위장 비율동성 당뇨환자에서 족삼리(足三里)($ST_{36}$) 전침처치의 위전도 조절 영향 사례군 연구

오달석,최준용,정소영,신미숙,김애란,강경원,김종인,최선미,Oh, Dal-Seok,Choi, Jun-Yong,Jung, So-Young,Shin, Mi-Suk,Kim, Ae-Ran,Kang, Kyung-Won,Kim, Jong-In,Choi, Sun-Mi 대한침구의학회 2008 대한침구의학회지 Vol.25 No.4

Objectives : This study was to investigate the regulatory effect of electro-acupuncture on Jogsamni ($ST_{36}$) in bradygastric condition or gastroparesis which is a neuropathic complication of type 2 diabetes mellitus(T2DM), assessed using 4-channel electrogastrography (EGG). Methods : It was a case series study. Each patient was given electro-acupuncture(EA) one point, Jogsamni($ST_{36}$) or Gyeonu($LI_{15}$) bilaterally for thirty minutes with 2Hz bipolar square wave frequency and moderate intensity of stimulation. With attaching electrodes around stomach region throughout pre-acupuncture, acupuncture, and post-acupuncture session, these parameters were produced; percent rate of bradygastria power compared to sum of power in all kind of gastric rhythm(% bradygastria), dominant frequency(DF) and dominant power(DP). Parameter was analysed per each channel's variable change from pre-acupuncture session by paired t-test. Results : There was statistically significant decrease in % bradygastria parameters on one of the $ST_{36}$ treated patients from pre-acupuncture session and to post-acupuncture session(P=0.015, P=0.008 respectively). A marginal significant decrease of DP was shown in the other $ST_{36}$ treated patient from pre-acupuncture session through post-acupuncture session(P=0.049). Combined data of two $ST_{36}$ Treated patients showed that there was significant decrease of %bradygastria from pre-acupuncture session to acupuncture session(P=0.020), and was decrease of DP from pre-acupuncture session to post- acupuncture session(P=0.020). Conclusions : EA at $ST_{36}$ resulted in statistically significant decrease in %bradygastria and DP for dysrhythmic condition in T2DM gastroparesis patients. Considering this limited results, further study will be needed to elucidate the effect of multiple-acupuncture on gastric myoelectrical activities.

Loperamide로 억제된 위장관 운동에 대한 사관혈의 자침효과

오달석(Dal-Seok Oh),정소영(So-Young Jung),김애란(Ae-Ran Kim),강위창(Wee-Chang Kang),박지은(Ji-Eun Park),구창모(Chang-Mo Koo),최준용(Jun-Young Choi),정희정(Hee-Jung Jung),최선미(Sun-Mi Choi),손창규(Chang-Gue Son) 대한한의학회 2008 대한한의학회지 Vol.29 No.1

절식보조음료 감로수(甘露水) 개발을 위한 선행연구: 증례보고

오달석 ( Dal Seok Oh ),김동환 ( Dong Hwan Kim ),신현택 ( Hyun Taeg Shin ),신승우 ( Seung Uoo Shin ) 한방비만학회 2015 한방비만학회지 Vol.15 No.2

감로수는 궁중음료인 제호탕과 동의보감의 생맥산에서 유래한 절식보조음료이다. 감로수를 이용한 절식요법의 보완과 향후 예정된 임상시험을 위한 임상지표 선정을 위해 정상인 1예, 비만인 1예, 고도비만인 1예를 대상으로 10일간의 절식요법 전, 후로 증례를 관찰하였다. 절식 후 체중은 평균 -6.3%, 체지방은 평균 -6.5%, 근육은 평균 -6.6% 감소하였고, 영양지표에 해당하는 RBC, hemoglobin, hematocrit, T-protein, albumin의 수치는 증가하였고 염증지표에 해당하는 hs- CRP, CRP, ESR, WBC 수치는 감소하였다. 절식 후에도 간기능, 신기능, 전해질수치는 정상수준을 유지하였고, 산화스트레스는 감소하였으며, 항산화력이 증가하는 결과를 나타내었다. 피로도는 절식 전보다 다소 개선되었고, 절식기 동안 불면 이외에 별다른 불편증상을 호소하지 않았다. 다만 혈중 빌리루빈수치 상승, 케톤 증가로 인한 체액의 약산성화는 절식요법을 시행함에 있어 추후 보완해야 할 사안이라 생각된다. 결론적으로 감로수의 디톡스 프로파일은 적합하며 관찰된 결과는 후속연구에 고려될 것이다. Gamrosu is a modified fasting therapy beverage (431 kcal/d). A retrospective observational study was conducted to investigate the detoxification feasibility of Gamrosu. Three cases were reviewed which participants have finished the fasting with Garmrosu for 10 consecutive days. Detoxification profiles of Gamrosu were reviewed at pre- and post-fasting sessions. Post-Gamrosu session, -6.3% of average weight, -6.5% of average body fat mass and -6.6% of average muscle mass were reduced with the nutrition indices being improved. The inflammation indices showed the significant diminished profiles. Liver/kidney functions and the standard of electrolytes were maintained within normal range in stable manners, however, marginal elevation of total bilirubin and mild ketoacidosis were observed. The indices of oxidative stress decreased and those of antioxidative activity increased. The fatigue scale scores indicated lower scores except insomnia symptom. Taken together, detoxification profiles of Gamrosu were sufficiently feasible and the observed findings should be considered for further clinical studies.

본 임상시험을 대비한 천식 침치료 무작위 대조군 예비 임상시험 프로토콜

최준용 ( Jung Yong Choi ),오달석 ( Dal Seok Oh ),노영래 ( Young Lae Roh ),정희재 ( Hee Jae Jung ),정승기 ( Sung Ki Jung ),최선미 ( Sun Mi Choi ) 대한경락경혈학회 2008 Korean Journal of Acupuncture Vol.25 No.3

배경: 최근까지 이루어진 천식의 침치료 무작위 대조군 연구들에 의한 결과는 뚜렷한 효과를 보여주지 못하고 있다. 이러한 요인의 하나로 적절한 피험자 수를 정하기 위한 예비 임상시험의 부재가 거론되고 있다. 따라서 천 식에 대한 침치료의 본 임상시험에 앞서 이의 실행 가능성 및 규모를 예측하는 예비임상시험이 필요한 상황이다. 목적: 예비임상시험을 통해 서양의학적 치료를 받고 있는 천식환자들에 대한 침치료의 부가적 효과를 검증하기 위한 본 임상시험의 실현 가능성을 예측하기 위함. 방법: 본 시험은 무작위 단일 맹검 대조군 평행 설계 예비 임상시험이다. 1차 평가변수는 최대 호기량 검사기로 집에서 아침, 저녁으로 매일 측정한 수치로 구해진 최대 호기 유속 일중 변동률의 1주간 평균치 변화이며 2차 평 가변수는 의료기관에서 시행하는 폐기능 검사, 기준시점 호흡곤란 지수, 호흡곤란 변화에 대한 지수, 천식환자들 의 삶의 질 평가를 위한 설문 등이다. 피험자 수는 총 45명으로 선정 및 제외기준을 통해서 참여하게 되며 1주간 의 최대 호기 유속 기저치 평가 기간을 거친 후 진짜침 처치 군, 가짜침 처치 군, 대기군 세 군에 각각 무작위로 15명씩 할당된다. 모든 피험자에게 기존의 천식관련 약물의 사용을 허용하며, 진짜침 처치군 및 가짜침 처치군은 주 3회 4주간 해당 처치를 받고 2주 후에 각 평가 항목에 대하여 추적, 관찰하게 된다. 대기군은 기존의 천식관리를 유지하면서 2주마다 방문하여 총 6주간 평가를 받고 진짜침 처치를 4주간 받게 된다. 고찰: 본 연구는 국내에서 최초로 이루어지는 천식에 대한 침 무작위 대조군 예비 임상시험으로 향후 적절한 피 험자수와 실행가능성을 예측할 수 있으리라 기대된다.

자하거(紫河車) 약침의 기관지 천식 치료 가능성에 대한 소고(小考)

최준용 ( Jun Young Choi ),오달석 ( Dal Seok Oh ),정희재 ( Hee Jae Jung ),최선미 ( Sun Mi Choi ),정승기 ( Sung Ki Jung ) 대한경락경혈학회 2008 Korean Journal of Acupuncture Vol.25 No.2

Objectives: The aim of this study was to find out some rationales for using Hominis placental extract(HPE) pharmaco-acupuncture on asthmatic patients, and to suggest an appropriate clinical research of HPE pharmaco-acupuncture on asthma. Methods: Articles regarding immunologic experiments about HPE and clinical reports about HPE-contained pharmaco-acupuncture on asthmatic patients were reviewed by on-line and off-line searching. Results and Conclusions: HPE is suggested to have several pharmacological effects on allergic diseases including asthma as well as autoimmune diseases. There are some observational studies of HPE-contained pharmaco-acupuncture on asthmatic patients. However, the designs of these studies are not sufficient to investigate the exact effect of HPE pharmaco-acupuncture on asthma. To investigate HPE pharmaco- acupuncture as a novel asthma therapy, it will be needed to perform further experiments about HPE`s pharmacological mechanism on asthma and to try further advanced clinical researches such as well-designed randomized controlled trial of HPE pharmaco-acupuncture.

주관적 체형인식이 체중조절방법 선택에 미치는 영향: 2012년 국민건강영양조사 자료를 이용하여

유정은 ( Jeong Eun Yoo ),오달석 ( Dal Seok Oh ),김남권 ( Nam Kwen Kim ) 한방비만학회 2014 한방비만학회지 Vol.14 No.1

This study was to investigate how body-shape perception could influence to weight control practice both in normal and obese group. Methods: We used 2012 Korea National Health and Nutrition Examination Survey to analysis 1) weight control practices of population; 2) consistency between body-shape perception and body mass index; 3) comparison weight control practices between normal group and body mass index (BMI) obese group in perceptional obese group; 4) odds ratio of BMI obese group using herbal drugs for weight control practice in perceptional obese group. Results: We found that study population tends to choose exercise, dietary restriction, meal skip, health functional food, one-food, drug, herbal drug, fasting and self-medication in order of frequency to control weight. The agreement between body-shape perception and BMI within obese group was approximately 64% with 0.40 of Cohen’s Kappa coefficient, ranging from 0.384 to 0.423. Within perceptional obese group, choosing each weight control practice methods ratios between normal BMI group and obese BMI group were not significantly different. Within perceptional obese group, obese BMI group showed significant odds ratio (2.58, 95% confidence intervals, 1.38∼4.85) than normal BMI group in choosing herbal medication for weight loss when adjusting other variables. Conclusions: We concluded that body-shape perception might be an important factor for choosing weight control program, and roles of Korean medical doctors thought to be enhanced for using herbal medication for weight loss.

감로수 절식요법을 적용한 고혈압 비만환자 증례보고

김동환(Dong Hwan Kim),오달석(Dal Seok Oh),신승우(Seung Uoo Shin),신현택(Hyun Taeg Shin) 한방비만학회 2016 한방비만학회지 Vol.16 No.1

Gamrosu was originally conceptualized from Jeho-tang, a selected thirst quencher of the kings in Chosun Dynasty and Saeng-Maek-san, a qi-vigorating summer beverage recommended by Dongeuibogam. It is a modified fasting therapy beverage which is manufactured from the single herbal medicines composed of those two prescriptions. This study was conducted on 6 obese patients with hypertension. A modified fasting therapy with Gamrosu was practised on them for 10 consecutive days. After the therapy, their average blood pressures were descended from 148/89 mmHg to 119/79 mmHg. The modified fasting therapy with Gamrosu is supposed to be more effective than general diet program or dietary sodium reduction on controlling hypertension. And, Gamrosu improves anti-hypertensive effect by reducing the side effects, such as fatigue, electrolyte imbalance, heartburn, nausea, and headache, during the modified fasting therapy.

임상시험 중 수면행위가 심박변이도에 미치는 영향 분석

이전(Lee Jeon),오달석(Oh Dal-Seok),이혜정(Lee Hae-Jung),최선미(Choi Sun-Mi),김종열(Kim Jong-Yeol) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.3

The object of this study is to evaluate confounding effect of sleeping behavior on heart rate variability (HRV) in healthy volunteers during a randomized clinical trial. From 6 healthy volunteer, we acquired circadian electrocardiography(ECG) with a Holter monitoring device(DigiTrak Plus, Philips). The compatible analytical program, Zymed, was used for calculation of RR intervals of 24h ECG signal. Then, we generated HRV signals and calculated 9 HRV parameters in time domain and frequency domain for every 30 minute with Matlab 6.x software. We also encoded participants' activities as follows; stable condition(l), sleeping behavior(2), eating behavior(3), and undefined condition(4). Using SPSS 12.0, we tested if there was any difference between HRV parameters of day-time and night-time and between those of a subject in stable condition and in sleeping behavior. As a result, one of the most important parameter-LF/HF ratio, which indicates the autonomic balance between sympathetic and parasympathetic nervous systems, as same the other parameters, showed large inter-individual variations in circadian profiles. And, the mean LF/HF ratio of each participant was different between in stable condition and in sleeping behavior (p<.05). Consequently, the effect of sleeping behavior must be considered when one or more of HRV parameters, especially LF/HF ratio, are used as assessment index in clinical studies.

진행성 비소세포성 폐암환자에 대한 항암플러스의 치료효능 : 연속증례보고

정홍매,윤정원,이연월,조종관,오달석,유화승,Zheng, Hong-Mei,Yoon, Jeung-Won,Lee, Yeon-Weol,Cho, Chong-Kwan,Oh, Dal-Seok,Yoo, Hwa-Seung 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.1

Objectives : A case series was conducted to investigate the therapeutic effects of Hang-Am Plus (HAP) on the tumor response and HRQoL (Health Related Quality of Life) in advanced non-small cell lung cancer (NSCLC) patients. Methods : Three patients were given 1,000-2,000 mg of HAP, three times a day (daily total dosage of 3,000-6,000 mg/day) for 12 weeks. Results : After the 3 month administration with HAP, three patients showed stable disease (SD) condition according to the chest computed tomography (CT), and two of the patients reported a decrease in pain levels. Conclusions : The observed NSCLC cases suggest treatment with HAP may be related to the observed tumor growth inhibition and pain reduction.

갱년기 여성의 안면홍조에 대한 침치료 다기관 임상시험: 프로토콜

박지은 ( Ji Eun Park ),오달석 ( Dal Seok Oh ),강경원 ( Kyung Won Kang ),김동일 ( Dong Il Kim ),최선미 ( Sun Mi Choi ) 대한경락경혈학회 2007 Korean Journal of Acupuncture Vol.24 No.3

Background: Hot flushes are general postmenopausal symptoms which about 75% of climacteric women undergo. They affect hotness, perspirations, systemic weakness, panic disorders, insomnia. Acupuncture is effective in alleviating hot flushes in practice. Assessment effectiveness and safety of acupuncture in hot flushes would be needed through multi-center trial. Objectives: Purpose of this study is to develope the protocol of effects of acupuncture on hot flushes, a postmenopausal symptom in climacteric women. Methods & Results: It will be a multi-centered, randomized, sham controlled, comparative trial. It will be performed by Good Clinical Practice after approval of Institutional Review Board. Selection criteria will be set according those of FDA above moderate degree. There will be a notice on concomitant medication, other herbs, dietary supplements. Superficial needling on sham points will be used for control group. Treatment period will be 8 weeks with 12 weeks` follow up. Some questionnaire scale will be used as the primary and secondary outcome. Conclusions: The clinical trials based on this protocol will be performed.