/㎜였다(p=0.036). 좌측 대퇴골의 가골에 대한 평가는 정상 대퇴골과 비교하여 최대 강도는 실험군에서 22.7±7.2%, 대조군에서는 29.7±3.5%였다(p=0.025). 골밀도 검사에서는 실험군에서 230±9 ㎎/㎠, 대조군에서 219±13 ㎎/㎠였다(p=0.0007). 파미드로네이트의 평균 골내 농도는 62.3±15.2ng/㎎였고 농도와 대퇴골의 최대 강도 사이에는 상관관계를 보였지만 통계적으로 유의하지 않았다 (p=0.067). 결론: 파미드로네이트는 난소 적출술 후 골 흡수로부터 대퇴골을 효과적으로 보호하였고, 강도와 강성을 유지하였지만, 파미드로네이트의 장기 투여로 골절 치유가 지연되었다. Purpose: We investigated the effects of the long-term administration of pamidronate on long bone strength and fracture healing in a rat osteoporosis model. Materials and Methods: We performed bilateral ovariectomies in sixty-six 3-month-old female Sprague-Dawley rats. Three months after the ovariectomies, the animals were randomized into two groups. Disodium pamidronate or saline was injected into the rats every month for 6 months. The left femoral shafts were fractured by a closed fracture technique. Five weeks after the fractures, the rats were euthanized and both femurs were removed. We evaluated the mechanical properties of the normal and fractured femurs and the bone mineral densities of the right femoral heads. Pamidronate concentration was determined by high performance-liquid-chromatography. Results: The maximum strength and stiffness of the right femurs were 154.4±17.5 N, 452.5±122.8 N/㎜ in the pamidronate-treated group and 129.7±28.0 N, 378.6±126.2 N/㎜ in the control group (p<0.05). The maximum strength of the calluses compared with the right femurs and the mean bone mineral density of the right femoral heads were 22.7±7.2%, 230±9 ㎎/㎠ in the pamidronate-treated group and 29.7±13.5%, 219±13 ㎎/㎠ in the control group (p<0.05). Conclusion: Pamidronate effectively protected the femurs from bone resorption and preserved bone strength and stiffness after ovariectomies. However, fracture healing was impaired during the early stage of healing after long-term administration of pamidronate.