교통사고로 인한 다발성 외상 환자의 국소진동을 동반한 물리치료 중재가 통증 및 관절운동범위, 심리적 상태에 미치는 영향

안승원,정영준,정상모,Ahn, Seung-won,Jung, Young-june,Jung, Sang-mo 대한정형도수물리치료학회 2019 대한정형도수물리치료학회지 Vol.25 No.2

Background: The purpose of this study was to investigate into the effects of physical therapy intervention with local vibration on pain, ROM (range of motion) and psychological status in multiple trauma patients caused by traffic accident. Methods: A patient with multiple trauma were recruited. Before treatment, he was evaluated using numeric pain rating scale (NPRS), Korean-version impact of event scale-revised (IES-R-K), Beck Depression inventory (BDI), passive and active range of motion, and were reevaluated after 4 and 8 weeks of treatment. Results: As a result of comparing the participant before and after the experiment, the score of the IES-R-K and BDI decreased. And the passive and active ROM increased. Conclusion: According to the results above, physical intervention with local vibration by Blackroll Releazer can help improve pain, physical function and psychological status. Also, physical intervention with Blackroll's Releazer technique was able to select interventions depending on the patient's conditional and the desired goal.

소도구를 활용한 연부조직가동술이 주관절 외측상과염 환자에게 통증과 악력, 기능, 고유수용성감각에 미치는 영향

안승원,유태근,Ahn, Seung-won,Yoo, Tae-geun 대한정형도수물리치료학회 2017 대한정형도수물리치료학회지 Vol.23 No.1

Background: The purpose of this study was to investigate into the effect of soft tissue mobilization using prop on the pain, grip strength and functional activity in patients with lateral epicondylitis. Methods: Fifteen patients with lateral epicondylitis were recruited. Before treatment, they were evaluated using visual analogue scale (VAS), grip strength, test, patient-rated tennis elbow evaluation (PRTEE), proprioception, and were reevaluated after six weeks of treatment. Results: As a result of comparing all participants before and after the experiment, the grip strength increased significantly (p<.05). And the VAS, PRTEE, and proprioception decreased significantly (p<.05). Conclusion: According to the results above, soft tissue mobilization using prop can help improve pain, grip strength, PRTEE and proprioception. Also, soft tissue mobilization using Blackroll's Twister technique was able to select interventions depending on the patient's condition and the desired goal.

만성 경부통을 가진 시내버스 운전기사에게 복합 운동프로그램의 효과 : 사례연구

안승원,정영준,Ahn, Seung-won,Jung, Young-june 대한정형도수물리치료학회 2015 대한정형도수물리치료학회지 Vol.21 No.1

Background: Although many of those who drive for a living are exposed to repetitive and awkward posture and whole body vibration which cause them cumulative trauma disorder, therapeutic studies related to the problems from the transport unit are still somewhat inadequate. The purpose of this case report is to identify the effect of combined exercise program on patients suffering chronic neck pain caused by long hour of intra-city bus driving. Method: A total of 4 subjects are selected as patients, all of whom have more than 10 years of experience in intra-city bus transportation services. These people have suffered from neck pain for years. We ran the combined exercise program 3 times a week for 4 weeks and respectively evaluated the results after the 2nd and 4th week. We implemented conventional physiotherapy for 40 minutes, another 40 minutes of combined exercise program, and then educated the patients to enable themselves to do active stretching program as a home program. The combined exercise program contained 3 different stages. 1st stage: active stretching program, 2nd stage combined stabilization exercise and strengthening exercise, 3rd stage: proprioceptive exercise Result: After 4 weeks of intervention, there was enhance in the range of motion. $12^{\circ}$ increase in flexion, $10^{\circ}$ in extension, $6^{\circ}$ in lateral flexion respectively, and $10^{\circ}$ in rotation on average. VAS(visual analgue scale) decreased by 33% on average, NDI(neck diability index) by 28% and fatigability by 23%. Conclusion: There were improved results in the range of motion, NDI, VAS, and in fatigability after applying combined exercise program to intra-city bus drivers exposed to whole body vibration and cumulative trauma disorder.

원발성 손바닥 다한증 환자에서 20% 알루미늄 클로라이드 용액과A형 보툴리눔 독소 주사의 치료효과 비교

안승원 ( Seung Won Ahn ),김연진 ( Yeon Jin Kim ),김범준 ( Beom Joon Kim ),김명남 ( Myung Nam Kim ),이동훈 ( Dong Hun Lee ),허창훈 ( Chang Hun Huh ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.3

Background: Primary hyperhidrosis carries a substantial psychological and social burden. Early detection and management can significantly improve a patient`s quality of life. A large number of therapeutic options are used, such as the application of topical agents, iontophoresis, sympathectomy, and botulinum toxin injection. Objective: We aim to comprehensively evaluate the effects of botulinum toxin type A and 20% aluminum chloride on primary palmar hyperhidrosis. Methods: A total of 55 patients with clinical diagnosis of primary hyperhidrosis were treated by botulinum toxin type A and 20% aluminum chloride solution. To prospectively assess the effects on primary palmar hyperhidrosis, we checked corneometer at baseline, 2 and 4 months later. By regular meetings with patients, including telephone interviews, we analyzed patients` subjective satisfaction scores and complaints during the follow-up periods. Results: During the 2-month period, as compared with that of the control group, the level of corneometer of both groups declined. In the 4-month period, the group treated with 20% aluminum chloride sustained a lower level of corneometer. In the questionnaire, in the 2-month period, the group treated with botulinum toxin resulted in a lower level of overall treatment scores than that of the group treated with 20% aluminum chloride. However, in the 4-month period, the group treated with aluminum chloride showed lower scores. Conclusion: Both botulinum toxin type A and aluminum chloride solution were safe and well tolerated, producing high levels of patient satisfaction. However, considering the long-term efficacy of treatment, aluminum chloride may be a more suitable mode of treatment for primary palmar hyperhidrosis. (Korean J Dermatol 2008;46(3):334∼340)

전방머리자세를 가진 초등학생에게 복합운동프로그램이 자세변화와 보행, 균형능력에 미치는 영향: 사례연구

이윤상,안승원,정상모,박현식,주태성,Lee, Yoon-sang,Ahn, Seung-won,Jung, Sang-mo,Park, Hyun-sik,Ju, Tae-seong 대한정형도수물리치료학회 2017 대한정형도수물리치료학회지 Vol.23 No.1

Background: The purpose of this case study was to investigate into the effect of complex exercise program on the postural change, gait and balance ability in elementary school students with forward head posture. Methods: Four patients with forward head posture were recruited. They were evaluated pre-treatment, and after 6weeks, using neck disability index (NDI), numeric pain rating scale (NPRS), balance ability, foot pressure (fore foot/rear foot peak pressure ratio, F/R ratio), gait ability (cadence, toe out angle, stance phase). Results: First, the angle of forward head posture (craniovertebral angle; CVA and cranialrotation angle; CRA) was decreased in all subjects. The NPRS and NDI were decreased in all subjects. Also, The cadence, toe out angle and F/R ratio were increased in all subjects. The stance phase of gait cycle was positively change in all subjects. Lastly, the static balance ability improved in all subjects. Conclusion: According to the results above, the complex exercise program for students with forward head posture can help improve the postural change, gait and balance ability. Also, the complex exercise program was able to select interventions depending on the patient's condition and the desired goal.

비탄력 테이핑이 슬개대퇴관절 통증증후군 환자의 슬개건 통증과 슬관절부 근력, 보행에 미치는 영향 비교

정상모,정영준,안승원,Jung, Sang-mo,Jung, Young-jun,Ahn, Seung-won 대한정형도수물리치료학회 2019 대한정형도수물리치료학회지 Vol.25 No.2

Background: Ground repulsion or impact on the ground during daily activities, sports, or occupational activities may cause injury to the knee when walking. Non-elastic taping is effective in treating these problems in previous studies. Non-elastic taping strengthens the structure of the soft tissues of the injured knee joint to maintain constant tension, improves muscle rearrangement and function, and improves proprioception. Based on previous studies, we intended to see the therapeutic changes of non-elastic taping in patients with patellofemoral joint pain syndrome. Methods: The non-elastic taping application method was applied to the patient three times for five hours for one week. Non-elastic taping was applied to the patellar tendon with little space above the skin segment of the patellar femur, with both sides fixed by taping. Muscle strength and gait change were evaluated with non-elastc taping. Results: The knee flexion, extension strength and gait evaluation of the knee joint with inelastic taping showed significant differences after treatment. There was a significant difference in the comparison between the two groups after the treatment method was applied (p<.05). Conclusion: As a result, this study confirms that the non-elastic taping method applied for the treatment of patellar femoral joint pain syndrome is effective in the treatment.

안드로겐성 탈모증 환자에서 사이토퓨린(Cytopurine)과 펜타데칸산글리세리드(Pentadecanoic Glyceride) 배합 육모제의 유효성 및 안전성 평가에 관한 임상연구

홍창권 ( Chang Kwun Hong ),한태영 ( Tae Young Han ),강한철 ( Han Chyul Kang ),안승원 ( Seung Won Ahn ),안지영 ( Ji Young Ahn ),서성준 ( Seong Jun Seo ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12

Background: Androgenetic alopecia (AGA) is the most common type of hair loss found in both males and females. Oral finasteride and topical minoxidil are the only drugs approved, till now, by the Food and Drug Administration of USA for the treatment of this condition. Unfortunately, these treatment options are not satisfactory. Therefore, it has been necessary to develop new agents for this psychologically frustrating disease. Objective: This is a 16-week, double-blinded, placebo-controlled, randomized clinical trial to determine whether a new topical agent, cytopurine/pentadecanoic glyceride topical solution, is effective in showing clinical improvements in patients with AGA. Methods: A total of 74 men and 21 women (24∼55 years old) with AGA were treated either with the new topical solution or a placebo, twice daily. Efficacy was evaluated by daily shed hair count, phototrichogram and patients` subjective and investigators` subjective assessments for clinical improvement. All adverse effects were reported during the study. Results: After 16 weeks of therapy, combination cytopurine/pentadecanoic glyceride topical solution treatment resulted in a significant improvement from the baseline in total hair count and daily shed hair count. But there were no statistically significant differences in anagen hair count, mean hair diameter, patients` subjective and investigators` subjective assessments for clinical improvement and side effects between the cytopurine/pentadecanoic glyceride treated and placebo group. Conclusion: We have confirmed the efficacy of combination cytopurine/pentadecanoic glyceride topical solution in treating AGA, by an objective assessment with phototrichogram. (Korean J Dermatol 2007;45(12):1233∼1239)

자가면역용혈빈혈 후 순수적혈구무형성증 발생한 전신홍반루푸스 1예

김미희 ( Mi Hee Kim ),최지연 ( Ji Yeon Choi ),이상민 ( Sang Min Lee ),안승원 ( Seung Won Ahn ),정승민 ( Seung Min Jung ),김현정 ( Hyun Jung Kim ),원혜성 ( Hye Sung Won ) 대한내과학회 2016 대한내과학회지 Vol.90 No.6

전신홍반루푸스 환자에서 드물게 자가면역용혈빈혈과 순수적혈구무형성증이 함께 발생할 수 있다. 따라서 본 증례에서와 같이 자가면역용혈빈혈 환자가 치료 도중 스테로이드에 저항성을 보이고 빈혈이 악화된다면 순수적혈구무형성증과 같은 다른 빈혈의 원인을 검토해보아야 한다. 또한 자가면역용혈빈혈 또는 순수적혈구무형성증 환자에서 다른 기저질환의 동반 가능성을 고려하여 이에 대한 검사를 진행해야 한다. Pure red cell aplasia (PRCA) is a rare hematological disorder characterized by severe normochromic normocytic anemia and reticulocytopenia due to erythroid progenitor depletion in an otherwise normal bone marrow. Autoimmune hemolytic anemia (AIHA) is caused by autoantibodies directed against red blood cells with normocytic or macrocytic anemia with reticulocytosis. Both diseases can develop in conjunction with various underlying diseases, such as immunological disorders. Although rare, there have been a few cases of AIHA followed by PRCA. Here, we report a patient who developed PRCA following AIHA and was later diagnosed with systemic lupus erythematosus. (Korean J Med 2016;90:554-558)

Expression of b-defensins mRNA in Human Skin

서성준 ( Seong Jun Seo ),김유진 ( Yu Jin Kim ),안승원 ( Seung Won Ahn ),김명남 ( Myung Nam Kim ),홍창권 ( Chang Kwun Hong ),노병인 ( Byung In Ro ) 대한피부과학회 2002 초록집 Vol.40 No.10

Dendritic Epidarmal T Cell 에서 유래된 Keratinocyte Growth Factor 유전자의 Transfection 이 각질형성세포의 증식과 분화에 미치는 영향

김용준,서성준,안승원,홍창권 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.6

Background : Dendritic epidermal T cell(DETC) resident in mouse epidermis is ?? δ-T lymphocytes. Most of them express V 5/V δ 1 T cell receptor. Compared with α β-T lymphocytes, physiologic and/or pathologic role of DETC are not fully understood. Keratinocytes under the conditions such as irradiation, viral and bacterial infection, and exposure to carcinogen may express keratinocyres self-antigen. DETC may have the ability to recognize stressed and malignant keratinocytes. Moreover, specific chemokines released from DETC may contribute to inflammatory response, which maintain skin integrity and homeostasis. Objective : The purpose of this study was to investigate the effects of transfection of keratinocyte, growth factor(KGF) gene derived from DETC on the keratinocyte proliferation and differentiation in cell culture. Methods : RT-PCR using KGF primer to confirm the KGF mRNA in DETC and Keratinocyte MTT assay to evaluate the effect of keratinocyte proliferation and immunohistochemical staining using anti keratin(K)14 mAb, anti K1,10 mAb and anti involucrin mAb as a marker to elucidate the effect of keratinocyte differentiation were done. Results : 1. The KGF specific PCR product was demonstrated in DETC, normal positive control of cultured fibroblast and KGF gene transfected cultured keratinocytes, but it was not observed in normal cultured keratinocytes by RT-PCR using KGF-specific primer. 2. Numbers of keratinocytes in normal control group were (2.5±0.5)*10^4, (8.8±1.5)*10^4, (8±0.5)*10^4, (10.5±0.7)*10^4 after 1st, 2nd, 3rd and 4th days, respectively. Numbers of keratinocytes with KGF gene transfected group were (1.5±1.0)*10^4, (9.5±0.2)*10^4, (9.8±0.5)*10^4, (13±2.0)*10^4 after 1st, 2nd, 3rd and 4th days, respectively. In comparison to the control, the numbers of keratinocytes were increased in the KGF gene transfected group from the 3rd and 4th day(p<0.05). On the MTT assay, compared with the control, the numbers of keretinocytes were also increased in the KGF gene transfected group at 3rd day(p<0.05). 3. In the immunohistochemical staining with mAb to k1,10 and involucrin, to evaluate the degree of differentiation of keretinocytes reveals that KGF gene transfected cells with Ca^+^+(0.5mM) were stained weaker than the degree of differentiation of Ca^+^+(0.5mM) treated group. Immunohistochemical staning with mAb to K14 reveals that KGF gene transfected cells with Ca^+^+(0.5mM) were stained stronger than the degree of differentiation of Ca^+^+(0.5mM)treated group. Conclusion : The above results strongly suggest that KGF, which produced by activated DETC, have a role in stimulating the proliferation and suppressing the differentiation of keratinocytes in the skin. In conclusion, DETC may involved in the control of proliferating activity of neighboring keratinocytes through KGF commonication, which play an important role in the maintenance of epithelial integrity.