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- 저자 : 안성구 ( Sung Ku Ahn ) (검색결과 174 건)
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역 모낭성 각화증의 임상적 고찰 및 Human Papillomavirus의 검색에 관한 연구
안성구,이인욱,최응호,이원수,이승헌,이동원 ( In Wook Lee,Eung Ho Choi,Sung Ku Ahn,Won Soo Lee,Seung Hun Lee,Dong Won Lee ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.6
Background : Inverted follicular keratosis has distinctive histopathological features and is infre quently encountered by dermatologists. To date, the pathogenesis of inverted follicular keratosis has not, been concluded. Many authors have suggest,ed several theories for the nature of invert.ed follicular keratosis including vearuca vulgaris with squamous eddies, irritated seborrheic keratosis and dist,inctive follicular tumors. Objective : It is the purpose of this study to observe and compare the clinical features of in verted follicular keratosis with previous studies and evaluate the possible relationship between in verted follicular keratosis and human papillomavirus to clarify the nature of this condition. Methods : We studied 9 patients with inverted follicular keratosis for clinical features including the duratiori of the disease, the location and size of the lesions, the clinical impressions at the first visit and we made a record of the patients age and sex. To evaluate the relationship be tween inverted follicular kerato is and the human papillomavirus, we performed immunohistochvm ical staining using polyclonal antibodies to the human papillomavirus common antigen. We also used the polymerase chain relation to detect hurnan papillomavirus DNA in inverted follicular keratosis from paraffin embedded tissue preparation. Results : 1. Seven of the 9 patients,vere male and the ages ranged fiom 36 to 77 years(mean 53 years). The lesions were situat d on the face(4/9),abdomen(1/9), back(1/9), chest(1/9), scapular area(1/9) and leg(1/9). The average size of the lesions was 1.5 cm. Verruca vulgaris was the most common clinical diagnosis(3/9), followed by seborrheic keratosis(2/9), soft fibroma(2/9), pigmented nevi(1/9), and granioloma pyogenicum(1/9). 2. Immunohistochemical stainiiigs using polyclonal antibodies to the human papillomavirus common antigen were negative for all 9 cases. 3. Polymerase chain reaction; using primers for human papillomavirus DNA were negative for all 9 cases. Conclusipn : In general, our linical findings are similar to those of others in previous studies. Our results of immunohistocheriiical staining and the polymerase chain reactions suggest, that in vert,ed follicular keratosis is ncl, related to the human papillomavirus. Further investigat.ions inf'o the nature of invert,ed follicular keratosis, should be centered on initated seborrheic keratosis and distinct follicular tumor s. (Korean J Dermatol 1997;35(6): 1074-1081)
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안성구(Sung Ku Ahn),이승현(Seung Hun Lee),이성낙(Sung Nack Lee) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.1
We Report a hibernoma which ocurred in a 30-year-old male, who had 2cm sized, well-marginated, subcutaneous mass on the right side of the scapula. Histopathologic finding showed the tumor was composed of uniform granular or multivacuolated, eosinophilic, round to ovoid cells with small and peripherally plnced nuclei. Total exrision of the tumor was performed. No recurrence was observed for 5 months after surgical excision. (Kor J Dermatol 29(1):100 103, 1991)
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안성구(Sung Ku Ahn),강원형(Won Hyoung Kang),이성낙(Sung Nack Lee) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.6
A,50-year-old man developed 3cm sized, well-marginated, subcutaneous mass on the right upper back. Histopathologic finding showed the lipomatous tissue was replaced by a mixture of uniform spindle cells and mature fat cells that were closely associated with a mucoid matrix and a varying number of collagen fibers. The patient had been treated with excision and showed no evidence of recurrence. (Kor J Dermetol 28(6):810 813, 1990)
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안성구 ( Sung Ku Ahn ),이은희 ( Eun Hee Lee ),홍승필 ( Seung Phil Hong ),최응호 ( Eung Ho Choi ),이승헌 ( Seung Hun Lee ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.1
Background: Water exposure is considered an important causative factor of irritant contact dermatitis. It is also known that water exposure can disrupt the stratum corneum (SC). However, there are only a few morphologic studies on the effect of water contact on the skin. Objective: The aim of our study was to investigate the effects of prolonged water exposure on the permeability barrier and the ultrastructure of the SC intercellular lipids. Methods: After prolonged water exposure of hairless mouse skin in vivo for 24, 36, 48, and 72 hrs respectively, the permeability barrier function was assessed by transepidermal water loss (TEWL) measurement, and the ultrastructure of SC by electron microscopy using osmium tetraoxide and ruthenium tetraoxide postfixation and calcium ion capture cytochemistry. Additionally, the lipid composition was evaluated using confocal microscopy with nile red stain and the integrity of the SC assessed using a lanthanum tracer. Results: After prolonged water exposure, water caused a significant increase in TEWL with disappearance of the calcium gradient, but this did not significantly influence the recovery rate of TEWL. The intercellular lipids were disrupted, and multiple lacunae containing abnormal delaminated materials within the intercellular spaces were observed. Lanthanum tracer penetrated into the intercellular space of the SC. There was a progressive decrease in nile red staining with neutral lipid content. With increasing exposure to water, these results were more evident. Conclusion: Our results provide a better understanding of the disruptive effect of prolonged water exposure on barrier lipids, the penetration-enhancing effect of water and the increased susceptibility to irritants, with regard to duration of water exposure. (Korean J Dermatol 2007;45(1):23~33)
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안성구(Sung Ku Ahn),안형진(Hyung Jin Ahn) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.1
Vaccination is defined as the introduction of vaccine into the body for the purpose of inducing immunity. Vaccine contain many antigens, e.g., active antigen in DTP, tissue culture fluid in the suspension of vaccine, aluminum complexes in MMR, preservatives, anti-infectives, and antibiotics which induce many allergic reactions. B.C.G vaccine induce specific and nonspecific dermatological complications on inoculation site or out of vaccination. DPT or TT vaccine induce infection site granuloma due to aluminum on inoculation site, angiolymphoid hyperplasia with eosinophilia, and livedoid skin necrosis. Hepatitis B vaccine can induce many dermatological complications, e.g., urticaria and angioedema, erythema nodosum, systemic lupus erythematosus, lichen planus and thrombocytopenic purpura. Gianoti-Crosti syndrome is caused by MMR vaccine and influenza vaccine. Sweet's syndrome and acute exanthematous pustular dermatitis are developed after pnuemococcal vaccintation. Herpes zoster can be developed after chicken pox vaccination. Erythema and edema can be developed after injection of botulinum toxin. Benign and malignant tumor can be induced by various vaccination, too. (Korean J Dermatol 2000;38(1):1~14)
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Ethyl Carbamate와 그 대사산물의 피부종양 유발에 관한 조직학적 연구
안성구 ( Sung Ku Ahn ),정준 ( Joon Chung ),박윤기 ( Yoon Kee Park ),박광균 ( Kwang Kyun Park ) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.4
Background : Ethyl crbmate(EC) has been identified at low microgram quantities in various fermented beverages, destiled products and tobacco smoke. EC has long been known as a carcinogen. Oxidation of the ethyl group of EC is followed by dehydration to yield the carcinogen vinyl carbamate (VC). This is further oxidized to vinyl carbamate epoxide(VCO). VC and VCO proved to be much more carcirogenic than EC. Object: The objective of this study is to compare the potency of carcinogenic ability and histologic changes in skin tumors induced by EC, VC, or VCO. Methods : In this exeriment, the tumor induction was performed by painting the mouse skin once a week for five weeks with EC, VC and VCO solution, and then 12-0-tetradecanoyl-phorbol-13-acetate(TP2) was treated in the same manner twice a week for 35 weeks. We biopsied the skin at B 0, 15, 25, 30 and 35 weeks and stained the specimens with hematoxylineosin. Results : The time period for the first appearance of papilloma was 6 weeks in the VC-TPA and VCO-TPA group, but, 15 weeks in the EC TPA group. The average number of papilloma showed a statistically sign.ficant difference after 15 weeks between the EC-TPA, VC-TPA and VCO-TPA group. The occurrence of keratoacanthoma and squamous cell carcinoma was 16 and 21 weeks respectively. Histologic changes, such as epidermal layers, pseudohorncysts, degree of hyperkeratosis, hypergranulosis, dysplasia and dyskeratotic cells were more prominent in the papil loma than in the non-papilloma lesion. Dermal changes disclosed similiar findings, that is, increased dermal thicknes, proliferation of vessels and hair follicles, and fibrosis of the dermis. Squamous cell carcinomis and keratoacanthomas were produced only in the VCO-TPA group. Conclusion : From the above results it is concluded that VC and VCO have a more potent carcinogenic potential than EC. Various skin tumors, such as papilloma, keratoacanthoma or squamous cell carcinoma were prorduced by the above carcinogens. (Kor J Dermatol 1995;33(4): 599-610)
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안성구 ( Sung Ku Ahn ),이해진 ( Hae Jin Lee ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.10
A defoliant is a toxic chemical agent used to remove leaves. Defoliants are classified into 6 types (purple, pink, green, blue, white and orange). From 1962 to 1971, due to removing leaves and securing their ability to see, the U.S. Army Chemical Corps veterans handled and sprayed defoliant in Vietnam. This resulted in exposure to Agent Orange and its contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). This agent induces many medical problems in humans. Since 1992 in Korea, exposure to defoliants have given rise to several problems. However, there were few reactions due to the lack of data, social apathy, and international relationships. In this article, we review characteristics and diseases related to defoliants. (Korean J Dermatol 2011;49(10):863∼871)
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