HPMC의 입도에 따른 염산벤라팍신 및 카바마제핀 서방성 정제의 용출 특성

백현호(Hyun Ho Beak),차재욱(Jae Uk Cha),차자현(Ja Hyun Cha),홍준기(Jun Kee Hong),이성완(Sung Wan Lee),고원화(Won Hwa Ko) 한국고분자학회 2012 폴리머 Vol.36 No.3

본 연구는 약물의 용해도에 따른 서방성 용출 거동의 특성을 파악하기 위해 수행되었으며, 이에 따라 고 분자의 입도에 따른 염산벤라팍신과 카바마제핀의 정제를 제조하였다. 사용된 고분자는 경구를 통한 서방성 약 물전달 시스템 설계에 가장 널리 사용되는 히드록시 프로필 메틸셀룰로오스(HPMC)이며, HPMC의 입도 분포 에 따른 팽윤 속도의 차이는 중요한 특성으로 약물의 용출에 큰 영향을 미친다. HPMC 입도에 따른 정제 표면 을 분석하기 위해 SEM을 사용하였으며, 결정학적 특성을 파악하기 위해 DSC를 이용하여 분석하였고, 용출 특 성의 주요 메카니즘을 파악하기 위해 용출 모델식을 적용하였다. 본 연구를 통해 약물의 용해도 및 HPMC의 입 도에 따라 약물의 용출 거동을 조절할 수 있었다. The primary objective of this work is to find the properties of sustained release dissolution pattern depending on solubility of drugs, so venlafaxine HCl and carbamazepine tablets were made by using polymer wich various particle size. Hydroxy propyl methyl cellulose (HPMC) has been utilized in this study as an excipient that is one of the most widely used polymers for an oral sustained release formulation, and drug release pattern was strongly influenced by swelling rate depending on particle size of HPMC. Scanning electron microscope (SEM) was employed to investigate the surface of tablets with various HPMC particle size, and differential scanning calorimeter (DSC) was employed to investigate the crystallization of drugs in tablets. The release model equation was applied to analyze the main mechanism of drug release pattern. The results demonstrate that drug release pattern is controlled by the drug solubility and HPMC particle size.

보문 : Mealan-a 세포에서 흰전동싸리 에탄올 추출물과 흑마늘 열수 추출물의 피부미백 효능

백현기 ( Hyun Gi Beak ),황지연 ( Ji Yeon Hwang ),홍성희 ( Sung Hee Hong ),김영철 ( Young Chul Kim ) 대한미용학회(구 대한미용과학회) 2015 대한미용학회지 Vol.11 No.1

This study was conducted in order to compare the whitening efficacy of Melilotus alba Medicus ethanol extract (MAEE) and black garlic water extract (BGWE). The total polyphenol contents of MAEE and BGWE were 122.65 and 5.5 mg/g, respectively, and the total flavonoid contents were 130.24 and 5.4 mg/g, respectively. The electron donating abilities of MAEE and BGWE at a concentration of 1,000 μg/mL were 74.4% and 37.2%, respectively. The maximum permissible levels of MAEE and BGWE in melan-a cells were ascertained as over 200 μg/mL. MAEE and BGWE at 50 μg/mL reduced the melanin contents by 27.5% (p/0.01) and 3.7%, respectively. MAEE and BGWE at 50 μg/mL reduced intracellular tyrosinase activity by 3.5% and 7.6%, respectively. Collectively, the results of this study suggested that MAEE and BGWE effectively inhibited melanin synthesis, while their tyrosinase inhibition activities were found to be weak. Additionally, the antioxidant activity and whitening efficacy of MAEE were higher than those of BGWE.

청소년의 스마트폰 중독과 마음건강과의 관계에서 학교생활적응의 매개효과

하태현 ( Tai Hyun Ha ),백현기 ( Hyeon Gi Beak ) 한국컴퓨터교육학회 2014 컴퓨터교육학회 논문지 Vol.17 No.6

본 연구는 스마트폰 중독에 영향을 미치는 요인으로서 마음건강의 주 효과를 검증하고, 이들 관계에 학교생활적응의 매개효과를 검증해봄으로써 스마트폰 중독 예방을 위한 다양한 실천적 함의를 제공하는데 그 목적이 있다. 이를 위해 스마트폰을 사용하는 지역 소재 초등학교 260명을 대상으로 설문조사를 실시하였다. 스마트폰 중독, 마음건강 및 학교생활적응 간의 관계를 구조방정식 모형으로 설정해 학교생활적응의 매개효과를 검증하였다. 연구결과 학교생활적응은 마음건강과 스마트폰 중독 사이의 관계를 완전히 매개하는 변인으로 나타났다. 학교생활적응의 매개효과는 Sobel 검증을 통해서 통계적 유의미성이 검증되었다. 이러한 결과는 마음건강이 학교생활적응과 같은 부정적 정서의 발생을 감소시켜주며, 이는 다시 스마트폰의 중독적 사용 가능성을 낮춰주는데 영향이 있음을 제시하고 있다. 이를 토대로 본 연구는 스마트폰 중독 예방을 위해 마음건강 향상과 같은 보호요인의 강화 노력이 무엇보다 중요하며, 매개 변인으로서 스마트폰 중독에 영향을 미치는 학교생활적응과 같은 위험요인을 관리하기 위한 장·단기적 개입이 필요하다는 점을 시사하고 있다. This study aims to offer a wide range of practical implications for Smartphone addiction prevention by verifying the effect of mind health as a factor that is influenced by Smartphone addiction, and testing the relationships between Smartphone addiction and mind health with school life adaptation as a mediation effect. For this research, a survey was conducted of 250 elementary school students who use Smartphones. The relationships between Smartphone addiction, mind health and school life adaptation were set as the structural equation model, and they were verified by the mediation effect of school life adaptation. The results showed that school life adaptation turned out to be an entirely mediating variable on the relationship between mind health and Smartphone addiction. The statistical significance of the effect on school life adaptation was verified by the Sobel test. The mediation effect resulted in mind health reducing the occurrence of negative emotion of school life adaptation, and also reinforced decreased Smartphone use.

보문 : 인체피부섬유아세포에서 자주달개비 메탄올 추출물의 항노화 효능

황지연 ( Ji Yeon Hwang ),백현기 ( Hyun Gi Beak ),박별례 ( Byoul Rye Park ),김영철 ( Young Chul Kim ) 대한미용학회(구 대한미용과학회) 2015 대한미용학회지 Vol.11 No.1

The objectives of this study were to evaluate the effects of Tradescantia reflexa methanol extract (TRME) on collagen synthesis and the inhibition of collagen degradation in human dermal fibroblasts. Total polyphenolics and flavonoids in the TRME were 148.3 mg/g and 95 mg/g, respectively. At concentration of 1,000 μg/mL, the electron donating ability of TRME was 10.3%. Collagenase and elastase inhibition of TRME at 10 mg/mL was 82.5% and 49.8%, respectively. As determined with a 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay, the maximum permissible level for treating human dermal fibroblasts with TRME was shown to be over 200 μg/mL. In comparison with the control, TRME at 200 μg/mL significantly (p/0.01) increased type I procollagen synthesis by 58.9%, while TRME at 200 μg/mL significantly (p/0.01) decreased matrix metalloproteinase-1 mRNA expression by 49.1%. These results suggested that TRME had very low toxicity in human dermal fibroblasts, and had high efficacy on the stimulation of collagen synthesis and the inhibition of collagen degradation in human dermal fibroblasts. Therefore, TRME may be used as a functional cosmetic material for the prevention or alleviation of skin-wrinkle formation induced by ultraviolet rays.

Double Covering 기법을 이용한 고강도 실크 직물 개발

최주현(Choi, Ju Hyun),백현국(Beak, Hyeon Kuk),조윤진(Cho, Yun Jin) 한국전시산업융합연구원 2014 한국과학예술융합학회 Vol.16 No.-

최근 친환경적이면서 기능적인 소재가 주목받고 있다. 이에 본 연구는 실크 더블커버링사를 개발하고, 개발된 실크 더블커버링사를 이용해 기능성 실크 직물을 제직하고자 하였다. 개발 결과는 다음과 같다. 첫째, 하나의 심사에 두 개의 초사를 서로 다른 방향으로 꼬아서 커버링을 시도한 실크 더블커버링사를 개발하였다. 둘째, 개발된 실크 더블커버링사로 실크 직물을 제직하였으며, 개발 직물의 원단 강도가 일반 연사를 이용한 경우보다 우수한 것으로 나타났다. 셋째, 개발된 직물에 기능성 가공을 실시한 결과 실용성이 향상되었다. 따라서 본 개발 직물은 향후 인테리어용, 지갑이나 가방과 같은 패션잡화, 그리고 신발용 갑피로도 사용 가능할 것으로 기대된다. The volume of the functional textile market is gradually growing in Korea. This study intended to develop the double covering yarn and high strength silk fabric. The key findings were as follows: Firstly, silk double covering yarn was developed. To improve the stretch and anti-bacterial, functional double covering yarn using nano silver was developed. Secondly, using double covering yarn, functional silk fabric was developed and its stretch was improved. Thirdly, to improve its functionality, the fabric was treated in nano silver padding and water repellency and antibacterial performance was improved. The results showed that high strength silk fabric could be used for the interior fabric and the upper part of shoes.

상지동맥 혈관계의 모델링과 혈유동의 전산수치해석

김기원(Keewon Kim),김재욱(Jaeuk U. Kim),백현만(Hyun Man Beak),김성균(Sung Kyun Kim) 대한기계학회 2016 大韓機械學會論文集B Vol.40 No.4

하지혈관에 비해 상지혈관질환은 드물기 때문에 상지혈관계에 대한 실험적, 수치해석적 연구는 매우 드물다. 본 논문에서는 최초로 MRA 영상데이터로부터 한국 성인 왼팔의 혈관계, 상완동맥에서 1 ㎜ 이상의 손가락동맥들에 이르는, 3차원 컴퓨터 모델을 제작하였다. 이 모델에 대해 수치해석을 수행하여 정상, 주기유동에 대한 속도장, 압력장을 계산하였고 주요 분지관에서의 유량분배와 벽전단응력분포에 대해 분석하였다. Since arterial disease in the upper extremity is less common than that in the lower extremity, experimental and numerical investigations related to upper extremity have been rarely performed. We created a three-dimensional model of the arteries, larger than approximately 1 mm, in a Korean adult"s left hand (from brachial to digital arteries), from 3T magnetic resonance imaging (MRI) data. For the first time, a three-dimensional computational fluid dynamic method was employed to investigate blood flow velocity, blood pressure variation, and wall shear stress (WSS) on this complicated artery system. Investigations were done on physiological blood flows near the branches of radial and deep palmar arch arteries, and ulnar and superficial palmar arch arteries. The flow is assumed to be laminar and the fluid is assumed to be Newtonian, with density and viscosity properties of plasma.

성별과 연령에 따른 기능성 소재 의류제품 평가기준과 정보원 연구

조윤진(Yun Jin Cho),최주현(Ju Hyun Choi),백현국(Hyeon Kuk Beak) 한국복식학회 2010 服飾 Vol.60 No.9

In Korea, recent trends indicate an increase in the volume of the functional clothing market. This study investigated the evaluative criteria and information sources of functional clothing according to gender and age. A total of 756 responses were analyzed using descriptive statistics, MANOVA, and Duncan`s test. The main effect of gender on the evaluative criteria and information sources of functional clothing was identified. Compared with male consumers, female consumers gave more importance to price and aesthetic criteria. Female consumers take advice from colleagues and companions, as well as use information obtained from mass media to a greater extent than male consumers. Age was seen to have an effect on evaluative criteria and information sources in purchasing functional clothing. Respondents in their forties and fifties took textile quality and durability more seriously. Information available on the Internet and following the dressing styles of celebrities were preferred by respondents in their twenties.

Bacillus subtilis BK-17 유래 혈전용해효소(Bacillokinase)의 고체배양

정영기(Yong-Kee Jeong),백현(Hyun Beak),서민정(Min Jeong Seo),김민정(Min Jeong Kim),이혜현(Hye Hyeon Lee),주우홍(Woo Hong Joo),김정인(Jeong In Kim),최영현(Yung Hyun Choi),정경태(Kyung Tae Chung) 한국생명과학회 2009 생명과학회지 Vol.19 No.10

곡물을 소재로 혈행개선에 효과 있는 물질을 개발하기 위하여 Bacillus subtilis BK-17을 이용하여 고체 배양을 시도하였다. 고체배양에 접종하는 미생물은 영양세포보다 포자 접종이 혈전용해효소 생산에 효과적이었다. 포자 생산을 위한 배지는 SFM (0.8% nutrient broth, 0.05% yeast extract, 10?¹ M MgCl₂, 10?³ M FeCl₃, 10?⁴ MnCl₂, 10?? M dipicolic acid, pH 6.5)이 최적이었고, 포자 생성에 대한 최적 pH 와 온도는 각각 pH6과 30℃ 였으며 포자는 배양 후 60 시간에서 가장 많은 생산을 보였다. 각종 곡물을 기질로 하였을 때 녹두가 혈전용해능이 가장 높았으며 강낭콩, 검정콩, 대두, 옥수수는 녹두의 약 90% 수준의 활성으로 높은 혈전용해능을 보였다. 반면에 보리와 밀과 같은 탄수화물 곡물은 낮은 활성을 보였다. 고체 배양한 발효 대두는 단백질과 지질 함량에 있어 발효하지 않은 대두보다 약 10% 이상의 높은 수치를 보였다. 또한 필수 아미노산과 일반 아미노산의 함량 역시 발효 대두 쪽이 약 5 - 20% 높은 것으로 보아 혈행개선기능성 뿐만 아니라 식품으로 실용 가능성이 높은 것으로 사료된다. A solid-state culture based on grain materials was attempted to produce a fibrinolytic enzyme for blood circulation improvement using Bacillus subtilis BK-17. The spore, rather than vegetative cell inoculation, of B. subtilis BK-17 on the solid-state culture was effective in the production of a fibrinolytic enzyme. Maximum spore production was obtained with a SFM medium (0.8% nutrient broth, 0.05% yeast extract, 10?¹ M MgCl₂, 10?³ M FeCl₃, 10?⁴ MnCl₂, 10?? M dipicolic acid, pH 6.5). Optimal pH and temperature were pH 6 and 30℃, respectively. The spore production reached a maximum at 60 hours of incubation. Bacillus subtilis BK-17 on the mung bean solid-state culture produced greater fibrinolytic activity, and less activity was seen in other grains such as kidney bean, soybean and corn. Protein and lipid contents of fermented soybeans were about 10 - 30% more than those of unfermented soybeans. Amino acid content was also 5 - 20% more than that of unfermented soybeans. These results indicated that fermented solid-state culture medium, fermented soybean in this case, can be utilized as a food supplement.