Tris(2-cyclohexylaminoethyl)amine-Zn(II) 착물의 안정성

신용운,백현숙,양재경,김진은,서무룡,Yong Woon Shin,Hyun Sook Baek,Jae-Kyung Yang,Jineun Kim,Moo Lyong Seo 대한화학회 2003 대한화학회지 Vol.47 No.2

Tris(2-cyclohexylaminoethyl)amine (L) was synthesized by the Schiff base condensation reaction of tris(2-aminoethyl)amine with cyclohexanone, followed by reduction. The thermodynamic characteristics, mole ratio and formation constant of [Zn(II)-L] complex were measured by the cyclic voltammetry and isothermal titration. In the case of Zn(II), well-defined cathodic and anodic peak were obtained at -1.02V and -0.48V vs Ag/AgCl , respectively. For the [Zn(II)-L] complex, both peaks were obtained at -1.19V and -0.45V vs Ag/AgCl, respectively. In addition, the peak height gradually increases as the scan rate increases, suggesting that the currents obtained were diffusion - controlled. The mole ratio and stability constant of the complex measured cyclic voltammerty were 1:1 and logK$_f$= 5.8, respectively. And the mole ratio and stability constant of the complexe calculated by isothermal titration method was 1:1 and logK =5.4, respectively. ${\Delta}$H, ${\Delta}$G and T${\Delta}$S for the complex formation were -53.0 kJ/mol, -31.1 kJ/mol, and -21.9 J/K at 25 ${\circ}$C, respectively. Cyclohexanone,과 tris(2-aminoethyl)amine을 이용하여 Schiff 연기 축합반응으로 tren의 유도체인 tris(2-cyclohexylaminoethyl)amine (L)을 합성하였다. 또한 합성한 tren의 유도체인 tris(2-cyclohexylaminoethyl)amine (L)과 Zn(II) 착물의 열역학적 특성과 안정도 상수, Zn(II)와의 착물 조성비 등을 순환전압전류법과 열량계법으로 측정하였다. Zn(II)과 [Zn(II)-L] 순환전압전류 곡선을 0${sim}$-1.5 V vs. Ag/AgCl의 가전압 범위에서 측정하였다. 금속인 경우, -1.02V와 -0.48V vs. Ag/AgCl에서 각각 환원피이크와 산화피이크가 나타났으며, 금속착물인 경우에는 -1.19V와 -0.45V vs. Ag/AgCl에서 각각 환원피이크와 산화피이크가 나타났다. 또한 피이크 전류(IP)는 주사속도의 평방근 $(v^{1/2})$에 비례하였으며 이것은 전류의 유형이 확산 지배적인 전류임을 나타낸다. 그리고 [Zn-L] 착물에 대해서 전압전류법적으로 구한 안정도상수는 logK$_f$ = 5.8, 결합비는 1:1을 나타내었다. 또한 열량계법적으로 [Zn-L] 착물의 열역학적 파라메타를 조사한 결과, 리간드 L과 Zn(II)는 1:1의 4 배위수를 가지는 착물을 이룬다는 것을 알 수 있었고, 이때 25 ${\circ}$C에서 logK=5.4, ${\Delta}H$= -53.0 kJ/mol, ${\Delta}$G의 값은 -31.1 kJ/mol이었으며 T${\Delta}$S는 -21.9 J/K${\cdot}$mole이었다.

유리체강 내 베바시주맙, 트리암시놀론 및 혼합약제 주입 후 장기간 안압변동 관찰

신용운,조희윤,이윤정,성민철,Yong Woon Shin,Hee Yoon Cho,Yoon Jung Lee,Min Chul Seong 대한안과학회 2011 대한안과학회지 Vol.52 No.5

Purpose: The present study investigates the onset and frequency of increased intraocular pressure (IOP) after injections of intravitreal Bevacizumab, Triamcinolone, and a combination of both drugs. Methods: Patients were classified into three groups: Bevacizumab group (group A), Triamcinolone group (group B), and combined drug group (group C), irrespective of the underlying causes. The IOP was measured 30 minutes prior to followed by one day, one week, one month, two months, three months, six months, and one year after injection. The measured IOP at each time point was compared with the pre-injection IOP and the differences in IOP among the three groups were statistically analyzed. The relationships between various factors possible of increasing IOP were also analyzed. Results: A total of 259 subjects were enrolled in the present study. An IOP increase of more than 5 mm Hg was observed in 25 eyes (15%) in group A, 34 eyes (40%) in group B, and 40 eyes (50%) in group C. There was no statistically significant mean IOP change after injection in group A, but in groups B and C there was an increase in mean IOP up until two and three months after injection, respectively. However, eyes in group A with a history of glaucoma showed statistically significant increases in IOP. Conclusions: The onsets and frequencies of increased IOP were different with the different drugs. Proper follow-up for increased IOP after injection is necessary based on the type of drug used. J Korean Ophthalmol Soc 2011;52(5):574-581

족관절부의 만성 골수염으로 오인된 유전성 감각 및 자율신경병증 제 4형 환아(1예 보고)

신용운,정형진,오종석,Shin, Yong-Woon,Chung, Hyung-Jin,Oh, Jong-Seok 대한족부족관절학회 2009 대한족부족관절학회지 Vol.13 No.2

We experienced a case of congenital insensitivity to pain with anhidrosis mimicking a chronic osteomyelitis of the talus, with recurrent ankle swelling and intermittent fever. He was misdiagnosed as low virulence osteomyelitis at other hospital in annual recurrence for 3 years. A Charcot joint in children is a very rare condition and diagnosis should be made in a careful approach.

황반질환에 따른 스펙트럼 영역 빛간섭단층촬영의 다양한 오류 분석

신용운,이주향,전재연,송유미,조희윤,이병로,Yong Woon Shin,Ju Hyang Lee,Jae Yeon Jun,Yumi Song,Hee Yoon Cho,Byung Ro Lee 대한안과학회 2010 대한안과학회지 Vol.51 No.8

Purpose: To report the frequency, severity and various types of artifacts associated with spectral-domain optical coherence tomography (SD-OCT) based on macular pathologies. Methods: Data was collected retrospectively from 116 eyes of 116 subjects. SD-OCT (3D-1000, Topcon Corp., Japan) imaging was performed in 40 healthy eyes, 45 eyes with intraretinal pathology (IRP) and 31 eyes with subretinal pathology (SRP). The scan protocol was 12×6 mm radial scan. The frequency and types of artifacts were investigated in each scan and were analyzed based on macular disease. Additionally, the effect of artifacts on the measurement of macular thickness was studied. Results: Errors occurred in 77 eyes (66.38%). Inner retinal boundary misidentification (IRBM) was the most common error (25.86%), with the frequencies of other types of artifacts being 10.34% for off-center fixation, 15.52% for degraded image and 8.6% for outer retinal boundary misidentification (ORBM). The overall error rate of SD-OCT in the retinal pathology group was much higher than that in the normal group. Macular thickness was underestimated in the IRP group because the outer retinal boundary of the IRP group tended to be misidentified toward the inner retina (p<0.01). Conclusions: SD-OCT can frequently cause various types of artifacts in patients with macular disease. When interpreting OCT images, the artifacts of SD-OCT should be considered in order to obtain accurate macular thickness and to prevent erroneous clinical decisions. J Korean Ophthalmol Soc 2010;51(8):1084-1091

소아 요골 원위부 불안정 골절의 캐스트 후 안정성에 영향을 미치는 요소

신용운(Yong-Woon Shin),손종민(Jong Min Sohn),박상윤(Sang-Yoon Park) 대한정형외과학회 2021 대한정형외과학회지 Vol.56 No.3

목적: 소아 요골 원위부 골절은 가장 흔한 골절이면서 불안정 골절의 경우 정복 후에도 재전위 위험성이 높아 주의가 요망된다. 이러한 재전위에 영향을 미치는 요인들에 대하여 평가해 보고자 한다. 대상 및 방법: 2011년 2월부터 2018년 6월까지 완전 전위된 소아 요골 원위부 불안정 골절로 본원 외래에서 보존적 치료한 6세에서 14세까지의 환자들을 대상으로 후향적 연구를 하였다. 전체 대상 환자 44예 중 재전위된 환자들에서 연령, 성별, 석고 지표, 간격 지표, 3점 고정 지표, 골절면 경사도, 관절면에서 골절선까지 거리를 환산한 골절 높이 비, 요골-제2 중수골 각도 등을 측정하여 마지막 골유합 상태에서 남은 각형성의 정도로 결과를 평가하여 비교를 하였다. 결과: 평균 9.2도(0-32.8도) 각형성이 남았으며 범주 내의 결과를 기준으로 하여 10도 미만이 29예, 10도 이상이 15예로 확인되었다. 정복 후 재전위가 발생한 군과 대조군 사이에 평가된 요소들 중 석고 지표들은 두 군 간에 차이가 없었다. 연령, 성별에서도 군 간에 차이가 없었고, 골절면 경사도, 요골-제2 중수골 각도도 차이가 없었다. 관절면에서 골절선까지의 거리를 환산한 골절 높이비가 가장 의미 있는 안정요소로 평가되었고(p=0.001) 척골 골절이 동반된 경우도 불안정한 요소로 평가되었다p(=0.019). 결론: 소아 요골 간단부 완전 전위 골절, 특히 요골 골간단-골간 이행부의 골절의 경우 불안정한 골절로 평가되므로 좀 더 주의가 필요하며 충분한 재형성을 기대하기 어려운 연령에서는 만족스러운 결과를 위하여 수술적 치료가 선호될 수 있다. Purpose: Distal radius fractures in youth are treated conservatively in most cases, but there are some cases of redisplacement in the follow-up period after cast immobilization, even after complete reduction. This study examined the risk factors of redisplacement in reduced unstable distal radius fractures. Materials and Methods: From February 2011 to June 2018, 44 unstable distal radius fractures were managed with a closed reduction and cast immobilization. The patients were aged between 6 and 14 years. The cases of redisplacement were analyzed with the fracture characteristics (fracture obliquity, fracture level ratio, ulnar fracture combined), cast qualities (gap index, cast index, 3 point index, and radius-2nd metacarpal angle) and host factors (age, sex). Results: The mean angulation in the union was 9.2° (0°–32.8°). In the categorical grouping 29 cases were within 10° angulation, and 15 cases were more than 10°. No significant differences in the factors of the cast indices or host factors were noted. The meaningful factor was the fracture level calculated by the relative width of the fracture site divided by the sum of width of diaphysis and epiphysis (p=0.001) and combined ulnar fracture (p=0.019). Conclusion: Unstable distal radius fractures should be treated with more stubborn guidelines lest the fracture loses its anatomical alignment. In particular, in patients with less remodeling power, operative treatment would secure a better result if the fracture occurs in a more proximal location.

임상연구 : Thiopental-Sevoflurane 마취 유도 후 기관내삽관 시 혈역학적 변화를 예방하기 위한 Remifentanil의 적정용량

신용운 ( Yong Woon Shin ),안태훈 ( Tae Hun An ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.1

Background: Tracheal intubation is accompanied by varing degrees of sympathetic stimulation as reflected by increases in the heart rate and blood pressure. Several trials with pharmacologic agents have been conducted to reduce changes in blood pressure and heart rate. The aim of this study was to determine the appropriate dose of remifentanil required to prevent hemodynamic changes immediately after tracheal intubation in patients anesthetized with sevoflurane-N2O-O2. Methods: Ninety ASA class I or II patients scheduled for elective surgery were divided randomly into 6 groups: I, II, III, IV, V, and VI. After induction of anesthesia with thiopental, vecuronium, and sevoflurane 2 vol% with N2O/O2 50/50 via a face mask, saline, 0.3, 0.4, 0.5, 0.6, and 0.7μg/kg of remifentanil were given to group I, II, III, IV, V, and VI, respectively. Tracheal intubation was carried out for 90 seconds after drug administration, for patients in each group. The heart rate (HR), mean arterial pressure (MAP), and end tidal sevoflurane concentration (ETSEVO) were measured at preanesthesia, before intubation, and at 1 min after intubation, for each patient. Results: HR and MAP at 1 min after intubation were increased in groups I and II, and were unchanged in groups III, IV, V and decreased in group VI, as compared to preanesthetic values. Conclusions: A single injection of 0.4, 0.5, 0.6μg/kg of remifentanil was an appropriate dosage to prevent hemodynamic changes after tracheal intubation without adverse effects in patients anesthetized with sevoflurane-N2O-O2. (Korean J Anesthesiol 2007; 53: 67~71)

소아에서 트램폴린 손상의 발생 빈도

신용운(Yong-Woon Shin),홍치운(Chi Woon Hong),이의종(Oei Jong Lee),박상윤(Sang-Yoon Park) 대한정형외과학회 2018 대한정형외과학회지 Vol.53 No.2

목적: 소아 외상 환자 중 근래 들어서 트램폴린 손상 환자의 빈도가 높아지고 있어서 실질적인 트램폴린 손상 환자의 발생 빈도와 손상의 중증도를 함께 알아보고자 하였다. 대상 및 방법: 2015년 9월부터 2017년 2월 사이에 1개 수련 병원 응급실을 방문하여 정형외과에 의뢰된 15세 이하의 환자들의 응급실 방문 기록을 후향적으로 조사하였고 이 중 외상 환자만을 선별하여 외상 원인을 조사하였다. 환자의 나이와 원인별 분석을 통하여 트램폴린 손상의 상대적인 빈도를 분석하였고 손상의 중증도를 함께 조사하였다. 결과: 18개월간 외상 환자는 1,807명이 내원하였고 이 중 트램폴린 손상 환자는 71명이었다(3.9%). 특이사항으로 4세 이하 환자에서 손상이 28명으로 상대적으로 발생률이 높았고 대신 이 군에서는 경증 손상이 14명이었다. 반면 5-15세에서는 43명의 환자들 중좌상 환자는 4명, 중등도 손상이 20명, 중증 손상이 19명이었다. 5-15세 연령에서 손상의 중증도 비율을 비교할 때 트램폴린 손상이 다른 스포츠 손상에 비하여 경도 손상은 적고(9.3% vs. 34.0%) 중증 손상은 더 많은 발생률을 보여 (44.2% vs. 26.3%) 상대적으로 위험한 운동으로 보인다(p=0.002). 결론: 트램폴린 손상이 최근에 손상 중 높은 발생 빈도를 차지하고 있고 손상 중증도도 더 높았다. 따라서 손상 예방 대책 마련이 필요하며, 보호자들에게도 손상에 위험성을 인식시킬 필요가 있다. Purpose: Recently, there has been increasing number of trampoline injuries at our pediatric orthopedic clinic and emergency room. Therefore, this study is to analyze the prevalence of the trampoline injuries with emergency room surveillance. Materials and Methods: Between September 2015 and February 2017, all patients under the age of 15 years, who visited emergency room of a teaching hospital with trauma and referred to the department of orthopedic surgery, was included; the cause of trauma was analyzed. The severity of injury was also evaluated and compared according to the cause of injury. Results: There were a total of 1,807 patients under the age of 15 years who visited our emergency room during the study period. There were a total of 71 trampoline injuries (3.9%). There were 28 patients below the age of 5 years, and among them, 14 minor injury were recorded; 43 patients were over the age of 5 years and with 4 minor, 20 moderate, and 19 severe injuries. In the age between 5 and 15 years, the prevalence of mild injury was lower in trampoline injury compared with those of other sports injuries (9.3% vs . 34.0%) and the prevalence of severe injury was higher in trampoline injury (44.2% vs . 26.3%) (p=0.002). Conclusion: Our findings indicate that the incidence of trampoline injury was lower than other country, but it was more severe than injuries from other sports. With increasing incidence of trampoline injuries, parents should be more mindful that trampolines are not safe and stricter supervision may be necessary.

급성 위장관출혈로 발현한 다발성 결절동맥염

신용운(Yong Woon shin),정원재(Won Jae Chung),김진희(Jin Hee Kim),한명희(Myung Hee Han),김영범(Young Bum Kim),김기수(Chi Su Kim),김치열(Chi Youl Kim),김경국(Kyung Gook Kim),주영채(Young Chae Joo) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3

Polyarteritis nodosa, one of the necrotizing vasculitis involving predominantly small and medium sized arteries is rare disease.Polyarteritis nodosa may afiect many organs such as kidney, heart, liver,gastrointestinal tract and muscle, so that non-specific symptorns ate characteristic and diagnosis is very difficult. Gastrointestinal Ivoivement was reported in about 50% of cases, but bleeding complication is rere and results in poor prognosis.Recently we experionced a case of plolyarteritis nodosa complicating massive upper gastrointestinal bleeding, which was diagnosed by pathologic wxamination of stomach apecimen surgically removed.

축·수산물 중 폴리브롬화비페닐류 모니터링

신용운 ( Yong Woon Shin ),신춘식 ( Choonshik Shin ),이지은 ( Ji-eun Lee ),서수진 ( Sujin Seo ),권진욱 ( Jin-wook Kwon ),강길진 ( Gil-jin Kang ) 한국환경농학회 2019 한국환경농학회 학술대회집 Vol.2019 No.-

Polybrominated biphenyls (PBBs) are a class of brominated hydrocarbons with 209 possible compounds, referred to as PBB congeners. PBBs are lipophilic compounds with a low vapour pressure and low water solubility which decreases with increasing degree of bromination and chemically stable, persistent in the environment and bioaccumulative. Especially, hexabrominated bipheyls (HBBs) of PBBs are most widely used for plasticizers and flame retardants were designated as persistent organic pollutants (POPs) by Stockholm Convention in 2009. As a part of the food safety management of POPs, six PBBs which are mainly concerned and prioritized to investigate, were monitored from domestically distributed fisheries and animal products in Korea. Gas liquid chromatography-high resolution mass spectrometry was used with selected ion monitoring and stable isotope dilution method (GC-HRMS-SIM) for qualification and quantitation. LODs and LOQs were set at the levels of 3 pg/g and 10 pg/g on the wet weight basis, respectively. Frequencies of occurrence of PBBs from the 154 foods; 77 fisheries and 77 animal products, were 6.7 % in fisheries, and 2.4 %, respectively in animal product with detection of different congeners below or at the levels of LOQs.

식도에서 원발한 악성 흑색종

신용운(Yong Woon shin),정원재(Won Jae Chung),김영범(Young Bum Kim),김치열(Chi Youl Kim),주영채(Young Chae Joo),우재순(Jae Soon Woo),김응진(Eung Jin Kim) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.4

Primary malignant melanoma of the esophagus is a rare lesion accounting for only 0.1% of primary esophageal malignant neoplasms and almost invariably neoplasms of adulthood. To be interpreted as primary, a mucosal melanoma should ideally have overlying or lateral junctional change, approximately half of all patients had clinically, surgically or pathologically detected metastasis at the time of diagnosis and very poor prognosis. A 28 years-old-female was admitted because of dysphagia and odynophagia for 6 months. Confirm diagnosis of primary malignant melanoma of the esophagus was made by endoscopic biopsy. The case presented here is of interest because it is the first case in the Korea.