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RISS 인기검색어
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- 저자 : 오용호(Yong Ho Aoh) (검색결과 3 건)
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김창엽(Chang Yup Kim),이무상(Moo Sang Lee),김광문(Kwang Moon Kim),유세화(Se Hwa Yoo),오용호(Yong Ho Aoh),이종구(Jong Gu Lee) 한국의학교육학회 1995 Korean journal of medical education Vol.7 No.1
The medical specialty system of Korea, as those of many developed countries, is faced with challenges of efficiency and quality as more and more physicians are involved in. For improvement and reform of the system, various proposals have appeared without any definitive conclusion since late 1980s. Initiated by the health reform proposal of the Korean government, however, medical specialty system has been focused again as a target for reform. For this reform to be promoted, as in other health policies, most related professions have to be included into a supportive group. Before proceeding to policy issues in details, therefore, it seems necessary that opinions of physicians on some issues should be analyzed. For this purpose, a survey was conducted with randomly sampled members of the Korean Medical Association (KMA), for a month in 1994. Structured questionnaire were mailed to sampled physicians and answers were returned. The total number of respondents was 614 among 2,000 subjects. To summarize responses, major findings were as follows; 1) The number of specialty would be increased and introduction of sub-specialty system would be inevitable. 2) In stead of the government, voluntary organizations such as KMA or academic societies should be in charge of operation of medical specialty system. 3) The existing system of rotating internship program has to be maintained. 4) Over-production of specialists have to be repressed with expansion of training programs for primary care physicians. For designing of new system, above mentioned opinions should be seriously considered as a basis of development of sound medical specialty system in Korea.
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주문맥침범이나 원격전이가 있는 간세포암 환자에서 Cisplatin 간동맥투여 및 전신적 알파인터페론 병합요법의 효과
송일한(Il Han Song),정영화(Young Hwa Chung),고문수(Moon Soo Koh),이영상(Yung Sang Lee),이문규(Mun Gyu Lee),성규보(Kyu Bo Sung),오용호(Yong Ho Aoh),서동진(Dong Jin Suh) 대한내과학회 1996 대한내과학회지 Vol.50 No.5
N/A Objectives: Hepatocellular cearcinoma(HCC) patients presenting with vascular involvement or extrahepatic metastasis are usually contraindicated to surgery or chemoebolization, and median survival of those has been reported to be only a few weeks. Recent several studies suggested that certain chemotherapeutic agent or recombinant interferonalpha(rIFN-α) may be useful in a proportion of patients with inoperable HCC. Methods: To evaluate the effect of intraarterial cisplatin infusion and systemic rlFN-α in the treatment of HCC, 68 HCC patients with major portal vein thrombosis or distant metastasis were randomized to three groups: group A(n=19) treated with cisplatin and rIFN-α, group B(n-23) with cisplatin and group C(n=26) with supportive care only. Cisplatin of 2mg/kg body weight was infused transarterially every 8weeks and rIFN-α of 3×10(6) IU/m2 Bady Surface area was administered subcutaneously three times per week. Patients with severe hepatic decompensation(serum bilirubin>3.0 mg/dL, albumin<3.0g/L, prothrombin time<60%), hypersplenism(peripoheral WBC count <3,000/mm3, platelet count<40,000/mm3), uncontrolled ascites, active gastrointerstinal bleeding, cardiac or renal dysfunction were excluded in this study. The effects of therapy were assessed by the changes of tumor size and durations of survival. Results: The partial response rate assessed by the change of tumor size in group A was significantly higher than that in group B(33 vs 14%: p<0.05). 1 year survival rate of group A (27%) was also significantly higher than that of group B (9%) or C (0%) (p<0.05, p<0.01, respectively). Furthermore, median survival period of group A (19weeks) was significantly longer than that of group B(11weeks) or C(5weeks) (p<0.05, p<0.01, resectively). Side effects of combined therapy were flu-like symptoms, gastrointestinal upset, transient elevation of serum creatinine or ALT level, leukopenia, thrombocytopenia, and oral ulcer. However, these were transient and well tolerated by all of the patients. Conclusion. These data suggest that combined therapy of intraarterial cisplatin infusion and systemic rIFN-α administration may be useful in the treatment of HCC patients with major portal vein thrombosis or distant metastasis, in terms of tumor response or prolonging survival period.
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간세포암에 대한 화학 색전요법에 있어서 Cisplatin과 Adriamycin의 효과
이정신,정영화,민영일,양석균,성규보,이문규,오용호 대한소화기학회 1992 대한소화기학회지 Vol.24 No.4
A prospective and randomized trial was carried out from June 1989 to December 1991 to evaluate the effects of cisplatin and adriamycin in the chemoembolization therapy for the patients with unresectable hepatocellular carcinoma (HCC). A total of 56 cases became the subjects of this study, including 14 patients with HCC less than 5 cm in diameter, 33 patients 5 to 10 cm, and 9 patients larger than 10 cm. We used cisplatin (Group A), adriamycin (Group B) and both (Group C) in 23, 20 and 13 cases, respectively, to compare the effects of chemotherapeutic agents. The therapeutic effects of chemoembolization were assessed by the changes of tumor size in initial and follow-up computed tomography, serum alpha-fetoprotein level in cases with elevated initial value, and duration of survival. The partial response rates of group A and C were 52% and 54%, respectively, whieh were significantly higher than that of group B (35%). Chemoembolization using cisplatin or cisplatin combined with adriamycin could prolong the 1-year-survival rate (65% and 53%) compared with treatment using adriamycin (26%). But the partial response rate and 1-year-survival rate of group A and C were not different. In conclusion, it was suggested that cisplatin is more effective and significant than adriamycin as a chemotherapeutic agent in the chemoembolization therapy for patients with unresectable HCC.
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