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결핵 환자에서 결핵균 베타 ( β ) 항원에 대한 혈청 항체가의 의의
서지원(Ji Won Suhr),김남재(Nam Jae Kim),홍석철(Seok Cheol Hong),정연채(Yeon Chae Jeong),김주옥(Ju Ock Kim),김선영(Sun Young Kim),백태현(Tae Hyun Paik),김화중(Hwa Jung Kim),최병태(Byong Ai Choi) 대한내과학회 1990 대한내과학회지 Vol.39 No.6
N/A We extracted beta antigen from M. tuberculosis Aoyama B and purified it from the cell extract of Mycobacterium tuberculosis by affinity chromatography with 5F3F2 monoclonal antibody. We measured the values of IgG, IgM, and IgA antibodies to this beta antigen using ELISA method in patients with tuberculosis and normal healthy controls. The results are summarized as follows: 1) The mean ELISA values of IgG and IgA antibodies to purified beta antigen in the serum of 73 tuberculous patients and 100 normal controls were 0.5560±0.2879 and 0.2177±0.1394, 0.3732±0.2011 and 0.1530±0.1272 (optical density: O.D.), respectively. This difference between the tuberculosis patients and normal controls was statistically significant (p<0,001). 2) On the results of sputum AFB stain, patients with negative AFB, 1+, 2+, and 3+ AFB findings showed significantly elevated levels of IgG antibodies to beta antigen in the value of 0.4930±0.2300, 0.7884±0.3560, 0.5736±0.3820, and 0.5310±0.1680, respectivly, when compared to that of the normal controls. Elevations of IgA antibodies to beta antigen were noted in patients with 1+, 2+, and 3+ AFB on smear staining with the value of 0.2510±0.1550, 0.2540±0.1370, and 0.2440±0.1240 when compared to that of the normal controls. 3) The mean values of IgG and IgA antibodies to purified beta antigen in patients with moderately advanced pulmonary tuberculosis were 0.5425±0.3580, 0.2128±0.1620, and in patients with far advanced pulmonary tuberculosis, 0.5336±0.2793 and 0.2721±0.2210, which were more significantly elevated than in the normal controls of 0.3732±0.2911 and 0.1530±0.1272, respectively(p<0.05). 4) In patients with superficial cervical tuberculous lymphadenitis, the mean values of antibody to purified beta antigen were not significantly different from that of the normal controls. 5) In patients with tuberculous pleurisy, the mean value of IgG antibody to purified beta antigen was elevated to 0.5520±0.4090 compared to 0.3732±0.2011 of the normal controls (p<0.005). 6) The mean values of antibodies to purified beta antigen follwing treatment showed a desreased tendency, but there was no statistical significance. In conclusion, patients with tuberculosis showed statistically significant elevations of IgG and IgA antibodies to purified beta antigen, and the measurement of these values may be useful for the diagnosis of tuberculosis-related diseases.
당뇨성 케톤산증에서 폐부종과 유사하게 나타난 폐모균증 (Pulmonary Mucormycosis) 1예
유승철,서지원,배혜경,이종민,문화식,송정섭,박석영,이은희,박성학,Yu, Seung-Chul,Suhr, Ji-Won,Bae, Hye-Kyung,Lee, Jong-Min,Moon, Hwa-Sik,Song, Jeong-Sup,Park, Seok-Yeong,Lee, Eun-Hee,Park, Sung-Hak 대한결핵및호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.1
Pulmonary mucormycosis is an uncommon, but important opportunistic fungal infection associated with diabetes mellitus, leukemia, lymphoma and other immunocompromised states. Mucor species grow best in acidic-high glucose medium. which explaining the particular susceptibility of diabetic patient who are ketoacidic. Early consideration of this diagnosis, along with aggressive diagnostic evaluation, is critical to effective therapy and patient survival. We have experienced a case of pulmonary murcomycosis mimicking bilateral pulmonary edema on chest Xray that associated with diabetic ketoacidosis. A brief review of the literature was given.
Pulmonary Artery Involvement As First Manifestation in Takayasu`s Arteritis
이상학 ( Sang Haak Lee ),송소향 ( So Hyang Song ),이숙영 ( Sook Young Lee ),김석찬 ( Seok Chan Kim ),최영미 ( Young Mi Choi ),서지원 ( Ji Won Suhr ),김치홍 ( Chi Hong Kim ),안종현 ( Joong Hyun Ahn ),김관형 ( Kwan Hyung Kim ),문화 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-
서지원,정연채,김남재,홍석철,김주옥,김선영,노흥규 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1
To evaluate the effect of 6-month short term antituberculosis chemotherapy with INH, Rifampin, Ethambutol, and Pyrazinamide(2HREZ/4HRE) in the patients with pulmonary and/or extrapulmonary tuberculosis, the authors prescribed 2HREZ/4HRE regimen in 79 tuberculosis patients for 6 months with measuring the sputum staining for AFB, chest X-ray findings, recurrence rates and possible side reactions of the treatment. The result were as follow; 1. Pulmonary Tuberculosis 1) Among the 56 pulmonary tuberculosis patients who had taken 2HREZ/4HRE regimen. 32 patients showed initial positivity in sputum AFB smear stain(57.2%). Negative conversion occurred usually within 2 months after initiation of chemotherapy and the mean period of negative conversion was 1.4 months. 2) Among the 56 pulmonary tuberculosis patients, chest X-ray finding changed in 41 patients (37.21%). From these 41 patients 39 patients showed continuous improvements in chest X-ray finding, though 3 patients showed initial aggravation in spite of continuous medication. The remainder 2 cases aggravated due to the failure of treatment. 3) Treatment failure occurred in 2 patients (3.57%) during the chemotherapy among 56 patients of pulmonary tuberculosis and they were infected with secondary drug-resistant strains of M. tuberculosis. 2. Extrapulmonary tuberculosis. Among 8 patients with tuberculous pleurisy and 15 patients with superficial tuberculous lymphadenitis, there were no evidence of treatment failure after completion of antituberculosis chemotherapy for 6 months with 2HREZ/4HRE regimen. 3. Follow-up study was performed from 6 months to 50 months after completion of antituberculosis chemotherapy and the relapse was not noted in both pulmonary and extrapulmonary tuberculosis patients group during this period. 4. Serum AST/ALT elevated in 9 patients(11.4%) during the treatment and this occurred usually within 3 months after the initiation of antituberculosis chemotherapy. However treatment interruption occurred in 2 patients (2.5%) due to the development of hepatitisone due to drug-induced hapatitis and the other due to type B viral hepatitis. In conclusion, we could find this 2HREZ/4HRE 6-months short-term antituberculosis regimen is effective and could be recommanded as a promising regimen for the treatment of tuberculosis.