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절제불가능한 간세포암에서 간동맥화학색전술 치료반응 예측에 인터루킨17과 C-반응성 단백질 발현의 연관성
송명준 ( Myeong Jun Song ),이승원 ( Sung Won Lee ),오은지 ( Eun-jee Oh ),장보현 ( Bohyun Jang ),장정원 ( Jeong Won Jang ),배시현 ( Si Hyun Bae ),최종영 ( Jong Young Choi ),윤승규 ( Seung Kew Yoon ) 대한간암학회 2016 대한간암학회지 Vol.16 No.2
Background/Aims: Transarterial chemoembolization (TACE) is the standard locoregional treatment in patients with unresectable hepatocellular carcinoma (HCC). Angiogenesis and inflammation play important roles in tumor growth in HCC. In this study, we evaluated the associations between the levels of growth factors and inflammatory markers and clinical prognosis in patients with unresectable HCC treated with TACE. Methods: The clinical outcomes of 58 HCC patients treated with TACE at the Catholic Medical Centers from January, 2012 to February 2015 were evaluated. Baseline levels of the growth factors vascular endothelial growth factor, fibroblast growth factor, platelet-derived growth factor, and hepatocyte growth factor and the inflammatory cytokines interleukin (IL)-17 and high sensitivity C-reactive protein (hs-CRP) were compared with the treatment outcomes. The primary endpoint was time to progression (TTP); the secondary endpoint was overall survival (OS). Results: During the 20.8 months of follow-up, TTP was significantly delayed in patients with low levels of hs-CRP (≤0.15) and IL-17 (≤0.94) and a maximal tumor diameter ≤5 cm (P =0.010, P =0.015, and 0.048, respectively). Patients with HCC with low hs-CRP and IL-17 levels had a longer survival than that of those with high hs-CRP levels and IL-17 (35.1 vs. 22.5 months, P =0.000; 41 vs. 21.8 months, P =0.000, respectively). However, any baseline growth factors were not significantly correlated with TTP and OS. Conclusions: Elevated IL-17 and hs-CRP may be predictive of a poor outcome in patients with HCC treated with TACE. A better understanding of this relationship will require further investigation of the immune mechanisms underlying tumor progression. (J Liver Cancer 2016;16:108-117)
한국인에서 만성소화장애증 선별검사인 조직 트랜스글루타미나제 항체 검사의 임상적 가치
박재명 ( Jae Myung Park ),최명규 ( Myung Gyu Choi ),백창렬 ( Chang Nyol Paik ),오정환 ( Jung Hwan Oh ),조유경 ( Yu Kyung Cho ),이인석 ( In Seok Lee ),김상우 ( Sang Woo Kim ),정인식 ( In Sik Chung ),오은지 ( Eun Jee Oh ),박연준 ( Y 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.1
목적: 만성소화장애증의 증상은 과민성장증후군과 유사하여, 서양에서는 과민성장증후군 진단과정 중에 만성소화장애증의 배제가 권고되고 있다. 본 연구의 목적은 한국인 기능성 위장관 장애의 진료에서 만성소화장애증 선별검사의 의의를 알아보는 것이다. 대상 및 방법: 소화기내과를 방문한 총 694명의 연속적으로 수집된 환자를 대상으로 하였다. 만성소화장애증 선별검사법은 민감도와 특이도가 높은 조직 트랜스글루타미나제 항체 검사법을 사용하였다. 결과: 환자의 나이는 58세(16세-96세), 남자는 388명이었다. 기능성 위장관 장애는 128명이었고, 기질적 장질환 환자는 모두 566명이었다. 조직 트랜스글루타미나제 항체 양성으로 나온 환자는 총 6명(양성율 0.86%)이었으며, 기능성 소화불량증, 크론병, 식도궤양, 간암, 감염성 대장염, 담낭염 환자였다. 항체 양성 환자들은 만성소화장애증을 의심할 만한 증상, 검사실 및 내시경 소견이 없어서 위양성으로 판독하였다. 만성소화장애증의 진단기준을 충족하는 환자 1예는 조직 트랜스글루타미나제 항체 음성이어서 위음성으로 판독하였다. 조직 트랜스글루타미나제 항체 검사의 특이도는 99.1%로 매우 높았다. 과민상장증후군 환자 49명 모두 조직 트랜스글루타미나제 항체 음성이었다. 결론: 한국에서는 기능성 위장관 장애의 진단적 접근 방식으로 만성소화장애증의 혈청학적 선별 검사법은 의의가 매우 낮을 것으로 생각된다. Background/Aims: Screening for celiac disease is recommended as part of the evaluation for irritable bowel syndrome in the Western countries due to the similarities in symptoms in the two diseases. The aim of this study was to investigate whether screening for celiac disease would be important in patients with functional gastrointestinal (GI) disorders in Korea. Methods: A total of 694 patients, who visited the GI clinic, were enrolled consecutively. Screening was performed by human recombinant anti-tissue transglutaminase (anti-tTG) IgA ELISA assay. Results: 128 patients with functional GI disorders, who met the Rome II criteria, and 566 patients with organic GI disorders were subjected to this evaluation. Anti-tTG was positive in six patients (0.86%). None of the six patients met the diagnostic criteria for celiac disease, and the antibody positive results were regarded as false positive results. The final diagnoses for these six patients were: functional dyspepsia, Crohn`s disease, esophageal ulcer, hepatocellular carcinoma, infectious colitis and cholecystitis One patient fulfilled the diagnostic criteria of celiac disease; however, the antibody test was negative in this patient. The specificity of anti-tTG was 99.1%. The antibody tests for all patients with functional colonic disorders were negative. Conclusions: Screening for celiac disease did not add any benefit to the evaluation of Korean patients with the functional GI disorders. (Kor J Neurogastroenterol Motil 2006;12:35-40)
배시현 ( Si Hyun Bae ),장정원 ( Jeong Won Jang ),김민수 ( Min Soo Kim ),오현종 ( Hyun Jong Oh ),최종영 ( Jong Young Choi ),한남익 ( Nam Ik Han ),윤승규 ( Seung Kew Yoon ),한준열 ( Joon Yeol Han ),오은지 ( Eun Jee Oh ),김동구 ( Don 대한소화기학회 2005 대한소화기학회지 Vol.45 No.5
Liver transplantation is the only curative therapy for patients with end-stage liver disease. The high success rate and the increasing demand for the transplantation sometimes calls for ABO-compatible but nonidentical blood group orthotopic liver transpla
Teicoplanin 내성 staphylococci의 출현
박연준,오은지,강문원,김병기,김선무,심상인 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1
최근 Teicoplanin에 내성을 보이는 coagulasenegative staphylococci(CNS)가 전체 CNS의 1.44%인 높은 비율로 분리되었으므로 보고하는 바이다. Over a period of 6 months, We have recovered 7 clinical isolates of coagulase-negative staphylococci (CNS) exhibiting either decreased levels of susceptibility or true resistance to teicopalnin [Minimal Inhibitory concentrations(MICs), 16 to 128㎍/㎖] ; these isolates make up 1.44% of the total CNS isolated by our hospital. All of the strains were also methicillin resistant but all were susceptible to vancomycin. All strains were nosocomially acquired but occurred sporadically. We briefly reviewed clinical findings of seven patients. We should do surveillence of staphylococci to determine resistance to glycopeptides.