A Retrospective Analysis of Eight Cases of Merkel Cell Carcinoma

오승일,진웅식,장학,권성택,민경원,Oh, Seung Il,Jin, Ung Sik,Chang, Hak,Kwon, Sung Tack,Minn, Kyung Won Korean Cleft Palate-Craniofacial Association 2013 Archives of Craniofacial Surgery Vol.14 No.1

Background: Merkel cell carcinoma (MCC) is a rare locally aggressive cutaneous neuroendocrine carcinoma with a high incidence of local recurrence, regional lymph node metastasis, followed by distant metastasis. Because of shortage of the retrospective study, standard treatment has not been established. The purpose of this study was to present the surgical treatment and outcome of 8 patients with MCC. Methods: We report our experiences with 8 patients who underwent treatment for MCC at our institution from 2000 through 2012. Two men and 6 women received treatment for MCC. The mean age was 76.4 years (range, 53 to 93 years). Results: The follow-up period ranged from 7 to 26 months (mean, 22.9). During the follow-up period, three of 8 patients had a relapse (mean time before recurrence, 10 months; 1 month, 7 months, and 22 months). After primary surgery, 3 patients underwent radiotherapy, and 1 patient received chemotherapy. Conclusion: MCC is an aggressive skin cancer with a high rate of local recurrence. Complete surgical excision is the mainstay of local treatment, but adjuvant radiotherapy should be considered for better local control.

전외측 대퇴부 천공지 피판을 이용한 슬관절부의 연부조직 결손의 재건

오승일,은석찬,백롱민,Oh, Seung Il,Eun, Seok Chan,Baek, Rong Min 대한미세수술학회 2011 Archives of reconstructive microsurgery Vol.20 No.2

Reconstruction of soft tissue defect of knee joint area has been remained a challenging task for plastic surgeons. The earlier the normal tissue saved and the necrotic tissue removed, the less the patients had complications and functional disability. But such defects are difficult to manage for its poor vascularity, rigid tissue distensibility, easy infectability and a relatively long healing period. The goal of flap coverage in the knee joint should not only be satisfactory wound coverage, but also acceptable appearance and minimal donor site morbidity. We have treated five cases using the anterolateral thigh perforator flaps for reconstruction successfully. In conclusion, we believe that in cases of knee joint area soft tissue defects, flaps like anterolateral thigh perforator flap should be considered as the first line of treatment.

측두근의 외상성 골화성 근염

오승일,이윤호,Oh, Seung Il,Lee, Yoon Ho 대한두개안면성형외과학회 2013 Archives of Craniofacial Surgery Vol.14 No.1

Myositis ossificans is a condition characterized by ossification within a muscle. It is a rare and unusual pathologic entity that has defied medical efforts to establish a definite etiology, pathogenesis, and satisfactory treatment of the disease. The condition predominantly affects the flexor muscles of the upper limbs and thighs, but rarely the head and neck area. A 53-year-old male patient visited our medical institution complaining of trismus, defined as limited mouth opening. The patient had a history of trauma to the facial bones and the computed tomography scans revealed calcification in the left temporalis muscle. The patient underwent surgical removal of the calcified mass with bilateral coronoidectomy under general anesthesia. Mouth opening at the end of post-operative 2 months was 28 mm. His oral intake of food was satisfactory. Myositis ossificans of the temporalis muscle is a very rare case. Satisfactory outcome was obtained by combining surgical excision of the affected muscle, coronoidectomy, and detachment of the insertion site of the ossified muscle.

류마티스 관절염 치료시 저용량의 코르티코스테로이드, 비스테로이드성 항염제 사용의 비용-효과 분석

오승일 ( Seung Il Oh ),윤형란 ( Hyung Ran Yun ),배상철 ( Sang Cheol Bae ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.4

Objective: Low dose corticosteroids (steroid) (≤10 mg/day prednisolone) in the treatment of RA is controversial. Although it is effective and possibly disease modifying, concerns exist about potential adverse events (AEs). We reported steroid were dominant compared to nonsteroidal anti-inflammatory drugs (NSAIDs) in terms of cost and effectiveness (Arthrtis Rheum 41:S249, 1998). However, those works were done in the US and the US health care system is different from the Korean. Therefore we assessed costs and health effects of steroid compared with NSAIDs in Korea. Methods: Markov (state-transition) models were used to simulate a cohort of RA patients with 50 years, taking disease modifying anti-rheumatic drugs and either steroid or NSAIDs. The regimens were assumed to be equally effective for the control of RA. Data on incidence and consequences of AEs from steroid and from NSAIDs were taken from the literature. Direct medical costs were measured in 2000 Korean Won; health effects expressed as quality-adjusted life years (QALYs). Sensitivity analyses were performed including best-case scenarios (0.5×AE rate) and worst-case scenarios (1.5×AE rate). Results: In the base-case analysis, the incremental C/E ratio between steroid and NSAIDs was 1,423×103 Won/QALY (1,197 US$/QALY). The sensitivity analyses of AE rate, using best-case and worst-case scenarios showed that the result was sensitive to each combination of AE rate. In contrast, the sensitivity analyses of costs, age and utilities were robust. Using misoprostol or omeprazole prophylaxis with NSAIDs would make steroid dominant. Compared to NSAIDs with cyclooxygenase 2 (COX-2) specific inhibitor, the incremental C/E ratio between COX-2 specific inhibitor and NSAIDs was 139,322×10(3) Won/ QALY (117,274 US$/QALY). Conclusion: Steroid are more cost-effective than NSAIDs in the long-term treatment of RA in Korea.

전신성 홍반성 루푸스 환자에서 대장천공을 유발한 거대세포바이러스 대장염

오승일 ( Seung Il Oh ),이오영 ( Oh Young Lee ),오광택 ( Kwang Taek Oh ),이재형 ( Jae Hyung Lee ),박재홍 ( Jae Hong Park ),엄완식 ( Wan Sik Uhm ),이혜순 ( Hye Soon Lee ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.1

Cytomegalovirus (CMV) infection is a common human viral infection, affecting 40% to 100% of normal adult, especially in the immune compromised patients. CMV infection can produce variable gastrointestinal (GI) diseases in healthy adults, but can cause severe life-threatening illness involving many organs, including lung, retina, central nervous system, liver and GI tract in immunocompromised host. We experienced CMV colitis with colon perforation in a SLE patient during low dose steroid and azathioprine therapy, and she recovered after medical treatment without surgical interventions. A 33-year-old woman was diagnosed as SLE 7 years ago and treated with low dose, immunosuppressive therapy during 6 years. She complained of a severe abdominal pain and hematochezia. She was diagnosed as CMV colitis with colon perforation by pathologic, immunologic and image studies. After medical treatment, such as intravascular ganciclovir, there was progressive medical improvement, but has been a recurrent CMV colitis with lower GI bleeding.

한역본(韓譯本) 『텬로력뎡』 시가(詩歌)의 토착화 번역양상 연구

오승일 ( Oh Seung-il ),오순방 ( Oh Soon-bang ) 중국학연구회 2018 중국학연구 Vol.- No.86

이 논문은 한역본 『텬로력뎡』에 나오는 詩歌 23수를 연구대상으로 하여 『텬로력뎡』에 나타난 번역양상과 번역 특성을 집중적으로 고찰하고자 한다. 한역본 『텬로력뎡』에 나오는 23수의 詩歌는 영어원작에 나오는 詩歌 20수 중에 18수가 번역되었고, 官話譯本 33수와 文言譯本 32수의 시가 중에서 다섯 수가 번역되어 이들이 합쳐져서 이루어진 것이다. 네 가지 텍스트를 비교 분석한 결과, 한역본 『텬로력뎡』에 나오는 詩歌의 배열순서는 영어원작의 시가에 맞추어 번역 배치되었다는 사실을 발견하게 되었다. 뿐만 아니라 韓譯本의 詩歌 23수 중에서 18수가 영어원작의 배열순서와 일치하거나 유사한 것을 알 수 있었는데 이것으로 미루어 볼 때, 韓譯者가 詩歌를 배열할 때 영어원작의 수량과 순서에 입각하여 詩歌를 번역하고 편집하였다는 사실을 알게 되었다. 내용면에 있어서는 영어원작의 내용을 번역한 것이 아니고, 윌리엄 번스의 文言譯本과 官話譯本을 번역한 것도 아니었다. 단지 文言譯本과 官話譯本의 단어와 문장을 차용하여 번역하였다. 이렇게 단어와 문장만을 차용한 이유는 두 가지로 요약된다. 첫째, 역자가 번역의 용이함을 위해서나 혹은 역어환경의 독자들이 쉽게 받아들일 수 있게 하기 위함이었다. 둘째, 한역본 시가는 영어원작의 자유시도 아니고, 中譯本의 漢詩도 아닌 조선 후기에 한국에서 유행하던 時調의 형식을 빌어 한국화 하였는데, 이 시조란 장르는 定型性을 가지고 있기 때문에 형식적 제약이 대체로 강한 편이다. 이러한 시조형식에 맞추기 위해서 韓譯者는 中譯本의 漢字 단어나 문장을 차용하여 번역했던 것이다. 한역자는 시가의 형식을 역어환경의 독자들의 정서에 맞도록 조선 후기에 성행했던 시조의 형식을 취하여 한역본 『텬로력뎡』시가의 한국토착화를 구현해 내었다. 23수의 시가는 정형성을 기준으로 하여 평시조, 엇시조, 사설시조로 나누어지고, 형식에 따라 완전과 불완전 및 미완의 시조로 나누어진다. 23수 시가를 모두 한국적인 시조형식으로 표현해 낸 것은 영어원작과 두 가지 중역본에서는 볼 수 없었던 역자 제임스 스카스 게일의 탁월한 한국화 번역책략을 구현해낸 독창적인 성과라고 하겠다. 本文以韓譯本 『텬로력뎡(天路歷程)』中的23首詩歌爲硏究對象, 考究韓譯本 『텬로력뎡(天路歷程)』的飜譯樣態及飜譯特点。韓譯本 『텬로력뎡(天路歷程)』的23首詩歌是由20首英文原著中的18首及官話譯本33首和文言譯本32首中的5首飜譯合幷而成的。通過比較分析四種文本, 可知韓譯本 『텬로력뎡(天路歷程)』中的詩歌排列順序與英文原著的詩歌編排順序一致, 据此可以推知韓譯本譯者是根据英文原著的詩歌數量及順序飜譯編排而成的。 從內容上看, 韓譯本幷非以英文原著爲底本做的飜譯, 也不完全等同于賓爲霖(William Chalmers Burns)的文言譯本和官話譯本, 僅是借用了文言譯本和官話譯本的部分詞匯或句子飜譯而成。選擇只借用詞匯或句子的理由有二:其一底爲飜譯便利起見或爲使譯語環境讀者更容易理解接受譯文;其二底韓譯本詩歌體裁不同于英文原著的自由體,也不同于中譯本的漢詩體, 而是借用了流行于朝鮮后期的時調體飜譯成的韓國本土化詩歌體。“時調”這一體裁因具備“定型性”特点,故形式上所受限制較爲明顯。爲符合這樣的時調體式, 韓譯本譯者借用中譯本的漢字詞匯或句子進行了飜譯。韓譯本 『텬로력뎡(天路歷程)』的譯者爲使譯出的詩歌符合譯語環境讀者的欣賞情趣, 采用了朝鮮后期盛行的時調體裁, 這充分體現了該譯作中詩歌飜譯的韓國本土化特点。23首詩歌以固定的格律形式爲准, 可分爲“平時調(短型時調)”底“旕時調(中型時調)”底“辭說時調(長型時調)”三種。根据形式的不同又可分爲“完全時調”底“不完全時調”及“未完時調”。23首詩歌全部采用韓國傳統時調體裁飜譯, 其內容及表現形式體現出韓譯者奇一(James Scarth Gale)卓越的韓國本土化飜譯策略。這在英文原著及兩種中譯本中是看不到的,成爲韓譯者的獨創性飜譯成果。

소형경량 $1.5{\mu}m$ 대역 발진용 레이저 매질 및 포화 흡수체의 비교분석

박도현,오승일,배효욱,김대성,Park Do-Hyun,Oh Seung-Il,Bae Hyo-Wook,Kim Dae-Sung 한국군사과학기술학회 2004 한국군사과학기술학회지 Vol.7 No.4

Laser materials for eyesafe wavelength generation and Q-switching crystals for short pulse operation were studied and compared with each other. Er,Yb:phosphate glass as a laser material and $Co^{2+}:MgA1_2O_4$ as a saturable absorber were found to be an effective pair for a compact, light-weight passively Q-switched eyesafe laser operation. Simplified rate equation was used to estimate pulse parameters of the diode-pumped passively Q-switched laser.

류마티스 질환에서의 이차성 아밀로이드증

김태종 ( Tae Jong Kim ),오승일 ( Seung Il Oh ),박준성 ( Joon Sung Park ),김태엽 ( Tae Yeob Kim ),박재홍 ( Jae Hong Park ),엄완식 ( Wan Sik Uhm ),이혜순 ( Hye Soon Lee ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),배상철 ( Sang 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.1

Objective: To study the clinical features and outcomes in 10 cases of secondary amyloidosis with rheumatic disease. Methods: The secondary amyloidosis associated with rheumatic disease was studied clinically in 10 patients (4 men and 6 women), who have suspicious tissue dysfunction. The diagnosis of amyloidosis was established by histological examination of biopsy materials. We evaluated them by medical record review; clinical features at onset, organ involvement, cause of death. Results: The mean age and mean duration of rheumatic disease were 52.9±17.27 years and 10.9±10.33 years respectively. The common initial clinical features were generalized edema, diarrhea and abdominal pain. The mainly involved organs were kidney and colon. Causes of death were DIC due to sepsis and renal failure. Conclusion: Renal and gastrointestinal symptoms are cardinal features of secondary amyloidosis with rheumatic disease in Korea.

COX-2 특이적 억제제와 인지기능에 대한 예비 연구

최연수 ( Yeon Soo Choi ),오승일 ( Seung Il Oh ),이장환 ( Jang Whan Lee ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),정성수 ( Sung Soo Jung ),유대현 ( Dae Hyun Yoo ),배상철 ( Sang Cheol Bae ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.3

Objective: New nonsteroidal anti-inflammatory drugs (NSAIDs) with highly selective cyclooxygenase-2 (COX-2) inhibition afford protection against gastropathy, but their acute and long-term effects on the central nervous system are unclear. Our aim was to investigate the influence of COX-2 specific inhibitor (celecoxib) on cognitive function. Methods: Within the context of a randomized controlled parallel trial of NSAIDs for osteoarthitis (OA), we performed a battery of neuropsychological tests in consecutive 10 osteoarthritis patients with celecoxib (200 mg/day) and 13 osteoarthritis patients with diclofenac (100 mg/day) before and after 4 weeks by clinical psychologists who were not involoved in the study and unaware of study protocols and treatment allocation. The tests were performed randomly in sequence in order to minimize learning effect. The examed cognitive domains included memory, reasoning/problem solving, simple and complex attention, visual-spatial processing, and psychomotor speed. Results: Demographic characteristcs (age, sex, disease duration, functional status measured by patient`s and physician`s global assessment and KWOMAC, CES depression score, education level) were not significantly different between both treatment groups. In all cognitive domains, we did not find out significant cognitive decline before and after treatments either with celecoxib or diclofenac. There was no difference in the change of cognitive function between both treatment groups. Conclusion: The short-term use of COX-2 specific inhibitor as well as conventional NSAID may not impair cognitive function. The long-term follow up study using large number of patients is in progress.

식품 3D-프린팅 기술과 식품 산업적 활용

김종태 ( Chong-tai Kim ),맹진수 ( Jin-soo Maeng ),신원선 ( Weon-son Shin ),심인철 ( In-cheol Shim ),오승일 ( Seung-il Oh ),조영희 ( Young-hee Jo ),김종훈 ( Jong-hoon Kim ),김철진 ( Chul-jin Kim ) 한국산업식품공학회 2017 산업 식품공학 Vol.21 No.1

Foods are becoming more customized and consumers demand food that provides great taste and appearance and that improves health. Food three-dimensional (3D)-printing technology has a great potential to manufacture food products with customized shape, texture, color, flavor, and even nutrition. Food materials for 3D-printing do not rely on the concentration of the manufacturing processes of a product in a single step, but it is associated with the design of food with textures and potentially enhanced nutritional value. The potential uses of food 3D-printing can be forecasted through the three following levels of industry: consumer-produced foods, small-scale food production, and industrial scale food production. Consumer-produced foods would be made in the kitchen, a traditional setting using a nontraditional tool. Small-scale food production would include shops, restaurants, bakeries, and other institutions which produce food for tens to thousands of individuals. Industrial scale production would be for the mass consumer market of hundreds of thousands of consumers. For this reason, food 3D-printing could make an impact on food for personalized nutrition, on-demand food fabrication, food processing technologies, and process design in food industry in the future. This article review on food materials for 3D-printing, rheology control of food, 3D-printing system for food fabrication, 3D-printing based on molecular cuisine, 3D-printing mobile platform for customized food, and future trends in the food market.