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송영기(Young Kee Shong),박경수(Kyong Soo Park),조보연(Bo Youn Cho),고창순(Chang Soon Koh),오승근(Seung Keun Oh),박성희(Seong Hoe Park),김용일(Yong Il Kim) 대한내과학회 1986 대한내과학회지 Vol.30 No.6
N/A Five cases of differentiated carcinoma of thyroid associated with brain metastasis are reported. All of the patients had distant metastatic diseases or massive invasion of the surrounding tissue at the initial diagnosis. Metastatic lesions in the brain were not detected by conventional radioiodine whole body scan but by computerized axial tomography. TSH suppression, external radiotherapy, and radioactive iodine were tried but no consistently satisfactory effects were achieved. The prognosis of the patients with brain metastasis was poor, four patient diedat two to four months after detection of brain metastasis and only one patient is alive two months after detection, at the time of writing this paper.
Graves 병 환자에서 갑상선 아전절제술 후 갑상선자극항체와 갑상선자극홀몬 결합억제 면역글로불린의 변화
송영기(Young Kee Shong),이병두(Byoung Doo Rhee),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),오승근(Seung Keun Oh) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A The authors measured changes in thyroid stimulating antibody (TSAb) and thyrotropin binding inhibitor immunoglobulin (TBII) in 15 patients with Graves' disease treated with subtotal thyroidectomy. Before surgery all 15 had detectable TBII actvities, and 11 had TSAb activities. During the 12 month postoperative follow-up, TBII disappeared in 7 out of 15, and TSAb disappeared in 6 out of 11. Twelve months after surgery, 10 patients with negative TSAb (including 4 patients whose TSAb activities were negative before surgery) remained in remission, Of 5 patients whose TSAb remained persistently positivie during the 12 month observation period, one remained in remission, two experienced relapse, and two became hypothyroid. In the persistently positive TSAb and TBII group, their activities did not change after surgery. There was no difference in clinical and laboratory findings save for the higher TSAb and TBII activity preoperatively between the persistently positive group and disappearing group. In summary, after subtotal thyroidectomy, TSAb and TBII disappeared in some of the patients. Disappearance of TSAb is associated with remission but persistence of TSAb has no prognostic implication. The production sites of thyrotropin reccptor antibody are thought to be intrathyroidal, but in some patients extrathyroidal production might contribute significantly, due to the pattern of postoperative changes in thyrotropin receptor antibody activities.
백서 고환 간질 세포에서 TSH 와 TSH 수용체 항체에 대한 cAMP 와 Testosterone 의 반응
송영기(Young Kee Shong),조보연(Bo Youn Cho),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),이문호(Mun Ho Lee) 대한내과학회 1988 대한내과학회지 Vol.35 No.3
N/A To investigate the physiological role of TSH receptor in testes and the effect of various TSH receptor antibodies (TRAb), we measured cAMP production ad testosterone release in enzymatically dispersed rat testicular interstitial cells under the stimulation of TSH and TRAb, and compared the results with in those of tests done in FRTL-5 cells. TSH increased cAMP production and testosterone release in a dose-dependent manner similar to hCG. TSAb which stimulated thyroid adenylate cyclase (AC) were able to stimulate teaticular interstitial cell AC in 8 out of 30 patients (277p) and testosterone release in 12 out of 30(40%) patients with Graves' disease. Blocking type TRAb inhibited TSH-induced cAMP production and testosterone release in a dose-dependent manner but had no effect on basal cAMP production and testosterne release, These findings suggest that TSH receptors in testes might have a somewhat dissimilar nature from that in the thyroid and that testicular TSH receptor might be involved in testosterone production.
송영기 ( Young Kee Shong ) 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.1
18F-fluorodeoxyglucose positron-Emission Tomography (FDG-PET) is very useful for the follow up of differentiated thyroid carcinoma. FDG-PET could determinate the recurrent or metastatic foci of thyroid cancer in 70∼90% of patients with elevated thyrogobulin level during thyroid hormone withdrawal, especially whose I-131 whole body scan were negative. However, currently neck ultrasonography (USG) is the primary choice to detect recurrent disease in neck because FDG-PET is rather expensive and available only in limited center. FDG-PET could be recommended in patients with negative USG result or for detecting distant metastasis in patients with local recurrence. The number of patients with incidentally found FDG uptake in thyroid gland after FDG-PET or PET/CT was increased. Diagnostic procedures such as USG and cytological examination or pathological examination including hemithyroidectomy were essential for these patients due to the high risk of malignancy. FDG-PET did not have any advantage for the preoperative evaluation comparing other diagnostic modalities. It could be selectively used in the high risk patients.
간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 당뇨병 환자에서의 담낭운동성에 관한 연구
민영일(Young Il Min),이성구(Sung Koo Lee),김명환(Myung Hwan Kim),임채만(Chae Man Lim),송영기(Young Kee Shong),이기업(Ki Up Lee),문대혁(Dae Hyuk Moon),이명혜(Myung Hae Lee) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
N/A Cholesterol gallstone is known to occur two to three times more frequently in diabetes than in normal population. Hypotheses such as hypercholesterolemia or obesity were presented to explain the higher incidence of gallstone disease in diabetes but failed to show strong cause-effect relationship. We compared the gallbladder emptying of a diabetic group who had not ever had gallstone disease with that of a control group using Tc-99m cholescintigraphy and also made assessment about several metabolic factors in diabetic group to know which one was closely related with the impaired gallbladder emptying. The results are as follows. 1) Gallbladder emptying (ejection fraction) was significantly reduced in diabetes group (72.9 +- 19.8%) compared with normal control (89.6 +-9.6%) (p<0.05). 2) Gallbladder emptying in the diabetes group with autonomic neuropathy (64.2 +- 21.6%) was impaired to a greater extent than in the diabetes without autonomic neuropathy (82.3 +- 12.3%) (p< 0.05). 3) Severe impairment of gallbladder emptying (EF < 70%) in diabetes was not related with obesity, Hb A,C level, disease duration or serum lipid level but related with the presence of autonomic neuropathy (p<0.01). In conclusion, gallbladder emptying is impaired in diabetes and such an impairment was more prominent in the diabetic patient complicated autonomic neuropathy, which may lead to bile stasis and allow for cholesterol crystal formation.
첫 세포검사에서 양성이며 추가 세포검사에서 악성의 증거는 없었으나 경과 관찰 중 현저한 크기 증가로 인하여 수술하게 된 갑상선결절의 수술 후 결과
김의영 ( Eui Young Kim ),김원구 ( Won Gu Kim ),김태용 ( Tae Yong Kim ),공경엽 ( Gyungyup Gong ),류진숙 ( Jin-sook Ryu ),윤종호 ( Jong Ho Yoon ),홍석준 ( Suck Joon Hong ),김원배 ( Won Bae Kim ),송영기 ( Young Kee Shong ) 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.2
Background and Objectives: Fine needle aspiration (FNA) cytology is the best test to diagnose malignancy in thyroid nodules. However, cytologic interpretation of FNA specimens is difficult in case that follicular neoplasm is suggested. The aim of this study was to evaluate the rate of malignancy in thyroid nodules which were cytologically diagnosed as benign at the first FNA cytology but the size of nodules increased during the observation period. Materials and Methods: Patients who underwent thyroid surgery in Asan Medical Center from 1996 to 2001 were enrolled. Patients who diagnosed as benign at the first FNA cytology and relatively rapid increase in the nodule size during the observation period were included in this retrospective study. Results: Total 283 patients were included in this study. Their mean age was 42 years and mean tumor size was 4.89 cm (range 2.0∼12.0 cm). In pathologic results, 223 (80.9%) patients had benign thyroid nodules with 191 nodular hyperplasia, 37 follicular adenomas and 1 hashimoto’s thyroiditis, respectively. Fifty four patients (19.1%) had malignancy with 35 follicular carcinomas, 17 papillary thyroid carcinomas and 2 poorly differentiated carcinomas, respectively. Conclusion: Surgical treatment could be recommended for patients with significant increase in size of thyroid nodule, even though the results of their initial FNA were benign.
이애영(Ai Young Lee),김기호(Ki Ho Kim),김정애(Jeong Aee Kim),이유신(Yoo Shin Lee),송영기(Young Kee Shong),조보연(Bo Youn Cho) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.5
A case of pretibisl myxederna in typical Graves disease was described. A 50-year-old woman revealed diffuse toxic goiter, exophthalmos, and pretibial myxedema. From light and electron microscopic findings, large amount of acid mucopolysaccharides were deposited in the stroma and fibroblssts. In spite of elevation of TBII (a kind of thyroid stimulatory factors, negative direct immunofluorescence of lesional skin and no response. of pretibial myxedema to the treatment with antithyroid drug (propylthiouracil) suggested stimulstory factors of fibroblasts might be different from those of thyroid gland.
배양된 쥐 갑상선세포 성장에 미치는 각종 성장인자들과 TSH 수용체항체간의 상호작용 및 그 기전에 관한 연구
조보연(Bo Youn Cho),송영기(Young Kee Shong),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min) 대한내과학회 1989 대한내과학회지 Vol.37 No.3
N/A To evaluate the interaction of various growth factors and TSH receptor antibodies (TRAb) on the growth of cultured rat thyroid cells, FRTL-5 cells, and to verify their mechanisms of action, we measured 3H-thymidine incorporation into FRTL-5 cells with various combinations of TSH, Graves' IgG and other growth stimulators (insulin, IGF-I, multiplication stimulation activity, forskolin, dBcAMP and phorbol ester). We evaluated the effects of blocking TRAb and adenosine on the growth factor-stimulated growth of FRTL-5 cells. Insulin, IGF-I and MSA increased 3H-thymidine incorporation into FRTL-5 cells and showed a synergistic effect when incubated simultaneously with TSH or Graves IgG. Forskolin, PGE2, and dBcAMP also increased 3H-thymidine incorporation by themselves and their effects were synergistically potentiated by insulin and IGF-I. Adenosine inhibited both TSH and Graves' IgG induced 3H-thymidine incorporation into FRTL-5 cells. Blocking TRAb inhibited both TSH and Graves' IgG induced 3H-thymidine incorporation, but did not inhibit the effects of insulin, IGF-I, forskolin and dBcAMP on the growth of FRTL-5 cells. Phorbol ester (TPA) did stimulate the growth of FRTL-5 cells by itself and inhibited both TSH and Graves IgG induced 3H-thymidine incorporation into FRTL-5 cells. These results suggest that 1) there might be two or more signal transduction systems for the growth of thyroid cells; TSH and Graves IgG stimulate the growth of thyroid cells through the adenylate cyclase-cAMP system, and IGF-I and other growth facors act through another system, and 2) blocking TRAb may inhibit the growth of thyroid cells by inhibiting TSH-stimulated cAMP generation.