국내 농약 제품표지 내용 및 유독성 표시의 적절성

오범진,노형근,김원,조규종,손유동,강희동,임경수,Oh Bum Jin,Roh Hyung-Keun,Kim Won,Cho Gyu Chong,Shon Yoo Dong,Kang Hui Dong,Lim Kyoung Soo 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2

Purpose: The morbidity of pesticides are largely related with accidental ingestion in human. The four principal ideals of clarity, completeness, conformity and consistency of label are important to make a correct usage and prevent unnecessary health risk. The aim of this study is to evaluate the appropriateness of pesticides labelling practice in Korea. Methods: The photographic label images of pesticide products were gathered through visiting thirteen manufacturers that produce pesticide products in Korea. We scored labelling practice by guidelines of Food and Agriculture Organization of the United Nations in 1995. Results: From August 2005 to November 2005, we gathered 1,296 label images of pesticide and $58.3{\%}$ (755/1,296) of images were scored by check lists for reviewing label content. The average score of four check list categories was $71.9{\pm}2.2$. Each categorical score were $91.7{\pm}0.9$ for the information appearing on the label, $31.3{\pm}0.0$ for safety precaution, $77.7{\pm}2.0$ for instructions for use, $87.0{\pm}8.7$ for general configurations. In safety precaution, the sentence of keeping locked up the product and two mandatory safety pictograms were missed in all label images. In general configurations category, there was score difference in product package types between bottle and bag container ($85.1{\pm}9.0$ vs. $90.3{\pm}7.2$, p < 0.01). Conclusion: Although there was no comparable previous data, the score of safety precaution was lowest than other categories because the two mandatory safety pictograms and locked up warning sentence were missed. In general configurations, the colour contrast was more inappropriate in the labels on bottle than bag container.

중독감시체계를 이용한 중독정보 수집 및 분석: 후향적 기초조사

오범진,김원,조규종,강희동,손유동,이재호,임경수,Oh Bum-Jin,Kim Won,Cho Gyu-Chong,Kang Hui-Dong,Shon Yoo-Dong,Lee Jae-Ho,Lim Kyoung-Soo 대한임상독성학회 2006 대한임상독성학회지 Vol.4 No.1

Purpose: Toxic Exposure Surveillance System (TESS) is widely used for poisoning data collection and making a counterplan. But, there were few reports about poisoning data collection using TESS in Korea. The aim was to collect poisoning data using TESS report form and investigate the recognition of emergency physician about the necessity of TESS as preliminary survey. Methods: Retrospectively, we gathered data from hospital records about the patient who admitted hospital emergency room due to poisoning. Date were gathered by paper and/or web client system report form in patients recruited by ICD-10 codes Results: From Jun 2004 to May 2005,3,203 patients were enrolled in 30 hospitals and their mean age was $44.9{\pm}20.3years$ old(male: female = 1,565: 1,638). The most frequent site of exposure was their own residence (73.2%, 2,345/3,203) and most of reported patients were older than 20 years(89.7%, 2,871/3,203). Frequent substances involved in poisoning were medication(41.9%) and pesticide(33.3%). Intentional poisoning was 60.7%(1,954). In fatality, overall frequency was 5.1%(162/3,203) and the most frequent route of exposure was ingestion(96.3%, 156/162) and the most frequent substance was pesticide(85.2%, 138/ 162). Antidotes were administered in 202 patients(2-PAM, atropine, antivenin, N-acetylcystein, vitamin K, flumazenil, ethanol, methylene blue, naloxone, calcium compound). 19 of 20 emergency physicians agreed with necessity of TESS. Conclusion: Data collection using TESS report form showed preliminary poisoning events in Korea. Frequent poisoning substance were medication and pesticide. The fatality was mainly related with pesticide ingestion. Many doctors in emergency room recognized the necessity of TESS.

급성 버섯중독으로 인한 간손상의 추적 조사

오범진,김원,임경수,Oh, Bum-Jin,Kim, Won,Lim, Kyoung-Soo 대한임상독성학회 2004 대한임상독성학회지 Vol.2 No.2

Purpose: Several risk factors related with chronic complications and mortality related with liver injury of mushroom poisoning were reported. But, there were few reports about the long term outcomes. The aim was to evaluate the long term clinical outcomes in mushroom poisoning regarding the risk factors. Methods: Clinical data were reviewed and outcomes were evaluated with medical records and/or telephone interviews. The patients who had one or more risk factors such as markedly elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT), prolonged prothrombin time (PT) were classified into high risk group. Patients had no risk factor classified into low risk group. Results: From June 1989 to December 2003, nineteen mushroom poisoning patients admitted to Asan Medical Center, seven were male, and mean age was $58\pm9$ years old. All the patients accidentally ingested and the interval from ingestion to symptom onset was $9\pm4$ hours. There were four patients in high risk group, and fifteen in low risk group. In high risk group, peak AST was $2,263.3\pm1,303.0IU/L$most prolonged PT was $38.0\pm27.4\%$, and stuporous mental status was shown in one patient. In low risk group, laboratory values returned to the normal values but histological evaluation revealed specific features of toxic hepatitis on sixth hospital day. Chronic complications such as persistent or chronic hepatitis, mortality was not occurred during follow up period (from 10 months to 16 years) in both groups. Conclusion: Although the number of patients were small, there were no chronic complications or mortality related with liver injury after mushroom poisoning regardless risk factors of chronic complications and mortality.

연직 불연속면이 존재하는 얕은 심도의 사질토 지반에서 2-arch 터널 단계별 굴착에 따른 하중전이에 관한 실험적연구

오범진,이상덕,Oh, Bum-Jin,Lee, Sang-Duk 한국터널지하공간학회 2011 한국터널지하공간학회논문집 Vol.13 No.3

본 논문에서는 연직 불연속면을 포함하는 지반에서 얕은 심도 2-arch 터널 굴착에 따른 거동특성을 실험적으로 연구하였으며, 2-arch 터널 굴착에 따른 필러부 하중전이 특성을 관찰하였다. 연직 불연속면의 위치를 변화시키고, 2-arch터널 시공단계별로 모형실험을 수행하였다. 실험결과, 2-arch 터널 굴착에 따른 이완하중이 불연속면이 위치한 곳에 집중되었고, 불연속면에 차단되어 불연속면을 넘어서까지 하중이 전이되지는 않았다. 또한 인접한 터널의 하반을 굴착할 때보다 상반을 굴착할 때에 필러부와 지반변형에 더 큰 영향을 미치는 것으로 나타났다. In this study, the behavior of a shallow 2-arch tunnel during the excavation in the sandy ground containing vertical discontinuity plane was experimentally studied. Load transfer mechanism in the pillar caused by a 2-arch tunnel excavation was observed. The position of the vertical discontinuity plane was varied. Model tests were carried out in the normal construction sequence of 2-arch tunnel. Test results-showed that the load transfer caused by the 2-arch tunnel excavation was concentrated in the discontinuity plane, and was cut by the discontinuity plane, so no load transfer took place above the discontinuity plane. It was also shown that the effect of adjacent tunnel excavation on the pillar load and the ground deformation was greater when excavating the upper half-face of the main tunnel, more than when excavating the lower half-face.

독립성분 분석과 E-M을 이용한 혼합영상의 분리 기법

오범진(Bum-Jin Oh),김성수(Sung-Soo Kim),유정웅(Jeong-Woong Ryu) 한국정보과학회 2003 정보과학회논문지 : 정보통신 Vol.30 No.1

이 논문에서는, 독립성분해석기법과 EM 기법을 이용한 새로운 혼합영상분리 방법을 제안한다. 독립성분해석기법은 통계적으로 독립된 랜덤변수들의 선형조합으로 측정대상 랜덤신호를 표기하는 여러 통계신호처리 기법 중의 하나로, 정보의 분리, 특징 추출 등의 응용분야에 적용되고 있다. 기술적으로는, 독립성분기법은 주성분 분리기법의 확장이라 볼 수 있고, 근래에 혼합정보의 분리에 관련하여 많이 연구되고 있다. 현재까지의 연구 결과로는 혼합영상의 분리에 있어 독립성분해석기법만으로는 혼합영상분리의 해를 얻지 못하고 있다. 이러한 독립성분해석기법의 약점을 보완하는 방법으로, 최근에 이노베이션 프로세서를 전처리로 하는 독립성분해석기법을 혼합한 시스템을 이용한 혼합영상 분리가 시도되었다. 이노베이션 프로세서를 전처리로 첨가한 혼합영상분리의 과정도 독립성분해석기법만을 사용한 경우 보다는 향상된 혼합영상분리를 하지만, 분류된 영상들이 원래의 혼합 전의 영상과 많이 다른 결과를 내고 있다. 기존의 방법들인 독립성분해석기법이나 이노베이션이 전처리로 적용된 경우에도 혼합이전의 영상간의 상관관계가 클 경우, 혼합영상의 분류가 잘 이루어지지 않는다. 본 논문에서는 이 약점을 보완하기 위하여, EM이론을 기존의 시스템에 전처리로 첨가하여 혼합 영상의 분리를 향상시키고자 하였다. 실험 결과에서는 최근에 연구된 이노베이션의 방법보다 EM을 적용시킨 경우가 향상된 혼합영상의 분리의 결과를 보여 주고 있다. In this paper, a new method for the mixed image separation is presented using the independent component analysis, the innovation process, and the expectation-maximization. In general, the independent component analysis (ICA) is one of the widely used statistical signal processing schemes, which represents the information from observations as a set of random variables in the form of linear combinations of another statistically independent component variables. In various useful applications, ICA provides a more meaningful representation of the data than the principal component analysis through the transformation of the data to be quasi-orthogonal to each other, which can be utilized in linear projection. However, it has been known that ICA does not establish good performance in source separation by itself. Thus, in order to overcome this limitation, there have been many techniques that are designed to reinforce the good properties of ICA. The innovation process is one of the methods that were employed in image separation using ICA , which improves the mixed image separation.Unfortunately, the innovation process still needs to be studied since it yields inconsistent result due to the randomness of images mixing weights. In order to improve the performance of the innovation process that is attached to the ICA, the expectation and maximization process is added.The results presented in this paper show that the proposed improves the image separation as presented in experiments.

위세척의 올바른 이해와 적용

오범진 ( Bum Jin Oh ),노형근 ( Hyung Keun Roh ) 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.1

Gastric lavage is one of gastrointestinal decontamination methods which have been controversial in the clinical toxicology field for a long time. Expert groups of American and European clinical toxicologists have published the position papers regarding gastric lavage three times since 1997. They recommended that gastric lavage should not be used as a routine procedure in the management of acute intoxication, because they thought that there is no certain evidence of improving clinical outcome by its use. However, the studies they reviewed were not well-controlled randomized trials, which cannot be conducted in the clinical toxicology field due to variability of patients and ethical problems. Therefore, the results from these studies should be interpreted with caution. They also insisted that gastric lavage can be undertaken within 60 minutes of ingestion. The limitation of one hour after ingestion is too arbitrary and may cause a lot of misunderstanding. Formation of pharmacobezoar or gastric hypomotility after ingestion may significantly delay the gastric emptying time so that gastric lavage can be useful even after several hours or more in case of highly toxic substances or severe intoxication. Furthermore, as there are a number of serious intoxication by toxic pesticides with large amount in suicidal attempts in Korea, it seems that gastric lavage may be used more frequently in Korea than in Western countries. When deciding whether or not to use gastric lavage, all the indications, contraindications, and possible adverse effects should be taken into account on the basis of risk-benefit analysis. If the procedure is decided to be done, it should only be performed by well-trained experts.

유기염소계 농약 중독 환자 임상 양상

조준호,오범진,서주현,권운용,박준석,어은경,이미진,이성우,노형근,박인철,Cho, Jun-Ho,Oh, Bum-Jin,Suh, Joo-Hyun,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Lee, Mi-Jin,Lee, Sung-Woo,Roh, Hyung-Keun,Park, In-Cheol 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.1

Purpose: To analyze the general characteristics and clinical aspects of the organochlorine intoxicated patients in Korea. Methods: We prospectively evaluated the organochlorine intoxicated patients visiting to the 38 emergency medical centers in Korea from the 1, Aug. 2005 to the 31, Jul. 2006. Results: There were 38 patients intoxicated by the organochlorine during the study periods. The mean age of patients was 55.1 years old. The mean amount of the organochlorine intoxicated is 246.1 mL. The most frequent place where the patients got and took the organochlorine was their home. Twenty eight patients(73.7%) intended to suicide. Nine patients out of 38 patients(23.7%) were died and they all intended to suicide. Conclusion: There were 38 patients intoxicated by the organochlorine during the study periods. The suicidal attempts and the number of the dead were higher in Korea than the developed countries.

Chlorophenoxy계 제초제 중독 환자 임상 양상

조영순,김호중,오범진,서주현,권운용,박준석,어은경,이미진,이성우,노형근,임훈,Cho, Young-Soon,Kim, Ho-Jung,Oh, Bum-Jin,Suh, Joo-Hyun,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Lee, Mi-Jin,Lee, Sung-Woo,Roh, Hyung-Keun,Lim, Hoon 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.2

Purpose: There have been relatively few reports of chlorophenoxy herbicide poisoning. The purpose of this study is to analyze the general characteristics and clinical aspects of the chlorophenoxy herbicide intoxicated patients in Korea. Methods: We prospectively evaluated the chlorophenoxy herbicide intoxicated patients visiting to the 38 emergency medical centers in Korea from the 1 August 2005 to the 31 July 2006. Results: 24 patients were enrolled during the study periods. Their mean age was 55.7 years old. The median amount of the chlorophenoxy herbicide intoxicated is 150 mL. The most frequent location where the patients obtained and took the chlorophenoxy herbicide was their home. Frequent compounds involving chlorophenoxy herbicide poisoning were dicamba(66.7%), MCPP(16.7%), and 2,4-D(12.5%). The most common symptom of the patients was confusion and vomiting. 16 patients(66.7%) intended to suicide. 3 patients out of 24 patients(13.0%) were died. Conclusion: There were 24 patients intoxicated by the chlorophenoxy herbicide during the study periods. The mortality rate was 13.0%. The suicidal attempts and the numbers of death involving chlorophenoxy herbicide were high in Korea.

식물 제제와 연관된 급성 독성 간염으로 인한 간이식 : 원인 제제와 손상 유형에 대한 후향적 분석

손창환,차명일,오범진,여운형,이재호,김원,임경수,Sohn, Chang-Hwan,Cha, Myung-Il,Oh, Bum-Jin,Yeo, Woon-Hyung,Lee, Jae-Ho,Kim, Won,Lim, Kyoung-Soo 대한임상독성학회 2008 대한임상독성학회지 Vol.6 No.2

Purpose: Acute toxic hepatitis is a common cause of acute liver failure (ALF). We investigated the causes, clinical manifestation, and outcomes of ALF patients who underwent liver transplantation due to acute toxic hepatitis caused by herbal medicines and preparations. Methods: Between January 1992 and May 2008, we retrospectively reviewed the medical records of 24 patients who were transplanted due to acute toxic hepatitis caused by herbal medicines and preparations. We applied the RUCAM score to patients with acute toxic hepatitis and assessed the relationship between herbal preparations and liver injury. We studied the patients' medication history, liver function tests, and clinical outcomes. Results: The type of liver injury was divided into three groups: hepatocellular type, 14 patients (58.3%); cholestatic type, 4 patients (16.7%); and mixed type, 6 patients (25%). Polygonum multiflorum Thunberg (3 cases) was the most common cause of acute toxic hepatitis, followed by Acanthopanax senticosus (2 cases), pumpkin juice (2 cases), Dictamnus dasycarpus Turcz (2 cases), Hovenia dulcis (1 case), Phellinus linteus (1 case), and Artemisia capillaries (1 case). One year survival after liver transplantation was 76%. Conclusion: We identified the herbal preparations leading to acute liver failure. Many patients consider herbal remedies to be completely free of unwanted side effects. However, we found that many herbal products have biological activities that can lead to severe hepatotoxicity.

국내 유기인계 농약 중독 환자의 특성 분석 - 다기관 연구 보고 분석 -

이미진,권운용,박준석,어은경,오범진,이성우,서주현,노형근,Lee, Mi-Jin,Kwon, Woon-Yong,Park, Joon-Seok,Eo, Eun-Kyung,Oh, Bum-Jin,Lee, Sung-Woo,Suh, Joo-Hyun,Roh, Hyung-Keun 대한임상독성학회 2007 대한임상독성학회지 Vol.5 No.1

Purpose: Organophosphate (OP) compounds insecticides are the most commonly associated with serious human toxicity all over the world. The aim of this study was to identify sociocultural factors that contribute to high incidence of pure OP poisoning and prevent OP poisoning in order to reduce the factors responsible for deaths in South Korea. Methods: This is the 38 multi-centers survey and prospective study of pure OP poisoning by structural reporting system and hospital records from August 2005 to July 2006. 238 patients with acute pure OP poisoning were enrolled. We collected patient information regarding poisoning, clinical, and demographic features. Results: The mean age was $55.32{\pm}17.3$ years old. The most frequent site of exposure was their own residence(85.7%). Frequent compounds involving pure OP poisoning were dichlorvos(22.7%), methidathion(8.4%), and phosphamidon(6.7%). Intentional poisoning was 77.9%. The most frequently route of exposure was ingestion(94.5%). The mean arrival time to hospital after poisoning was 12.7 hours and mean hospitalization duration was 12.9 days. 2-PAM was administered to 101 patients in mean doses of 6.3 g/day intravenously. Atropine was administered to 81 patients in mean doses of 74.6 mg/day (maximal 910 mg/day). The presence of lower level of GCS score, respiratory complications, hypotension, acute renal failure, and serious dysrhythmia was associated with serious and fatal poisoning. Overall final mortality in pure OP poisoning was 9.7%(23/238). Conclusion: This study highlights the problem of pure OP poisoning in South Korea as a basic national survey. Futhermore this might help the establishment of strict policies availability of OP and the statistics of OP poison exposure in South Korea.