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[논문철회] 저장에 따른 상추의 카로티노이드와 안토시아닌 함량 및 항산화능 변화
박우성(Woo Sung Park),김혜진(Hye Jin Kim),정혜진(Hye-Jin Chung),천만석(Man Seog Chun),김성태(Seong Tae Kim),서승연(Seung Yeon Seo),임성호(Seong Ho Lim),정영학(Yeong Hak Jeong),천지원(Jeewon Chun),안선경(Sun Kyoung An),안미정(Mi-Jeong 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.9
저장기간과 저장방법에 따른 청치마상추와 적치마상추 중의 카로티노이드 성분과 안토시아닌 성분의 함량 변화를 관찰하고, 함량 변화에 따른 항산화 활성을 알아보기 위하여 본 실험을 수행하였다. 그 결과 실온에서 보관한 청치마상추의 경우 저장기간이 지남에 따라 총 카로티노이드의 함량이 현저하게 줄어드는 것을 볼 수 있었으나 냉장보관의 경우 수확 후 9일이 지난 시료에서도 함량의 유의적 변화가 관찰되지 않았다. 적치마상추 중의 안토시아닌 함량 변화에 있어서는 실온에서 보관한 경우와 냉장에서 보관한 경우 간의 유의적인 차이점이 관찰되지 않았으며 저장기간에 따른 차이점도 관찰되지 않았다. 따라서 청치마상추 중의 카로티노이드 성분은 실온에서보다 냉장보관에서 더 안정하다는 것을 알 수 있었으며, 적치마상추 중의 안토시아닌 성분은 저장기간과 저장온도에 있어서 카로티노이드 성분보다 안정하다는 것을 알 수 있었다. 한편 DPPH 라디칼과 ABTS 라디칼을 이용한 항산화 활성을 측정한 결과 ABTS 라디칼을 이용한 항산화 활성 방법이 총 카로티노이드의 함량에 비례하여 항산화 활성을 보였다. 또한 안토시아닌 추출물이 카로티노이드 추출물보다 높은 활성을 보였는데, 이러한 결과는 안토시아닌 성분의 항산화 활성이 카로티노이드 성분보다 높아서라기보다는 총 안토시아닌 함량이 총 카로티노이드 함량보다 약 5배 이상 높은 점과 비타민 C와 같은 상추에 함유되어 있는 다른 수용성 항산화 물질로 인한 것으로 추정하였다. Lettuce (Lactuca sativa) is an important dietary leafy vegetable that is primarily consumed as a fresh or salad material. It has a number of cultural varieties with green and/or red color. Carotenoids and anthocyanins are known to be responsible for these two colors, respectively. In this study, carotenoid and anthocyanin contents were determined to evaluate the stability of these functional pigments during storage at home. Analyses were carried out at the beginning, 3, 6, 9, and 12 days after harvest. In the course of storage at room temperature, total carotenoid levels rapidly decreased, and the decrease was found to be greatest during the first 3 days. Meanwhile, carotenoid level slightly changed within the first 9 days at 4°C after harvest. This result suggests that carotenoids in green lettuce are more stable when refrigerated than at room temperature. Meanwhile, total anthocyanin content in red lettuce did not significantly decrease during storage at room temperature and 4°C, which indicates that anthocyanins have higher stability during storage compared with carotenoids in green lettuce. Anthocyanin extract exhibited higher antioxidant activity than carotenoid extract based on 2,2-azino-bis(3-ethylbenzothazoline-6-sulfonic acid) (ABTS) radical scavenging assay. Antioxidant activity of anthocyanin extract may also be estimated directly by the presence of another potent hydrophilic antioxidant compound, which is ascorbic acid in this extract. In addition, anthocyanin extract showed about a 5-fold higher amount of anthocyanins than carotenoids in the carotenoid extract. The high correlation between carotenoid content with ABTS radical scavenging activity indicates that ABTS assay is more suitable than 1,1-diphenyl- 2-picrylhydrazyl radical scavenging assay for detecting antioxidant capacity of carotenoid extract from lettuce.
늑막액에서 Cholesterol 측정의 진단적 의의에 관한 연구
이원돈(Won Don Lee),김옥란(Ok Ran Kim),이재용(Jae Young Lee),성천모(Chun Mo Sung),배혜상(Hae Sang Bae),서승천(Seung Cheon Seo),최병휘(Byung Hue Choi),허성호(Sung Ho Hue) 대한내과학회 1989 대한내과학회지 Vol.36 No.1
N/A The cholesterol of pleural fluids was measured in 30 patients various diseases with pleural effusion to investigate the utility of differential diagnosis of exudates from transudates. Six cases were pleural transudates and 24 cases were pleural exudates as by classified predefined criteria. The results were as follows: 1) Mean protein level in group 1 (transudates) was l.9±0.8 g/dl and 4.8±0.9 g/dl in group 2 (exudates). Mean pleural fluid to serum ratio in group 1 was 0.30±0.11 and 0.80±0.48 in group 2. 2) Mean LDH level was 40X29 IU in group 1 and 325+271 IU in group 2. Mean pleural fluid to serum ratio was 0.20±0.11 in group 1 and 2.01±1.90 in group 2. 3) Mean cholesterol level was 37±14 mg/dl in group 1 and 97±42 mg/dl in group 2. Mean pleural fluid to serum ratio was 0.18±0.06 in group 1 and 0.71±0.32 in group 2. 4) A protein level of 3.0 g/dl, LDH level of 200 IU, cholesterol level of 60 mg/dl and their pleural fluid to serum ratios of 0.5, 0.6 and 0.3 respectively were used as dividing lines separating transudates from exudates, and 0% was misclassified in group 1. Misclassified effusions in group 2 for each single parameter were: protein 0%, protein ratio 4%, LDH 29%, LDH ratio 20%, cholesterol 20%, cholesterol ratio 0%, and Light criteria 4%. We found the use of cholesterol level to be superior to the measurement of LDH level and inferior to protein level. The ratio of pleural fluid to serum cholesterol markedly improved the result. On the basis of the above results, it is suggested that pleural fluid cholesterol is a useful index in differentiating exudative from transudative pleural effusions.
악성 , 결핵성 및 비특이성 흉막염 환자의 임상적 특성
김봉식(Bong Sik Kim),김상훈(Sang Hoon Kim),성윤업(Yun Up Sung),이상표(Sang Pyo Lee),박인원(In Won Park),최병휘(Byung Whui Choi),허성호(Sung Ho Hue),서승천(Seung Chun Seo) 대한내과학회 1995 대한내과학회지 Vol.48 No.1
N/A Objectives: The role of pleural biopsy in the evaluation of unexplained exudative pleural effusion has been well established. Although repeat pleural biopsy will increase the diagnostic yield in patients ultimately proven to have malignant or tuberculous pleuritis, it will increase the expense and morbidity of patients with nonspecific pleuritis. The identification of patients who should undergo additional diagnostic procedures is a difficult but important clinical problem. The purpose of this study was to determine if patients with nonspecific pleuritis could be distinguished from those with malignant or tuberculous pleuritis by clinical criteria. Methods: The medical records and chest roentgenograms of 93 patients who had pleural tapping and pleural biopsy performed during the five-year period from January 1986 to December 1990 at the department of Internal Medicine, Chung-ang University Hospital were reviewed. Results: The five clinical criteria, ie, fever, weight loss, pleurtitic chest pain, above moderate amount of pleural effusion, lymphocytosis of greater than 90 percent in pleural fluid, were observed significantly more often in the patients who were diagnosed to have either malignant or tuberculous pleuritis. The positive predictive value of the criteria, ie, the probability of the patient having tuberculous or malignant pleural disease, was 89 percent when one criterion was present and increased to 95 percent if two criteria were present. Conclusions: Based on our observations, we recommend the following diagnostic approach to the evaluation of an unexplained exudative pleural effusion. If the initial pleural biopsy reveals nonspecific pleuritis only in a patient without any of the above five criteria, further pleural biopsies are not needed, and the patient is followed up clinically. When two or more criteria are present, an aggressive diagnostic approach including repeat pleural biopsy is recommended.
만성 신부전 환자의 혈액투석중 폐기능 변화에 관한 연구
이지훈(Jee Hoon Lee),김기영(Ki Young Kim),김성수(Sung Su Kim),박인원(In Won Park),강응택(Eung Taek Kang),최병휘(Byeung Whui Choi),허성호(Sung Ho Hue),유석희(Suk Hee Yu),박선규(Sun Kyu Park),서승천(Seung Chun Seo) 대한내과학회 1990 대한내과학회지 Vol.39 No.2
N/A Hypoxemia has occurred during the first 30-60 minutes of hemodialysis in patients with chronic renal failure who bad undergone hemodialysis regularly. It is primarily caused by hypoveniilation, secondary to carbon dioxide losses via dialysates and leukopenia associated with pulmonary vascular leukostasis which was induced by complement activation due to cuprophane membrane. However, there is still controversy over whether hypoxemia might be the result of bronchoconstriction during hemodialysis. To assess the relationship between hypoxemia and the changes of peripheral white blood cell counts and pulmonary function test when cuprophane membrane and acetate buffer solution had been used, arterial blood gas analysis, white blood cell counts, pulmonary function test during the first 120 minutes of hemodialysis were measured. The results were as follows: 1) The major falls of arterial blood oxygen tension occurred 15 minutes after the start of hemodialysis(p<0.05), and the biearbonate concentration significantly and gradually increased 30 minutes and 120 minutes after the start of hemodialysis(p<0.05). 2) The pulse rate significantly increased 15 minutes and 30minutes after the start of hemodialysis(p<0.05). 3) The arterial white blood cell counts and the precentage of neutrophil significantly decreased 15 minutes after the start of hemodialysis and then gradually recovered to a predialytic level(p<0.05), but the percentage of lymphocytes significantly increased 15 minutes after the start of hemodialysis and then gradually recovered to a predialytic level (p<0.05). 4) MMF, PEFR, and FEF75 significantly increased, but no significant changes of FEV1/FVC occurred during hemodialysis. Therefore, we suggest that acute hypoxemia may occur not due to bronchoconstriction, but due to pulmonary vascular leukostasis associated with complement activation.