嶺南地域 瓦窯에 관한 硏究

孫豪晟(Son Ho-sung),柳智賢(Ryu Jee-hyeon) 경주사학회 2010 경주사학 Vol.31 No.-

부여 쌍북리 119안전센터부지 출토 목간의 내용과 판독

손호성(Son Ho-sung) 한국목간학회 2011 목간과 문자 Vol.7 No.-

부여지역의 발굴은 금강사지, 임강사지, 부여 부소산성, 관북리 백제유적, 익산 미륵사지 등의 추정 왕궁지, 사지, 관아지에 대한 조사를 시작으로 본격화되었다. 특히 백제의 사회상을 직접적으로 나타내는 목간이 부여의 나성내에서 출토되고 있다. 이는 한자의 사용이 일반민보다 상위지배층을 중심으로 사용되었다는 것을 반영한다. 이러한 목간자료 가운데 부여 쌍북리 119안전센터 신축부지내 유적에서 출토된 부찰목간에 주목하고자 한다. 부찰목간은 단독간으로 사용되었으며, 물품의 꼬리표로 사용되기 때문에 단편적인 자료에 많은 의미를 내포하고 있다. 부여 쌍북리 119안전센터 신축부지에서 출토된 목간의 묵서명은 “五(玉)石六(九)十斤”으로 판독되며, 도교의 선약, 옥석의 중량, 5가지의 광물질 등으로 해석되고 있어 용도와 성격을 명확하게 파악하기가 쉽지 않다. 이러한 문제점을 해결하기 위해서 유적의 성격과 공반유물에 대해서도 살펴보았다. 그 결과, 유적은 웅진-사비로의 남천과 도성제를 정비하는 과정에서 왕실 건물지, 제사지, 귀족의 주거지, 관아지, 공방지 등으로 건축된 벽주건물지가 확인되었다. 또한 벽주건물지 주변에서 금속을 녹이는 용해로가 확인되었다. 그리고 공반유물에서 다종다양한 도가니가 출토되었으며, 도가니에 부착된 슬래그를 분석하여 구리, 주석, 납, 비소를 검출되었다. 이와 같이 유적과 공반유물의 분석을 통해서 부찰목간은 중앙정부에서 관리하는 공방지에서 사용되었으며, 청동을 주조하기 위한 주재료를 나타내거나 첨가물의 중량을 표시하였을 것이다. 이를 근거로 부찰목간의 묵서명을 살펴보면, “五石六十斤”은 5가지의 광물로 판독할 수 있을 것이다. Excavation of Buyeo area began with an investigation of presumed 'Wangkungji' (sites of royal palaces), 'saji' (temple sites) and 'Kwanaji' (sites of government offices) such as Kumkang temple site, Imgang temple site, Buyeo Buso mountain fortress, Gwanbukri Baeje relics, and Iksan mireuk temple site. Especially, 'mokgan' (a piece of wood or bamboo on which letters are written) which directly represents social situations of Buyeo, are being excavated in Nasung, Buyeo. This reflects that Kanji was used more commonly by higher ruling class people rather than among common people. Among 'mokgan' items, our study focused on 'Buchal mokgan' (mokgan used for a tag of goods) which was excavated in the site of new 911 safety center in Ssangbukri, Buyeo. 'Buchal mokgan' was used alone and because they were used as a tag of goods, they contain a great significance to the fragmentary data. However, the tablet of the 'mokgan' excavated at the site of new 911 safety center in Ssangbukri, Buyeo, was decoded as "五(玉)石六(九)十斤". This has been interpreted as elixir in Taoism, weight of boulders, five minerals, etc., showing that clearly identifying the use and the nature of 'Buchal mokgan' is not so easy. In order to solve this problem, the nature of the ruins and relics of 'kongbangji' (the sites of shaman's religious practice) were also examined. The result of our study reveals that the ruins were identified as 'Byeokjugeonmulji' (construction sites made by hammering woods) constructed in the course of modifying Woojin-Sabiro's Namcheon and Dosungje, for royal building area, aristocratic residences, site of government office, site of memorial rites, and 'kongbangji' (site of construction and civil engineering department). In addition, around the 'byeokjugeonmulji', melting furnace which melt metals were identified and a wide variety of melting pots were unearthed in the site of shaman's religious practice, and from the analysis of slag attached to melting pots, copper, tin, lead, and arsenic were detected. OThus, through the analysis of the remains and sites of shaman's religious practice we can estimate that 'buchalmokgan' was used at the site of construction and civil engineering department managed by central government, so as to indicate the main ingredient for bronze casting or the weight of additives. Based on this information, the tablet in buchalmokgan can be read as "五石六十斤".

한국형 인공심장 (AnyHeart)의 인체적용의 해부학적 적합성 평가

김태식(Tae Sik Kim),선 경(Kyung Sun),손호성(Ho Sung Son),김 현(Hyun Kim),박선화(Sun Hwa Park),김광택(Kwang Taek Kim),민병구(Byoung Goo Min),김형묵(Hyoung Mook Kim) 대한해부학회 2003 Anatomy & Cell Biology Vol.36 No.4

체내 이식형 의료장치들은 개발과정에서 임상적용전 사체실험(preclinical cadaver fitting test)을 실시하게 된다. 이를 통해 기계장치의 크기와 모양 및 구조 등이 인체 해부구조에 적합한지를 평가하고, 체내 이식에 적합한 최적의 위치를 결정하며, 임상에 적용가능한 수술술기를 완성할 수 있다. 저자들은 고려대학교 해부연구위원회의 승인을 받은 총 12구의 사체를 이용하여 자체 개발한 한국형 인공심장(AnyHeart)의 인체적용의 해부학적 적합성을 평가하였다. 관찰목표는 서로 다른 가슴안 접근법(복장뼈정중절개술, 오른쪽 개흉술, 왼쪽 개흉술, 복장뼈횡절개술)에서 인공심장의 적절한 이식 위치, 유입로와 유출로의 확보 및 도관의 삽입 위치 등이었다. 연구 결과 한국형 인공심장의 인체적용의 해부학적 적합성은 뛰어났으며, 특히 새로운 수술기법인 오른쪽 개흉술을 통한 인공심장 이식술을 가능하게 하였다. 본 연구를 통해 향후 본격적인 임상 시도의 토대를 마련하였고, 체내 이식형 의료장치의 개발과정에서 해부학적 적합성 평가의 중요성을 확인하였다. Preclinical cadaver fitting study is paramount in the development of various implantable medical devices. It helps to evaluate the fitness of the size, shape, structure of the devices in the human anatomy, to locate the most optimal site for implantation, and to develope the clinically available surgical techniques. The purpose of this study was to observe the anatomical feasibility of Korean artificial heart (AnyHeart) in 12 human cadavers after obtaining the permission from the Korea University Anatomical Research Committee. The observation was focused on proper position of the artificial heart in various thoracic incisions (median sternotomy, right thoracotomy, left thoracotomy, transsternal incision), localization of inflow as well and outflow tract, cannulation sites, and so on. Results showed that Korean artificial heart had excellent anatomical feasibility in the human body and that a novel surgical technique of right thoracotomy approach was proved to be clinically applicable. Conclusively, the above results will provide the rationales of clinical trial and demonstrate the significance of human cadaver study in development of implantable medical devices.

만성 C 형 간염 환자에서 인터페론치료에 의한 갑상선질환의 발생

김민대(Min Dae Kim),전익수(Ik Soo jeon),강승수(Seung Su Kang),엄재섭(Jae Sup Eum),손호성(Ho Seung Son),박현용(Hyung Lyong Park),윤병철(Byung Cheol Yun),이상욱(Sang Uk Lee),한병훈(Byung Hoon Han) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.6

Background/Aims: It has been suggested that hepatitis C virus is associated with the autoimmune disease and interferon also induces hepatic and non-hepatic autoimmune reaction. We conducted this study to assess the effect of interferon-alpha (INF-α) on the induction of thyroid autoantibodies and clinical thyroid disease and to know whether the thyroid autoantibodies affect the IFN-α efficacy in patients with chronic hepatitis C. Methods: Twenty-nine patients with chronic hepatitis C were enrolled. Anti-thyroglobulin antibody (ATA), anti-microsomal antibody (AMsA), thyroid stimulating hormone and free thyroxine were measured before, during, and after IFN-α therapy. Results: Two of the 29 patients (6.5%) were positive for ATA and AMsA before IFN-α therapy. Of these two patients, one patient was a woman, who showed hyperthyroidism druing IFN-α therapy. Of the 27 patients who had been negative for ATA and AMsA, one female patient became ATA positive with the development of hyperthyroidism, and 3 male patients became AMsA positive during IFN-α therapy. There was no difference in the efficacy of INF-α therapy between the thyroid autoantibody positive and negative groups. Conclusions: IFN-α therapy induced thyroid disease with high prevalence in the patients with chronic hepatis C. Thus, thyroid status should be checked even in patients without thyroid autoantibodies, especially in woman. Antithyroid autoantibodies seem unlikely to affect the efficacy of IFN-α therapy. (Korean J Gastroenterol 2001;37:436-442)

궤양성 대장염의 임상적 관찰

손호성,장성훈,정연순,정한호,송수근,박무인,박선자,구자영 고신대학교 의학부 1999 高神大學校 醫學部 論文集 Vol.14 No.1-2

Background Ulcerative colitis is a chronic inflammatory disease of colon, which is common in western countries but relatively rare in Korea. As the colonoscopic examination becomes popular, early detection rate is increasing in oriental countries, but its precise clinical aspects are still obscure in Korea due to its rarity. The purpose of this study is to review the clinical features and trends of newly diagnosed cases in Korea. Methods We studied 54 patients of ulcerative colitis, who were diagnosed by clinical findings, laboratory examinations, barium enema, sigmoidoscopic and colonoscopic examinations at Kosin Medical Center from January 1987 to December 1997. Results The most prevalent age was 4th decade, male to female ratio was 1 : 1.57 and the duration of symptoms was less than 1 year in 63% of the cases, and the recent increase in the incidence of total cases and cases of proctitis was evident. The most common clinical manifestation was bloody diarrhea, while anemia (37.3%) was the most common labo atory abnormality, and the most common complication was abnormal liver function (11.1%). Among the diseases misdiagnosed as ulcerative colitis, imtable bowel syndrome and internal hemorrhoid were common. The most common sigmoidoscopic finding was mucosal friability and the most common histopathologic change was non-specific inflammation (92.3%), while crypt abscess was present in 27.8% of cases. In 29 cases (53.7%), disease severity was of mild degree, while severe course was observed in 2 cases. We found positive correlation between the severity of disease and the extent of colitis (p<0.05), and marginal relationship between the seventy of disease and endoscopic grading (p=0.062), but there was no correlation between the severity of disease and the duration of disease(p=0.146). Of all cases, 35 cases (70%) showed longterm improvement to medical therapy, but 11 (22%) had recurrence. Operations were performed in 9 cases and its indications were confirming diagnosis in 3 cases, intractibility in 4 cases, severe dysplasia by histology in 1 case and accompanying adenomatous polyposis in 1 case. Conclusions For the accurate and early diagnosis of ulcerative colitis, routine use of sigmoidoscopy in suspected cases is mandatory, especially to exclude hemorrhoid, cancer or irritable bowel syndrome. As the incidence of ulcerative colitis is apparently increasing in this study, more extensive, systematic, nationwide study for ulcerative colitis may be needed for the better description and management of this disease in korea.

다발성 폐경색, 상대정맥 증후군 및 종격동 임파선 종대를 동반한 베체트 증후군 1예

장성훈,손호성,정연순,김진구,오세진,박무인,박선자,구자영 고신대학교 의학부 1999 高神大學校 醫學部 論文集 Vol.14 No.1-2

Behcet's syndrome is a multisystemic disease involving mucocutaneous, cardiovascular, central nervous system, renal, articular, gastrointestinal, skin, pulmonary and lymphatic system. Intrathoracic manifestations of Behcet' s syndrome are thromboembolism of vena cava, arterial aneurysm, vasculitis, pulmonary infarct, pulmonary hemorrhage, pleural effusion, and rarely mediastinal or hilar lymphadenopathy. We report a case of Behcet's syndrome manifested as pulmonary infarct, superior vena cava syndrome, and mediastinal lymphadenopathy.

한국형 인공심장에 대한 동물실험(AnyHeart™)

선경,손호성,이성호,신재승,이혜원,김승철,원용순,이경갑,정종태,김종원,노양래,이혁수,민병구 제주대학교 인공심장이식연구소 2001 인공심장 연구 Vol.2 No.2

말기심부전증의 새로운 치료대안으로 제시되는 한국형 인공심장(AnyHeartTM)의 효용성과 안정성을 평가하기 위하여 동물실험을 실시하였다. 지난 2년간 고려대학교 안암병원과 제주대학교 동물병원에서는 총 28마리(송아지 18, 면양 4, 실험견 3, 말 2, 산양 1마리)의 다양한 동물에서 한국형 인공심장 이식실험이 실시되었으며, 좌심보조장치로 적용한 1예와 체외휴대형으로 적용한 각 1예를 제외하고 모두 심장보존형 인공심장(이식형 양심보조장치)의 형태로 완전 이식하였다. 수술방법은 주로 우측개흉법을 (Korea University Technique)을 사용하였다. 펌프 박출량은 최대 6 L/min로 평균 3-3.5 L/min를 유지되었으며, Fitting test 4례와 초기 적응과정의 2마리를 제외하고 모두 수술에서 회복되었다. 최장 관찰기간은 37일로 합병증 없이 건강한 상태에서 기초자료 확보를 위해 관찰을 임의종료하였다. 모든 생존동물에서 기계장치와 관련된 부작용은 발견되지 않았고, 임상적으로 나타나는 혈전전색 소견이나 간기능, 신기능, plasma hemoglobin, fibrinogen 등에 이상은 없었다. 적절하게 조기부검이 이루어진 경우에는 인공심장 내부에 혈전이 발견되지 않았고, 간/콩팥/비장 등의 중요장기에 병리검사에서도 전색소견은 발견되지 않았다. 결론으로, 한국형 인공심장은 생체 내에 이식하였을 때 안정적이며 기능이 우수한 것을 알 수 있었다. 한국형 인공심장은 현 상태에서 임상에 적용할 수 있다고 판단되며, 가까운 시일 내에 인체 내 안정성와 유효성에 대한 평가가 가능할 것으로 기대한다. Korean artificial heart (AnyHeartTM) is a new vision in the management of end stage heart failure. We performed the animal experiments to evaluate the performance and safety of AnyHeart. For last 2 years, 28 various animals (cattle 18, sheep 4, canine 3, goat 1) underwent AnyHeart implantation at Korea University Medical Center and Cheju University Animal Hospital. AnyHeart was applied as an implantable BVAD except a case of implantable LVAD or wearable BVAD. A standard technique of implantation was a right thoracotomy approach (Korea University Technique). The pump output was 6 L/min in maximum and 3-3.5 L/min in average. Other than 4 cases of fitting tests and 2 in the early learning period, all animals were recovered from the operation. The longest observation was made until 37th postoperative day, and the observation was terminated to get a control data while the animal was healthy without complications. All survivors were free from device-related morbidity, and there were no evidence of clinically significant thromboembolic episode, liver functions, renla function, plasma hemoglobin, fibrinogen abnormalities. Appropriate autopsy did not show thrombus in the device or embolism in the organs. Conclusively, AnyHeart has been proved efficient and safe during in-vive implantation. The authors believe that AnyHeart can be applied to clinical situations at the moment and expect to perform a clinical trial to test safety and efficacy in the human body within near future.

위암환자의 진단 및 병기 결정에 있어서 혈청 CA72-4의 유용성

송수근,김현주,손호성,정연순,장성훈,정한호,권기범,박무인,박선자,구자영 고신대학교 의학부 2000 高神大學校 醫學部 論文集 Vol.15 No.1

Background/Objective Various methods including upper GI series, endoscopy, ultrasound, CAT scan are used with serum tumor markers, especially CEA and CA19-9, for the diagnosis and evaluation of gastric carcinoma. In this study the clinical utility of serum CA72-4 of 300 gastric carcinoma patients for the diagnosis and management of gastric carcinoma was evaluated. Methods Serum level of CA72-4 was measured using <Centa> Core CA72-4 RIA Kit(Packerd, USA). The cutoff level of serum CA72-4 was 4U/㎖. The serum levels were correlated with the stage, the location of lesions, the gross type, the depth of invasion, the nodal and distant metastasis. Results 1) Overall positivity of CA72-4 was 32.0%(96 cases). 2) There was no difference in the positivity of serum CA72-4 according to locations and gross types of carcinoma, but significant(p<0.05) difference in the positivity of serum CA72-4 was noted between cases of early gastric carcinoma(12.3%) and advanced gastric carcinoma (37.4%). 3) The positivity of serum CA72-4 of stage Ⅲ and Ⅳ(49.5%) was significantly(p<0.05) higher than those of stage Ⅰa(12.1%) and Ⅱ(16.0%). Furthermore, 87.5% of the cases of positive serum CA72-4 belonged to stage Ⅲ or Ⅳ. 4) The positivity of serum CA72-4 were 12.3%, 14.3%, 34.7% and 52.6% for T1, T2, T3 and T4, respectively, showing relatively good correlation between CA72-4 positivity and depth of invasion. And 86.5% of the cases of positive serum CA72-4 belonged to T3 or T4 group. 5) The positivity of serum CA72-4 of N1 and N2 groups(35.1% and 41.7%, respectively) was significantly(p<0.05) higher than those of N0 group(12.2%) and 89.6% of the cases of positive serum CA72-4 belonged to node positive cases. 6) In the cases of metastasis present, CA72-4 positivity was 47.4%, which was significantly(p<0.05) higher than that of metastasis-negative cases(28.4%). Among sites of metastasis, there was no difference in the positivity of CA72-4. Conclusions Serum CA72-4 was not useful as a screening test in the diagnosis of gastric carcinoma, but may be useful in differentiating between early and advanced cases, in determining stage of the disease, depth of invasion, serosal invasion, and especially in detecting nodal metastasis, and also useful when used with imaging modalities of diagnosis.

위암환자의 진단 및 병기 결정에 있어서 혈청 CA72-4의 유용성

송수근,김현주,손호성,정연순,장성훈,정한호,권기범,박무인,박선자,구자영 고신대학교 의학부 2000 고신대학교 의학부 학술지 Vol.15 No.1

Von Recklinghausen;s Disease 환자에서 소장에 발생한 GIST 1예

김성만,장성훈,정연순,손호성,정한호,박무인,박선자,구자영,백승언 고신대학교 의학부 2000 고신대학교 의학부 학술지 Vol.15 No.1