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한국인에서 전립선암으로 호르몬치료를 받는 환자의 대사성 변화
박창후(Chang Hoo Park),성기택(Gi Teck Sung),김세영(Sea Young Kim),김성진(Sung Jin Kim),홍성우(Sungwoo Hong),김종원(Jongwon Kim),박창면(Chang Myon Park),김한권(Han Kwon Kim),박종연(Jong Yeon Park) 대한비뇨기종양학회 2010 대한비뇨기종양학회지 Vol.8 No.2
Purpose: In men with prostate cancer, Androgen deprivation therapy shows a variety of well recognized metabolic alteration. But it is not known in Korean men with prostate cancer. To better characterize the metabolic effects of androgen deprivation therapy in Korean men, we evaluated the changes in fat thickness, bone mineral density (BMD), body mass index (BMI), and levels of hemoglobin (Hb) and cholesterol. Materials and Methods: From December 2002 to December 2008, 148 Korean men treated with leuprolide depot and bicalutamide for prostate cancer and 100 healthy subjects were investigated included change from baseline to month 12 in fat thickness, bone mineral density (BMD), body mass index (BMI), and levels of hemoglobin (Hb) and cholesterol. Fat thickness was estimated from subcutaneous fat thickness at T10 level through CT or MRI image. We also compared them with data from healthy subjects. Results: The mean fat thickness was significantly increased by 22.9% from baseline (16.6mm) to month 12 (20.4mm) in men with prostate cancer (p<0.001). The BMD was significantly decreased by 4.2% from 0.95 to 0.91 (p<0.001). The BMI was significantly increased by 4.8% from 23.0kg/m² to 24.1kg/m² 43 (p<0.001). The hemoglobin level was significantly decreased. In contrast, the cholesterol levels did not change significantly. The patients with prostate cancer had significant changes in fat thickness, BMD, and BMI, compared with healthy subjects (p<0.005, respectively). But there are no significant changes in hemoglobin and cholesterol levels. Conclusions: Our results show that Korean men with prostate cancer have increased abdominal subcutaneous fat and BMI and have decreased BMD during androgen deprivation therapy. These increases the risk of bone fracture and obesity related complication. Therefore, BMD will be checked periodically and carry out exercise program to prevention obesity during androgen deprivation therapy.
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