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세침흡입술 및 조직생검으로 진단한 부신 골수지방종 1예
박재복,안기성,신현수,배정동,손호상,김이근,이영환,박미옥,장성국,이상채,정영식,황준호,양전호 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.1
Adrenal myelolipomas are rare, benign tumors cornposed of mature fat and bone marrow elements. Most are small, asymptomatic tumors found incidentally at postmortem examination, Fine needle aspiration biopsy can be used to confirm the diagnosis and avoid an unnecessary operation. We report a case of adrenal myelolipoma confirmed by fine needle aspiration biopsy. A 77-year-old woman with complaining of upper abdominal pain for 2 days was found to have an adrenal mass. She took dexamethasone frequently for 3 years due to multiple arthralgia. Ultrasono- graphy showed a 6cm-sized, suprarenal mass and a stone in the gall bladder with thickened wall. Computed tomography and magnetic resonance imaging scan also presented a suprarenal mass. Endocrinologic results were within normal limits. Adrenal myelolipoma was confirmed by computed tomography-guided fine needle aspiration biopsy without surgery. (J Kor Soc Endocrinol 12:105-110, 1997)
내시경 생검으로 얻은 위선암조직에서의 Microsatellite 불안정성 분석
최병렬,김진아,정운복,홍수형,김정완,이창형,손윤경,조창호,배정동,김호각,양전호 대한소화기학회 2000 대한소화기학회지 Vol.35 No.5
Background/Aims : Microsatellite instability (MSI) is a genetic alteration observed frequently in gastric carcinoma (GC). To assess the role of microsatellite instability (MSI) in gastric cancer (GC), we investigated the incidence of MSI, especially widespread MSI (MSI-H). Methods : Endoscopic biopsy specimens from 59 gastric adenocarcinomas were analyzed for MSI at 13 loci. Paraffin-embedded GC samples from the same 59 GC were analyzed for p53 protein overexpression using immunohistochemical staining. Results: MSI was detected in 33/59 (56%). MSI-H in which over than 40% of investigated loci had MSI, was observed in 7 cases (12%) and low MSI (MSI-L), in which less than 40% of the loci had MSI, was observed in 26 cases (44%). All MSI-H found in 7 cases (12%) were located in distal stomach. There was no difference in the incidences of MSI and MSI-H according to the histology of Lauren's classification, TNM stage, presence of metastasis to lymph node and family history of GC. Overexpression of p53 protein was detected in 43/59 (73%) GC, but MSI-H was not related to the p53 overexpression. MSI in interferon-αR was observed more frequently in GC with family history than GC without family history (55% vs 3%)(p=0.0002). Conclusions : MSI and p53 mutation are involved frequently in oncogenesis of GC. MSI-H is frequently observed in distal GC, but is not related with tumor progression and family history of GC.
이상은,이규철,이형석,임병욱,노재욱,류웅,김경아,이준성,양전호,문영수,김한성,이우진 인제대학교 백병원 2003 仁濟醫學 Vol.24 No.1
The hyperplastic gastric polyps are common gastric lesions characterized by hyperplastic foveolae with variable amounts of inflamed stroma. They comprise 75%~85% of all gastric epithelial polyps. The pathogenesis of malignant transformation of hyperplastic polyp is not fully understood. Usually, there is no cellular atypism, so coincidental gastric carcinoma has rarely been reported. We report a 75-year-old female patient with well-differentiated adenocarcinoma and adenoma arising from two hyperplastic gastric polyps. On the gastroscopic examination, two polyps were noted and their sizes ranged from 1.0 cm to 3.0 cm. She underwent the endoscopic polypectomy with detachable snare and endoscopic mucosal resection. Microscopically, focal cancerous change was observed in the largest one (3㎝ size, Yamada's type Ⅳ) on the anterior wall of antrum.