유리체출혈의 원인으로서의 망막열공과 열공망막박리의 비교 분석

신광훈,남동흔,이대영,Kwang Hoon Shin,Dong Heun Nam,Dae Yeong Lee 대한안과학회 2011 대한안과학회지 Vol.52 No.4

Purpose: To analyze retinal tears and to compare the clinical outcomes between retinal tear and rhegmatogenous retinal detachment (RRD) as the cause of dense non-diabetic vitreous hemorrhage in patients who underwent vitreoretinal surgery. Methods: In a retrospective case series, the medical records of patients who presented dense non-diabetic vitreous hemorrhage and who underwent vitreoretinal surgery between January 2005 and June 2009 were reviewed. Among the 134 patients, 27 patients had dense vitreous hemorrhage caused by retinal tears. The first group had retinal tears only and the second group had accompanying RRD. A comparison of clinical features and postoperative prognoses between the two groups was performed. Results: Among the 27 eyes with non-traumatic retinal tear and RRD, 18 were categorized into the retinal tear group and 9 to the RRD group. The demographic findings between the two studied groups exhibited no significant differences except for time between onset of symptoms and diagnosis. However, the time to diagnosis was significantly delayed in the group with RRD (22.67 ± 37.47 days) compared to the retinal tear group (5.00 ± 3.41 days) (p = 0.035). The amount of visual improvement was also greater in the retinal tear group than the RRD group (p = 0.002). Conclusions: Retinal tears are a major cause of non-diabetic vitreous hemorrhage. Vitreous hemorrhage caused by retinal detachment may result in delayed diagnosis and poor visual recovery. Therefore, early examinations in suspicion of RRD and appropriate treatments are needed in non-diabetic vitreous hemorrhage. J Korean Ophthalmol Soc 2011;52(4):448-453

유리체절제술을 받은 눈에서 시행한 23게이지 무봉합 유리체절제술

신광훈,이대영,손희진,남동흔.Kwang Hoon Shin. MD. Dae Yeong Lee. MD. Hee Jin Sohn. MD. Dong Heun Nam. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.5

Purpose: To investigate the incidence and risk factors of major complications including postoperative hypotony after 23-gauge transconjunctival sutureless vitrectomy in previously vitrectomized eyes. Methods: The authors retrospectively reviewed medical records of 52 eyes, which underwent 23-gauge transconjunctival sutureless vitrectomy of previously vitrectomized eyes by a single surgeon. Major outcomes were postoperative hypotomy (<6 mmHg), intraoperative sclera shrinkage during sclerotomy,and other postoperative complications. Multiple logistic regression analysis was performed that included 212 eyes with primary vitreoretinal surgery in order to validate secondary vitreoretinal surgery as a significant risk factor of postoperative hypotony. Results: Postoperative hypotony occurred in 4 eyes (7.7%) out of 52 eyes that underwent a second vitrectomy. The odds ratio of the second vitreoretinal surgery (OR=1.15, p=0.283) was not significant by multiple logistic regression analysis that included age, sex, axial length of globe, and the number of surgeries as the independent variables. Choroidal detachment occurred in one eye but disappeared three days later. The intraocular pressure was normalized within one week in all cases. Scleral shrinkage during sclerotomy occurred in five eyes (9.6%), and there were no other major complications, such as endophthalmitis. Conclusions: A 23-gauge transconjunctival sutureless vitrecomy of previously vitrectomized eyesshowed a 7.7% incidence of postoperative hypotony and favorable prognosis. J Korean Ophthalmol Soc 2010;51(5):716-720

간헐 외사시에 대한 양안 외직근 후전술 후 발생한 속발 내사시 치료를 위한 외직근 전진술의 장기 효과

신광훈,위재민,백혜정,Kwang Hoon Shin,Jae Min Wi,Hae Jung Paik 대한안과학회 2014 대한안과학회지 Vol.55 No.8

Purpose: To investigate the long-term outcome of lateral rectus (LR) advancement for consecutive esotropia following bilateral LR recession for intermittent exotropia. Methods: Medical records of 25 patients who underwent LR advancement for consecutive esotropia after bilateral LR recession and who were followed up for more than 24 months postoperatively were reviewed. Patients were divided into two groups: bilateral lateral rectus recession (BLR) group included 16 patients with consecutive esotropia greater than or the same magnitude as the initial exotropia and who underwent bilateral LR advancement; Unilateral lateral rectus recession (ULR) group included nine patients with consecutive esotropia less than the initial exotropia and who underwent unilateral LR advancement. Main outcome measurements were motor and sensory outcomes and the dose-effect relationship calculated from observed overall and group changes in the angle of deviation per millimeter. Motor success was defined as alignment from orthotropia to exodeviation less than 10 PD at distance. Sensory outcome was described by comparing the Titmus stereoacuity test before and after LR advancement. Sensory successvwas defined at 100 seconds of arc. Results: Eighteen patients (72.0%) showed satisfactory long-term motor and sensory outcomes. Seventeen (77.3%) of 22 patients showed favorable stereopsis of 100 seconds of arc or more at final observation. The long-term motor success rate of the ULR group was better than that of the BLR group (<em>p</em> = 0.025). The average observed change in the angle of deviation was 3.6 PD/mm at the final visit in all patients. A greater dose-effect relationship was observed in the ULR group than in the BLR group at the final visit (<em>p</em> = 0.043). Conclusions: LR advancement showed favorable motor and sensory outcomes in the majority of patients. The surgical outcome was not favorable in patients in the BLR group with consecutive esotropia of the same magnitude as the initial exotropia. These results require further investigation for verification. J Korean Ophthalmol Soc 2014;55(8):1180-1186

성인전파 Chlamydia trachomatis 병원체 감염에 대한 조사연구

신광훈 (Kwang-Hoon Shin ),김호훈(Ho-Hoon Kim),송기준(Ki-Joon Song),신영학(Young-Hack Shin ) 大韓微生物學會 1990 大韓微生物學會誌 Vol.25 No.1

우리나라 一部地域의 接待婦에 對한 梅毒檢査 成績

辛光勳(Kwang Hoon Shin) 서울대학교 보건환경연구소 1973 보건학논집 Vol.10 No.2

한국에서 분리된 Neisseria gonorrhoeae 약제내성 plasmid 및 혈청군

신광훈(Kwang-Hoon Shin),신영학(Young-Hack Shin),이복권(Bok-Kwon Lee),김순남(Sun-Nam Kim),강연호(Yeon-Ho Kang),송기준(Ki-Joon Song),김호훈(Ho-Hoon Kim) 大韓微生物學會 1990 大韓微生物學會誌 Vol.25 No.4

국내에서 분리된 Shigella flexneri에 대한 역학적 특징과 PFGE 양상

전정훈(Jeong Hoon Chun),김성한(Seong Han Kim),전형근(Hyeong Geun Jeon),김준영(Jun Young Kim),강연호(Yeon Ho Kang),신광훈(Kwang Hoon Shin),이복권(Bok Kwon Lee) 대한미생물학회 2002 Journal of Bacteriology and Virology Vol.32 No.1

20프리즘디옵터 간헐외사시의 한눈 또는 두눈 외직근후전술 후 외편위로의 회귀 양상

박수진(Su Jin Park),신광훈(Kwang Hoon Shin),백혜정(Hae Jung Paik) 대한안과학회 2016 대한안과학회지 Vol.57 No.12

목적: 20프리즘디옵터(prism diopter, PD) 간헐외사시의 한눈 외직근후전술과 두눈 외직근후전술 후 장기 수술결과와 술 후 시간 경과에 따른 외편위로의 회귀 양상을 비교해 보고자 하였다. 대상과 방법: 20PD 간헐외사시를 진단 받고 8.5 mm 한눈 외직근 후전술 또는 5.0 mm 두눈 외직근후전술을 시행 받은 후 최소 2년 이상 추적 관찰이 가능했던 82명의 의무기록을 후향적으로 분석하였다. 각 군의 술 후 1주, 1개월, 6개월, 1년, 2년째 사시각과 외편위로의 회귀양상을 비교분석하였고, 10PD 미만의 수평편위와 100초 이내의 입체시를 보일 때 성공이라 판단하였다. 결과: 두눈 수술군 44명, 한눈 수술군 38명의 술 후 1주째 안구위치는 각각 4.7 ± 5.1PD, 1.2 ± 4.2PD 내편위로 두눈 수술군이 수술초기 유의하게 과교정되었으나(p=0.001), 술 후 1주, 1개월, 6개월, 1년, 2년에 외편위로의 회귀가 발생하였다. 반면 한눈 수술군은 술 후 1주, 1개월, 6개월 외편위 회귀를 보인 이후 안구위치가 안정되었다. 술 후 2년 뒤 관찰 시 두눈 수술군 4.0 ± 4.2PD, 한눈수술군 2.6 ± 4.2PD로 각각 75.0%, 81.6%의 성공률을 보였다(p=0.717). 결론: 20PD 간헐외사시의 외직근후전술은 한눈 수술의 경우 수술 직후 과교정이 적고, 초기 6개월까지 외편위로의 회귀가 일어나나 그 이후에는 안구위치가 안정화되었고 술 후 2년 이상 경과 관찰상 두눈 수술군과 유사한 성공률을 보이는 것으로 판단되었다. Purpose: In the present study, the surgical outcome and postoperative exodrift pattern between bilateral lateral rectus recession (BLR) and unilateral lateral rectus recession (ULR) in intermittent exotropia of 20 prism diopters (PDs) were compared. Methods: In this retrospective study, 5.0 mm BLR or 8.5 mm ULR was performed on 82 patients for the treatment of intermittent exotropia of 20 PDs with a follow-up period of 2 years. The main outcome measures were postoperative 1-week, 1-month, 6-month, 1-year and 2-year exodeviation angles with their patterns and success rates. A surgical success was considered an alignment within 10 PDs and sensory success was defined at 100 seconds of arc. Results: The mean deviation angles at postoperative 1 week were 4.7 ± 5.1 PD esodeviation in the BLR group (44 patients) and 1.2 ± 4.2 PD esodeviation in the ULR group (38 patients). The BLR group was significantly more overcorrected than the ULR group (p = 0.001), but postoperative exodrift occurred in the BLR group at 1 week, 1 month, 6 months, 1 year, and 2 years. In the ULR group, the postoperative exodrift occurred at 1 week, 1 month, and 6 months which was followed by stabilized alignment. Surgical success rate at the postoperative 2-year follow-up was 75.0% in the BLR group and 81.6% in ULR group (p = 0.717). Conclusions: ULR showed less overcorrection and early exodrift up to only 6 months, resulting in stabilization of the alignment afterwards; surgical success rate at the final 2-year follow-up was similar to BLR.

한국에서의 백일해 면역력에 대한 조사 연구

민홍기(Hong Ki Min),신광훈(Kwang Hoon Shin),김순남(Soon Nam Kim),이명숙(Myong Sook Lee),유시형(Si Hyung Yoo),김지윤(Ji Yun Kim),강진한(Jin Han Kang) 大韓微生物學會 1999 大韓微生物學會誌 Vol.34 No.6

급성골수성백혈병 환자에서 내과적 치료 후 빠른 회복을 보인 유리막하출혈과 망막중심정맥폐쇄

손희진(Hee Jin Sohn),신광훈(Kwang Hoon Shin),이대영(Dae Young Lee),남동흔(Dong Heun Nam) 대한검안학회 2008 Annals of optometry and contact lens Vol.7 No.1

목적: 급성골수성백혈병 환자에서 양안의 심한 유리막하출혈과 망막중심정맥폐쇄가 빠른 회복을 보인 1예를 경험하였기에 보고한다. 대상과 방법: 1주 전 시작된 창백, 기침을 주소로 2일 전 소아과에 입원하여 급성골수성백혈병을 진단받은 13세 여환이 1주일 전 시작된 양안의 시력 감소를 주소로 진료 의뢰되었다. 교정시력은 우안 안전수지 30센티미터, 좌안 0.02, 양안에 심한 유리막하출혈과 정맥확장 및 사행성 변화, 망막출혈, 유두부종을 보였다. 혈액학 검사에서 혈색소 5.2 g/dl, 헤마토크릿 15.6%, 백혈구 30,710/mm3, 혈소판 32,000/mm3였다. 결과: 일 주일 뒤 교정시력은 우안 0.02, 좌안 0.08로 호전되었으며 망막중심정맥폐쇄와 유두부종은 감소되었다. 한 달 후 유리막하출혈과 유두부종이 현저히 감소하였고 혈색소 8.6 g/dl, 헤마토크릿 24.1%, 백혈구 1,300/mm3, 혈소판 348,000/mm3로 회복되었다. 6개월 뒤 교정시력은 우안 1.0, 좌안 0.5였으며 양안에 미약한 황반부종 소견만 보였다. 결론: 급성백혈병에서 급성으로 발생한 백혈병망막병증은 심한 안저변화가 동반되더라도 내과적 치료 후 빠른 회복을 보일 수 있을 것으로 생각한다. Purpose: To report a case of rapid resolution of subhyaloid hemorrhage and central retinal vein occlusion after medical treatment in acute myeloid leukemia Methods: A 13-year-old girl who had been diagnosed to have acute myeloid leukemia (AML) in the department of pediatrics was referred to the ophthalmologic clinic because of blurred vision in her both eyes for 1 week. Initial best corrected visual acuity was FC 30 cm in the right eye, 0.02 in the left eye. Fundus examination showed severe subhyaloid hemorrhage, dilated and tortous vein, retinal hemorrhage and papilledema. Hematologic tests revealed hemoglobin 5.2 g/dl, hematocrit 15.6%, white blood cell count 30,710/mm3 , platelete count 32,000/mm3. Results: After 1 week later, the findings of central retinal vein occlusion and papilledema were decreased and best corrected visual acuity was improved to 0.02 in the right eye, 0.08 in the left eye. 1 month later, subhyaloid hemorrhage and papilledema were markedly improved and hematologic findings was recovered to hemoglobin 8.6 g/dl, hematocrit 24.1%, white blood cell count 1,300/mm3 , platelete count 348,000/mm3. Finally, best corrected visual acuity was 1.0 in the right eye, 0.5 in the left eye and minimal macular edema was exist in the both eye. Conclusions: We suggest that the leukemic retinopathy in AML can be recovered rapidly after medical treatment in spite of severe retinal change.