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만성 B형간염에서 B형간염 표면 항원 정량의 임상적 의의
연종은 ( Jong Eun Yeon ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.6
Since the discovery of HBsAg in the early 1960s, presence of HBsAg in serum has only served to diagnose hepatitis B. Recent development in the quantitative measurement of serum HBsAg has enabled us to improve our understanding on the management of chronic hepatitis B. The surface antigen (sAg) level is at its highest in immune tolerance phase and decreases to the lowest level in immune control/inactive phase when HBeAg is cleared from the serum. Combination of serum sAg titer less than 1,000 IU/mL and serum HBV DNA less than 2,000 IU/mL can identify true inactive carrier from e antigen (eAg) negative hepatitis with diagnostic accuracy of 95%. During the natural course of chronic hepatitis B, changes or absolute level of sAg less than certain level can predict spontaneous sero-clearance of HBsAg. Although the decline of sAg is very slow in interferon (IFN)/pegylated interferon (PEG-IFN) or oral nucleos(-t)ide treated patients, interferon based therapy results in a greater decrease of sAg level and sAg loss. Lack of any decline in sAg titer during PEG-IFN therapy could identify the group of patients who do not response to IFN/PEG-IFN therapy. With the aid of serum HBV DNA, quantitative measurement of serum HBsAg level can be used to optimize the management of chronic hepatitis B in our daily practice. (Korean J Gastroenterol2014;63:335-340)
연종은 ( Jong Eun Yeon ) 대한간학회 2013 Postgraduate Courses (PG) Vol.2013 No.-
Insulin resistance is the main pathophysiologic hall mark of Nonalcohlic fatty liver disease (NAFLD). Progression of simple steatosis to steatohepatitis (NASH) has been proposed by two hit hypothesis, the accumulation of lipid in the form of triglyceride as a first hit and oxidative stress leading to lipid peroxidation as a second hit which is needed for the development of NASH. But, emerging evidences from animal and human study points to metabolites of fatty acid as the real culprits in the hepatocellular injury in NASH. Increase free fatty acid release from adipose tissue to the liver, plays a key role in the onset of lipotoxic liver injury and progression. Ectopic fat accumulation in liver & muscle and subsequent activation of inflammation pathway causes cellular dysfunction. Cross talk between dysfunctional adipocytes and the liver recruits multiple cell population including macrophage and other immune cell. In this review, the role of lipotoxicity, fatty acid metabolites, inflammation, ER stress and genetic predisposition in the pathogenesis of NAFLD will be discussed.
대한간학회지 제6차 춘계학술대회 초록집 : 구연 ; 만성 B형 간질환에서 Lamivudine투여 후 혈소판 수의 변화와 Thrombopoietin의 역할
연종은 ( Yeon Jong Eun ),김경오 ( Kim Gyeong O ),손수민 ( Son Su Min ),김윤홍 ( Kim Yun Hong ),공휘 ( Gong Hwi ),김지훈 ( Kim Ji Hun ),서연석 ( Seo Yeon Seog ),박상훈 ( Park Sang Hun ),권오상 ( Kwon O Sang ),변관수 ( Byeon Gwan S 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
연종은(Jong Eun Yeon) 대한임상노인의학회 2023 대한임상노인의학회지 Vol.24 No.3
Worldwide, more than 100 million people were infected with chronic hepatitis C (CHC). Prevalence in Korea was estimated at as much as 0.6%. Because of the progressive aging of hepatitis C virus-infected people, the number of cases of CHC in older adults has been increasing. In older patients with CHC, greater acceleration of fibrosis with aging and higher risk of hepatocellular carcinoma development have been reported. Currently, with the popular all-oral combination of direct-acting antiviral (DAA) treatment of CHC, the rates of sustained virologic response and treatment-related adverse events between patients younger and older than 65 years are not significantly different. Although clinicians should consider drug-drug interactions, comorbid medical condition, risk of disease progression, and long-term benefits of viral eradication by DAA, older age should not be a barrier to treatment.
연종은(Jong Eun Yeon),박상훈(Shang Hoon Park),김진호(Jin Ho Kim),권소영(So Young Kwon),변관수(Kwan Soo Byun),이창홍(Chang Hong Lee),최상용(Sang Yong Choi),박철민(Cheol Min Park),차인호(In Ho Cha),원남희(Nam Hee Won) 대한내과학회 1997 대한내과학회지 Vol.52 No.1
N/A Hepatocelluar adenoma is a rare benign tumor, the incidence of which has increased since the introduction of oral contraceptives. We recently experienced a case of hepatocellular adenoma with ovarian Mucinous cystadenoma in a 36 year old female patient who had no history of oral contraceptives usage. The radiologic and pathologic differential diagnosis is discussed in this patient.