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NC/Nga 마우스에서 생약 복합 조성물 YJ-1의 아토피성 피부염 치료 효능
이금선(Geum Seon Lee),이기만(Ki Man Lee),심홍(Hong Shim),김진홍(Jin Hong Kim),정재훈(Jae Hoon Cheong),강태진(Tae Jin Kang) 대한약학회 2012 약학회지 Vol.56 No.2
This study was conducted to determine if YJ-1, a novel herbal complex from a mixture of six oriental herbs (Hydnocarpi Semen, Sesami Semen, Dictamni Radicis Cortex, Momordicae Semen, Xanthii Fructus, and Sophorae Radix), has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD like symptom-induced NC/Nga mice by 1-chloro 2,4-dinitrobenzene (DNCB), the effectiveness of YJ-1 on AD was evaluated. Elidel cream?? (1% pimecrolimus) was used as a control. Dermal application of YJ-1 reduced major clinical signs of AD such as erythema, pruritus, lichenification, edema/escoriations, and dryness. Interestingly, YJ-1 more improved AD-related symptoms including decrease of spleen weight, IL-4, and IgE level in the serum as well as reduction of scratching counts and clinical skin severity in the NC/Nga AD mouse model. Especially, treatment of YJ-1 at 20% in NC/Nga mice more effected than Elidel cream. These results suggest that the ointment of YJ-1 may enhance the process of AD healing by alleviating allergic reaction and has potential for therapeutic reagent for the treatment of AD.
단보 : 제주긴뿌리동충하초와 풍뎅이동충하초 배양액의 Nitric Oxide 생성 저해
이기만 ( Ki Man Lee ),이금선 ( Geum Seon Lee ),심홍 ( Hong Shim ),남성희 ( Sung Hee Nam ),강태진 ( Tae Jin Kang ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.1
During search for novel bioactive materials from natural resources with the potential as health food and alternative medicine, the culture broth of Cordyceps longissima (CL) J106, J144 and C. scarabaeicola (CS) J94, J123 were prepared, and their effect on cytotoxicity and nitric oxide (NO) production in RAW 264.7 cells were investigated. Whereas the culture broth of CL J144 and CS J123 had cytotoxicity in RAW 264.7 cells, that of CL J106 and CS J94 did not. The culture broth of CL J106 and CS J94 suppressed NO production in RAW 264.7 cells activated with lipopolysaccharide (LPS) at a dose-dependent manner. These results suggest that culture broth, a by-product of Cordyceps, may have active compounds with anti-inflammatory effect. In addition, it appears that their biological activity is dependent on the strains in spite of the same species.
심홍임 한국음성과학회 2004 음성과학 Vol.11 No.3
This was a preliminary study for standardizing speech rate and fluency of normal adult Korean speakers and comparing speech rate and fluency of normal speakers with those of professional speakers. The purposes of this study were to investigate (a) the speech rates (the overall speech rate and the articulation rate) and the disfluency characteristics of normal adult speakers and (b) the speech rates (the overall speech rate and the articulation rate) and the disfluency characteristics between normal adult speakers and professional speakers. The results were as follows: The most frequent disfluency type was 'interjection' in story-telling, 'revision' in text reading and announcing of professional speakers. The professional speakers had the fastest speech rates (overall speech rate and articulation rate) among the 3 groups.
문맥적 상황중심의 그림 그리기 과업이 중증의 베르니케 실어증과 브로카 실어증에 미치는 영향
이옥분,심홍임,정옥란 한국음성과학회 2003 음성과학 Vol.10 No.3
This study attempted to determine the effect of a context-based drawing task on the language expression of a severe Wernicke's and Broca's aphasic. The subjects in this study showed a poor auditory comprehension and naming performance. They also showed paraphasia and preservation. This study focused on improving language expression by a drawing task based on conversation at hand. Ten target words were chosen which were easily drawnable and familiar to the subjects. The results showed that the context-based drawing task was effective on improving the subjects' confrontation naming ability and expressive language ability in terms of explanation of sentences. In addition, the Broca's aphasic showed improved naming ability when the contextual cues were given and he was supposed to spontaneously name words.