당귀 추출물 정맥 주사가 Middle Cerebral Artery Occlusion 모델 흰쥐에서 Gliosis 억제에 미치는 영향

송봉근,전용철,김선애,심안나,성기문,이언정,Song, Bong-Keun,Jeon, Yong-Cheol,Kim, Sun-Ae,Shim, An-Na,Seong, Kee-Moon,Lee, Eon-Jeon 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.3

Objectives : Gliosis becomes physical and mechanical barrier to axonal regeneration. Reactive gliosis induced by middle cerebral artery occlusion is involved with up-regulation of CD81 and GFAP (Glial fibrillary acidic protein). The current study is to examine the effect of the Angelica gigas Nakai(intravenous injection. 100 mg/kg twice in a day) on CD81 and GFAP of the rat in the brain after middle cerebral artery occlusion. Methods : Cerebral infarction was induced by middle cerebral artery occlusion. And after intravenous injection of water extract of Angelica gigas Nakai, the size of cerebral infarction was measured. Examination of optical microscope were also used to detect the expression of CD81 and GFAP in the brain of the rat. Results : The following results were obtained : We found that size of cerebral infarcion induced by MCAO (Middle Cerebral Artery Occlusion) in rats were decreased after intravenous injection of Angelica gigas Nakai. We injected the extract of Angelica gigas Nakai to the MCAO in rats, and the optical microscope study showed that Angelica gigas Nakai had effect on protecting the cells of hippocampus. We found that GFAP, CD81 and ERK of the brain in rats with cerebral infarction after MCAO were meaningfully decreased after intravenous injecting Angelica gigas Nakai. We found that c-Fos expression of the brain in rats with cerebral infarction after MCAO were significantly increased after intravenous injecting Angelica gigas Nakai. Conclusions : These results indicate that Angelica gigas Nakai could suppress the reactive gliosis, which disturbs the astrocyte regeneration in the brain of the rat with cerebral infarction after MCAO by controlling the expression of CD81 and GFAP. And the effect may be modulated by the up-regulation of c-Fos and ERK.

전립선(前立腺) 질환(疾患)에 대한 활혈거어법(活血祛瘀法)의 효과(效果)

송봉근,김중길,박승원,송운용,정인석,Song, Bong-Keun,Kim, Joong-Kil,Park, Seung-Won,Song, Un-Yong,Jeong, In-Seok 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.4

Objective : The prostatic disease is characterized as relatively incurable, chronic and recurrent illness. Because of this property, we have the difficulty in treating this illness. Besides, the drug selectivity is restricted to the specific prostatic membrane, the barrier of prostate. This study was to evaluate the efficency of the activating blood flow and removing blood stasis Method to Prostatic disease. Methods : We investigated 51 prostatic patiens with NIH chronic prostatitis symptom index, digital rectal examination(DRE), expressed prostatic secretion(EPS). After investigation we treated the patients with herb which was aimed to activate the blood flow and remove the blood stasis method to prostatic disease. Results : After the treatment, symptom index score of the prostatic patients was reduced from 11.7 to 7.4. The cure rate of 51 prostatic patients was 76.5%. Also the cure rate of the patients who was treated over 4 weeks was higher than the patients treated below 4 weeks, 87.5% to 66.7% respectively. conclusions : These results indicate that oriental medical theraphy is useful enough to treat the prostatic patients. Therefore, the more research about the herb which has activating blood flow and removing blood stasis effect is necessary.

습부항이 혈액학적 성상에 미치는 영향에 대한 연구

송봉근,박승원,김중길,김요한,이시우,정인석,Song, Bong-Keun,Park, Seug-Won,Kim, Joong-Kil,Kim, Yo-Han,Lee, Si-Woo,Jeong, In-Seok 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4

Objectives: We examined if their hematological status could be changed by blood loss in patients treated with bleeding pressure therapy. Methods: The patients were divided into two groups as follows: The Subject group(B) were 42 cases treated with bleeding pressure therapy. The Control group(N) were 43 cases treated with negative bleeding pressure therapy, We checked CBC & differ cell count of two groups. Results: The means of RBC, Hb count and Hct were slightly decreased after 1 week. but they were recovered after 2 weeks. Conclusions: These results indicate that Bleeding Pressure Therapy don't reduced RBC, Hb count and Hct in Patients.

한.양약의 병행투여가 요추간판탈출증의 보전적치료에 미치는 영향

송봉근,정인석,김중길,Song, Bong-Keun,Jeong, In-Seok,Kim, Joong-Kil 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1

Objectives : Herniated lumbar intervertebral disc (HIVD) is one of the cause of low back pain and radiculopathy. To evaluate the efficiency of simultaneous administration of herb medicine and non-steroid-anti-inflamatory drugs (NSAIDs), we investigated 48 HIVD patients confirmed by CT or MRI and treated with acupuncture, bed rest, herb medicine, physical therapy and NSAIDs. Methods : The patients were divided into four groups as follows : The A group were 11 cases treated with only herb medicine A. The A+W group were 14 cases treated with herb medicine A and NSAIDs. The B group were 11 cases treated with herb medicine B. The B+W group were 12 cases treated with herb medicine Band NSAIDs. We evaluated the pain degree by visual analog scale (VAS). Results : The mean VAS was reduced to $4.89{\pm}2.62$ after 2 weeks therapy and pain decrease was the most prominent in the group having within a week duration ($3.25{\pm}2.49$). Pain scale was decreased to $4.57{\pm}2.95$ in A+W group, $4.91{\pm}1.97$ in A group, $4.72{\pm}2.68$ in B group, and $5.41{\pm}2.67$ in B+W group after 2 weeks therapy. Conclusions : These results indicate that oriental medical theraphy is useful enough to treat the HIVD patients and herb medicine decrease the pain of the HIVD effectively. Therefore, the more research about herb medicine for pain killing drugs should be done.

전립선암 치료의 한방 임상 진료 지침

송봉근,이언정,유화승,Song, Bong-Keun,Lee, Eun-Jung,Yoo, Hwa-Seung 대한암한의학회 2016 大韓癌韓醫學會誌 Vol.21 No.2

Objectives : The aim of this preliminary study is to suggest a clinical approach on prostate cancer through the analysis of existing clinical practice guidelines or clinical studies. Materials and Methods : The data related on the treatment of prostate cancer were collected using various search engines such as Pub Med, KIOM OASIS, CNKI. Then, data were analyzed to evaluate the validity of recommendation of treatment. Results : Prostate cancer has the highest prevalence around the world. Recently, the incidence of prostate cancer in Korea is rapidly increasing. Especially, it was reported that incidence rate rose up to 80% by age 80 years. In recent studies, applying combined traditional and conventional medicine were reported to improve the survival, quality of life, immune function, and suppress of tumor growth in prostate cancer. However there has not been an objective and systemic clinical guideline for prostate cancer in Korean Medicine. Accordingly, it has been difficult for doctors to apply optimized therapeutic treatment in clinics. This study will show a preliminary approach to establish clinical practice guideline for prostate cancer of Korean Medicine. Conclusion : Further objective and systemic clinical studies by Korean Medicine are needed to develop more advanced clinical practice guidelines of prostate cancer.

산업보건의 현재와 미래

송봉근,Song, Bong-Geun 대한산업보건협회 2003 산업보건 Vol.184 No.-

Comparison of ASTER Satellite and Ground-Based Surface Temperature Measurements for Urban Heat Island Studies

송봉근,박경훈,Song, Bong-Geun,Park, Kyung-Hun The Korean Association of Geographic Information S 2017 한국지리정보학회지 Vol.20 No.3

본 연구는 대한민국 창원시의 도시지역을 대상으로 현장에서 측정된 표면온도자료를 활용하여 토지이용유형별로 ASTER 표면온도 자료의 정확성을 분석하고 보정모형을 도출하고자 하였다. 토지이용유형은 공원과 상업시설, 단독주택, 아파트를 고려하여 총 8개를 선정하였다. ASTER 표면 온도는 2012년부터 2014년까지 6월과 9월에 촬영된 주간 및 야간의 8개 영상을 수집하였고, 현장측정은 위성영상이 촬영된 시간과 동일한 시기에 실시하였다. 또한 현장에서 측정된 표면온도의 방사보정을 위해 5일 동안 21개의 토지피복재질에 대해 방사율을 측정하였다. 주간시간은 현장에서 측정된 표면온도가 위성영상의 것보다 약 $5{\sim}10^{\circ}C$ 정도 높았고, 건물의 밀집된 지역일수록 차이가 큰 것으로 분석되었다. 표면온도 보정모형은 도시공원을 제외한 나머지 지역에서 설명력이 60%로 모형의 신뢰성이 있다고 분석되었다. 야간시간은 여름철인 8월을 제외하고 주간시간과 반대로 ASTER 표면온도가 약 $2^{\circ}C$ 다소 높은 것으로 분석되었다. 그러므로 위성영상의 표면온도를 활용하기 위해서는 반드시 현장자료를 바탕으로 정확성을 검증하고 보정할 필요가 있다. 본 연구의 결과는 이러한 측면에서 매우 의미가 있으며, 앞으로 도시지역의 열섬 문제를 개선하기 위해 도시 및 환경계획 분야에서 활용가치가 뛰어날 것으로 생각된다. This study aimed to validate the ASTER surface temperature using field measurements over various land use types in the urban area of Changwon City, South Korea. The ASTER surface temperature was measured by collecting eight images during daytime and nighttime in June and September from 2012 to 2014, and field measurements were conducted over the same period when the satellite images were taken. The analyses showed that the surface temperature measured in the field during the daytime was higher than that of satellite imageries by $5{\sim}10^{\circ}C$, and the gap was higher in built-up areas. The calibration models of surface temperature showed a 60% explanatory power in areas other than parks, indicating that the models are reliable. During nighttime, except for the summer month of August, ASTER surface temperature was determined to be approximately $2^{\circ}C$ higher in contrast to daytime.

노림(勞淋)의 치방(治方)에 관(關)한 문헌적(文獻的) 연구(硏究)

송봉근,Song Bong-Geun 대한한의학방제학회 1992 大韓韓醫學方劑學會誌 Vol.3 No.1

발기부전(勃起不全) 환자(患者)의 음경(陰莖) 체열촬영 소견(所見)

송봉근,정인석,송운용,양재훈,이소영,박승원,Song, Bong-Keun,Jeong, In-Seok,Song, Un-Yong,Yang, Jae-Hoon,Lee, So-Young,Park, Seung-Won 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4

Objective : Infrared thermal image is usually utilized for the diagnotic value of verious disease. We investigated the penile temperature of erectile dysfunction patient. Methods : We mesured the thermal difference of penile infrared thermal image in erectile dysfunction patient group and control group. Results : 1. Patient group's thermal degree is lower than Control group's in Kwanwon, Left scrotum, medial part of thigh. 2. The Kwanwon's temperature is especially showed lower than other mesured point's in erectile dysfunction patient group. Conclusion : According to the above results, it could be suggested that penile infrared image help us diagnostic value of erectile dysfunction patient.

셀레늄과 세라믹 혼합분말을 사용한 Cu_0.9In_0.7Ga_0.3Se₂ 분말층의 소결거동 연구

송봉근,황윤정,박보인,이승용,이재승,박종구,이도권,조소혜,Song, Bong-Geun,Hwang, Yoonjung,Park, Bo-In,Lee, Seung Yong,Lee, Jae-Seung,Park, Jong-Ku,Lee, Doh-Kwon,Cho, So-Hye 한국태양광발전학회 2014 Current Photovoltaic Research Vol.2 No.3

$Cu(In,Ga)Se_2$ (CIGS) thin films have been used as a light absorbing layer in high-efficiency solar cells. In order to improve the quality of the CIGS thin film, often selenization step is applied. Especially when the thin film was formed by non-vacuum powder process, selenization can help to induce grain growth of powder and densification of the thin film. However, selenization is not trivial. It requires either the use of toxic gas, $H_2Se$, or expensive equipment which raises the overall manufacturing cost. Herein, we would like to deliver a new, simple method for selenization. In this method, instead of using a costly two-zone furnace, use of a regular tube furnace is required and selenium is supplied by a mixture of selenium and ceramic powder such as alumina. By adjusting the ratio of selenium vs. alumina powder, selenium vaporization can be carefully controlled. Under the optimized condition, steady supply of selenium vapor was possible which was evidently shown by large grain growth of CIGS within a thin powder layer.