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감초부자탕(甘草附子湯)이 Papain으로 유도된 골관절염에 미치는 실험적 연구
최재영 ( Jae Young Choi ),오민석 ( Jae Young Choi ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.4
Objectives : This study intends to clarify how Kamchobuja-tang(Gancaofuzi-tang, here in after referred to KBT) affect mice of C57BL/10 whose osteoarthritis was induced by papain. Methods : Osteoarthritis was induced into mice by injecting papain in its knee joint. Mice are divided into a total of 4 groups(n=6). Normal group are not treated at all without inducing osteoarthritis whereas control group(OAC-control) were induced for osteoarthritis by papain and oral medicated with 200 ul of physiological saline per day. Positive comparison group(OAC-Joins®) was injected with papain and after 7 days, 100 mg/kg of Joins® was medicated with 200 ul of physiological saline mixed. Experimental group(OAC-KBT) was injected with papain and after 7 days that was medicated with 400 mg/kg of KBT mixed with 200 ul of physiological saline. OAC-Joins® and OAC-KBT were oral medicated for each substance a total of 4 weeks with one time per day. After experiments(from 1 week after injection of papain to 4 weeks elapsed), the functions of liver and kidney, inflammation cytokine values within serum, degree of revelation for inflammation cytokine genes, immune cells within blood, metabolism of arachidonic acid and amount of cartilage were measured and histopathological variations for knee joint structures were observed. Results : 1. Functions of liver and kidney were not affected. 2. IL-6((interleukin-6), IL-1β(interleukin-1β), MCP-1(monocyte chemoattra- ctant protein-1) and TNF-α(tumor necrosis factor-α) are meaningfully reduced. 3. After analyzing inflammation cytokine in joints with mRMA(messenger ribonucleic acid), revelation of IL-1β, IL-6 and iNOS-Ⅱ(inducible nitric oxide synthase-Ⅱ) were all meaningfully reduced. And revelation of TNF-α and COX-2 gene were also reduced but meaningless. 4. Neutrophil and monocyte for WBC(white blood cell) within serum were meaningfully reduced. 5. PGE2(prostaglandin E2), TXB2(thromboxane B2) and LTB4(leukotriene B4) were meaningfully reduced. 6. Destruction of cartilage on micro CT(computed tomography)-arthrography was meaningfully reduced. 7. In terms of histopathology, infiltration of inflammation, proliferation of synovial membrane, subsidence of cartilage and bone due to penetration of excessive formation of synovial cell and destruction of cartilage were small(H&E(hematoxylin and eosin), Safranine-O staining). Conclusions : Based on all results mentioned above, KBT is believed to be meaningful for suppressing the progress of osteoarthritis and its treatments because of its anti-inflammatory effects and alleviation of pain with histopathological effective efficacy.
최재영 ( Jae Young Choi ),정현아 ( Hyun A Jung ),오민석 ( Min Seok Oh ) 대전대학교 한의학연구소 2011 혜화의학회지 Vol.19 No.2
Objective: The purpose of this study was to review on exercise therapy of oriental medicine and investigate the effect of Oriental medicine`s exercise therapy. Methods: We have researched and analyzed theories and literatures of Oriental medicine`s exercise therapy. Result: The following results were obtained in this study. 1. The Doin therapy is one of Oriental medicine`s traditional rules for one`s health which based on ``Unity of Heaven and Man``. It grow and supply the ``Qi`` for improve health, and connote solution of modern society`s various diseases. 2. The Chuna therapy is one of Oriental medicine`s traditional therapy that treat harden, set in or malposition of musculoskeletal system 3. Meditation refers to all activities that concentrate the consciousness to current stale, have physiological and psychological effects such as pain and stress management. 4. Oriental medicine`s exercise therapy connote the strength that apply to medical care for the aged and psychical disorders of modern man. 5. For revitalization of Oriental medicine`s exercise therapy, need more active public relations, develop modern methods of Qigong and Significant clinical research on the effects must be carried out. Conclusion: Oriental medicine`s exercise therapy can be a solution to various diseases of modern society, and need significant research for revitalization.
좌골신경 손상에 대한 한약물 치료효과에 대한 실험논문 분석 - 국내외 한의계 연구를 중심으로 -
이치호 ( Chi-ho Lee ),이재은 ( Jae-eun Lee ),최영준 ( Young-jun Choi ),이은정 ( Eun-jung Lee ),오민석 ( Min-seok Oh ) 대한한의학회 한방재활의학과학회 2016 한방재활의학과학회지 Vol.26 No.4
Objectives This study is to review the effect of herbal medicine on treatment of sciatic nerve injury induced animal models reported in domestic & foreign journals. Methods 5 electronic databases (Pubmed, CAJ, RISS, Oasis, Koreantk) were searched with term as sciatic nerve injury, and animal study reports on sciatic nerve impairment with herbal medicine treatment were extracted. Results 31 articles were reviewd. All studies used SD rat. 26 studies used crush injury at the sciatic nerve using haemostatic forcep and 5 studies used sciatic nerve transection. 15 studies used single herb extract and 16 studies used complex herb medicine. Angelica gigantis radix was the most frequently used herb. Each study showed significant changes of improvement indicators from sciatic nerve impairment. Conclusions Various herb medicine are expected to have positive effects on sciatic nerve impairment. (J Korean Med Rehabil 2016;26(4):9-21)