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제2형 당뇨병 환자에게 엽산과 아스코르브산 보충이 혈장 호모시스테인 농도와 산화 스트레스에 미치는 영향
황미리(Hwang Mi-Ri),소주련(Soh Ju-Ryoun),임현숙(Lim Hyeon-Sook) 韓國營養學會 2009 Journal of Nutrition and Health Vol.42 No.2
In patients with type 2 diabetes, oxidative stress could be increased by their metabolic changes. Elevated plasma homocysteine is considered as one of markers of enhanced oxidative stress. Due to oxidative stress, some complications like cardiovascular or renal diseases may develop in type 2 diabetes patients. Plasma homocysteine concentration may be increased if folate status were inadequate. Protective effects against oxidative stress may be diminished if the status of anti-oxidative nutrient as vitamin C was poor. It is, therefore, important to maintain adequate status of folate and vitamin C in type 2 diabetes patients. Thus, this study was performed to determine the effects of supplementation of folate and/or ascorbate on blood glycated hemoglobin (HbA1c) level, serum concentrations of homocysteine and cholesterol, plasma oxidized low density-lipoprotein (LDL), concentration and plasma glutathione peroxidase (GSH-Px) activity in the patients with type 2 diabetes. A total of 92 type 2 diabetes patients participated voluntarily with written consents. They were divided into one of the four experimental groups; Control (C), Folate-supplemented (F), Ascorbate-supplemented (A), and Folate plus ascorbate-supplemented (FA). The subjects in C were taken placebo, those in F were supplemented 1 mg of folate, those in A received 1,000 mg of ascorbate, and those in FA were given 1 mg of folate plus 1,000 mg of ascorbate daily for 4 weeks. Supplementation of folate or ascorbate resulted to increase serum folate level or plasma ascorbate concentration apparently, respectively. Folate supplementation not ascorbate seemed to decrease plasma concentrations of homocysteine and oxidized LDL and reduce plasma GSH-Px activity. There might not be synergic effect of the supplementation of folate plus ascorbate. The results indicate that oxidative stress in the patients with type 2 diabetes may lower mainly by folate supplementation.
차연수(Youn-Soo Cha),김형연(Hyung-Youn Kim),소주련(Ju-Ryoun Soh),오석흥(Suk-Heung Oh) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.5
콩나물 콩의 발아에 따른 크기별, 부위별 유리카르니틴, 단쇄 및 중쇄카르니틴, 총 카르니틴의 함량변화를 측정하였다. 콩나물 콩은 건조시료 그램당 약 136 nmol의 총 카르니틴을 함유하고 있었고, 발아가 진행됨에 따라 유리카르니틴, 단쇄 및 중쇄카르니틴, 총 카르니틴이 모두 증가하였다. 부위별 카르니틴 함량은 콩나물의 머리에 해당하는 자엽 부위에는 유리카르니틴 함량이 많고 뿌리의 분열조직 부위에 단쇄 및 중쇄카르니틴이 많았다. 이와같은 결과를 종합하여 볼 때 카르니틴 함량은 콩의 발아정도와 발아부위에 따라 상이함을 알 수 있었다. The changes of carnitine levels including nonesterified-carnitine (NEC), acid-soluble acylcarnitine (ASAC) and total carnitine (TC) were investigated in developing soybean sprouts. The concentrations of carnitines were determined in ungerminated and germinated soybean seeds, and in dissected axis segments and cotyledone of the germinated sprouts. Soybean seeds contain 136 nmol of TC per gram dry weight. The contents of NEC, ASAC, and TC were increased during the germination of soybean seeds. The concentrations of NEC and ASAC were highest in cotyledone and in meristematic tissues, respectively. These data indicate that developmental differences of carnitine levels do exist in plants, and that in developing soybean sprouts the levels of NEC and ASAC are highest in the cotyledone and in the youngest meristem, respectively.