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진행성 위암 환자에서 수술 후 홍삼엑기스에 의한 면역 조절자 역할에 관한 전향적 연구
서성옥(Sung Ock Suh),김진(Jin Kim),조민영(Min Young Cho) 고려인삼학회 2004 Journal of Ginseng Research Vol.28 No.2
The aim of this study was to evaluate prospectively the impact of the red ginseng extract on circulating interleukin (lL) 2 and l0 in advanced gastric cancer during chemotherapy after operative treatment. Analysis of circulating IL2 and 10 was performed in 50 patients with advanced gastric adenocarcinoma who underwent a curative surgery or with an unresectable gastric adenocarcinoma by using ELISA and monoclonal antibodies at preoperative day I, postoperative months 1 and 3. Twenty-five patients as the control group, twenty-six patients as the non-ginseng (NG) group, and twenty-four patients as the ginseng (G) group were eligible in this study. All plasma IL-2 of the NG and G groups was significantly lower than that of the control group on preoperative I day. These values of the G group were more increase than these of the NG group during the postoperative chemotherapy. The mean value of serum IL-1of the control group (0.608pg/ml) was signiticantly lower than that of the advanced gastric cancer patients including the NG (12.015 pg/ml) and G group (9.409 pg/ml) (p<0.001). These values of the G group were reduced progressively during the postoperative chemotherapy. The mean value of the G group were only close to that of the control group on postoperative months 3 (p=0.003). The number of patients who were enrolled in this study was relatively small to fully evaluate the immunologic effects of the red ginseng extract on circulating IL-2 and 10. Despite this limitation, these results suggest that the postoperative intake of the red ginseng extract have potential to improve earlier anti-cancer immunity with recovering IL-2 and reducing IL-10 from the depressed IL-2 and elevated IL-10 by gastric cancer during the postoperative chemotherapy. This study will be based on the future study to evaluate the anti-immunity of the red ginseng extract.