젊은 성인에서 신체 불만족과 성격 특성 및 스트레스와의 관계

김재헌,김정란,왕성근,지익성,Kim, Jae-Heon,Kim, Jeong-Lan,Wang, Seong-Keun,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : The aims of this study was to evaluate relationship between body dissatisfaction, personality characteristic, and stress in young adults. Methods : One hundred and ninety five young, healthy, and normal participants filled out all 3 types of self-reported questionnaire, the Body Dysmorphic Disorder Examination-Self Report (Korean version of BDDE-SR ; K-BDDE-SR), Neuroticism, Extraversion, Openness-Five Factor Inventory (NEO-FFI) and Stress Scale of Korean version of the Depression Anxiety Stress Scale (K-DASS-21). Results : Out of the 195 participants, 30% (n=59) was male and 70% (n=136) was female. There was no statistical difference between high K-BDDE-SR group (K-BDDE-SR score 75 percentile or higher, n=50) and low K-BDDE-SR group (K-BDDE-SR score below than 75 percentile, n=145) in terms of weight, height, and BMI. In high K-BDDE-SR group, neuroticism was significantly higher than low K-BDDE-SR group, and extraversion, agreeableness, conscientiousness were significantly lower than low K-BDDE-SR group. Also, level of stress in high K-BDDE-SR group was significantly higher than low K-BDDE-SR group. Conclusion : Our study revealed that individual's with more body dissatisfaction were more neurotic and stressful. Thus, body dissatisfaction and diverse psychiatric diseases should be considered in treating neurotic and stressful young adults.

젊은 성인에서 대인관계문제 및 신체불만족이 자살사고에 미치는 영향

이재민,김정란,왕성근,지익성,Lee, Jae-Min,Kim, Jeong-Lan,Wang, Seong-Keun,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : The aim of this study was to investigate the relationship between interpersonal problems, body dissatisfaction, and suicidal idea. Methods : Two hundred ninety-four participants filled out the self-reporting questionnaires : Body dissatisfaction was measured with Body Dysmorphic Disorder Examination-Self Report (BDDE-SR) ; Interpersonal problems was measured with Korean Inventory of Interpersonal Problem (KIIP) ; Suicidal Ideation Questionnaire (SIQ) was used to assess suicidal idea. A path analysis was conducted to identify the impact of interpersonal problems and body dissatisfaction on the suicidal ideas. Results : 'Socially inhibited (KIIP_C4)', 'overly-accommodating (KIIP_C6)', age, and gender had a direct effect on their body dissatisfaction, and those factors had a indirect effect on the suicidal ideas. Also, 'cold (KIIP_C3)' and body dissatisfaction had a direct effect on the suicidal ideas. Conclusions : These findings can help to identify how interpersonal problems and body dissatisfaction influence the suicidal ideas of people. It would be useful to consider and assess suicidal ideas in the patients with 'cold (KIIP_C3)', 'socially inhibited (KIIP_C4)', 'overly-accommodating (KIIP_C6)'.

한국인 조현병 환자와 도파민 D2 수용체 유전자 다형성과의 관련연구

김태성,차승민,왕성근,김정란,이영호,최혜인,지익성,Kim, Tae-Sung,Cha, Seung-Min,Wang, Seong-Keun,Kim, Jeong-Lan,Lee, Young-Ho,Choi, Hye-In,Chee, Ik-Seung 대한생물정신의학회 2012 생물정신의학 Vol.19 No.1

Objectives : This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. Methods : TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. Results : There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. Conclusions : These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.

청소년 물질 남용, 의존 환자에서 세로토닌수송단백질 유전자의 다형성

이선우(Sun-Woo Lee),왕성근(Seong-Keun Wang),신윤오(Yun-O Shin),지익성(Ik-Seong Chee),이영호(Yoeng-Ho Lee),이현정(Hyun-Jung Lee),조정혜(Jung-Hye Jo),김준호(Jun-Ho Kim),서홍석(Hongseok Seo) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.1

목적 : 최근 청소년에서 약물 남용 문제가 늘어나고 그 시작하는 연령이 어려지고 심각도에서 지속적으로 심해지는 실정이다. 특히 청소년의 경우에는 인격형성 및 신체적 성장 단계에 있기 때문에 이러한 예민한 시기에 막대한 악영향을 미치게 되는 것이다. 약물 남용으로 인하여 신체적 및 정신적 약물의존 상태 뿐만 아니라 약물 중독에 이르게 되어 이러한 정도가 심해지면 환각, 망상과 같은 정신병적 증상에서부터 각 약물의 금단 및 중독 증상을 일으켜 건강에 심각한 해를 끼칠 수 있으며, 건전한 가치관의 발달에도 영향을 미처 인성 발달에 지장을 초래하게 될 것이다. 이에, 연구자는 최근 우리사회에서 문제가 되는 청소년 약물환자에 초점을 맞추어 기존에 많이 연구되어진 사회심리학적 연구 및 실태 연구보다 근원적인 원인을 알아보기 위하여, 기존의 알코올리즘 및 니코틴 중독 환자에서 보고된 기능적 세로토닌 운반체 유전자의 연관성을 청소년 약물 남용 환자에서 알아보기 위하여 본 연구를 시행하였다. 방법 : 국립감호정신병원에 입원한 물질남용이나 물질의존으로 진단 받은 55명의 청소년 환자와 62명의 정상 대조군을 대상으로 하였다. 기능적 세로토닌 운반체 유전자형을 판별하기 위해 중합효소 연쇄반응과 제한효소 및 전기영동을 시행하여, 유전자형 및 대립유전자의 분포를 비교하였다. 또한 환자군은 가족력의 유무, 사용한 약물 횟수, 약물 사용의 빈도, 범죄 동반유무 등과 같이 다양한 임상 변수에 따라 두 군으로 나누어 비교하였다. 결과 : 환자군과 정상대조군 사이의 유전자형(χ²=3.915, df=2, p=0.041)에서는 차이는 없었으나, 대립유전자(χ²=3.966, df=1, p=0.046) 빈도에는 통계적으로 유의미한 연관성을 보이고 있었다. 환자군에서 흡연하는 아집단에서는 흡연하지 않은 아집단에 비해 SS 유전자형 분포가 통계적으로 의미 있게 높았으며(χ²=8.615, df=2, p=0.017), S 대립유전자 빈도가 통계적으로 의미 있게 높았다(χ²=9.92, df=1, p=0.002). 또한 물질에 대한 금단증상이 있었던 아집단이 금단 증상이 없었던 아집단보다 S 대립유전자가 통계적으로 의미 있게 높았다(χ²=3.929, df=1, p=0.047). 결론 : 본 연구의 결과 환자군과 정상대조군 사이에 기능적 세로토닌 운반체의 대립유전자 분포에서 유의한 차이를 발견하였다. 이는 기능적 세로토닌 운반체 유전자의 다형성이 한국인 청소년 물질 남용 발병에 유의한 영향을 끼칠 수 있음을 추정할 수 있다. 또한 S 대립 유전자와 흡연, 금단증상과의 연관성은 세로토닌 운반체 유전자의 다형성이 물질 남용의 아형 내지는 증상발현에도 부분적인 영향을 끼칠 수 있음을 예상케 한다. 따라서 추가 대상자 확보와 함께 향후 후속 연구가 필요할 것으로 사료된다. Objectives : This study was carried out to explore the relationship between adolescents diagnosed with either substance abuse or dependence and a polymorphism of the promoter region of the 5-HTT gene(5-HTTLPR). Methods : We compared the genotype distributions and allele frequencies of the serotonin transporter gene polymorphism in 55 adolescents diagnosed with either substance abuse or dependence and 62 normal subjects. In addition, further studies were conducted on the substance abuse or dependence group, in order to investigate the association between serotonin transporter gene polymorphisms and various clinical factors, including the age of onset, the number of criminal events, the use of alcohol, the history of smoking, the type of substance use disorder, level of education and family history of substance use. Results : We found significant differences in the allele frequency(χ²=3.966, df=1, p=0.046) between patients and controls. When the genotype distribution and allele frequency of the serotonin transporter gene were compared in the patients according to the clinical variance, the distribution of the SS genotype(χ²=8.615, df=2, p=0.017) and S allele(χ²=9.92, df=1, p=0.002) were significantly higher in those patients with smoking than without smoking. And the distribution of S allele(χ²=3.929, df=1, p=0.047) were also significantly higher in those patients with withdrawal symptom than without withdrawal symptom. Conclusion : These results suggest that the 5-HTTLPR polymorphism seems to have a potential role as the genetic factor of substance abuse or dependence in adolescent. Further systematic researches including varying variables of phenotype would be required.

수면 박탈에 의한 인지기능 장애에 대한 카페인의 효과

김형섭(Hyung-Seob Kim),왕성근(Seong-Keun Wang) 대한생물치료정신의학회 2005 생물치료정신의학 Vol.11 No.1

목적: 본 연구는 수면 박탈로 유발되는 인지기능저하에 대한 카페인의 효과를 알아보고자 하였다. 방법: 이를 위해 18명의 피검자를 대상으로 다음 상황에서 검사를 시행하였다 ; 평상시와 같은 충분한 수면, 완전 수면 박탈, 완전 수면 박탈 후 카페인 150㎎ 투여, 완전 수면 박탈 후 카페인 300㎎ 투여. 결과: 하룻밤의 완전 수면 박탈 시행 후 정상 수면일과 비교하여, 피검자들의 주관적 주간 졸음과 객관적 주간 졸음정도는 모두 심해졌다. 경계력은 경하게 저하되었으나, 지속적 주의력과 단기 기억력은 유의한 변화가 없었다. 하룻밤의 완전 수면 박탈 후 카페인 150㎎ 투여 시에는, 주관적인 주간 졸음을 유의하게 개선시키지만 정상 수면을 취한 날 수준으로는 개선시키지 못하였고, 객관적인 주간 졸음정도는 정상 수면을 취한 날과 유의한 차이가 없는 수준까지 개선시켰다. 경계력의 저하는 정상 수면을 취한 날과 유의한 차이가 없는 정도까지 개선시킨다. 하룻밤의 완전 수면 박탈 후 카페인 300㎎ 투여 시에는, 주관적인 주간 졸음을 유의하게 개선시켰지만 정상 수면을 취한 정도로까지는 개선시키지 못하였고, 객관적인 주간 졸음정도는 정상 수면을 취한 날과 유의한 차이가 없는 정도까지 개선시켰다. 경계력의 저하는 정상 수면을 취한 날과 유의한 차이가 없는 정도까지 개선시킨다. 결론: 요약하면, 정상 성인에 있어 하룻밤의 완전 수면 박탈 후에는 주간 졸음이 유발되고 경계력은 경하게 저하된다. 지속적 주의력과 단기 기억력의 장애는 없다. 카페인은 이러한 주관적 주간 졸음을 상당 부분 개선시킨다. 특히 입면 잠복기로 측정된 객관적 주간 졸음은 정상 수면을 취한 날과 유의한 차이가 없는 정도까지 개선되었다. 그리고 카페인은 수면 박탈에 의해서 유발된 일부 인지기능 저하를 정상 수면을 취한 날과 유의한 차이가 없는 정도까지 개선시킨다. Objective : The aim of this study is to investigate the effects of caffeine on cognitive dysfunction induced by sleep deprivation. Method : For this, 18 subjects were examined under following conditions ; normal usual sleep, one night sleep deprivation, 150㎎ of caffeine ingestion after one night sleep deprivation, and 300㎎ of caffeine ingestion after one night sleep deprivation. Results : After one night total sleep deprivation, Subjects felt daytime sleepiness compared to baseline. Objective sleepiness was increased. Vigilance was slightly impaired while continuous attention and short term memory showed no significant change. After one night total sleep deprivation and 150㎎ of caffeine ingestion, Impaired daytime sleepiness was improved, but not to the level of baseline. Increased objective sleepiness was improved almost to the level of baseline. Vigilance was improved to the level of baseline. After one night total sleep deprivation and 300㎎ of caffeine ingestion, Impaired daytime sleepiness was improved, but not to the level of baseline. Increased objective sleepiness was improved almost to the level of baseline. Vigilance was improved to the level of baseline. Conclusion : One night total sleep deprivation developed daytime sleepiness, and slightly decreased vigilance, with preserved continuous attention and short-term memory. Caffeine ingestion could significantly improve these subjective daytime sleepiness. Especially for objective sleepiness measured as sleep latency, caffeine could reverse it almost to the level of baseline. And caffeine could improve some impaired cognitive functions, caused by sleep deprivation, to those level of baseline level.

뇌 Single Photon Emission Computer Tomography 영상을 이용한 정신분열병 환자의 초기 증상 차이에 대한 연구

이진구,김성민,서영덕,김기성,왕성근,지익성,김정란,Lee, Jin-Gu,Kim, Seong-Min,Seo, Young-Duk,Kim, Ki-Seong,Wang, Seong-Keun,Chee, Ik-Seung,Kim, Jeong-Lan 대한생물정신의학회 2010 생물정신의학 Vol.17 No.3

Objectives : This study was conducted to compare between hallucination group and delusion group in patient with schizophrenia, using Brain $^{99m}Tc$-ECD PECT. Methods : Among 16 patients with less than 3 schizophrenic episodes, 8 patients whose initial symptom was hallucination were assigned to the hallucination group, and other 8 patients with initial sumptom of delusion were assinged to the hallucination group. All of the patients clinically evaluated using the PANSS and BPRS. Both groups of patients and 8 healthy subjects underwent $^{99m}Tc$-ECD PECT. Results : Score of thinking disturbance subscale of BPRS were significantly lower in the hallucination group than the delusion group. In SPECT analysis, the hallucination group showed significantly increased perfusion in some areas of the right temporal lobe, bilateral limbic lobes and left parietal lobe compared to delusion group. Both group had a reduced rCBF in some areas of the frontal lobe. Conclusion : The hallucniation group, compared with the delusion group, showed significantly increased regional cerebral blood flow in some regions. Therefore, this data suggests that different neural substrates may affect the process of auditory hallucination and delusion.

노년기 정신장애 환자의 기본적 일상생활 기능에 영향을 미치는 우울 및 인지 요인에 대한 예비연구

박한결(Han-Kyul Park),왕성근(Seong-Keun Wang),이종범(Jong-Bum Lee),김진성(Jin-Sung Kim),배대석(Dai-Seok Bai),구본훈(Bon-Hoon Koo) 대한생물치료정신의학회 2010 생물치료정신의학 Vol.16 No.1

노년기 정신장애 환자들의 우울증상과 인지기능장애의 특성이 일상생활 기능에 미치는 영향을 알아보고자 114명을 대상으로 노인 우울증 집단, 알쯔하이머형 치매 집단, 신경증적 장애 집단으로 구분하여 서울신경심리검사를 시행한 결과 다음과 같은 결론을 얻었다. 일상생활 기능에 영향을 미치는 우울증상과 인지기능 장애의 구체적 요인을 살펴보면, 노인 우울증 집단에서는 인지기능 요인보다는 우울증상 요인, 특히 초조감이 일상생활 기능에 영향을 미치는 것으로 나타났다. 알쯔하이머형 치매 집단의 경우 일상생활 기능에 영향을 미치는 인지기능 요인은 전두엽/실행기능과 연관된 범주 또는 의미 유창성이었고, 우울증상 요인은 사회적 철수 경향과 불행감이었다. 신경증적 장애 집단은 결혼 상태와 질환의 이환기간, 그리고 우울증상 중 초조감이 일상생활 기능에 영향을 주는 것으로 나타났다. 따라서 노인성 정신장애 환자에서 우울증상과 인지기능장애가 일상생활에 영향을 미치는 정도나 특정요인은 각 질환마다 다양하며 이에 따른 개입방법 및 향후 대책이 필요할 것으로 생각된다. Objectives:The purpose of this study is to investigate specific factors of depression and cognitive dysfunction that affect on basic activities of daily living among psychiatric disorders in elderly patients. Methods:Groups with geriatric depression, Alzheimer’s disease and neurotic disorders in elderly patients were selected, and were performed Seoul Neuropsychological Screening Battery(SNSB). Results:In group with geriatric depression, agitation can affect on activities of daily living rather than factors of cognitive dysfunction. Factor of cognitive dysfunction that affect on activities of daily living in group with Alzheime'r’s disease is category/semantic fluency relation to frontal/executive function, and factors of depression that affect on activities of daily living in group with Alzheimer’s disease are social withdrawal tendency and feeling of unhappiness. And, factor that affect on activities of daily living in group with neurotic disorders in elderly patients is agitation rather than factors of cognitive dysfunction. Conclusion:The degrees and specific factors of depression and cognitive dysfunction that affect on basic activities of daily living among psychiatric disorders in elderly patients are variable in each specific illness. Clinicians should consider these kind of specific factors in the treatment of elderly patients.

정신과 외래 우울증 환자에서 분노 경험

안병훈(Byung-Hoon Ahn),지익성(Ik-Seung Chee),왕성근(Seong-Keun Wang),홍주봉(Joo-Bong Hong),박권수(Kwon-Soo Park),김영란(Young-Lan Kim),김정란(Jeong-Lan Kim) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.2

Objectives: This study was conducted to evaluate the degree and type of anger experienced by patients with depressive disorders and to determine which type of anger is correlated with symptom severity. Methods: One hundred-six psychiatric outpatients with depressive disorders and ninety normal control subjects completed the Korean version of Aggression Questionnaire(AQ) and Korean version of Depression, Anxiety, and Stress Scale (DASS). Comparison between two groups was conducted to evaluate which type of anger are prominent in the depressed group. Therefore, correlation and partial correlation between the scores of 4 subscales(Anger, Hostility, Verbal aggression, and Physical aggression) of AQ and the scores of 3 subscales(Depression, Anxiety, and Stress) of DASS were assessed. A multiple regression analysis was performed to determine which type of anger predicted symptom severity. Results: Total AQ score, hostility, anger and physical aggression scores were significantly higher in patients with depressive disorders. After the score of Stress and Anxiety subscale of DASS were controlled; the depression score was significantly correlated with total AQ score, physical aggression and hostility score. The Hostility score was a major predictor of the depressive symptom severity. In addition, the Anger score was a major predictor of the anxiety and stress symptom severity. Conclusion: Anger is frequently found symptom in patients with depressive disorders. Therefore, it is important that clinicians routinely evaluate the degree and type of anger in patients with depressive disorders.

후기 발생 조증 환자의 정신병리와 임상적 특징

김드레(Dre Kim),이미지(Miji Lee),안소현(Sohyun Ahn),왕성근(Seong Keun Wang),신윤오(Yun O Shin),지익성(Ik-Seung Chee),이선우(Sun Woo Lee),김정란(Jeong Lan Kim) 대한생물치료정신의학회 2015 생물치료정신의학 Vol.21 No.1

한국판 분노반응검사의 표준화 연구

조영우(Young-Woo Cho),김정란(Jeong-Lan Kim),김수영(Soo-Young Kim),왕성근(Seong-Keun Wang),지익성(Ik-Seung Chee) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.2

Objectives: The purpose of this study was to standardize the Korean version of the Reaction Inventory(K-RI) for measuring an individual's propensity for anger arousal. Methods: After translating the Reaction Inventory into the K-RI, the K-RI, Korean version of the Aggression Questionnaire(K-AQ), and Korean version of the Depression Anxiety Stress Scale-21(K-DASS-21) were administered to 424 Korean medical college students. The re-test was conducted with a 2-week interval of 119 students. Results: 1) The internal consistency of K-RI was 0.96(Cronbach's α, p<0.01). The test-retest reliability of K-RI was 0.68(Pearson's correlation coefficiency, p<0.01). Convergent validity was examined by Pearson's correlation coefficient between K-RI and K-AQ, which was 0.48 (p<0.001). 2) Four factors from K-RI were extracted by factor analysis with Varimax Rotation. The factors of K-RI were "Unpredictable disruptions and disturbances factor", "Embarrassing circumstances factor", "Personal disrespect factor", and "Unpleasant encounters factor". Conclusion: These results indicate that the Korean version of Reaction Inventory is a reliable and valid instrument to assess anger reaction.