설하신경 기원의 신경초종 1례

양해동(Hae Dong Yang),강주완(Ju Wan Kang),김성수(Seong Soo Kim),진윤미(Yoon Mi Jin) 대한두경부종양학회 2002 대한두경부 종양학회지 Vol.18 No.2

Schwannoma is a relatively rare benign tumor which may occur from nerve sheath of the peripheral, sympathetic and cranial nerves and so on except optic and olfactory nerves which have no nerve sheath themselves. Although it occur most frequently in the head and neck region especially in the acoustic nerve, the schwannoma originated from the motor nerves including hypoglossal nerve is very rare. Recently, we have experienced a case of schwannoma originated from hypoglossal nerve in a 47-year-old female. We report this case with literature review.

요골측 전박유리 피판 실패 후 경장근 피판과 피부이식으로 재건한 하인두후벽암 1례

양해동(Hae Dong Yang),정상호(Sang Ho Chung),권오휘(Oh Hwi Kwon),홍원표(Won Pyo Hong) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.2

There are many approaches in surgery of posterior hypopharyngeal wall cancer according to location, extent, and invasion depth of primary cancer. And many reconstruction methods have been used in reconstruction of surgical defect remaining after wide resection of primary cancer. Posterior hypopharyngeal wall cancer is relatively rare, so its surgical experiences are fewer than those of pyriform sinus cancer and there have been few reports of surgical approaches and reconstruction methods of posterior hypopharyngeal wall cancer. Recently, we experienced a case of posterior hypopharyngeal wall cancer reconstructed with longus colli flap and skin graft after failure of radial forearm free flap in a 72-year -old man and report it with the review of the literatures.

하인두에 발생한 지방육종 1예

양해동(Hae Dong Yang),김현직(Hyun Jik Kim),김성헌(Sung Huhn Kim),이원애(Won Ae Lee) 대한두경부종양학회 2003 대한두경부 종양학회지 Vol.19 No.1

Liposarcoma is one of the most common malignancies originating from human soft tissue. Because most of liposarcoma occur in the lower extremities or retroperitoneum, there are few reports about liposarcoma of head and neck region, including larynx and pharynx. Histologically, there are four types of liposarcoma, and prognosis and recurrence rate are different according to histologic subtype. Wide excision is the treatment of choice and liposarcoma hardly respond to primary radiotherapy. A 56-year-old man presented with voice change and foreign body sensation in laryngopharynx. Hypopharyngeal liposarcoma was diagnosed by surgical biopsy and performed totallaryngopharyngoesophagectomy and gastric pull-up. Here we report our experience on this case with review of literature.

Lactobacillus acidophilus RMK567의 동결건조 컬쳐로 제조한 요구르트에서 GABA 생성력

임상동,유성호,양해동,김상기,박승용,Lim, Sang-Dong,Yoo, Sung-Ho,Yang, Hae-Dong,Kim, Sang-Ki,Park, Seung-Yong 한국축산식품학회 2009 한국축산식품학회지 Vol.29 No.4

${\gamma}-Aminobutyric$ acid (GABA) producing lactic acid bacteria, Lactobacillus acidophilus RMK567 was cultivated in 50 L of sterilized MRS broth using a fermenter at $40^{\circ}C$ for 24 h. The cell number was increased to $10.04{\pm}0.13$ Log CFU/mL with a growth rate constant (k) of 0.454 generation/h and a generation time (g) of 2.303 h after a lapse of a lag phase (L) of 5.16 h. A total of 487 g of cell paste with 40.5% moisture was harvested with viable cell number of 12.48 Log CFU/g cell paste. The cell pastes after preparation with glycerol, glucose, and polydextrose as cryo-protectants were lyophilized under a vacuum of 84 m torr. A total of 408 g of freeze dried (FD) cell powders were mixed with a commercial strain of Streptococcus thermophilus to prepare of three types FD starter cultures with the viable cell numbers of 12.42 (FDA-GY), 12.60 (FDBGG) and 12.91 (FDC-GP) Log CFU/g. During preservation the FD cultures at -$18^{\circ}C$, the cell viability of the FD starter cultures were rapidly dropped to below 3.24% of the day of storage. No significant difference was found in the cell viabilities among three types of FD starters cultures, but significant difference (p<0.01) was found in storage periods. Yoghurts fermented through FD starter culture of L. acidophilus RMK567 were determined to contain $155.16{\pm}8.53$ ppm, $243.82{\pm}4.27$ ppm, and $198.64{\pm}23.46$ ppm of GABA, respectively. This study shows that GABA production activity of L. acidophilus RMK567 is not affected during the freeze drying process and would be available for commercial production of yoghurt containing high GABA content.

전자코를 이용한 다양한 유형의 치즈 제품 풍미성분 분석

홍은정,김기화,박인선,박승용,김상기,양해동,노봉수,Hong, Eun-Jung,Kim, Ki-Hwa,Park, In-Seon,Park, Seung-Yong,Kim, Sang-Gee,Yang, Hae-Dong,Noh, Bong-Soo 한국축산식품학회 2012 한국축산식품학회지 Vol.32 No.5

본 연구는 전자코를 이용하여 한국에서 시판되는 피자용 모짜렐라 치즈 슈레드 제품과 슈레드 제품 혼합용 원료 치즈에 해당하는 모짜렐라 치즈 블록, 체다 치즈, 흰 곰팡이 숙성 치즈 등 3종류의 국내산 및 수입산 치즈를 대상으로 단기간 저장 및 가열처리에 의한 풍미패턴의 변화를 분석하였고 국내 임실치즈농협에서 새로 개발한 임실 치즈 제품이 국내산 및 수입산 치즈의 향미패턴과의 차이 유무에 대해 접근하여 보고자 하였다. 치즈 종류뿐만 아니라 조리온도 및 저장유무에 따른 향기패턴을 판별함수 분석을 이용하여 통계처리 후 비교 분석한 결과, 피자용 모짜렐라 슈레드 제품의 경우 저장유무보다는 조리온도에 따라 풍미패턴의 차이가 더 구분되었으며 피자용 모짜렐라 슈레드 제품에 혼합용으로 사용되는 치즈의 종류 및 원산지에 따라서 풍미패턴이 각각 다른 것으로 나타났다. 또한 새로 개발된 국내산 임실 치즈는 기타 국내산 치즈와 외국산 치즈와 비교하였을 때 이들의 중간 향에 해당하면서도 독특한 향미를 지니는 것으로 판별되었다. The objective of this study was to analyze the flavor pattern of different varieties of cheeses. Four of the each following cheese varieties such as shred type pizza cheese, Cheddar cheese, Mozzarella block cheese, and white mold-ripened cheeses, stored at $4^{\circ}C$ during 2 wks were examined before and after cooking at $70^{\circ}C$ and $160^{\circ}C$. Flavor patterns of these cheeses were analyzed using an electronic nose system based on mass spectrometer. All data were treated by multivariate data processing based on discriminant function analysis (DFA). The results showed the discriminant model by DFA method. Data revealed that flavor patterns of pizza cheeses were well separated as storage prolonged and obviously discriminated as the higher the cooking temperature. The result of pattern recognition analysis based on discriminant function analysis showed that new brand of pizza cheese produced by Imsil Cheese Cooperative was located at middle between the flavors of the imported brands of pizza cheese and those of domestic brand of pizza cheeses. Imsil cheese has a unique flavor pattern among other variety of cheeses. Application of pattern recognition analysis by electronic nose might be useful and advanced technology for characterizing in flavor pattern of cheese products from different origins and different categories of cheeses.

황토의 역학적 특성에 관한 실험적 연구

김순철(Kim, Soon-Chul),양일승(Yang, Il-seung),양해동(Yang, Hae-Dong) 한국생태환경건축학회 2007 한국생태환경건축학회 논문집 Vol.7 No.3

갑상선 수술시 피대근 절개가 음성에 미치는 영향

고중화,소의영<SUP>1<.SUP>,양해동<SUP>2<.SUP>,전정민,김영주,이승주,Joong-Wha Koh,M.D.,Euy Young Soh,M.D.<SUP>1<.SUP>,Hae-Dong Yang,M.D.<SUP>2<.SUP>,Jeong-Min Chun,M.D.,Youngju Kim,M.D. and Seongju Lee,M.D. 대한갑상선-내분비외과학회 2001 The Koreran journal of Endocrine Surgery Vol.1 No.2

Purpose: Voice change after thyroidectomy has generally been the result of damage to the recurrent or superior laryngeal nerve. But many patients complain voice alteration without laryngeal nerve injury after thyroidectomy. The purpose of this study is to investigate whether strap muscle division results in any subjective or objective functional sequelae in voice, through long-term follow-up prospectively. Methods: Twenty-two female patients who had undergone thyroid surgery between July 1998 and December 1999, were studied. The patients who were planned for neck dissection, who had benign laryngeal disease or vocal cord paresis, and whose vocal cord paresis were developed after thyroid surgery, were excluded from this study. Twelve patients had undergone thyroidectomy via retraction of strap muscle and ten patients had undergone thyroidectomy via cutting of strap muscle. For evaluation of voice, questionnaires for changes of voice, acoustics (fundamental frequency, jitter, shimmer, signal to noise ratio, noise to harmonic ratio, voice range), and aerodynamic (maximal phonation time) analyses were done. Results: The subjective voice symptoms after thyroidectomy were disturbances of high pitch, singing, loud voice, and easy fatigue at phonation. There were no significant differences in voice parameters on acoustic and aerodynamic analyses between the strap muscle retraction group and the cutting group through long-term follow-up. Conclusion: We conclude that strap muscle division does not result in any subjective or objective functional problems in voice. We suggest that surgical division and reconstruction of these muscles should be employed routinely when opera-ting on large, toxic or neoplastic glands. (Korean J Endocrine Surg 2001;1:237-243)

유산균 발효유 및 starter에서 항생제내성 유산균 분리 및 전달성 R plasmids 분포조사

백귀정 ( Kui Jeong Baek ),서형석 ( Heyng Seok Seo ),노영선 ( Young Sun Roh ),양해동 ( Hae Dong Yang ),허부홍 ( Boo Hong Hur ),서이원 ( Lee Won Seo ),정동석 ( Dong Suk Joung ),송희종 ( Hee Jong Song ) 한국가축위생학회 2006 韓國家畜衛生學會誌 Vol.29 No.3

Plasmids are covalently closed circular molecules of DNA that are stably inherited and replicate somewhat independently of the bacterial chromosome. Genes carried on plasmids can mediate a wide variety of important functions, including antibiotics(R plasmids) and heavy metals resistance, toxins production, cell penetration, iron chelation, complement resistance, and metabolic characteristics such as sucrose and lactose fermentation. Fifty strains of lactobacilli were isolated from 26 staters and 29 fermented milk products. They were classified 27 strains as Lactobacillus paracasei subsp paracasei , 11 stains as Lactococcus lactis subsp cremoris, 6 strains as L delbrueckii subsp lactis, 4 strains as L acidophius, and 2 strains as L delbrueckii subsp bulgaricus. All of these strains were examined for drug resistance and transferability of R plasmids. All of the isolates were sensitive to Am, C, CF, E, NB, P, T, and Te. But resistant to SXT 94%(47 strains), K 66%(33 strains), S 56%(28 strains), ENR 50%(25 strains), NOR 38% (19 strains) CIP 38%(19 strains), GM 16%(8 strains), and N 14%(7 strains), in order. And 32 different resistant patterns were found. The most frequently encountered patterns were CIP-ENR-K-NOR-S-SXT (5 strains). In vitro R plasmids transfer experiment, 57 antibiotic resistant strains which were not trans-fer to the recipient 2 Escherichia coli strains by conjugation. These results indicate that Lactobacillus in internal trade market` stater recognize R factor but transmissible R plasmid is not existed.

광범위한 국소재발 및 경부, 종격동 전이를 동반한 유두상 갑상선암 1례

최홍식(Hong Shik Choi),이주형(Ju Hyoung Lee),김재원(Jae Won Kim),양해동(Hae Dong Yang) 대한두경부종양학회 1997 대한두경부 종양학회지 Vol.13 No.1

The papillary carcinoma is the most common malignant neoplasm of thyroid gland and the prognosis is better than anyother type of thyroid carcinoma. However, the thyroid is closed to the important organs such as esophagus, trachea and larynx, there are some possibilities to invade these organs. In case of advanced disease, not only surrounding structures but also mediastinum and cervical lymphatic chain can be involved or distant metastasis develops frequently. Therefore in these cases the prognosis is worse and the rate of inoperable case is more than those of non-metastatic group. Generally, the treatment modality for papillary thyroid carcinoma consists of surgery, postoperative thyroid hormone and radioiodine therapy. If the tumor invades surrounding structures, cervical lymph node or mediastinum, total thyroidectomy and wide excision of tumor invaded area including mediastinal dissection and neck dissection is necessary. Recently, the authors have experienced a case of locally invasive and recurred papillary thyroid carcinoma without treatment for 7 years. The patient was performed previously thyroid lobectomy and isthmusectomy 13 years ago. We had determinded surgical therapy for this patient and performed mass excision with overlying skin, completion total thyroidectomy, right type I modified radical neck dissection, left lateral neck dissection, thoracotomy with supramediastinal dissection, shaving of diffusely involved trachea and skin defect reconstruction with pectoralis major myocutaneous flap. After operation 2 cycles of radioiodine therapy were taken. Now the patient is following up at the outpatient base and no evidence of disease state for postoperative 16 months. So we report on this case with a brief review of literature.

돌발성난청 환자에 대한 성상신경절 차단술의 치료효과

이호기,양해동,김문석,한재욱,전경명,김희남 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.3