아토피피부염의 변증과 평가방법에 대한 고찰

손병국,최인화,Son, Byeong-Kook,Choi, In-Hwa 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.3

Objective : An adequate measurement for Atopic Dermatitis(AD) is essential for studies about the treatment of AD. To establish a new and adequate scoring system for AD in Korean medicine, we reviewed existing studies on AD outcome measurement in Korean medicine. Method : We searched for reviews on measurements of AD or studies which used an AD outcome measurement at the Korean Traditional Knowledge Portal from 1995 to June, 2008. And then we reviewed the pattern identification in AD patients and the outcome measurements for AD in each study. Results : 1. Among 25 studies, the most common measurement for AD was SCORAD(the severity SCORing of Atopic Dermatitis index), there were 16 studies. There was one study which used the Jakob T scoring system, one study which used ADSI(the Atopic Dermatitis Severity Index), and there were 7 studies which established or used a new severity scoring system for AD. 2. In Korean medicine, AD caused by Damp-Heat is accompanied by erythema, papulation, oozing and crust, Damp-Heat accompanied by Spleen-Gi deficiency is frequently found in pediatric patients, and in adults who have indigestion. Symptoms of AD caused by blood deficiency and Wind-Dryness include lichenification, dryness, scale and pigmentation. AD caused by toxic Heat in the blood system has symptoms similar to some Damp-Heat pattern along with symptoms of blood deficiency and Wind-Dryness. Conclusion : We need to establish a new severity scoring system which reflects pattern identifications and treatments with Korean medicine, and we should assess the validity, reliability, and sensitivity of the new scoring system.

의성지역 경상누층군의 열적진화와 속성작용

손병국,정태진,오재호,곽영훈,Son Byeong-Kook,Cheong Tae-Jin,Oh lae-Ho,Kwak Young-Hoon 한국석유지질학회 1994 한국석유지질학회지 Vol.2 No.2

의성지역 경상누층군에 대하여 유기지화학적 방법과 일라이트 결정도 측정방법을 사용하여 유기물의 열성숙도와 속성 작용정도를 연구하였다. 신동층군의 흑색셰일은 $0.5{\~}2{\%}$의 유기물을 함유하고 있으며, 이 유기물들은 타이프 Ⅲ에 해당하는 고등식물 기원이다. 열분석 Tmax 값은 $578{\~}595^{\circ}C$이며, 비트리나이트 반사도는 진주층에서 약 $2.9{\%}Ro$, 낙동층에서 약 $3{\~}4{\%}Ro$로 유기물의 열적 성숙단계가 건성가스 생성단계에 도달하였음을 보여준다. 비트리나이트 반사도 측정결과에 의하면, 유기물의 열적성숙은 주로 매몰에 의하여 이루어졌으며, 국부적으로 화성암체의 관입에 의하여 이차적인 영향을 받은 것으로 판단된다. 일라이트 결정도값은 층서상의 위치에 따른 규칙적 인 변화를 보이지 않으며, 낙동층, 하산동층, 진주층, 일직층 일부에서는 속성 정도가 속성 작용 영역과 앵키존 영역의 경계부에 해당된다. 이들보다 상위 지층인 일직층, 후평동층, 점곡층, 사곡층의 일라이트 결정도값은 앵키존의 중간부에 위치한다. 층서적으로 보다 상위인 일직층, 후평동층, 점곡층, 사곡층들의 변성도가 높게 나타나는 것은 이 지층이 분포하는 지역에 관입한 화성암체에 의한 열변질에 기인한 것으로 해석된다. 유기물의 열성숙도와 일라이트 결정도에 의한 탄화수소 생성단계는 서로 잘 일치하며, 비트리나이트 반사도와 일라이트 결정도는 모두 관입체의 영향을 지시한다. 연구지역의 속성작용은 전체적으로는 매몰에 의하여 이루어 졌으며, 국부적으로는 관입체에 의한 이차의 영향을 받은 것으로 해석되는 데, 매몰에 의한 고지온은 약 $200^{\circ}C$로 추정된다. Thermal maturation and diagenesis of the Gyeongsang Supergroup in the Euiseong area are studied by means of organic geochemical techniques and illite crystallinity. Black mudrocks of the Singdong Group contain organic matter of $0.5{\~}2{\%}$ derived from higher plants, being compared to type Ⅲ. Thermal maturity of organic matter reached dry gas generation phase. Tmax by Rock Eval pyrolysis varies between $578^{\circ}C$ and $593^{\circ}C$ regardless of stratigraphic position and localities, and vitrinite reflectance is about 2.9 and $3{\~}4{\%}Ro$ in the Jinju and the Nagdong Formations, respectively. Vitrinite reflectance measurements indicate that the maturation is mainly due to burial and partly to be affected by post-depositional intrusions. Illite crystallinity values from the Nagdong, Hasandong, Jiniu Formations and part of the Iljig Formation are plotted around the boundary between diagenesis and anchizone, indicating dry gas generation stage. However, the values are not dependent on stratigraphic position. The values from the Iljig, Hupyeongdong, Geomgog, and Sagog Formations fall into the range of anchizone, probably resulted from the post-depositional intrusions which occur locally. Both organic geochemical and illite crystallinity data indicate thermal maturation stage of dry gas generation. Diagenesis of the Gyeongsang strata is mostly controlled by burial, and partly affected by post-depositional intrusions. Paleotemperature of the Sindong Group is estimated at around $200^{\circ}C$ on the basis of illite crystallinity.

여드름의 치료예후에 영향을 미치는 인자들에 대한 상관성 고찰

손병국,최인화,Son, Byeong-Kook,Choi, In-Hwa 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.1

Objective : The purpose of this study was to explore the correlation between efficacy and various factors of the acne patients. Method : We reviewed 30 acne patients who visited Allergy/Derma-cosmetic Clinic at Kyung Hee Neo Medical Center from June, 2006 to December, 2007 and were treated with herbal medicine and acupuncture for 4 weeks. We investigated premenstrual aggravation of acne, facial burning sensation, constipation, Heart Rate Variability(HRV) results and regional distribution of acne. And we evaluated inflammatory acnes according to the Korean Acne Grading System(KAGS). Results & Conclusions : 1. The average age of total patients was 23.0 years old. The most frequent age group was 21-25 years old. Patients evaluated as KAGS Grade 2 were most common. 2. In total patients, inflammatory acne were reduced significantly after 4 weeks of treatment. 3. The result of analysis on premenstrual aggravation of acne, facial burning sensation and constipation, there weren't any difference of treatment results on statistical meaning. 4. The results show that there were significant correlations between the Low Frequency at HRV and the rate of acne reduction. (Pearson correlation = -0.565) 5. If the distribution of acne did not involve the T-zone of the face, chest, or back of the body, inflammatory acne were significantly decreased after 4 weeks of treatment.

습열(濕熱)로 변증한 급성기 아토피 피부염 환자 치험 6례

손병국,최인하,Son, Byeong-Kook,Choi, In-Hwa 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.2

Objective : This study investigated results of treatment of Atopic Dermatitis(AD) patients diagnosed as damp-heat type with herbal medicine and wet dreesing. Method : Six AD subjects diagnosed as damp-heat type were selected from the outpatient department of East-West Neo Medical Center in the period of Dec. 2006 to Feb. 2007. Each subject was treated with herbal medicine and wet dressing. Severity Scoring of Atopic Dermatitis(SCORAD) was used to evaluate the effect of treatment and pictures were taken of the Atopic dermatitis lesions. Result & Conclusion : We observed improvement on SCORAD score, especially intensity score of damp-heat type when they were treated with herbal medicine and wet dressing. However, it is less effective and AD often recurs in case of chronic adult-type AD. In addition, nipple eczema in some patients has showed a tendency to improve slowly and recur easily compared to other lesions.

치밀가스 저류층의 이해와 탐사개발

손병국,Son, Byeong-Kook 한국석유지질학회 2008 한국석유지질학회지 Vol.14 No.1

비재래형 탄화수소 자원의 하나인 치밀저류층 내의 천연가스는 중요한 탐사개발 대상이 되고 있다. 치밀가스 저류층은 가스를 배태하고 있는 저류암으로서 투수율이 0.1 md 미만인 저류층을 말한다. 치밀가스 저류층은 광범위하게 두꺼운 층으로 산출되며, 재래형의 가스 집적체와는 달리 과대압력이나 저압력의 비정상적인 압력상태로 나타나는 것이 특징이다. 재래형 가스가 구조트랩이나 층서트랩에서 산출되는 것에 비하여 치밀가스는 이들 트랩들과는 무관하게 산출되고 있다. 치밀저류층에서 가스를 생산하기 위해서는 수압파쇄(hydraulic fracturing)와 같은 인공 자극법에 의해서만 가능하다. 치밀가스 저류층의 최적 생산지역을 스위트 스폿이라고 하며, 생산성을 높이기 위해서는 지질학적 자연균열 상태를 이해하여야 한다. 친환경 연료자원으로 주목을 받고 있는 치밀가스는 탐사기술과 회수방법이 발전함에 따라서 상업적으로 생산되고 있다. 자연균열대를 가로지르는 방향으로 수평시추나 경사시추를 수행할 때 생산성을 극대화할 수 있다. 실제로 미국과 캐나다 등에서는 치밀저류층에서 많은 양의 가스를 생산하고 있으며, 생산량은 해마다 증가하고 있다. 특히, 미국의 치밀사암층에서 생산되는 가스의 경우 1990년에 미국의 총 가스 생산량의 11.1%를 차지하였지만 2005년에는 총 가스 생산량의 24.1%를 차지하고 있다. 국내 대륙붕에서도 치밀가스의 존재 가능성이 제시되고 있으며 이를 개발하기 위해서는 기존의 재래형 가스자원의 탐사 및 개발의 파라다임을 완전히 바꾸는 것이 필요하다. Natural gas in tight reservoirs, one of unconventional hydrocarbon resources, has become a significant exploration and exploitation targets. Tight gas reservoirs are the gas-bearing rocks that commonly have a permeability of less than 0.1 millidarcy (mD). Tight gas reservoirs are characterized by extensive and deep locations as well as abnormal pressure such as over- or under-pressure. The tight gas reservoirs are independent of structural or stratigraphic traps, whereas conventional gases normally occur at these traps. Tight gas reservoirs can be productive when stimulated by hydraulic fracturing. Better production areas within the tight reservoir beds are referred to as sweet spots that are commonly caused by natural fractures, which should be understood and identified to enhance the recovery of the gas from tight reservoirs. The exploration and production techniques allow the commercial production of tight gas, one of environmentally friendly resources. Slant and horizontal wells have best production when they intersect the fractures. Gas production from the tight reservoirs has rapidly grown in U.S. and Canada. Indeed, the U.S. gas production of tight sandstones increases from 11.1% in 1990 to 24.1% in 2005. The presence of tight gas reservoirs has been suggested on the Korean offshore block 6-1. Paradigm shift from conventional to unconventional tight reservoir is required to develop the tight gas from the block.

서울 강동지역 소재 한방병원 피부과 내원환자의 질환 빈도에 따른 임상적 관찰

손병국,최인화,Son, Byeong-Kook,Choi, In-Hwa 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.3

Objective and Methods : To study the prevalence and patterns of common dermatoses and compare these to previous reports, we reviewed 128 new outpatients who visited Allergy/Derma-cosmetic Clinic at Kyung Hee Neo Medical Center in Gang-Dong area of Seoul from January to June, 2007. Results : The results of this study are summarized as follows : 1. Among the 128 outpatients, the total number of male patients were 40(31.2%) and female patients were 88(68.8%). 2. In the age distribution, the most frequently visited age groups were 10-19 years old and 20-29 years old(each 21.1%). 3. The most common dermatoses were atopic dermatitis(27.3%), acne(14.1%), allergic contact dermatitis(11.7%), other eczemas(7.8%) and seborrheic dermatitis(7.0%). 4. Among atopic dermatitis patients, the most populated age groups were 0-9 years old and 10-19 years old(each 37.1%), these results are different from past studies revealing that 0-9 years old patients are dominant. 5. Among acne patients, the most frequent age groups were 20-29 years old(50%) and 30-39 years old(27.8%), these results are different from past studies revealing that 20-29 years old and 10-19 years old patients are dominant. 6. Among Allergic contact dermatitis patients, each age group showed no difference of population. And Allergic contact dermatitis patients visited outpatients department at early stage. Conclusion : This study shows that Oriental medicine is popular especially in atopic dermatitis, acne and allergic contact dermatitis. We should investigate long-period and multi-centered study in order to know prevalence tendency of dermatoses in Oriental Medicine. And it is nessessary to research using more efficient evaluation method and treatment for these special diseases.

제3기 해성퇴적층에서 산출되는 탄산염광물의 화학적 및 음극선 발광 특성

손병국 ( Byeong Kook Son ),김현태 ( Hyun Tae Kim ) 한국광물학회 2004 광물과 암석 (J.Miner.Soc.Korea) Vol.17 No.2

Carbonate minerals are examined by cathodoluminescence microscopy and chemical analysis to characterize the carbonate materials occurring in the Tertiary marine basin. The microscopic technique with cathodoluminescence gives new informations that are not obtainable by conventional microscopic techniques. The carbonate cements in sandstones appear to be uniform with transmitted light or with crossed prisms, but the inspection with cathololuminescence reveals foraminiferal tests and rhomb crystals in the carbonate cements. The chemical analysis indicates that the intense luminescence depends mainly on the presence of Mn^(2+) and Fe^(2+) as activator ions, but the Fe^(2-) also acts as an important quencher ion when Fe concentration in dolomite is over 10,000 ppm. The dolomites, which are rich in calcium, are formed at the early stage of diagenesis at a temperature of about 60~ 70℃.

논문 : 울릉분지 사암 내에 발달된 이팔면체 녹니석-스멕타이트 혼합층 광물

손병국 ( Byeong Kook Son ) 한국광물학회 2005 광물과 암석 (J.Miner.Soc.Korea) Vol.18 No.2

3-D petroleum system modeling of the Jeju Basin, offshore southern

손병국(Byeong-Kook Son),이호영(Ho-Young Lee) 대한지질학회 2018 지질학회지 Vol.54 No.6

일본 제3기 해성 퇴적분지에서의 스멕타이트 매몰 속성작용

손병국 ( Byeong Kook Son ) 한국광물학회 2006 광물과 암석 (J.Miner.Soc.Korea) Vol.19 No.4