고밀도 지단백 콜레스테롤과 베타 3-아드레날린성 수용체 유전자 변이와의 관련성

유병철(Byeng Chul Yu),전만중(Man Joong Jeon),이용환(Yong Hwan Lee) 한국생명과학회 2009 생명과학회지 Vol.19 No.5

지방분해와 열생산에 관여한다고 알려진 ADRB3 유전자의 염기서열 분석을 통하여 한국인에서 호발하는 유전자 다형성부위를 먼저 확인한 후 이 유전자 다형성들과 HDL-C와의 연관성에 대하여 조사하고자 2006년 5월에서 12월 사이에 부산지역의 일개 대학병원에서 건강진단을 받은 991명을 대상으로 신장, 체중, 체질량지수, 허리둘레, 고밀도 지단백 콜레스테롤, 중성지방, 공복 혈당을 측정하였으며, 대상자들의 혈액에서 DNA를 분리하여 ADRB3 유전자에서 흔히 발생하는 유전자다형성 부위를 확인하였다. 연구결과 한국인에서 ADRB3 유전자의 intron2 +3893T>C의 변이를 처음으로 발견하였으며 열성 대립형질의 발현빈도는 0.164이었다. Exon1의 +188T>C와 intron2의 +3893T>C의 열성 대립형질인 C형이 있을 경우 HDL-C의 농도가 낮았다. 따라서 ADRB 유전자 다형성은 HDL-C과 관련이 있을 것으로 생각된다. The β₃-adrenergic receptor (ADRB3) is expressed mainly in visceral adipose tissue and is thought to contribute to lipolysis and the delivery of free fatty acids to the portal vein. This study was aimed at evaluating the association between high-density lipoprotein cholesterol (HDL-C) and ADRB3 genetic polymophisms. A total of 991 healthy examinees who were examined in a university hospital, located in Busan City, between May and December 2006 were enrolled in this study. Height, weight, body mass index, waist circumference, and systolic and diastolic blood pressures of the subjects were examined. Intravenous concentrations of fasting blood glucose, total cholesterol, HDL-C, low-density lipoprotein cholesterol, and triglyceride were also measured. After extracting DNA from the subjects, mutations of the +188T>C (Trp64Arg) of exon 1 and +3893T>C of intron 2 on the ADRB3 gene were genotyped using the single base extension method. We have identified a novel mutation of ADRB3 that is located in intron 2. The frequency of its minor allele was 0.164. Both the +188T>C mutation of exon 1 and +3893T>C mutation of intron 2 were significantly associated with HDL-C. The mean concentration of serum HDL-C was significantly lower in the presence of their minor allele 'C'. These results suggest that both mutations of +188T>C of exon 1 and +3895T>C of intron 2 have significant associations with HDL-C in the Korean population.

부산, 울산 및 경상남도 만 19세 남자의 고도근시 유병률

이상준,엄상화,유병철,손혜숙,홍영습,노맹석,이용환,Lee, Sang-Joon,Urm, Sang-Hwa,Yu, Byeng-Chul,Sohn, Hae-Sook,Hong, Young-Seoub,Noh, Maeng-Seok,Lee, Yong-Hwan 대한예방의학회 2011 Journal of Preventive Medicine and Public Health Vol.44 No.1

Objectives: The purpose of this study was to estimate the prevalence and correlated factors of high myopia in 19 year-old men in Southeast Korea. Methods: This retrospective study was based on the medical checkup data of conscription during 2005. The study subjects were 19 years old men in Busan, Ulsan and Gyeongsangnam-do. The health checkup data of the conscripts consisted of noncycloplegic autorefraction test, the biometric data and social factors. To analyze the social and biometric effects, we classified the biometric factors into 4 or 5 groups and the social factors into 3 groups. High myopia was defined as a spherical equivalent of under -6.0 diopter. Data analysis was performed using the chi square test for trends and multiple logistic regression analysis. The SAS(version 9.1) program was used for all the analyses. Results: The prevalence of high myopia was 12.39% (6256 / 50 508). The factors correlated with high myopia were the residence area (OR, 2.07; 95% CI, 1.77 to 2.4 for small city; OR, 2.01; 95% CI, 1.72 to 2.34 for metropolis; the reference group was rural area), academic achievement (OR, 1.43; 95% CI, 1.34 to 1.53 for students of 4-and 6-year-course university; the reference group was high school graduates & under) and blood pressure (OR, 1.54; 95% CI, 1.10 to 2.16 for hypertension; OR, 1.09; 95% CI, 1.02 to 1.17 for prehypertension; OR, 1.10; 95% CI, 1.01 to 1.20 for hypotension; the reference group was normal blood pressure). Conclusions: More than one tenth of the young men were high myopia as one of the risk factor for visual loss. Further studies on high myopia and its complications are needed to improve eye health in Southeast Korea.

골격성 III급 부정교합자의 임상적 특성에 따른 심리상태

김선옥,진미영,유병철,Kim, Sun-Ok,Jin, Mi-Young,Yu, Byeng-Chul 한국치위생학회 2015 한국치위생학회지 Vol.15 No.2

Objectives: The purpose of the study is to investigate the psychological state of the patients according to skeletal class III malocclusion symptoms. Methods: The subjects were 200 skeletal class III malocclusion patients. The questionnaire consisted of general characteristics, clinical manifestation, and T score of Korean version of self-rated Symptom Checklist-90-Revision modified by Jae-hwan Kim. The data were analyzed using SAS version 9.2 and t-test, ANOVA, and ANCOVA were used. Clinical manifestation included subjective recognition and radiological analysis. The subjective recognition of the patients consisted of self-satisfaction of the appearance, phonation, mastication, and temporomandibular joint pain. T score consisted of somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism. Results: The most serious factor in 9 scales was the severe TMJ pain by ANCOVA. Male patients had a higher T score in phobic anxiety, psyochoticism, somatization and depression than female patients. Those having low appearance satisfaction had the problem in interpersonal sensitivity. Obsessive-compulsive symptoms were conspicuous in phonation difficulty and temporomandibular pain. Conclusions: The patients with skeletal class III malocclusion have more satisfaction with appearance, pronunciation, and phonation than those with skeletal class III malocclusion and overjet. Proper dental treatment will improve the communication and quality of life.

전문가 치주 예방관리 전, 후 치주지수와 치주질환 원인균 발현률 변화

진미영(Mi-Young Jin),유병철(Byeng-Chul Yu) 한국구강보건과학회 2020 한국구강보건과학회지 Vol.8 No.4

Objectives: The main cause of periodontal disease is due to anaerobic bacteria existing around periodontal tissue. Methods: A group of 36 people who visited the periodontal prevention center of G Dental Hospital in Changwon-si, Gyeongsangnam-do, and who performed 4 times of professional periodontal prophylaxis, was finally selected and entered into a self-filling ceremony from April 25, 2019 to September 20, 2019. Data were analyzed using the statistical package SPSS (ver 25) a chi-square test and frequency analysis were performed. Results: P. gingivalis showed a significant difference in CAL, probing depth and tongue index were not significant among the clinical periodontal indices. T.Forsythus and T.denticola showed significant differences in Probing Depth, CAL, and tongue index. P. gingivalis, T. forsythus, T. denticola all decreased before and after expert periodontal prophylaxis, but T. denticola showed a significant difference. (p<0.05) Conclusions: The results of this study implied that the professional periodontal preventative care greatly reduced the number of periodontal bacteria, not exterminate the periodontal bacteria.

치과위생사의 작업특성과 근골격계 증상의 상관성

이소영 ( So Young Lee ),유병철 ( Byeng Chul Yu ),엄상화 ( Sang Hwa Urm ),권현숙 ( Hyeon Sook Kwun ),박정희 ( Jung Hee Park ),김진범 ( Jin Bom Kim ),이용환 ( Yong Hwan Lee ) 대한예방치과·구강보건학회 2011 大韓口腔保健學會誌 Vol.35 No.4

Objectives. The purpose of this study was to estimate the prevalence of musculoskeletal symptoms and work-related factors of these symptoms in dental hygienists. Methods. This questionnaire survey was conducted during May to August 2010 with 269 dental hygienists recruited as study subjects. The presence of musculoskeletal symptoms was assessed using a questionnaire of musculoskeletal symptoms from the Korea Occupational Safety Health Agency and work-related factors, and consisted of 7 job environmental factors and 4 job positions. Data analysis was performed using the chi square test and multiple logistic regression analysis using the SAS (ver 9.1) software. Results. The overall prevalence of musculoskeletal symptoms was 86.30% (233/269). The specific prevalence of musculoskeletal symptoms for different regions of the body were as follows: 64.44% in shoulders, 51.48% in legs/feet, 48.15% in waist, 47.41% in neck, 43.33% in hands/wrists/fingers, and 17.78% in arms/elbows. The related factors of musculoskeletal symptoms in dental hygienists were type of work place (OR=2.86, 95% CI: 1.07∼7.65 in dental clinics; reference group-dental hospital), number of patients per day (OR=6.10, 95% CI: 1.06∼35.04 in 15∼19 patients per day; reference group-below 10 patients per day), subjective physical burden (OR=3.06, 95% CI: 1.18∼7.94 in presence of physical burden; reference group-absence of physical burden) and location of operation (OR=9.60, 95% CI: 1.80∼51.19 in back to side position; reference group front to side position). Conclusions. More than four-fifths of the dental hygienists experienced musculoskeletal symptoms. Improvements of working environments in dental clinics, reasonable number of patients for operation, methods for reducing physical burden, correct working positions and procedures are needed to prevent musculoskeletal disease development in dental hygienists.

치과위생사의 직무스트레스와 직무요인의 관계

이소영 ( So Young Lee ),유병철 ( Byeng Chul Yu ) 한국치위생과학회 2011 치위생과학회지 Vol.11 No.6

This study was purposed to evaluate the level of occupational stress and the work-related factors of occupational stress in dental hygienists. The study was conducted during the period from May to October 2010 with study population consisted of 316 dental hygienists. The occupational stress was estimated with questionnaire of the Korean Occupational Stress Scale(KOSS) and the work-related factors were consisted with 9 work characteristics. Data analysis was performed with t-test, ANOVA and multiple regression analysis using SPSS(win ver 18.0) program. The level of occupational stress was 52.42±4.95 in dental hygienists. The levels of sub-scales for occupational stress were 64.56±12.17 in interpersonal conflict, 59.85±13.59 in physical environment, 54.60±13.51 in organizational system, 52.37±11.47 in job demand, 51.71±10.58 in lack of reward, 48.14±12.97 in insufficient job control, 46.68±9.25 in job insecurity, 41.46±15.98 in occupational climate, respectively. According to multiple regression analysis, physical burden and daily repetitive working hour were work-related factors of occupational stress in dental hygienists. To conclude, the occupational stress in dental hygienists was higher than mean score of reference values of occupational stress in Korean workers and methods for reducing work load and work hours considering work characteristics of dental hygienist are needed to prevent occupational stress in dental hygienists

치위생과 신입생의 신체,정신건강과 대학 생활 스트레스 와의 관계

강현주 ( Hyun Joo Kang ),유병철 ( Byeng Chul Yu ) 한국치위생학회(구 한국치위생교육학회) 2014 한국치위생학회지 Vol.14 No.4

Objectives : The purpose of this study was to investigate the relationship between psychosocial stress and depression symptoms in dental hygiene freshman. Methods : A self-reported questionnaire of 45 questions was filled out by 207 dental hygiene students in Gyeongnam from December 9 to 11, 2013. Data were analyzed using SPSS WIN 18.0 program for descriptive statistics, t-test, ANOVA. Results : Religion tended to influence on positive effects on academic stress because those having religion had less academic stress. Economic condition also influenced on physical and mental stress in the students(8.52±5.63)(p=0.000). Low economic status influenced on academic problems(p=0.022), family problems(p=0.014), rational relationship problems(p=0.002), and interpersonal problems(p=0.007). There was no significant difference between future problems(p=0.125) and self-efficacy(p=0.076). The physical symptoms included digestive disorders(16.73±5.37), cardiac symptoms(14.61±5.51), headache(9.46±3.59), insomnia(8.32±3.67) (p=0.000). The mental symptoms included negative emotions(15.07±3.94)(p=0.000). Conclusions : In order to reduce the psychosocial stress symptoms in dental hygiene freshman, it is important to develop the stress debriefing program in the future.

구강보건교육 경험에 따른 유아기 어머니의 책임의식에 관한 연구

조갑숙 ( Gab Suk Cho ),유병철 ( Byeng Chul Yu ),조민정 ( Min Jeong Cho ) 한국치위생학회 2012 한국치위생학회지 Vol.12 No.3

Objectives: The study enquires into OHB and its importance of preschooler mothers, based on perceived experiences of OHE. It also investigates mothers` sense of responsibility for children`s oral health. The purpose is to enhance the effectiveness of OHE and its orientation. Methods: From April 20th to June 15th, 2011, 14 nurseries or preschools were randomly selected from childcare facilities of one gu(borough) in Busan. The objects of study are mothers of four to seven-year-old children. The collected survey data were analyzed using SPSS 12.0 for Windows. Results: 1. There is a statistically significant difference(p<0.01) in relations between the mothers` working status and perceived experiences on OHE. 2. On the survey about OHB practices, there are significant differences(p<0.001) in toothbrushing before breakfast, after meals, in three minutes and after refreshments Significant differences(p<0.01) are also shown in toothbrushing after eating fruits. 3. On the survey about the importance of OHB, there are statistical significances(p<0.001) in toothbrushing manner -rather than the number of it -toothbrushing in three minutes after meals and following the correct way of toothbrushing. There are also significant differences(p<0.05) in brushing teeth for more than three minutes. 4. There are significant differences(p<0.001) in mothers` periodic dental examination, children`s periodic dental examination and training experience on children`s toothbrushing. 5. On the survey about the sense of responsibility for children`s OHE based on experiences of OHE, there is a significant difference(p<0.05) in that many replied OHEis "much-needed" regardless of their experiences on it. Conclusions: The results show that of infants` mothers, those with experience on OHE, have an accurate knowledge about toothbrushing, due to the effectiveness of the education. Both groups, however, replied that children`s OHE is much needed, suggesting problems about the accessibility of the OHE.

중국인 유학생의 구강건강관련 삶의 질에 미치는 영향요인

박정현 ( Jung Hyun Park ),유병철 ( Byeng Chul Yu ),박민경 ( Min Koung Park ),조미숙 ( Mi Suk Cho ) 한국치위생학회(구 한국치위생교육학회) 2014 한국치위생학회지 Vol.14 No.4

Objectives : The purpose of this study is to investigate the correlation factors to oral health-related quality of life in Chinese students studyng in Korea. Methods : A self-reported questionnaire was filled out by 231 students from November, 2012 to January, 2013. Data were analyzed by t-test, one way ANOVA, and Duncan post-hoc test using SPSS version 19.0. Results : Male students and short period staying students tended to have a higher qualityof life. Smokers and large city dwellers tended to have a low oral health-related quality of life(p<0.05). The oral health-related quality of life in Chinese students in Korea was closely related to necessity of dental treatment and past experience of dental treatment services(p<0.05). Conclusions : To improve the oral health-related quality of life in foreign students, it is necessary to provide the early prevention of dental caries and periodontal diseases through the systematic and professional dental health care delivery program for the foreign students studying in Korea.

임플란트 완성 환자의 구강건강관련 삶의 질과 관련 요인

박정현,엄상화,권현숙,조갑숙,허승주,이소영,유병철,Park, Jung-Hyun,Urm, Sang-Hwa,Kwun, Hyeon-Sook,Cho, Gab-Suk,Heo, Seung-Ju,Lee, So-Young,Yu, Byeng-Chul 한국치위생학회 2011 한국치위생학회지 Vol.10 No.2

Objectives : This study was purposed to estimate the level of oral health quality of life and the relationship between health-related factors and oral health quality of life in patients with successful dental implants. Methods : This questionnaire survey was conducted during the period from December 2009 to March 2010 with 126 patients confirmed successful dental implants in Busan. The oral health related quality of life and oral health-related factors were estimated with OHIP-14 and 8 oral health characteristics, respectively. Data analysis was performed with descriptive analysis, t-test, ANOVA, multiple regression analysis using SAS(ver 9.1) program. Results : The score of oral health quality of life in patients with successful dental implants was $12.25{\pm}7.82$. The scores of subscale of the oral health quality of life were $1.24{\pm}1.35$ in social disability, $1.60{\pm}1.37$ in handicap, $1.60{\pm}1.44$ in psychological disability, $1.70{\pm}1.38$ in functional limitation, $1.81{\pm}1.35$ in physical disability, $2.14{\pm}1.46$ in physical pain, $2.17{\pm}1.46$ in psychological discomfort, respectively. The related factors of oral health quality of life in patients with successful dental implants were absence of other type prosthesis and experience of tooth brushing education. Conclusions : The oral health related quality of life in patients with successful dental implants was relatively good condition. Social supports and chances for high quality denture and tooth brushing educations are needed to improve oral health related quality of life in patients with dental implants.