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뇌혈류 평가용 99mTc - HMPAO 합성 및 분포에 관한 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),조보연(Bo Youn Cho),이범우(Bum Woo Lee),정재민(Jae Min Jeong),염미경(Mi Kyung Yeom),홍미경(Mee Kyoung Hong),최석례(Seok Rye Choi) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2
N/A HMPAO was synthesized by two step reaction. d, 1-HMPAO was separated from the racemic product by fractional recrystalization in ethylacetate, and the chemical structure and purity was confirmed by proton NMR spectroscopy. The synthesized d, 1-HMPAO was labeled with Tc- 99m and studied the biodistribution in mice. From the results we could find that liver uptake of synthesized Tc-99m d, 1-HMPAO was higher than that of Amersham kit, but no conspicuous difference was found in brain and other tissues (blood, lung, stomach, intestine, muscle, spleen and kidney).
Iodin-131I OIH와 99mTc - MAG3의 약물동력학 및 체내 분포에 관한 비교 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),조보연(Bo Youn Cho),이동수(Dong Soo Lee),이범우(Bum Woo Lee),정재민(Jae Min Jeong),염미경(Mi Kyoung Yeom),김문혜(Mun Hye Kim),박경호(Kyung Ho Park),송세흠(Sae Heum 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.1
N/A 99mTc-MAG, was synthesized, and biodistribution and blood clearance rate were compared with those of 131I-OIH in mice and rats respective]y. Finally renal image was obtained from a normal male volunteer before and after prescription of probenecid. The results obtained were as follows: 1) The uptalce of Tc-MAG, by kindey was higher than that of 131I-OIH in mice 10 mins after injection (n=6, p<0.05), but slightly lower uptakes were found in all organs (kindney, blood, stomach, mtestinge and liver) 2 hrs after injection. 2) For ' Tc-MAG, t1/2 a=2.4-+0.0 min, t1/2B=44.3+7.4 min, and blood clearance=3.4+0.5ml/min, and for 131I-OIH t1/2=1.8=0.2 min, t1/2=69.1+9.5 min, and blood clearance=1.3+O.l min were found in rats. 3) From the renogram of normal male volunteer, we could find that tmax=130 sec and t1/2=430sec before probenecid prescriptiori, and tmax 150-170sec and t1/2=810-1,170sec after probenecid prescriprion. From these results we concluded that Tc-MAG, can be used instead of 131I-OIH for obtaining renal irnage.