Short-, middle-, and long-term exposure of ambient air pollution is associated with blood levels of inflammation and coagulation-related biomarkers

Ji Hyun Kim(김지현),Hae Dong Woo(우해동),Sunho Choi(최선호),Dae Sub Song(송대섭),Jung Hyun Lee(이정현),Sung Soo Kim(김성수),Hyun-Young Park(박현영) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5

Ambient air pollution has been linked to multiple chronic diseases, and inflammatory responses and coagulation impairments were suggested as the underlying mechanism. We investigated the effects of short-, middle-, and long-term exposure to ambient air pollution on the markers of inflammation and coagulation using data from 56,643 participants in the Korean Genome and Epidemiology Study- Health Examinees Study between 2012-2017. Community Multiscale Air Quality system with surface data assimilation estimated exposures of criteria air pollutants for participants based on geo-coded residential addresses. Exposure time periods were categorized as short-term: day of visit and up to 7 days prior; middle-term: 1 and 3 months prior; and long-term: 6 months and 1 and 2 years prior for the average concentrations of PM10, PM2.5, SO2, NO2, CO, and O3. Multivariable linear regression models were applied to estimate the percent changes in high-sensitivity C-reactive protein (hs-CRP), white blood cells, fibrinogen, and platelets per interquartile-range increment for air pollutants. The strongest positive associations were observed between hs-CRP and 1-year PM10 (4.4% [95% CI: 3.2%, 5.7%]); white blood cells and 1-year NO2 (1.6% [95% CI: 1.3%, 2.0%]); and fibrinogen and 1-year PM10 (0.7% [95% CI: 0.5%, 0.9%]). The direction of associations of pollutants with markers remained similar across exposure windows, with a pattern of stronger effect estimate for longer terms. Our findings indicated that exposure to air pollution may play a role in the inflammation and coagulation process.

카드뮴 반응용량 곡선에서의 기준용량 평가를 위한 베이지안 분석연구

이민제,최태련,김정선,우해동,Lee, Minjea,Choi, Taeryon,Kim, Jeongseon,Woo, Hae Dong 한국통계학회 2013 응용통계연구 Vol.26 No.3

본 논문에서는 카드뮴의 반응-용량 모형에 대한 베이지안 분석을 실시하고 기준용량에 대한 추정값들을 유도하고 비교한다. 이를 위하여 독성물질에 대한 용량반응곡선에서 많이 활용되는 두 가지 모형을 사용하고, 카드뮴의 독성연구에 관련한 기존의 문헌으로 수집된 자료에 대한 성별, 연령, 인종, study code 등과 같은 소집단 간의 개별적 형질을 반영할 수 있는 베이지안 메타분석 관점에서의 모형분석을 실시한다. 이러한 두 가지 모형에 대한 베이지안 분석을 위하여 WinBUGS를 이용한 마르코프 연쇄 몬테칼로(Markov chain Monte Carlo; MCMC) 방법을 통하여 모수를 추정하고 이에 따른 다양한 기준용량들을 계산하고 비교해보았다. 베이지안 모형 적합뿐만 아니라 편차정보기준을 통해서 주어진 자료를 더 잘 설명하는 모형을 선택하는 베이지안 모형 선택을 고려하였고, 이를 실제 자료에 적용해본다. In this paper, we consider a Bayesian analysis of the dose-effect relationship of cadmium to evaluate a benchmark dose(BMD). For this purpose, two dose-response curves commonly used in the toxicity study are fitted based on Bayesian methods to the data collected from the scientific literature on cadmium toxicity. Specifically, Bayesian meta-analysis and hierarchical modeling build an overall dose-effect relationship that use a piecewise linear model and Hill model, where the inter-study heterogeneity and inter-individual variability of dose and effect such as gender, age and ethnicity are accounted. Estimation of the unknown parameters is made by using a Markov chain Monte Carlo algorithm based user-friendly software WinBUGS. Benchmark dose estimates are evaluated for various cut-offs and compared with different tested subpopulations with with gender, age and ethnicity based on these two Bayesian hierarchical models.

성별에 따른 본태성 고혈압의 유전학적 고찰

최준열(Jun Yeol Choi),우해동(Hae Dong Woo),김양지(Yang Jee Kim),우미옥(Mi Ok Woo),정해원(Hai Won Chung) 서울대학교 보건환경연구소 2006 보건학논집 Vol.43 No.1

볼에서의 체간운동이 뇌성마비아동의 앉은 자세 조절에 미치는 영향

노은민(Noh Eun-Min),허진강(Hur Jin-Gang),우해동(Woo Hae-Dong),고주연(Ko Joo-Yeon),이주상(Lee Ju-Sang),우지혜(Woo Ji-Hea) 대한치료과학회 2012 대한치료과학회지 Vol.4 No.2

Objective: This study examined how trunk exercise on the ball and trunk exercise on the mat influence the sitting postural control in children with cerebral palsy. Method: This study divided 24 children with cerebral palsy, who received pediatric physical therapy at Hospital C located in Gyeonggi-do from June to September, 2012, into each group of 12 children and applied ball trunk exercise and mat trunk exercise to the two groups respectively for a six-week period with two times each week and 30 minutes each time. In order to identify their sitting postural control function, the K-GMFM (Korean version of Gross Motor Function Measure), AIMS (Alberta Infant Motor Scale), and SEMG (Surface Electromyography) were measured before and after the training. Result: In comparing within each group, the two groups exhibited statistically significant differences (p<.05) before and after the training in all the measurements of K-GMFM, AIMS, and SEMG. When the two groups were compared, the AIMS showed no statistically significant differences. However, in the K-GMFM and the right-side abdominal muscles in the SEMG, the two groups revealed statistically significant differences (p<.05). Conclusion: Ball trunk exercise and mat trunk exercise were both effective training methods for the sitting postural control in children with cerebral palsy. However, ball trunk exercise was found to be a more effective method.

간격효과 적용이 지적장애 아동의 인지능력에 미치는 영향

이지은(Lee Ji-Eun),고주연(Ko Joo-Yeon),우해동(Woo Hae-Dong),김희수(Kim Hee-Soo),이주상(Lee Ju-Sang),우지혜(Woo Ji-Hea) 대한치료과학회 2012 대한치료과학회지 Vol.4 No.2

Objective: The objective of this study was to examine the effects of concentrative and spacing repetitions on language, number, and temporal memory of mentally retarded children. Method: Forty children with mental retardation who received occupational therapy at J hospital and H center located in Seoul from June to September 2012 were equally divided into a concentrative repetition training group and a spacing repetition training group. In order to look at their cognitive function, verbal memory, number memory, and temporal-spatial memory, Lowenstein occupational therapy cognition assessment (LOTCA), Hopkins verbal learning test (HVLT), digit span test (DST), and Rey-Osterrich complex figure test (ROCF), respectively, were conducted prior to and after the experiment. Results: In comparison within each group, there was significant difference between prior to and after LOTCA in both group (p<.05) and there was no significant difference between prior to and after temporal-spatial memory evaluation in both groups. In comparison between the two groups, there was significant improvement in the spacing training group in delayed recall among HVLT and backward memorizing among DST relative to the concentrative training group (p<.05). Conclusion: Spacing training is more effective than concentrative training as an efficient training method for the improvement of memory in mentally retarded children.

운동손상아동의 하지 근력훈련이 대동작 기능과 보행의 시공간적 변수에 미치는 영향

홍명희(Hong Myung-Hee),허진강(Hur Jin-Gang),우해동(Woo Hae-Dong),고주연(Ko Joo-Yeon),유영열(You Young-Youl),정신호(Chung Sin-Ho) 대한치료과학회 2012 대한치료과학회지 Vol.4 No.2

Objective: The purpose of the present study was to examine the effects of lower extremity muscle force training and general physical therapy training on the spatiotemporal variables of the gross motor functions and gaits of children with motor impairment. Method: Twenty-four children with motor impairment were divided into an experimental group of 12 children and a control group of 12 children. To examine the children's gross motor functions and ambulatory abilities, the gross motor function measure (GMFM), the pediatric evaluation of disability inventory (PEDI), and the gait analysis (GaitRite) were administered before and after the experiment. Result: After the intervention, greater improvement was seen in the GMFM scores in lower extremity muscle force training group than in the general physical therapy training group(p<.05). Conclusion: For children with motor impairment, lower extremity muscle force training is more effective in improving spatiotemporal variables of gross motor function than general physical therapy training.