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- 저자 : 안효현 ( Hyo Hyun Ahn ) (검색결과 44 건)
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Board Exam. Prep. Course 1-4 (BEPC 1-4) : Dermis: fibers, matrix, fibroblast, vessels, and nerves
안효현 ( Hyo Hyun Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
The dermis, as an integral system, contains fibrous matrix, filamentous and diffuse matrix component, cellular component, most importantly fibroblast, and nerve and vascular networks. In this section, these basic constituents of the dermis will be discussed specifically according to the important articles, which appeared in major dermatological journals from the year 2012 to 2013.The dermis, making up the majority of the skin, has functions such as protection from mechanical injury, binding water, thermal regulation, and sensory, because of its features of pliability, elasticity, and tensile strength. It also has unique interaction with epidermis during development or morphogenesis, maintaining, repairing or remodeling after skin wounds. The dermis is comprised of two major parts, the papillary dermis and the reticular dermis, which defines their characteristic histologic features.
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Insidious nodules on trunk: A case of metastatic cancer of the skin and its origin
안효현 ( Hyo Hyun Ahn ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
1. Learning objectives Guessing the primary tumor in case of metastatic adenocarcinoma 2. Clinical presentation A 50-year old male visited the clinic due to several palpable nodules on his trunk. The skin nodules were asymptomatic and not tender. He had experienced as rapid enlargement as two to three times larger during the recent a few months. One month before the visit, the patient had a painful sensation of right flank, and had been diagnosed as hydronephrosis of both kidneys as a cause of the pain. Then, he had got percutaneous nephrostomy on both sides and been inserted with double-J catheter. On his past medical history, he had received anti-tuberculosis medication for 6 months 2 years ago. However, the tuberculosis infection recurred after 1 year and required additional anti-tuberculosis treatment for 9 months for the cure. The largest nodule on the right aspect of upper back was incised for histopathologic examination. 3. Pathological presentation The histopathologic study showed tumor cells, which forms small nests of various size, and glandular structure in some areas, infiltrating irregularly into reticular dermis. The immunohistochemical stains revealed as follows: CEA (+), CK7 (+), CK20 (-), TTF-1 (+), surfactant (-), p63 (-), PAS/ dPAS(+/+), Mucicarmine (+). Considering the histopathologic examinations, he was diagnosed as having metastatic adenocarcinoma, of which the primary tumor is thought to be originated from the lung. 4. Discussion Cutaneous metastasis has very important aspects to the dermatologists. First, it could be the first manifestation of not yet diagnosed internal malignancy. Second, it could reveal the first sign of distant metastasis, which would affect the stage of the disease. The skin biopsy of the cutaneous metastasis might help to expect the primary tumor by the histopathologic examinations including proper immunohistochemical studies. 5. References 1. Alcaraz I, Cerroni L, Rutten A, Kutzner H, Requena L. Cutaneous metastasis from internal malignancies: A clinicopathologic and immunohistochemical review. Am J Dermatopathol 2012;34: 347-393 2. Saeed S, Keehn CA, Morgan MB. Cutaneous metastasis: a clinical, pathological, and immunohistochemicalappraisal. J Cutan Pathol 2004;31:419-430 3. Bang CH, Bae JM, Kim HS, Kim GM, Yu DS, Park HJ, et al. Recent trends (1991-2010) of metastatic skin cancers in Korea. J Korean Med Sci 2013;28:1083-1088
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Acne related autoinflammatory diseases
안효현 ( Hyo Hyun Ahn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Autoinflammatory diseases are disorders of the innate immune system of excessive immune responses, leading to uncontrolled systemic and organ inflammation. They are not characterized by circulating autoantibodies or autoreactive T cells. The most prominent manifestation is a recurrent sterile inflammation. And, they respond to anti-IL-1 or anti-IL-1 receptor therapy. They are an emerging group of inflammatory diseases distinct from infectious, autoimmune, allergic, and immunodeficiency diseases. Since the term ‘autoinflammatory syndrome’ was introduced in 1999, a number of autoinflammatory diseases have been identified and defined. SAPHO syndrome is an autoinflammatory syndrome clinically characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis. Hyperostosis of the anterior chest, palmoplantar pustulosis, hidradenitis supprativa, and acne fulminans are associated with SAPHO syndrome. SAPHO syndrome, that compromises the skin, joint, and bones, is rare, frequently unrecognized and misdiagnosed. Initially, it had been classified among the spondyloarthropathies, but, recent evidence suggests it fits in autoinflammatory syndrome. PAPA syndrome is a recently identified hereditary autoinflammatory syndrome manifested by sterile pyogenic arthritis, cystic acne, pyoderma gangrenosum. It has known that it is caused by mutations in CD2BP1 gene that encodes proline-serine-threonine-phosphatase-interacting protein 1 (PSTPIP1). It may also include sterile cutaneous abscesses, inflammatory bowel disease, and pancytopenia following administration of sulfa-containing drugs. It is very rare, and inherited in an autosomal dominant manner. PASH syndrome is also a new autoinflammatory syndrome, maybe distinct from PAPA syndrome, characterized by pyoderma gangrenosum, acute or remittent acne conglobate, hidradenitis supprativa, and lacked of pyogenic arthritis, unlike PAPA syndrome. PASS syndrome is a rare autoinflammatory syndrome characterized by pyoderma gangrenosum, acne vulgaris, hidradenitis supprativa, and ankylosing spondylitis. As dermatologists, we need to be able to recognize the cutaneous manifestations of these syndromes for proper diagnose and early treatment, which is vital for the quality of life and the survival of the patients.
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Symposium 3-2 (SYP 3-2) : The subtypes of rosacea and its triggers
안효현 ( Hyo Hyun Ahn ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
According to the patterns of physical findings, rosacea can be classified into four subtypes, i.e. rythematotelangiectatic(ETR), papulopustular(PPR), phymatous, and ocular. osacea is a common inflammatory skin disease of not fully understood pathogenesis. The preventive easures such as the recognition and minimizing the triggering factors are crucial and important part f the therapeutic plan in rosacea, irrespective of the clinical subtypes. And, the triggers could be a ey to the insight into the pathophysiology of rosacea. ommonly known triggers are heat/cold temperature, wind, hot drinks, spicy food, exercise/sports, lcohol, emotions, topical irritants, certain medications that promote flushing, and menopausal flushing. he subtypes of rosacea might be a heterogeneous reponses to these factors. Rosacea-prone persons ust have an inherent sensitivity to the triggers. However, trigger factors are specific for each patient, and common triggers don’t affect every rosacea patient. The inherent abnormalities of cutaneous vasculature is probably the most-sited pathogenetic theory. The increased oral temperature could affect a heat exchange mechanism, which in turn trigger vasodilation. And, the climatic exposure such as heat and sunlight could damage blood vessels and dermal connective tissue. The role of sunlight or ultraviolet light is important and have been supported by many evidences, and most rosacea patients show some degree of solar damage. Other climaticfactors e.g. wind, cold, and humidity are known to exacerbate rosacea. Topical steroid use for a long time may produce the signs and symptoms similar to rosacea. And, rosacea-prone persons are more susceptible for this reaction.
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안효현 ( Hyo Hyun Ahn ),김동준 ( Dong Jun Kim ),이길주 ( Kil Ju Lee ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3
Familial lichen planus is an uncommon disease, and there are 104 cases reported in the English literature. Several theories regarding the etiopathogenesis of lichen planus have been proposed. However, immunological mechanisms and genetic susceptibility have been emphasized the most. Several reports showed HLA analysis in lichen planus patients, and recently 2 cases have revealed an increased frequency of DR1 antigen in patients with lichen planus compared to a control group. We observed two brothers with typical skin lesions of lichen planus of almost simultaneous onset. We confirmed lichen planus by skin biopsies in both brothers and analyzed HLA typing. We also observed the occurrence of DR1 antigen in both of them. (Korean J Dermatol 1998;36(3): 473-476)
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Dermis: fibers, matrix, fibroblast, vessels, and nerves
안효현 ( Hyo Hyun Ahn ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
The dermis, as an integral system, contains fibrous matrix, filamentous and diffuse matrix component, cellular component, most importantly fibroblast, and nerve and vascular networks. In this section, these basic constituents of the dermis will be discussed specifically according to the major dermatological journals from the year 2011 to 2012. The dermis, making up the majority of the skin, has functions such as protection from mechanical injury, binding water, thermal regulation, and sensory, because of its features of pliability, elasticity, and tensile strength. It also has unique interaction with epidermis during development or morphogenesis, maintaining, repairing or remodeling after skin wounds. The dermis is comprised of two major parts, the papillary dermis and the reticular dermis, which defines their characteristic histologic features.
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