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기관지 세척액 검사를 이용한 MAGE 유전자 검사의 임상적 의의
김선희 ( Sun Hee Kim ),김수현 ( Su Hyun Kim ),이성태 ( Seong Tae Lee ),김연정 ( Yeon Jung Kim ),오혜진 ( Hye Jin Oh ),송숙희 ( Sook Hee Song ),손인 ( In Sohn ),한경훈 ( Kyung Hoon Han ),이승준 ( Seung June Lee ),윤명재 ( Myung Ja 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.6
Background: Melanoma antigen genes (MAGE) are expressed in many human malignant cells and are silent in normal tissues other than in testis and in placenta. But MAGE expression in benign lung diseases, such as pulmonary tuberculosis or cases with severe inflammation, needs further evaluation to overcome false-positive findings. We evaluated detection rates of the melanoma antigen genes (MAGE) RT-nested PCR in bronchoscopic washing samples from patients with benign lung disease, as well as in patients with malignancies. Methods: Bronchial washing fluid from 122 patients was used for cytological examination and MAGE gene detection using RT-nested-PCR of common A1-6 mRNA. We compared the results from the RT-nested PCR and the pathologic or bacteriologic diagnosis. We also analyzed the expression rate and false positive rate of MAGE gene. Results: Among 122 subjects, lung cancer was diagnosed in 23 patients and benign lung disease was diagnosed in 99 patients. In patients with lung cancer, the positive rate of MAGE expression was 47.8% (11/23) and in benign lung disease group, the expression rate was 14.1% (14/99). Among benign lung disease group, the expression rate of MAGE gene (25.0%) in patients with pulmonary tuberculosis (11/44) was especially high. Conclusion: MAGE A1-6 RT-nested PCR of bronchial washing fluid can be used as a complementary method in lung cancer, but that test results in a high false positive rate in tuberculosis patients.
유재영(Jae Young Yoo),신호균(Ho Kyun shin),고순희(Soon Hee Koh),김종혁(Jong Hyouk Kim),송숙희(Sook Hee Song),김규태(Kyu Tae Kim),김학양(Ho Kyun Shin),김진한(Jin Han Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4
Primary biliary cirrhosis is a relatively common liver disease with cholestasis in Western countries, especially in the middle aged women. The sex distributian of this disease between male to female was 1/9. 1n the Korean literatures, there were only 4 casea reported in female, not in male. We report a case of primary biliary cirrhosis with a review of literatures in a 62-year-old man whose serum bilirubin and alkaline phosphatase were persistently elevated.
간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 심한 재발성 간염을 일으킨 만성 B형 간염 환자에서의 인터페론의 치료효과
유재영(Jae Young Yoo),박충기(Choong Kee Park),김학양(Hak Yang Kim),임규성(Kyu Sung Lim),송숙희(Sook Hee Song),김규태(Kyu Tae Kim),박승욱(Seung Wook Park),조호준(Ho Jun Cho),김종혁(Jong Hyeok Kim),박신성(Shin Sung Park),김동준(Dong Ju 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
N/A We treated nine patients with chronic hepatitis B with recombinant interferon alpha who showed severe exacerbation of hepatitis activity. All had HBsAg for at least 5 years, and had multiple episodes of elevated serum transaminase levels. They were all men, ages 26~55 (mean 41) years. The range of serum AST was 131~885 (mean 326) U/L, the ALT 62~610 (mean 303) U/L, the bilirubin 1.3~37.3 (mean 12.0) mg/dl, total protein 4.4~8.7 (mean 6.6) g/dl, and the albumin 2.4~4.4 (mean 3, 1) g/dl. Seven patients had ascites by ultrasonogram and three showed clinical evidence of grade I hepatic encephalopathy. The needle biopsy of the liver was avalilable in 6 patients, and showed severe chronic active hepatitis with established macronodular cirrhosis. Interferon was administered in a dose of three million units subcutaneously every other day for 6 months and followed up for 12 to 24 months. The results were as follows: 1) Serum transaminases: The serum transaminases became normal in 8 patients during therapy but incresed again during the follow-up in two. One patient, whose transaminses decreased temporalily with therapy, died at the 45th days of therapy due to hepatic failure. 2) Serum bilirubin: In 7 patients with hyperbilirubinemia (2.4~37.3mg/dl), the bilirubin became normal in 5 during therapy, but incresed again in 2 during the follow up-period. In one dead case, the elevated bilirubin decreased transiently but increased again during treatment. 3) Serum albumin: In 4 patients with hypoalbuminemia, the serum albumin became normal in two, and in one became transiently elevated but decreased again during treatment. 4) Prothrombin time: In 6 patients whose prothrornbin time was prolonged, it became normal in 5 except in one patient who died. 5) Ascites: In 7 patients with ascites, the ascites disappeared in 3 during the treatment and in 3 during the follow-up period. But the ascites developed again in 2 of 6 patients. There was no change of ascites in an expired case. 6) Serum HBeAg and HBV-DNA: In 7 patients with serum HBeAg and HBV-DNA, these markers became negative in 5 during treatment, but positive again in one patient during the follow-up period. 7) Symptoms of hepatic encephalopathy: Among 3 patients who developed hepatic encephalopathy (Grade 1) before therapy, 2 patients were improved during therapy. In conclusion, this study, although not adequately controlled, suggested that alpha intreferon therapy may be effective and safe in patients with chronic hepatitis B who showed severe exacerbation of disease activity. A prospective controlled study is needed to assess the role of interferon in these patients.
이준호 ( Jun Ho Lee ),김의창 ( Eui Chang Kim ),임용석 ( Yong Seok Lim ),이현석 ( Hyun Suk Lee ),송숙희 ( Sook Hee Song ),김수현 ( Su Hyun Kim ),김혜옥 ( Hye Ok Kim ) 대한내과학회 2016 대한내과학회지 Vol.91 No.1
Thymic cysts are uncommon benign lesions in the anterior mediastinum. We here describe a 55-year-old male with spontaneous thymic cyst hemorrhage manifesting as a rapidly enlarging mediastinal mass that was resected completely with video-assisted thoracoscopic surgery. To the best of our knowledge, this is the first report of a spontaneous thymic cyst hemorrhage in Korea. In cases of rapidly enlarging mediastinal masses, spontaneous thymic cyst hemorrhage should be considered as a differential diagnosis. (Korean J Med 2016;91:62-65)
급성 천식발작 환자에서 치료 전후의 혈청 Eosinophil Cationic Protein 농도
김윤근(Yun Keun Kim),이상록(Sang Rok Lee),손지웅(Jee Wong Son),김우경(Woo Kyung Kim),박재경(Jae Kyung Park),지영구(Young Ku Jee),송숙희(Sook Hee Song),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한내과학회 1997 대한내과학회지 Vol.52 No.3
N/A Objectives: To prevent progression to fatal asthma it is essential to assess the severity of asthma and treat adequetely. But there was no objective index to evaluate the severity of airway inflammation in asthmatic patients, So we evaluated that serum ECP concentration is a objective parameter of airway inflammation in patients with acute severe asthmatic attack. Methods: We measured the parameters of asthamtic severtity(clinical parameter, FEV1, arterial blood gas, peripheral blood eosinophil counts, and serum ECP levels) before and after antiasthmatic treatment in 9patients with acute severe asthmatic attack, And we compared serum ECP concentrations of severe asthmatic patients with those of control patients with mild to moderate severity. Results: 1) The serum ECP levels in patients with acute asthmatic attacks compared to patients with mild to moderate, asthmatic severity were significantly increased. 2) The serum ECP levels and pheriperal blood eosinophil counts 2hours after antiasthmatic treatment were significantly lower than the value before treatment, but the total scores of clinical parameter, FEV1, and scores of arterial blood gases were not significantly different from the basal values, Conclusion: It is suggested that the serum ECP level is a objective parameter as a response to antiasthmatic treatment as well as a severity of airway inflammation in patients with acute asthmatic attack.