초자체내 Mitomycin C 의 망막독성

신재필(Jae Pil Shin),홍승표(Sung Pyo Hong),김상하(Sang Ha Kim) 대한안과학회 1995 대한안과학회지 Vol.36 No.4

가토의 정상 진동소파전위

신재필(Jae Pil Shin),김상하(Sang Ha Kim) 대한안과학회 1995 대한안과학회지 Vol.36 No.3

증식당뇨망막병증에서 유리체내 혈관내피세포증식인자의 발현정도와 유리체수술후 예후

김상옥 ( Sang Ok Kim ) , 신재필 ( Jae Pil Shin ) , 김진오 ( Jin Oh Kim ) , 오창석 ( Tschang Seog Oh ) , 김시열 ( Si Yeol Kim ) 대한안과학회 2004 대한안과학회지 Vol.45 No.9

고용량 스테로이드 치료에 추가 트리암시놀론 구후주사가 구후시신경염의 시력회복에 미치는 영향

박준호,신재필,전보영,Joon Ho Park,Jae Pil Shin,Bo Young Chun 대한안과학회 2013 대한안과학회지 Vol.54 No.1

Purpose: To evaluate the effect of additional retrobulbar triamcinolone acetonide (TA) injection on early recovery of visual acuity in retrobulbar optic neuritis patients. Methods: A prospective, randomized clinical study including 30 patients with retrobulbar optic neuritis was conducted between March 2003 and June 2007. Patients were divided into 2 groups: Group 1 (n = 9) with retrobulbar triamcinolone (TA, 40 mg/1 ml) injection on the first day of ONTT protocol, and group 2 (n = 21) with conventional ONTT protocol. The following parameters were measured and analyzed: patient’s sex, age, pupillary reactions, color vision, visual field, and best-corrected visual acuity before treatment, and after 1 day, 1 week, 2 weeks, 1 month, and 3 months of follow-up. Results: Mean visual acuity before treatment was 1.00 ± 0.89 log MAR units in group 1 and 0.98 ± 0.75 log MAR units in group 2. One day after injection, visual acuity was better in group 1 (0.50 ± 0.42 log MAR units) than in group 2 (0.73 ± 0.61 log MAR units), however, there was no statistically significant difference between the 2 groups (p = 0.07). There was no significant difference in visual acuity, recovery of RAPD, color vision, or visual field at 3 months of follow-up. No serious side effect related to retrobulbar TA injection was observed. Conclusions: Additional retrobulbar TA injection may help optic neuritis patients who have a need for prompt visual recovery. However, further studies are required to ascertain whether this procedure can help early recovery of visual acuity in retrobulbar optic neuritis patients.

신생혈관녹내장에서 아메드밸브삽입술의 장기 결과와 베바시주맙의 전방내 주사 효과

김종진,신재필,Jong Jin Kim,Jae Pil Shin 대한안과학회 2013 대한안과학회지 Vol.54 No.5

Purpose: To evaluate the long-term surgical results of Ahmed glaucoma valve implantation (AGVI) and the effects of intracameral bevacizumab injection in neovascular glaucoma (NVG) after diabetic vitrectomy. Methods: We reviewed the medical records of 57 patients with NVG after diabetic vitrectomy who underwent AGVI with or without intracameral bevacizumab injection. In each group, preoperative and postoperative intraocular pressure, the number of glaucoma medications, and best corrected visual acuity (BCVA) were compared. We analyzed the rates of surgical success, postoperative complications, and risk factors. Results: The cumulative probability of success was 87.7% at 1 year, 78.8% at 2 years, 70.5% at 3 years, and 61.6% at 5 years. Intraocular pressure and the number of glaucoma medications were significantly reduced and BCVA was significantly better at all postoperative follow-up time points in both groups. There were no differences in mean intraocular pressure, the number of glaucoma medications, BCVA, or the rates of surgical success between the two groups. The incidence of hypertensive phase was significantly reduced in the intracameral bevacizumab group, but neither the surgical success rate nor intraocular pressures were different compared with the control group. Conclusions: Ahmed glaucoma valve was a good therapeutic modality for long-term treatment of NVG occuring after diabetic vitrectomy. Intracameral bevacizumab injection had no effects on the surgical results of Ahmed glaucoma valve surgery. J Korean

당뇨황반부종에 대한 트리암시놀론의 유리체강내 주입술과 테논낭하 주입술의 비교

권순재,신재필,김시열.Soon Jae Kwon. M.D.. Jae Pil Shin. M.D.. Si Yeol Kim. M.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.1

`Purpose: To retrospectively evaluate the clinical effect of intravitreal (IVT) and posterior subtenon (PSTT) triamcinolone acetonide (TA) injection in diabetic macular edema. Methods: Fifty eyes of 43 patients with diabetic macular edema (DME) were included. Twenty-two eyes in the IVT group received 4 mg/0.1 ml intravitreal TA injections and 26 eyes in the PSTT group received 40 mg/1.0 ml subtenon TA injections. LogMAR visual acuity and intraocular pressure (IOP) were measured and, using OCT, central macular thickness (CMT) and total macular volume (TMV) were also measured before and 1, 3, and 6 months postoperatively. Results: Both groups showed significant decreases in the mean CMT and TMV. The mean CMT in the IVT group was significantly thinner than that of the PSTT group 1 month postoperatively. The percentage reduction in CMT and TMV were also greater in the IVT group than the PSTT group 1 month postoperatively. Both groups showed significant improvements in mean visual acuity, with no significant difference between the two groups. However, at 1-month postoperative improvement in visual acuity was significantly greater in the IVT group than the PSTT group. The mean IOP in the IVT group was also greater than that in the PSTT 1 month postoperatively. Conclusions: Both injections caused a significant increase in visual acuity and a decrease in CMT and TMV. The effect was more pronounced in the IVT group. However, the PSTT injection also appeared to be a safe and effective technique for the treatment of DME.`

반복된 유리체강내 베바시주맙 주입술 후 재발한 당뇨황반부종에 후테논낭하 트리암시놀론 주입술

김종호,박동호,신재필,김시열,Jong Ho Kim,Dong Ho Park,Jae Pil Shin,Si Yeol Kim 대한안과학회 2011 대한안과학회지 Vol.52 No.9

Purpose: To evaluate posterior sub-Tenon injection of triamcinolone acetonide (TA) for recurrent diabetic macular edema (DME) after repeated intravitreal bevacizumab (IVB). Methods: This is a retrospective interventional case series comprised of 35 eyes (32 patients) with recurrent clinically significant DME after two or more IVB treatments. All patients were administered TA 40 mg injections. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and intraocular pressure (IOP) were reevaluated at months 1, 3, and 6. Results: The baseline OCT showed five eyes with diffuse retinal thickening, 18 eyes with cystoid macular edema, and 12 eyes with serous retinal detachment. Mean BCVA improved at months 1 and 3, and mean CMT decreased at months 1 and 3. However, mean BCVA and CMT at six months was not different from baseline. Each DME pattern showed significant improvements in BCVA and CMT at three months. Mean IOP at months 1, 3, and 6 did not show any significant difference from baseline. No eyes showed complications including cataract progression or endophthalmitis. Conclusions: Posterior sub-Tenon injection of TA should be considered for patients with recurrent DME after repeated IVB. The studied eyes showed improvements in BCVA and CMT during three months in all of the three patterns of DME. J Korean Ophthalmol Soc 2011;52(9):1063-1070

경결막무봉합유리체절제술 후 발생한 안내염 1예

이지웅,김동주,신재필,김시열,Ji Woong Lee,M,D,Dong Ju Kim,M,D,Jae Pil Shin,M,D,Si Yeol Kim,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.1

Purpose: To report a case of endophthalmitis after 25-gauge transconjunctival sutureless vitrectomy. Methods: A 60-year-old male patient underwent 25-gauge transconjunctival sutureless vitrectomy through the epiretinal membrane. He was diagnosed as endophthalmitis on 7th postoperative day. Immediate vitrectomy and intravitreal antibiotics injection was done. Results: Coagulase-negative staphylococcus was identified in vitreous culture and incarcerated vitreous through the previous unsutured sclerotomies were found. During vitrectomy, we found generalized retinal necrosis and vascular occlusion with retinal hemorrhage, cheese like thick membrane firmly adherent to the retina due to inflammatory response. The organism was sensitive to antibiotics administered. After treatment, inflammatory response was controlled and the retina became stable but the visual outcome was poor. Conclusions: Vitreous incarceration through unsutured sclerotomy may occur after 25-gauge transconjunctival sutureless vitrectomy. This can be a possible conduit for bacteria in the eye and be a cause of endophthalmitis. Sutureless sclerotomy should be carefully monitered and managed postoperatively.

한국어판 미국 국립안연구센터 시각기능설문지 25의 타당성 및 신뢰도 연구

허장원,윤희성,신재필,문상웅,진희승,곽형우,Jang Won Heo,Hee Seong Yoon,Jae Pil Shin,Sang Woong Moon,Hee Seung Chin,Hyung Woo Kwak 대한안과학회 2010 대한안과학회지 Vol.51 No.10

Purpose: To translate and evaluate the reliability and validity of the Korean version of the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25). Methods: Two bilingual ophthalmologists independently translated the original English version of the NEI-VFQ-25 into written Korean. A panel of the Korean Retina Society reviewed the translations to form a single reconciled forward translation of the Korean version of the NEI-VFQ-25. Another ophthalmologist back-translated this first draft into English. Both the first draft and back-translated draft were edited by a professional translator. To evaluate the correlation and validity, results between the original NEI-VFQ-25 and the Korean version, completed by the bilingual participants, were compared. Results: The Korean version of the National Eye Institute Visual Functioning Questionnaire-25 was developed by translation, back-translation, and expert supervision. Results from 23 bilingual participants between the original NEI-VFQ-25 and the Korean version were compared and showed statistically significant correlation, with a Spearman’s correlation coefficient of 0.4 or greater. The Kolmogorov-Smirnov test results showed no statistically significant differences between the two questionnaires. Conclusions: Translation and validation of the Korean version of the NEI-VFQ-25 was achieved. J Korean Ophthalmol Soc 2010;51(10):1354-1367

당뇨병유두병증에서 유리체강내 베바시주맙 주입술 후 망막신경섬유층 두께의 장기간 변화 2예

김종진,임종찬,신재필,김인택,박동호.Jong Jin Kim. MD. Jong Chan Im. MD. Jae Pil Shin. MD. PhD. In Taek Kim. MD. PhD.Dong Ho Park. MD. PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.9

Purpose: To report long-term changes in the average retinal nerve fiber layer (RNFL) thickness in 2 patients who had intravitreal bevacizumab (IVB) injection for diabetic papillopathy. Case summary: A 36-year-old patient with diabetes complained of decreased visual acuity (20/200) in the right eye. The fundus examination showed optic disc swelling in both eyes. The average RNFL thickness based on optical coherence tomography (OCT) increased to 278 μm and Goldmann perimetry showed nasal visual field defect in the right eye. The IVB was injected into the right eye. Three weeks after the IVB injection, RNFL thickness decreased to 135 μm and visual acuity improved to 20/25 in the right eye. However, RNFL thickness increased from 126 to 207 μm and visual acuity decreased to 20/32 in the left eye. Thus, IVB was injected into the left eye. In week 3, RNFL thickness decreased to 147 μm and visual acuity improved to 20/20 in the left eye. At 12 months after IVB injection, RNFL thickness was 87 μm in the right eye and 109 μm in the left eye. A 57-year-old patient with diabetes complained of decreased visual acuity (20/200) and showed optic disc swelling in the right eye. The average RNFL thickness increased to 252 μm and Goldmann perimetry showed an enlarged blind spot in the right eye. IVB was injected into the right eye. After 3 weeks, RNFL thickness decreased to 136 μm and visual acuity improved to 20/70 in the right eye. Six months after IVB injection, RNFL thickness was 83 μm in the right eye. Conclusions: Visual acuity progressively improved within 3 weeks and RNFL thickness measured by spectral domain OCT showed progressive thickness reduction in 2 cases of diabetic papillopathy patients who had IVB injections.