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손정일 ( Chong Il Sohn ),김명곤 ( Myeong Kon Kim ),이기창 ( Kee Chang Lee ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),김성윤 ( Seong Yoon Kim ),정화순 ( Wha Soon Chung ) 대한류마티스학회 1994 대한류마티스학회지 Vol.1 No.1
호산구 증가증의 원인은 기생충 감염, 알레르기, 약제, 교원성 질환, idiopatic hypereosinophilic syndrme 등에서 나타나며 류마티스 관절염에서는 약 10%의 환자에서 호산구 증가증을 보인다고 한다. 류마티스 질환에서 호산구 증가증은 류마티스 관절염, 다발성 동맥염 및 혈관염, 유육종증 둥과 연관되고 idiopathic hypereosinophilc syndrme이나 골수 증식성 질환, 호산구성 백혈병 등과 감별을 요하며 집중적으로 추적 관찰해야 한다. 저자들은 53세 여자 환자에서 지속적이고, 심한 호산구 증가증이 동반된 류마티스 관절염 환자를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Eosinophilia is usually accompanied by parasite infestation, allergic condition, drug, collagen disease, and idiopathic hypereosinophilic syndrome. In about 10 to 40% of rheumatoid arthritis patients, peripheral blood reveals eosinophilia. Of the rheumatic disease, eosinophilia may occur in rheumatoid arthritis, sarcoidosis, polyarteritis nodosa and other vascultis. Patient with eosinophilia must be carefully followed up due to possibility of progression to eosinophilic leukemia or myeloproliferative disease. We experienced a case of rheumatoid arthritis with severe eosinophilia for a period of more than one year in a 53 year-old female patient, eosinophil more than 85% in the peripheral blood, but in spite of careful laboratory study, there was no evidence of parasite infestation, allergic disease and malignant condition that may cause eosinophilia. Therefore we concluded that her severe eosinophilia was associated with rheumatoid arthritis itself, and now she is intensively followed up at the outpatient department. We have to look for any malignant transformation during her clinical course. Marked eosinophilia associated with rheumatoid arthritis is very rare, so we report this case with a review of literatures.
만성 혈액투석 환자에서의 대사성 산혈증과 음이온차의 양상
손정일(Chong Il Sohn),김병훈(Byoung Hun Kim),신진호(Jin Ho Shin),양석철(Suck Chul Yang),박용수(Yong Soo Park),한동수(Dong Soo Han),안명주(Myung Ju Ahn),손주현(Ju Hyun Sohn),이인홍(In Hong Lee),김순길(Soon Kil Kim),이정희(Jung Hee Lee 대한내과학회 1996 대한내과학회지 Vol.51 No.2
N/A Objectives: The aim of the present study is to evaluate the prevalence of the various patterns of metabolic acidosis and anion gap among chronic hemodyalysis patients. Methods: Analysis of predialysis arterial blood gases and anion gap patterns was performed in 67 stable chronic outpatient hemodialysis patients(>1 year) with acetate buffer. Blood samples were drawn from the arterial line of the atreriovenous fistula for determination of blood electrolytes, chemistries, and analysis of blood gases at the beginning of hemodyalysis. Results: The degree of metabolic acidosis was mild to moderate with mean pH 7.33±0.039. 82% of a total 67 patients had pH between 7.30 and 7.39 with 18% of them between 7.20 and 7.29. Simple as mixed metabolic acidosis was shown in 49 of 67 patients(73%) and 18 of 67 patients(27%), respectively. In comparison of both groups, the group with mixed metabolic acidosis had significantly lower pH(7.29±0.04 vs 7.34±0.03, p<0.001) with higher pCO₂(38.5±3.4, p<0.005) and anion gap(19.6±4.1 vs 17.6±2.9, p<0.05). The classical high anion gap of end stage renal disease (range, 16 to 29 mEq/L) was also noted in 20 of 67 patients(30%). The linear regression analysis between anion gaps and total serum carbon dioxide contents (TCO₂) didn't show any significant correlation in all patients as well as the two subdivided groups with high and normal anion gap. Furthermore, only 13 of 67 patients(20%) were included between 80 and 120% in the ratio of delta anion gap(ΔAG) over delta TCO₂(dTCO₂). Therefore, the majority of hemodialysis patients (80%) showed the discrepancy between the degrees of d AG and ΔTCO₂. The analysis of unmeasured cations(K, Ca) and anions(albumin, phosphate) in the calculation of anion gap(Na ?Cl ?HCO₃) between two groups of high and normal anion gap of all patients as well as 49 patients of simple metabolic acidosis didn't reveal any discernible contributions to the changes of anion gap. Conclusion- This study therefore showed that the mixed acid-base balance and normal anion gap metabolic acidosis is not an exception in chronic stable hemodialysis patients. Also, the impact of hemodialysis in end stage renal disease patients seemed to lead the changes in values of unidentified anions besides fixed mineral acids and/or in those of unrecognized ionic equivalents of plasma constituents.
내장 동통 연구에 있어서 대장 팽창을 이용한 실험 동물모델
손정일(Chong Il Sohn) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.2
Functional gastrointestinal disorders are characterized by chronic or recurrent symptoms, which are not explained by structural or biochemical abnormalities. These disorders seem to relate with abnormalities in motility and/or afferent sensitivity modulated by the central nervous system. There has been an improvement in the study of mechanisms of visceral pain, due to the development of animal models that reasonably mimicis human visceral pain. Recently, it appeared that visceral hypersensitivity or visceral hyperalgesia is related with the main pathogenetic mechanism of functional gastrointestinal disorders. Experimental balloon distention of the gastrointestinal tract in animal models has been established to reproduce pathologically-experienced pain in terms of intensity, quality and area of the sensation. Colorectal balloon distention in rat model with irritable bowel syndrome, is most widely used as an experimental stimulus to induce the visceral pain. Gastric distention in rat model is also used for the study of functional dyspepsia. Various routes of drug administration including intrathecal and intrarostroventral medullary injection have been developed for evaluation of visceral pain mechanism. Mouse model for colorectal balloon distention is now developing. (Korean J Gastroenterol 2001;38:77-82)
간동맥 화학색전술 치료를 받은 간세포암 환자의 예후와 혈청 α1 - Antitrypsin 과의 관계
손정일(Chong Il Sohn),황선호(Seon Ho Hwang),박문승(Mun Seung Park),이오영(O . Young Lee),윤병철(Byoeng Chul Yoon),함준수(Joon Soo Hahm),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park),서흥석(Heung Suk Suh) 대한내과학회 1996 대한내과학회지 Vol.50 No.3
N/A Objectives: Hepatocellular carcinoma(HCC) has a poor prognosis, and only by early detection, cure can be expected by surgery. With development of chemoembolization therapy, we may expect better survival even in the advanced HCC, There many reports about prognostic factors for HCC treated with TAE. We examined relationship between survivals and prognostic factors especially serum a 1-antitrypsin levels in patients with HCC treated with TAE. Methods: 42 patients who had been diagnosed as HCC by ultrasonography and hepatic angiography from 1987 to 1994 were examined for prognostic factors and their survival. Results: Patient's survival who had a single mass was longer (average 21 months) than that of patients who had diffuse tumor(average 4 months, p=0.005). Patient's survival without portal vein thrombosis was longer (average 16 months) than that of patients with portal vein thrombosis (average 4 months, p<0.001). Serologically, patients with low α-fetoprotein level(AFP<40ng/ml) survived longer (average 14 months) than patients with high AFP level(AFP>400ng/ml, average 4 months, p<0.001). Patients with low αl-antitrypsin level (AAT<300 mg/dl) survived longer (average 14 months) than patients with high AAT level (AAT>300mg/dl, average 4 months, p<0.001). Especially, in HCC with low AFP level (AFP<400ng/ml), patients with low AAT level (AAT<300mg/dl) survived longer(average 21 months) than patients with high AAT level (AAT>300mg/dl, average 14 months, p=0.001). Patients with Child's classification A and B showed no signigicant differences in their survival. Conclusion: Serum AAT level may be an important prognostic index in patients with HCC and especially it may be more valuable in patients who had low serum AFP level.
위장암 : 대장암에서 HER-2/neu 발현에 관한 연구
박동일 ( Dong Il Park ),오석중 ( Suk Joong Oh ),박승하 ( Seung Ha Park ),윤중원 ( Jung Won Yun ),김홍주 ( Hong Joo Kim ),조용균 ( Yong Kyun Cho ),성인경 ( In Kyung Sung ),손정일 ( Chong Il Sohn ),전우규 ( Woo Kyu Jeon ),김병익 ( B 대한소화기학회 2004 대한소화기학회지 Vol.44 No.3
목적: HER-2/neu 단백은 상피성장인자 수용체와 구조가 거의 일치하기 때문에 정상 세포의 성장과 증식 과정에 관여한다. 유방암에서 HER-2/neu의 과발현은 나쁜 생존율을 예상할 수 있는 예후인자일 뿐 아니라 항암화학요법이나 호르몬요법에 잘 반응하지 않는 등 치료에 대한 반응을 예측할 수 있는 인자이며 HER-2/neu에 대한 단일클론 항체인 Herceptin(R)은 림프절에 전이된 유방암 환자에서 장기 생존율을 향상시켜 임상에서 활발히 사용되고 Background/Aims: The HER-2/neu protein is involved in normal cell proliferation and tissue growth because it is extensively homologous and related to epidermal growth factor receptor. As a prognostic marker, HER-2/neu is used to forecast the clinical cour
문원 ( Won Moon ),손정일 ( Chong Il Sohn ) 대한소화기기능성질환·운동학회 2009 Journal of Neurogastroenterology and Motility (JNM Vol.15 No.1
Collecting baseline information on how laboratories perform gastrointestinal motility testing is a reasonable first step towards establishing intra- and inter-laboratory standardization and quality control standards. A nationwide survey of laboratories where gastrointestinal motility tests are performed was carried out. A questionnaire, composed of 17 questions covering the main aspects of gastrointestinal motility tests, was distributed to 127 teaching hospitals from August 2008 to April 2009. Sixty-five hospitals responded. Of these, 46 hospitals performed gastrointestinal motility testing and the relevant staff completed the questionnaires. The number of laboratories per million persons was 0.94 with an even distribution according to administrative districts. In 2007, the number of laboratories performing gastrointestinal motility testing was 41 for esophageal manometry, 39 for esophageal pH monitoring, 38 for anorectal manometry, 30 for biofeedback therapy, 12 for electrogastrography, seven for gastroduodenal manometry, and three for breath hydrogen test. In total, 56 nurses and 12 technicians performed the tests. Registration of the gastrointestinal motility laboratories is needed for the standardization of the gastrointestinal motility tests with acceptable quality controls in Korea. (Kor J Neurogastroenterol Motil 2009;15:9-14)