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3-메톡시-6-알릴치오피리다진의 사람 췌장암 세포 사멸작용
강영신(Young Shin Kang),서연원(Yeon Won Suh),권순경(Soon Kyung Kwon),정춘식(Choon Sik Jeong),이용수(Yong Soo Lee) 대한약학회 2005 약학회지 Vol.49 No.4
In this study we investigated the effect of 3-methoxy-6-allylthiopyridazine on cell growth in BxPC3 and PANC1 human pancreatic cancer cells. The treatment with 3-methoxy-6-allylthiopyridazine for 48 h decreased cell viability and induced apoptotic cell death in a dose-dependent manner, assessed by using the MTT assay and the flow cytometry, respectively. These results suggest that 3-methoxy-6-allylthiopyridazine may be a good candidate for the therapeutic management of human pancreatic cancers.
박형근(Hyung Keun Park),윤서영(Seo Young Yoon),최종현(Jong Hyun Choi),고홍숙(Hong Sook Ko),서연원(Yeon Won Suh),이용수(Yong Soo Lee),김건희(Gun-Hee Kim),정미숙(Mi Sook Chung),정재훈(Jae Hoon Cheong) 대한약학회 2006 약학회지 Vol.50 No.6
The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500mg/kg body weight. Supplementation of CJ increase dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (360mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly, and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.
서연원,이용수 德成女子大學校 藥學硏究所 2004 藥學論文誌 Vol.15 No.1
Involvement of ion channels in apoptosis is linked to critical aspects of this complex cellular process such as coordination of the Ca^(2-) signal, cell shrinkage and mitochondrial integrity. The body of work described below demonstrates the large variety and critical involvement of ion channels in this cellular process. It highlights the emerging roles discovered for this diverse group of membrane proteins in non excitable tissue physiology and pathophysiology.
서연원,이화정,이용수 덕성여자대학교 약학연구소 2006 藥學論文誌 Vol.17 No.-
One of the most important factors in mammalian physiology is to maintain glucose homeostasis which is controlled for a most part by the pancreas. Specialized β cells residing in the Islets of Langerhans sense the blood glucose levels and secrete insulin, which signals these levels to the rest of the body. Ion channels play an essential role in many aspects of this cellular process and serve as targets for pharmacological interventions that treat diseases in which glucose homeostasis is impaired. In type-2 diabetes, the tight association between glucose sensing and insulin secretion appears to be damaged due to mutations as well as other genetic and acquired changes in a specific K+ channel and most medications for this condition target this channel. This short review describes the mechanisms underlying the physiology and pathophysiology of insulin secretion with emphasis on the function of ion channels in controlling and modulating it.
서연원,이용수 덕성여자대학교 약학연구소 2005 藥學論文誌 Vol.16 No.1
Calcium signal plays an essential role in both apoptotic and necrotic cell death. Intracellular calcium release through emptying of calcium stores and/or change in intracellular calcium concentrations appear to modulated cell death in almost all cell types. These calcium fluxes are only regulated by the activity of membrane channels normally under tight control. These calcium channels may be ligand activated or voltage dependent as well as being under the control of affector molecules such as calmodulin. Many calcium channels have been recently shown to be affected by reactive oxygen or reactive nitrogen species; ROS/RNS. This mechanism may be evoked by normal signaling pathways in the cell or by the actions of exogenously applied toxins. This review covers the recent literature on the role of these redox sensitive calcium channels associated with cell death.