공격성의 신경생물학

김기원,안은숙,이유상,박선철,Kim, Ki Won,An, Eun-Soog,Lee, Yu-Sang,Park, Seon-Cheol 대한생물정신의학회 2013 생물정신의학 Vol.20 No.4

Aggression can be defined as 'behavior intended to harm another' which can be seen both from humans and animals. However, trying to understand aggression in a simplistic view may make it difficult to develop an integrated approach. So, we tried to explain aggression in a multidisciplinary approach, affected by various factors such as neuroanatomical structures, neurotransmitter, genes, and sex hormone. Parallel with animal models, human aggression can be understood with two phenomena, offensive aggression and defensive aggression. Neurobiological model of aggression give a chance to explain aggression with an imbalance between prefrontal regulatory influences and hyper-reactivity of the subcortical areas involved in affective evaluation, finally in an aspect of brain organization. Serotonin and GABA usually inhibit aggression and norepinephrine while glutamate and dopamine precipitate aggressive behavior. As there is no one gene which has been identified as a cause of aggression, functions between gene to gene interaction and gene to environment interaction are being magnified. Contributions of sex hormone to aggression, especially molecular biologic interaction of testosterone and regulation of estrogen receptor have been emphasized during the research on aggression. This multidisciplinary approach on aggression with types, neurochemical bases, and animal models can bring integrated interpretation on aggression.

정신분열병과 Catechol-O-methyltransferase(COMT) 유전자 다형성의 연합

송은숙,양병환,박강규,이유상,안은숙,오동열,김종원,최인근,김길숙,채영규,Song, En-Sook,Yang, Byung-Hwan,Park, Kang-Kyu,Lee, Yu-Sang,An, Eun-Soog,Oh, Dong-Yul,Kim, Jong-Won,Choi, Ihn-Geun,Kim, Gil-Sook,Chai, Young-Gyu 대한생물정신의학회 1998 생물정신의학 Vol.5 No.2

An association study with Korean schizophrenic patients(N=84) and normal controls(N=87) was performed to find the relationship between catechol-O-methyltransferase(COMT) gene polymorphism and schizophrenia using polymerase chain reaction-restriction fragment length polymorphism. When we compared the allele and genotype frequencies of Bgl I COMT gene polymorphism in schizophrenics and normal controls, there was no significant difference between two groups. Our results do not support an association between the Bgl I polymorphism of COMT gene and schizophrenia.

남자 알코올의존 환자에서 가족력에 따른 우울 및 공격성, 가족환경과의 관계

이정식(Jung-Sik Lee),안은숙(Eun-Soog An),김형배(Hyung-Bae Kim),신용구(Yong-Gu Shin) 한국중독정신의학회 1999 중독정신의학 Vol.3 No.1

Objective:We intended to identify relationships among depression, aggression, and family environment in patients with alcohol dependence, and relationships in these variables according to the family history of alcohol dependence. Method:We examined 49 male patients with alcohol dependence (DSM-Ⅳ) who had been admitted in Yong-In Mental Hospital from June 1st 1998 to October 31th 1998. We performed semistructured interview for demographic and clinical characteristics, and family history. Self-report questionnaires for aggresssion (Buss- Durkee Hostility Inventory), depression (Beck Depression Inventory), and family environment (Family Environmental Scale) were given to all subject at least 4 weeks later after admission. We devided alcoholic patients into two groups according to family history of alcohol dependence, i. e. familial alcoholics (N=26) and non-familial alcoholics (N=23). Results:1) In alcoholic patients, there were statistically significant positive correlations between aggression and depression, especially between spontaneous aggression subscale and depression. 2) In non-familial alcoholics, there were statistically significant positive correlations between aggression and depression, especially between control of aggression subscale and depression. And there was a statistically significant negative correlation between family conflict subscale and depression. 3) In familial alcoholics, there was a statistically significant positive correlation between spontaneous aggression subscale and depression, but a statistically significant negative correlaion between expression oofaggression subscale and depression. Conclusions:We found that there was a positive correlation between aggression and depression in alcoholics. And we suggested that deression may be much more influenced by spontaneous aggression and temperamental factor in familial alcoholics and by family conflict and environmental factor innon-familial alcoholics relatively.

시설거주 노인들에서 주관적 기억장애 호소와 객관적 인지기능

이정식 ( Jung Sik Lee ),이우경 ( Woo Kyeong Lee ),박은미 ( Eun Mi Park ),이원혜 ( Won Hye Lee ),오홍석 ( Hong Seok Oh ),안은숙 ( Eun Soog An ),고영 ( Young Ko ) 한국정신병리진단분류학회 2006 精神病理學 Vol.15 No.1

Objectives: There are inconsistent results about relationships among the subjective memory complaints(SMC), objective memory functions, and depression. The Authors tried to examine the association of subjective memory complaints in the elderly with objective cognitive functions, depression and other demographic variables such as sex, age, and education. Methods: Total 175 participants living in the asylum for the aged had completed CERAD-K(the Korean version of the Consortium to Establish a Registry for Alzheimer`s Disease) to evaluate neuropsychological function. All of them were evaluated by four specific questions about everyday memory function. Symptoms of depression were evaluated by SGDS-K(Short Geriatric Depression Scale of Korean version). We divided the elderly into two groups(SMC+ group, SMC- group) to evaluate the differences in cognitive function and depression. Results: 109(62.3%) of the subject acknowledged having trouble with their memory. Memory decline and cognitive decline were associated with SMC. SMC+ group scored significantly lower on word delayed recall test than SMC- group, especially. Age, sex and education were significantly associated with SMC in total subject but not education in non-demented subject. Total score of SMC was explained partly by word delayed recall and depression variables in non-demented subject. Conclusion: This study suggested that association between SMC and objective memory function had clinical implication that SMC was a significant part of MCI criteria associated with early stage of Alzheimer`s Disease.

대학생에서 몰입과 NEO-PI-R로 측정한 성격 특성과의 관계

윤석민 ( Seok Min Yoon ),이준엽 ( Jun Yup Lee ),안은숙 ( Eun Soog An ),이정식 ( Jung Sik Lee ) 한국정신병리진단분류학회 2010 精神病理學 Vol.19 No.1

Objectives: Absorption is the mental state of operation in which a person in an activity is fully immersed in a feeling of energized focus, full involvement, and success in the process of the activity. For now, there are many studies to research in specific conditions and group of occupations. Through many studies, absorption has important meanings in general and clinical fields. It is worth to know persons who are doing well at absorption have what kind of personality. So, the present investigation sought to explore the relationship between absorption and personality dimensions. Methods: The relationship between absorption and personality dimension was investigated in a sample of 210 undergraduate students. Absorption was measured by the TAS(Tellegen Absorption Scale), personality characters was measured by the NEO-PI-R(NEO Personality Inventory Revised). We devided the students into two groups according to TAS[TAS≥16(N=95), TAS<16(N=115)]to evaluate differences in personality domains of NEO-PI-R. Chi-square test and t-test was used for differences in personality domains of NEO-PI-R and demographic variables according to variable. Pearson correlation test was used for relationship among the NEO-PI-R, TAS. We also used stepwise regression analysis to evaluate accountability of personality domains for absorption. Results: High TAS group had higher score of Neuroticism(t=3.319, p=.002), Extraversion(t=2.063, p=.040) and Openness(t=4.054, p=.000) domain than low TAS group. TAS was correlated with score of Neuroticism(r=.136, p<.05), Extraversion(r=.215, p<.01), Openness(r=.332, p<.01) in the total samples. In the stepwise regression analysis, TAS was explained partly by Openness and Neuroticism Conclusion: As hypothesized, The Neuroticism, Extraversion and Openness domain accounted for the great portion of variance in the absorption. Future study, It is necessary to explore in psychiatric patients for clinical application.