http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
제대혈 내 Matrix Metalloproteinase-9 농도와 제대염의 연관성
심순섭 ( Soon Sup Shim ),강혜심 ( Hye Sim Kang ),맹영희 ( Young Hee Maeng ),김영돈 ( Young Don Kim ) 대한주산의학회 2015 Perinatology Vol.26 No.1
Objective: Intrauterine inflammation (IUI) is a leading cause of preterm delivery. Although matrix metalloproteinase8 (MMP8) and intercellular adhesion molecule1 (ICAM1) are known to be related with IUI, it has not been fully elucidated whether MMP9 or ICAM3 is associated with IUI. We performed this study to determine whether the levels of tumor necrosis factoralpha (TNFα), MMP9 and ICAM3 in umbilical cord blood of preterm infants are associated with chorioamnionitis, funisitis or bronchopulmonary dysplasia. Methods: Eightytwo pairs of pregnant women and their preterm newborns <35 weeks gestation were enrolled. Levels of TNFα, MMP9 and ICAM3 in umbilical cord blood were measured using immunoassays and compared with results of histological examination of placenta and clinical data of the study participants. Results: The level of MMP9 in umbilical cord blood was significantly associated with the presence of funisitis (P=0.007). The level of TNFα in umbilical cord blood was significantly associated with the development of bronchopulmonary dysplasia ( P=0.030). However, presence of chorioamnionitis or funisitis was not associated with development of bronchopulmonary dysplasia. With the establishment of receiver operating characteristic (ROC) curve, the best cutoff value for umbilical blood MMP9 was 99.42 pg/mL in identification of funisitis. The area under a constructed ROC curve for prediction of funisitis was 0.847 (standard error, 0.112; 95% confidence interval, 0.7500.917). Conclusion: Measurement of MMP9 concentration in umbilical cord blood may be an alternative way to predict whether a preterm infant has been exposed to IUI. Further study with larger numbers of subjects will be necessary to elucidate the association between the presence of IUI and neonatal adverse outcome.
자궁강내 인공수정 후 단각자궁 비소통 흔적 자궁에 임신돤 환자의 자궁 파열 및 태아 생존
심순섭 ( Soon Sup Shim ),강혜심 ( Hye Sim Kang ) 대한주산의학회 2013 Perinatology Vol.24 No.2
Rudimentary horn is a rare uterine anomaly and pregnancy in the rudimentary horn is an extremely rare condition. We report a case of live birth in a non-communicating rudimentary horn pregnancy and rupture. The pregnancy was successfully delivered by cesarean section, with neonatal and maternal survival.
조기분만진통 환자의 산전 자궁내 감염 및 주산기 예후 예측에 관한 양수내 Monocyte Chemotactic Protein - 1 측정의 유용성
심순섭(Soon Sup Shim),박현수(Hyun Soo Park),임준희(June Hee Lim),심재윤(Jae Yoon Shim),천대우(Dae Woo Chun),박중신(Joong Shin Park),전종관(Jong Kwan Jun),윤보현(Bo Hyun Yoon),신희철(Hee Chul Syn) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.6
목적 : 양막파수가 없는 조기진통 산모에서 양수내 monocyte chemotactic protein-1 (MCP-1) 농도가 자궁내 감염과 임신 예후를 평가하는 데 유용한지 알아보고자 하였다. 연구 방법 : 양막파수가 없는 조기진통으로 양수검사를 받은 65명을 연구 대상으로 하였다. 양수는 호기성, 혐기성 세균 및 마이코플라스마 배양을 시행하였다. MCP-1은 민감하고 특이적인 면역검사법으로 측정하였다. 통계적 분석에는 Fisher`s exact test, Mann-Whitney U test, receiver operating characteristic curve, 생존 분석법, logistic regression, Spearman correlation을 사용하였다. 결과 : (1) 양수 배양 양성인 환자에서 배양 음성인 환자에 비하여 양수내 MCP-1 농도의 중앙치가 유의하게 높았다 (median, 9.0 ng/mL; range, 0.45-40.5 ng/mL; vs median, 0.82 ng/mL; range, 0.06-30.1 ng/mL; P<.01). (2) 임신 주수를 보정한 후에도 양수내 MCP-1 농도가 1.9 ng/mL보다 큰 환자에서 1.9 ng/mL보다 작은 환자에 비하여 분만까지의 기간이 유의하게 짧았고 조직학적 융모양막염, 2일 및 5일 이내의 조산과 증명되거나 의심 되는 선천성 패혈증의 발생이 많았다 (P<.05). (3) 양수내 MCP-1 농도와 양수내 interleukin-6 농도 사이에는 강한 연관성을 보였다 (r=.881, P<.001). 결론 : 양막파수가 없는 조기진통 산모에서 양수내 MCP-1 농도 측정은 자궁내 감염과 조산, 신생아 감염성 합병증을 평가하는 데에 유용하다. Objective : To examine if amniotic fluid (AF) monocyte chemotactic protein-1 (MCP-1) concentrations are useful in the identification of intrauterine infection and pregnancy outcomes in preterm labor with intact membranes. Methods : The study population consists of 65 patients who received amniocentesis for preterm labor with intact membranes. Amniotic fluid was cultured for aerobic and anaerobic bacteria, as well as mycoplasmas. MCP-1 was determined by a sensitive and specific immunoassay. Fisher`s exact test, Mann- Whitney U test, receiver operating characteristic curve, survival techniques, logistic regression, and Spearman correlation were used for statistical analysis. Results : (1) Patients with a positive amniotic fluid culture had a significantly higher median AF MCP-1 concentration than those with negative results (median, 9.0 ng/mL; range, 0.45-40.5 ng/mL; vs median, 0.82 ng/mL; range, 0.06-30.1 ng/mL; P<.01). (2) Patients with AF MCP-1 concentration of >1.9 ng/mL had a significantly shorter median interval to delivery, the higher rate of histologic chorioamnionitis, preterm delivery within 2 and 5 days, and the occurrence of congenital proven or suspected sepsis than did those with AF MCP-1 concentration of <1.9 ng/mL after adjustment for gestational age (P<.05). (3) There was strong correlation between AF MCP-1 concentrations and AF interleukin-6 concentrations (r=.881, P<.001). Conclusion : AF MCP-1 determinations are useful in the identification of intrauterine infection, preterm delivery, and neonatal infectious complication in preterm labor with intact membranes.
난자 세포질내 정자 주입술을 이용한 체외수정시술시 누적임신율에 관한 연구
김석현(Seok Hyun Kim),심순섭(Soon Sup Shim),지병철(Byung Chul Jee),최성미(Sung Mi Choi),김희선(Hee Sun Kim),류범용(Buom Yong Ryu),오선경(Sun Kyung Oh),서창석(Chang Suk Suh),최영민(Young Min Choi),배광범(Kwang Bum Bai),김정구(Jung Gu 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3
N/A Objective : To evaluate the cumulative pregnancy rate(CPR) of in vitro fertilization and embryo transfer(IVF-ET) with intracytoplasmic sperm injection(ICSI). Methods : Medical records of 260 infertile patients undergoing 519 cycles of IVF-ET with ICSI from January, 1994 to December, 1999 were retrospectively reviewed. The CPR beyond 12 weeks of gestation was estimated by Kaplan-Meier method. The CPRs were compared by log-rank test between groups divided by age of patients, indication of ICSI, and method of sperm retrieval for ICSI. Results : As 70 patients achieved an on-going pregnancy after IVF-ET with ICSI, the PR was 26.9% per patient and 13.5% per cycle. The overall CPR was 54.9% after 6 cycles of IVF-ET with ICSI. As expected, age had a significant strong effect on the CPR; CPRs afer 4 cycles of ICSI were 61.8% in the age group of 30 years(n=81), 43.7% in 31-35 years(n=106), and 15.3% in 36 years(n=73). There was no significant difference in the CPR between abnormal semen analysis group(n=184) and prior low fertilization rate group(n=66). In abnormal semen analysis group, the CPR of surgically retrieved sperm subgroup(n=60) was not significantly different from that of ejaculated sperm subgroup(n=124). Conclusions : The CPR of IVF-ET with ICSI was presented, and it could be of much help in the clinical counseling of IVF-ET patients. ICSI technique could be used successfully for IVF-ET in infertile couples who had the male factor infertility or the past history of low fertilization rate in the previous cycles.
이중엽(Joong Yeup Lee),심순섭(Soon Sup Shim),한수연(Soo Yeon Han),고은미(Eun Mi Ko),박중신(Joong Shin Park),전종관(Jong Kwan Jun),윤보현(Bo Hyun Yoon),신희철(Hee Chul Syn) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
Acardiac twin is a rare complication of multifetal pregnancy. The literatures report an incidence of 1% among monochorionic twin pregnancies, I. E. 1 of 35,000 pregnancies. The absence of identifiable fetal heart structures in one twin and reduction anomalies in many organ systems suggest the diagnosis. It has been hypothesized that in the presence of artery-to-artery and vein-to-vein anastomoses in a monozygotic placenta, blood is perfused by hemodynamically advantaged pump-twin to the recipient twin by retrograde flow. The principal perinatal problems associated with acardiac twinning are congestive heart failure of pump-twin, maternal polyhydramnios, preterm delivery and intrauterine death. The outcome is invariably fatal for the acardiac twin and 50-75% of the normal twin. Management options include observation, medical therapy, and selective termination of acardiac twin. The most appropriate intervention for the various clinical presentations of this disorder is undetermined, and conservative nonintervention is often appropriate. Long-term follow-up data on surviving pump twins are lacking. We experienced a case of acardiac twin gestation which showed satisfactory outcome with conservative management, so we present the case with a brief review of the literature.
체외수정 및 배아이식으로 발생된 정상임신과 부분포상기태의 쌍태임신
이유경 ( Yoo Kyung Lee ),성효숙 ( Hyo Sook Sung ),홍준석 ( Joon Seok Hong ),심순섭 ( Soon Sup Shim ),박중신 ( Joong Shin Park ),전종관 ( Jong Kwan Jun ),윤보현 ( Bo Hyun Yoon ),신희철 ( Hee Chul Syn ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.8
Hydatidiform mole, characterized by abnormal fetoplacental development and placental villous trophoblast hyperplasia, results from genetically abnormal conception. Twin pregnancy consisting of hydatidiform mole (H-mole) and a coexisting fetus occurs with
비면역성 태아수종: 임상양상과 신생아의 생존과 관련된 예후인자
이중엽 ( Joong Yeup Lee ),손유경 ( Yoo Kyung Sohn ),심순섭 ( Soon Sup Shim ),임준희 ( June Hee Im ),심재윤 ( Jae Yoon Shim ),박중신 ( Joong Shin Park ),전종관 ( Jong Kwan Jun ),윤보현 ( Bo Hyun Yoon ),신희철 ( Hee Chul Syn ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
목적 : 비면역성 태아수종의 발생빈도, 관련조건 (혹은 원인), 주산기 결과를 확인하고, 신생아 생존과 관련있는 예후인자를 밝혀내고자 하였다. 연구 방법 : 1988년 10월부터 2001년 2월까지 서울대학교병원 산부인과에서 진단된 54예의 비면역성 태아수종의 후향적 고찰을 통하여 발생빈도, 관련조건, 주산기 결과를 확인하였다. 아울러 생존하여 출산된 20예의 신생아를 28일 초과 생존한 군과 28일 이하에 사망한 군으로 구분하여 신생아 생존과 관련된 Objective : We undertook this study to find out clinical characteristics and prognostic factors of neonatal survival in nonimmune hydrops fetalis (NIHF). Methods : From Oct. 1988 to Feb. 2001, 54 cases of nonimmune hydrops fetalis diagnosed at Seoul Natio
윤상호(Sang Ho Yoon),천은경(Eun Kyung Chun),심순섭(Soon Sup Shim),임준희(June Hee Lim),박중신(Joong Shin Park),전종관(Jong Kwan Jun),윤보현(Bo Hyun Yoon),신희철(Hee Chul Syn) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7
목적 : 전체 임신의 약 1%를 차지하고 있는 모성 심 질환이 동반된 임신의 결과에 대해 알아보기 위함이다. 연구 방법 : 1994년부터 2001년까지 최소한 임신 20주 이후에 분만하였으며 모성 심 질환이 동반된 산모의 의무기록을 고찰하였다. 결과 : 심장질환을 동반한 산모는 총 195명으로 224예의 분만이 있었다. 224예의 임신 중 류마티스성 심질환군이 117예 (52.2%), 선천성 심 질환군이 96예 (42.9%)에 해당하였으며, 나머지는 11예로 부정맥, 심근병증, 승모판막 탈출 증후군 등이었다. 임신과 관련된 모성사망은 2예 (0.9%)가 있었으며, 대부분의 산모 (91.9%)가 분만 전, 분만 중, 분만 후의 뉴욕 심장협회 운동기능 평가상 class I, Ⅱ에 해당하였다. 태아의 평균 재태 기간과 출생시의 평균체중은 37.9주와 2883 gm 이었다. 주산기 사망률이 17.9/1000이며, 선천성 기형은 6예로 전체의 2.7%를 차지하였으며, 선천성 심기형의 재발률은 2.1%였다. 결론 : 모성 합병증 및 조산, 저 체중아의 대부분이 뉴욕 심장협회 운동기능 평가상 class Ⅲ, Ⅳ 심 질환 산모군에서 발생하였다. 산모의 운동기능상태 평가가 산모 및 태아의 예후에 중요한 인자라 할 수 있다. Objective : To assess the pregnancy outcomes complicated by maternal heart diseases. Methods : From 1994 to 2001, medical records of pregnant women who had reached at least 20 weeks of gestation with maternal heart diseases were reviewed. Results : 224 deliveries of 195 women were enrolled in this study. In 117 (52.2%) cases the heart diseases were of rheumatic origin, in 96 (42.9%) cases congenital, and the remaining 11 (4.9%) cases were miscellaneous group that included arrhythmia, cardiomyopathy, and mitral valve prolapse. There were 2 (0.9%) cases of maternal death related to pregnancy. Majority (91.9%) were in New York Heart Association functional classes I, Ⅱ before, during, and after delivery. Mean gestational age at birth and birth weight were 37.9 weeks and 2883 gm. Perinatal mortality rate was 17.9/1000 and the rate of congenital malformation was 2.7%. Recurrence risk of neonatal congenital heart disease was 2.1%. Conclusion : Most complications were developed in the pregnancies complicated by maternal heart diseases with New York Heart Association functional classes Ⅲ, Ⅳ. Functional status of the pregnant women is the important risk factor in maternal and fetal outcomes.