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유길종 ( Kil Jong Yu ),배종석 ( Jong Seok Bae ),서영진 ( Young Jin Seo ),이준엽 ( Juhn Yeob Lee ),임경진 ( Kyung Jin Lim ),조유리 ( You Lee Joh ),윤원찬 ( Wern Chan Yoon ),김채기 ( Chae Gi Kim ),송용호 ( Yong Ho Song ),최정윤 ( Ju 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.4
Adult onset Still`s disease (AOSD) is a rare, distinct clinical entity which affects predominantly young adults aged 16-35. It affects multiple organs, and at present, the etiology is still unclear. Because this disease has few diagnostic or confirmative test, the diagnosis is made by the differential diagnosis and by excluding other diseases. Several reports have suggested a viral trigger in the pathogenesis of this disease. It has some common clinical features; abrupt onset, high fever, sore throat, transient maculopapular rash, lymphadenopathy, and hepatosplenomegaly. We describe a 17-year-old man who fulfilled the proposed diagnostic criteria of AOSD and had evidence of acute Epstein-Barr virus infection. He complained of intermittent high fever and myalgia for a week. He also had maculopapular rash, sore throat, multiple right cervical lymphadenopahty, and right ankle pain and swelling. After admission, intermittent fever persisted for a month, but diffuse myalgia and migrating arthralgia fluctuated.
한국인 폐경 후 여성에서 골관절염과 비타민 D 수용체의 다형성과의 연관관계의 부족
임경진 ( Gyung Jin Lim ),김무곤 ( Moo Gon Kim ),배종석 ( Jong Seok Bae ),유길종 ( Kil Jong Yu ),조유리 ( You Lee Cho ),윤현대 ( Hyun Dae Yoon ),김은영 ( Eun Young Kim ),윤원찬 ( Wern Chan Yoon ),김채기 ( Chae Gi Kim ),송용호 ( Yon 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.1
Objective: To determine whether polymorphisms of the Vitamin D receptor (VDR) gene, known to be associated with osteoporosis and/or osteoarthritis (OA) in Caucasians, might also relate to the risk of OA and osteoporosis in Korean postmenopausal women Methods: A population of 130 postmenopausal women, including 76 healthy controls and 54 knee OA patients, were studied using anteroposterior radiographs of the knee, which were graded for OA according to the Kellgren classification system. The VDR genotype was determined by using polymerase chain reaction and by digestion with the three restriction enzymes Taq I, Bsm I, and Apa I. Femoral neck bone mineral density (BMD) was assessed in all participants by dual energy X-ray absorptiometry. Results: VDR genotype frequency distributions in Koreans were much different from Caucasian`s both in the OA group and the control group. Especially, tt, BB and AA genotype were very rare, prominently differentiating from Caucasians. But within Koreans, no significant differences in VDR genotype frequencies were observed between OA cases and controls. VDR genotype was not significantly associated with the radiographic grades of OA. And there were no significant relationships of VDR genotype with BMD scores in each group. Conclusion: In Korean postmenoposal women, the VDR gene polymorphisms do not significantly contribute to an increased prevalence of knee OA or to differences in BMD. VDR genotype analysis would not be helpful for assessing the risk of knee OA in Koreans because: (1) there is no correlation of VDR genotypes with the radiographic severity of OA; and (2) there is a more skewed distribution of VDR genotypes in Korean population compared to the Caucasian`s.
십이지장 궤양 출혈로 내원한 환자에서 진단된 C 단백 결핍증으로 인해 발생한 장간막 정맥 혈전증
우재곤 ( Jae Gon Woo ),이지은 ( Ji Eun Lee ),권오언 ( Oh Un Kwon ),정경원 ( Kyoung Won Jung ),정창욱 ( Chang Wook Jung ),조대현 ( Dae Hyeon Cho ),유길종 ( Kil Jong Yu ),심상군 ( Sang Goon Shim ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.1
Mesenteric venous thrombosis is a clinically very rare disease, and may cause bowel infarction and gangrene. Difficulty in the dignosis the disease due to its non-specific symptoms and low prevalence can cause a clinically fatal situation. Mesenteric venous thrombosis may be caused by both congenital and acquired factors, and protein C deficiency, which is a very rare genetic disorder, is one of many causes of mesenteric thrombosis. The authors experienced a case of mesenteric venous thrombosis caused by protein C deficiency in a patient with duodenal ulcer bleeding, so here we report a case together with literature review. (Korean J Gastroenterol 2011;57:34-37)