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송규상 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2
An immunohistochemical study was performed on the normal salivary gland, pleomorphic adenomas, mucoepidermoid carcinomas, adenoid cystic carcinomas, acinic cell tumor, and Warthin’s tumor. PAP kits for S-100 protein, vimentin, and epithelial membrane antigen were used and the results were as follows. 1. Myoepithelial cells of the normal salivary gland were positive for S-100 protein and vimentin, negative for EMA. Duct cells were stained positively for S-100 protein and EMA. Acinic cells were negative for all stains. 2. Neoplastic myoepithelial cells were strong positive for S-100 protein and vimentin. Areas of ductal differentiation were positive for EMA and occasionally positive for S-100 protein and vimentin. 3. Mucin secreting cells and squamous cells of mucoepidermoid carcinoma showed posive reaction for EMA. Intermediate cells revealed weak positivity for S-10 protein and EMA and were positive for vimentin. 4. Adenoid cystic carcinoma showed occasional positivity for S-100 protein and vimentin. Ductal areas were positive for EMA. 5. Warthin’s tumor showed positive reaction in epithelial cells for EMA. Acinic cell tumor were negative for all antibodies. These results suggested that the coexpression of S-100 protein and vimentin is useful in identify-ing the neoplastic myoepithelial cells and the myoepithelial cells play an important role in the histogenesis of pleomorphic adenomas, mucoepidermoid carcinomas, and adenoid cystic carcinomas.
백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구
송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.
위의 양성 및 악성병변에서의 Argyrophilic Nucleolar Organizer Regions발현에 대한 연구
송규상 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
The colloid silver staining technique to reveal argyrophilic nucleolar organizer regions (AgNOR) was performed in chronic atrophic gastritis, chronic gastritis with intestinal metaplasia, dysplasia, early gastric carcinoma, and advanced gastric carcinoma with or without regional lymph node metastasis. The results were as follows. 1. There was an increasing tendency of the mean number of AgNOR from benign lesions to malignant lesions. 2. The malignant lesions had significantly higher number of AgNOR than benign lesions. 3. The mean number of AgNOR in dysplasia was significantly higher than that of chronic atrophic gastritis. However, there was no statistical difference from other lesions. 4. There was no statistical difference between early gastric carcinoma and advanced gastric carcinoma or between advanced gastric carcinoma without metastasis and advanced gastric carcinoma with metastasis These results suggest that the number of AgNOR may have significance in differentiating between benign lesions and malignant lesions of the stomach, but may not be helpful for evaluating the depth of invasion and metastasis.