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한국인 성인에 있어서의 소장점막 내 유당분해 효소의 측정
황석기 ( Suck Key Whang ),김윤수 ( Youn Soo Kim ),송정석 ( Chung Suck Song ) 대한내과학회 1972 대한내과학회지 Vol.15 No.3
Previously we made a preliminary conclusion of lactase dificiency in majority of Korean adults after a study of lactose tolerance tests in 21 healthy subjects and in 5 patients. All of them showed a flat tolerance curve with at least one or more of G.I. sy
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Lactase Deficiency In Korean Adults
정명희,황석귀,김윤수,송정석,Chung, Myung-Hee,Whang, Suck-Kuy,Kim, Yoon-Soo,Song, Chung-Suk 생화학분자생물학회 1973 한국생화학회지 Vol.6 No.3
유당 분해 효소 lactase의 활성도는 일반적으로 분만과 동시에 최고치에 달하고 이유와 동시에 그 활성도는 서서히 떨어져서 성인에 이르르면 lactase 활성도는 민족에 따라서 다른 것으로 보고되고 있다. 그 원인이 그 민족의 환경 및 식사습성과의 관계 혹은 민족적 유전인자의 차이로 인한 것으로 설명하려 하고 있으나 어느쪽이 옳은 설명인지는 아직 모른다. 주위 환경과 음식 습성 및 민족의 기원이 상이한 한국인에 대한 이런 실험 보고는 아직 없기에 한국 성인을 대상으로 소정의 실험을 시도 하였다. 한국 성인에 유당을 부하하면 100%에서 유당분해효소 lactase가 결핍으로 오는 저혈당치를 보였으며 또한 한국성인에서 경구적으로 multipurpose rubin tube를 사용해서 얻은 생체 부검 조직내의 설탕분해 효소 sucrase는 정상치 인데 비하여 유당 분해 효소 lactase치는 실험대상 전원에서 그 활성도를 찾아 볼수 없었다. 이 원인이 한국인의 환경과 식이 습성에서 유래한 것인지 또는 조상때 부터 민족적인 어떤 유전인자 관계인지는 다른 민족에서 보고 된것 처럼 그 기전은 아직 모른다. Twenty six oral lactose tolerance tests were performed in 21 healthy subjects and five patients. Each subjects were given 50gm of lactose in 300ml of water. Venous blood sugar was measured at 0, 30, 60, 90 and 120 min. All 26 subjects showed a rise in blood sugar less than 25mg per 100ml (fiat curve) above the fasting level. At least one or more of G. I. symptoms such as bloating, abdominal cramps and/or diarrheas were experienced by all subjects during and/or after the tests. Additional glucose and galactose tolerance tests performed in 3 subjects were normal and this excluded the possibility of absorptive defect in these individuals. In order to determine the lactase activity of the Korean adults, peroral mucosal suction biopsies were done in another 10 subjects who were randomly selected. In all the subjects, the activities of lactase were absent whereas those of sucrase were normal. The majority, if not all, of Korean adults are expected to have lactase deficiency.
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국민학교 아동의 영양 조사. - 서울과 밀양 국민 학교 아동
조한영,황석귀,김현옥,송정석,Cho, Han-Yung,Whang, Suck-Kuy,Kim, Hyun-Ock,Song, Chung-Suk 생화학분자생물학회 1972 한국생화학회지 Vol.5 No.2
서울 미동국민학교와 밀양 밀주 및 태룡국민학교 5, 6학년 아동들에게 1967년 가을과 1968년 봄에 혈액내 carotene, 비타민 A 및 비타인 C 와 뇨중 thiamine, riboflavin 과 N-methylnicotinamide 배설량을 측정하여 다음과 같은 결론을 얻었다. 1) 밀주와 태룡국민학교 아동들의 혈액내 carotene 농도는 가을에 미동국민학교 아동들보다 윌등히 높았다. 이는 아마 가을에 지방아동들이 감을 많이 먹기 때문인것 같다. 봄에는 지방과 서울이 다같이 비슷함 농도를 보여 주었다. 2) 비타민 C 혈액내 농도는 가을에 있어서 서울과 지방아동들에게서 다 높았고 특히 지방 아동들에게서 높았으나 봄에 와서는 서울 아동들은 월등히 떨어졌었다. 이는 서울 아동들이 겨울에 채소를 적게 먹기 때문인것 같다. 3) Thiamine, ribof1avin, N-methylnicotinamide 뇨중 배설은 지방 아동등에서 약간 높았고 가을보다 봄에 뇨중 배설량은 서울과 지방 아동들이 다 같이 높았다. In autumn of 1967 and spring of 1968, determinations of carotene, vitamin A and vitamin C in blood and the excretion of thiamine, riboflavin and N-methylnicotinamide in urine were carried out on the 5th and 6th grade pupils of primary schools of Midong in Seoul and Milchoo and Taeryong in Milyang, Gyunsang Namdo Province, and the following conclusion was obtained. 1. The carotene level in blood of children of Milchoo and Taeryong was excellently higher than that in blood of children of Midong in autumn. This is probably due to higher intake of persimmon of rural children than that of Seoul children and the carotene blood level in spring was almost same between the children of Seoul and the rural area. 2. The vitamin C level was high in blood of both children of Seoul and Milyang, especially high in that of rural children but in spring the vitamin level was severely reduced in blood of Seoul children. This is probably due to less intake of vegetables during winter. 3. The amount of urinary excretion of thiamine, riboflavin and N-methylnicotinamide was slightly larger in the rural children than in those of Seoul, and it was larger in spring than in autumn.
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국민학교 아동의 영양 조사 서울과 밀양 국민 학교 아동
조한영,황석귀,김현옥,송정석 ( Han Yung Cho,Suck Kuy Whang,Hyun Ock Kim,Chung Suk Song ) 생화학분자생물학회 1972 BMB Reports Vol.5 No.2
In autumn of 1967 and spring of 1968, determinations of carotene, vitamin A and vitamin C in blood and the excretion of thiamine, riboflavin and N-methylnicotinamide in urine were carried out on the 5th and 6th grade pupils of primary schools of Midong in Seoul and Milchoo and Taeryong in Milyang, Gyunsang Namdo Province, and the following conclusion was obtained. 1. The carotene level in blood of children of Milchoo and Taeryong was excellently higher than that in blood of children of Midong in autumn. This is probably due to higher intake of persimmon of rural children than that of Seoul children and the carotene blood level in spring was almost same between the children of Seoul and the rural area. 2. The vitamin C level was high in blood of both children of Seoul and Milyang, especially high in that of rural children but in spring the vitamin level was severely reduced in blood of Seoul children. This is probably due to less intake of vegetables during winter. 3. The amount of urinary excretion of thiamine, riboflavin and N-methylnicotinamide was slightly larger in the rural children than in those of Seoul, and it was larger in spring than in autumn.
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Choline缺乏 肝硬化症 白鼠 遊離灌流 肝에서의 尿素生産에 關하여
金濟炫,Miller, L. L.,朴永薰,宋正錫 최신의학사 1975 最新醫學 Vol.18 No.8
Albino Sprague-Dawley rats were fed choline deficient, low protein diet for 142 to 229 days, and was cirrhosis produced. Glutamine and glucagon effects on urea production were observed in the isolated perfused liver. Perfusion was carried out by the method of Miller, and after 2 hours of perfusion glutamine oar glucagon was added for 4 hours at a constant rate with an infusion pump. Amounts of infusion were 10 pg per hour for glucagon and 0.25 or 0.5 mmole per hour for glutamine. The results were as follows: 1) Liver weight-25.5g, hepatic total lipids-28.7%, and bile flow during 6 hours perfusion-2.2ml were shown for the cirrhotic liver. 2) Although amino acid nitrogen accumulation was high, urea production and expired respiratory '?CO2 were less in the cirrhotic liver than in the control. 3) Glutamine increased urea production, and glutamine may play a role of not only substrate of urea but also others in the cirrhotic liver. 4) Glucagon did not increase urea production in the cirrhotic liver. 5) Urea excretion in 24 hours urine was 131.8mg in the cirrhotic rats and 184.4mg in the controls. The amounts were higher compared to urea production by the isolated perfused liver of cirrhotic rats. Negative nitrogen balance was showed in the cirrhotic rats.
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