Effect of Polyisobutylene and Sealant Treatments on Ethylcellulose-Walled Methyldopa Microcapsules

신상철,고익배,Shin, Sang-Chul,Koh, Ik-Bae 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.1

For the prevention of the aggregation during microencapsulation, the effects and role of polyisobutylene(PIB), as a protective colloid, were studied. The effects of sealant treatment on the microencapsulation were studied. Methyldopa was microencapsulated with ethylcellulose (EC) by polymer deposition from cyclohexane by temperature change using PIB. The EC-microencapsulated methyldopa was sealed with spermaceti. The dissolution of methyldopa was influenced by the drug to wall ratio. When PIB was used, low aggregation of microcapsules occurred and the surface was smooth with a few pores. Treatment of microcapsules with spermaceti retarded the release of methyldopa, the release being affected by the percentage of sealant used and the particle size of the product.

니코틴 산의 다공성 분체 흡착

신상철,조정원 ( Sang Chul Shin,Cheong Weon Cho ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1

N/A Nicotinic acid was mixed with glass powders such as controlled pore glass (CPG), glyceryl controlled pore glass (GPG) and glass beads (GB) at room temperature. The physicochemical properties of nicotinic acid in the various mixtures were examined by differential thermal analysis. X-ray diffraction study. Infrared spectroscopy and BET gas adsorption measurements. The peak area at the melting point from the various mixtures of nicotinic acid and CPG was increased with an increase of nicotinic acid concentration while the broad peak area was remained unchanged in the DTA curve. As shown in the powder X-ray diffraction patterns, the crystalline peaks of nicotinic acid disappeared in mixture with CPG, suggesting the interaction of nicotinic acid and porous powders. It was found that the larger the content of CPG, the higher the ratio of an amorphous state to a crystalline state. BET isotherm showed that as the amount of nicotinic acid was increased, the specific surface area was reduced proportionally to nicotinic acid content of up to 40% and remained constant thereafter. Sublimation of nicotinic acid from the mixture of nicotinic acid and CPG was examined. A large quantity of nicotinic acid was retained in the mixture when stored on various temperatures in vacuo for 10 hours. The nicotinic acid mixtures with CPG or GPG showed a high dissolution rates of nicotinic acid in aqueous solution, especially in the initial dissolution stage. CPG is expected to be a good pharmaceutical excipient to reduce the crystallinity of drugs and to prevent sublimation of drugs.

Studies on the Development of Sustained Release Preparation (I) Preparation and Evaluation of CAP Microcapsules of Sodium Ascorbate

신상철,고익배,Shin, Sang-Chul,Koh, Ik-Bae 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.4

Microencapsulation of sodium ascorbate with cellulose acetate phthalate(CAP) by coacervation/ phase separation method were carried out. Various factors affecting microencapsulation, i.e., surfactant concentration. CAP concentration, stirring speed and treatment of spermaceti as a sealing agent were studied. Dissolution rate. particle size distribution, surface feature and stability test were investigated. CAP microcapsules prepared using 0.5% span 80 as a surfactant showed smooth and round surfaces. The release of sodium ascorbate was retarded by microencapsulation with CAP and by sealant treatment with spermaceti. When triturated with sodium bicarbonate, CAP microcapsules were more stable than unencapsulated sodium ascorbate under various RH conditions at $37^{\circ}C$.

순환자원의 고부가가치 활용을 위한 ASCM 표준 개발 필요성

신상철,김진만,Sang-Chul Shin,Jin-Man Kim 한국건설순환자원학회 2023 한국건설순환자원학회지 Vol.18 No.1

폐기물처리업종에서의 정책지원 유효성 분석

신상철(Sang-Cheol Shin) 한국환경정책학회 2017 한국환경정책학회 학술대회논문집 Vol.2017 No.2

SNMP를 이용한 인터넷 분석 파라미터 추출 시스템의 설계 및 구현

신상철(Shin Sang Chul),안성진(Ahn Seong Jin),정진욱(Chung Jin Wook) 한국정보처리학회 1999 정보처리학회논문지 Vol.6 No.3

In this paper, we have designed and implemented a parameter extraction system for analyzing Internet using SNMP. The extraction system has two modules; one is collection request module, and the other is analysis request module. The collection request module generates a polling script, which is used to collect management information from the managed system periodically. With this collected data, analysis request module extracts analysis parameters. These parameters are traffic flow analysis, interface traffic analysis, packet traffic analysis, and management traffic analysis parameter. For management activity, we have introduced two-step-analysis-view. One is Summary-View, which is used to find out malfunction of a system among the entire managed systems. The Other is Specific-View. With this view we can analyze the specific system with all our analysis parameters. To show availability of this system, some analysis results are shown and analyzed about routers on real environments. The parameter extraction system will help a network manager grasp the current status of network elements and use the available data as indicators for line capacity planning, network redesigning, decision making of performance upgrade for a network device and things like that.

실시간 동적 GPS 측량에 의한 지형 해석

신상철(Shin, Sang-Cheol),김정동(Kim, Joung-Dong),박운용(Park, Woon-Yong) 한국측량학회 2001 한국측량학회지 Vol.19 No.3

러시아 극동 마피야의 부산지역 수산물 유통관련 범죄활동에 관한 연구

신상철(Shin Sang cheol) 한국공안행정학회 2014 한국공안행정학회보 Vol.23 No.2

우리나라 주변의 국제범죄는 21세기형으로 급속히 진화하고 있다. 우리나라를 둘러싸고 있는 국제범죄조직으로 중국 흑사회, 홍콩ㆍ마카오의 삼합회, 일본 야쿠자, 러시아 마피야가 있다. 특히 러시아 극동 마피야는 연해주 및 사할린에 거주하는 교포 2세와 현지 마피야조직원들이 서로 연계하여 국내 연고자들을 통해 거점을 모색한 후 우리나라에 투자하거나 영주(F-5)비자를 취득하여 입국한 후 표면적으로는 수산업이나 해상 무역업에 종사한다고 하면서 실질적으로는 밀수나 마약을 통해 제2차 범죄를 일으키고 있어 우리나라가 극동 러시아와 중국 홍콩을 오가는 각종 범죄의 중간 경유지가 되고 있다. 이러한 국제범죄조직에 대한 대응방안의 일환으로, 국제적인 연계망을 구축하여 관련 국가와 더불어 국제협력방안을 모색하고, 인터폴과 아센안폴을 통해 범죄정보를 교환하며, 국제 사법 공조를 포함해 범죄인 인도 및 요구로 국제조약에 따라 해당 국가간 국제범죄조직 퇴치를 위한 활발한 교류와 유대강화가 요구된다. Organized crimes around Korea are rapidly evolving into those of the 21st-century style. For example, the Pseudo-Underworld Society Crime Organization of China, the Triad of Hongkong and Macao, the Yakuza of Japan and the Russian Mafiya of the Far East region are all transnational organized crime groups. Especially, the Russian crime group is making connections between 2nd-generation Korean residents in Primosky Kra and their local gangsters. Then they are using some of the Korean residents who have relatives in Korea to set up their base in the country. After that, they are entering Korea under the name of investment or with F-5 visas. Since then, they are superficially doing the fisheries or marine trade business, but actually committing secondary crimes such as smuggling and drug trafficking. Thus, Korea is becoming a passage of lots of crimes among the Far East region of Russia, China and Hongkong. As an effort to cope with the transnational crime organizations, it is needed to build up international networks through which affected countries cooperate with one another. In addition, those countries should make active exchanges and strengthen ties with one another to crack down on transnational organized crimes by sharing crime information through the INTERPOL and the ASEANPOL, establishing the international mutual criminal assistance system and reciprocally following international treaties providing anti-organized crime actions including extradition and repatriation.

서중환경에서 시공되는 연직부재 콘크리트의 콜드 조인트에 미치는 타설시간의 영향

신상철(Shin, Sang Chul),코야마 토모유키(Koyama, Tomoyuki),이토 코레키요(Ito, Korekiyo),혼다 사토루(Honda, Satoru),김진만(Kim, Jin Man) 한국콘크리트학회 2016 한국콘크리트학회 학술대회 논문집 Vol.28 No.2

경찰의 초동수사와 한미SOFA협정문 쟁점사항 분석

신상철(Shin, Sang Cheol),임금섭(Lim, Gum Sub) 경찰대학 경찰학연구편집위원회 2018 경찰학연구 Vol.18 No.2

조약이란 국제법 주체들이 법적 구속력을 받도록 체결한 국제협정으로, 법적인 권리와 의무를 수반하고 있다. 한․미 상호방위조약은 한반도에서 전쟁을 억지하고 동북아지역의 평화와 안정에 기여하여 왔으나 미주둔군지위협정(SOFA) 제22조인 형사재판권은 주한미군 범죄에 대한 대한민국의 사법권 행사에서 많은 문제점을 내포하고 있다. 협약에는 SOFA 대상자들에 의한 범죄발생 시 미 대표는 1시간 내 출석을 명시하고 있으나 이를 제대로 지키지 않고 오히려 미군 피의자가 이를 악용하고 있으며, 미군 피의자 조사 시 미군당국의 비협조가 초동수사를 더욱 어렵게 하고 있다. 그리고 기소 전구금 요건 대상범죄(중요 12개 범죄)유형을 제한하고 있어 서민들이 많이 피해를 당하는 폭행과 재물손괴, 절도 등에 대해서는 기초조사 후 미군 측에 신병을 인도하고 있어 피해보상도 받지 못하는 경우가 허다하다. 무엇보다도 경찰의 초동수사를 강화하기 위해서는 한미합동위의 합의사항에 머물러 있는 초동수사 시 공동현장 접근 및 공동수사 등 협력방안과, 수사상 필요한 관련자료 제공 상호협조방안 등 미군의 형사사건 처리지침을 적극 실천 할 수 있는 강제방안을 마련하여야 하며, 경찰의 계속 구금권, 교통사고 보험가입 의무화, 압수 수색 등 경찰권행사, 범죄 후 미군부대로 도피한 미 군속․가족들의 체포권과, 미군 피의자에게 부여된 지나친 특권조항을 삭제하는 등 경찰의 초동수사를 저해하는 각 조항들을 우선적으로 개정하여야 한다. 또한 현행 협정이 인적 적용대상의 범위를 지나치게 확대하였기에 미 군법 적용자를 제외한 친척과 초청계약자 등은 적용대상에서 제외해야 한다. Treaty is an international pact that legally binds its parties under the rules of international law and provides legal rights and obligations for those parties. The Mutual Defense Treaty between the Republic of Korea and the United States has contributed to deterring war in the Korean peninsula and keeping the peace and stability of the entire Northeast Asian region. By the way, Article 22 of the Status of Forces Agreement(SOFA), which was stipulated according to Article 4 of the same treaty and contains the provisions of criminal jurisdiction, has many problems in relation to the exercise of judical power over crimes by US soldiers stained in Korea. To solve the problems, first of all, it should be obliged that if a US solider commit a crime, a US government representative for him appears before the police in less than 1 hour, but the representative is not allowed to involve in the investigation of the suspect. But actually, US soldiers caught in the act of crime misuse the provisions contained in Article 22 of SOFA. In addition, the above mentioned appearance is little performed. Thus, poor cooperation by the US forces makes preliminary police investigation even more difficult. Second, some SOFA provisions that limit the types of crimes(12 main crimes), for which custody prior to accusation is allowed and that show 4 prerequisites for custody extension should be eliminated. Third, the range of persons affected by the Status Forces of Agreement should be narrowed and restricted to ‘all persons who obey to the US military law’, excluding their relatives and invited contractors. In addition, measures to enforce the practice of US military guidelines for criminal case treatment such as mutual cooperation in preliminary police investigation, which includes joint approach to crime scenes and joint investigation, and in provision of materials necessary for investigation should be taken and implemented. Furthermore, the exercise of police authority, for example, holding US military criminals in custody, forcing US soldiers to be covered up by traffic accident insurance, performing search and confiscation and arresting civilian employees in the US forces or their families who fled to a US military base after committing a crime should be guaranteed. And, some SOFA provisions that put excessive privileges on US military suspects and block preliminary police investigation must be revised earlier than any other provisions.