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위장관 ; 경도 및 중등도 활동성 궤양성 대장염 환자에서의 VSL#3의 효능
이지현 ( Ji Hyun Lee ),문규 ( Gyoo Moon ),권혁진 ( Hyeok Jin Kwon ),정우진 ( Woo Jin Jung ),서평주 ( Pyoung Ju Seo ),백태윤 ( Tai Yoon Baec ),이주형 ( Ju Hyeong Lee ),김현식 ( Hyun Shig Kim ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.2
Background/Aims: Ulcerative colitis (UC) is a chronic disease that characteristically has a relapsing and remitting course. Probiotics might possibly induce remission in the treatment of active UC. Aims of our study were to assess the efficacy of VSL#3 on clinical response and colonic tissue cytokine concentration changes in patients with active UC. Methods: Twenty-four eligible patients with mild to moderate UC received open-label VSL#3 4 sachets daily in 2 divided doses for 8 weeks. The disease activity pre- and post-VSL#3 therapy was assessed by ulcerative colitis disease activity score and colonic tissue cytokine profiling done at baseline and at week 8. Results: Twenty-four patients (mean age, 43.7 years; range, 20-70 years; male/female, 15/9) were enrolled and 2 patients did not have the final endoscopic assessment. A total of 22 patients were analyzed. Intent to treat analysis demonstrated remission in 45.8% of subjects (n=11); partial response in 20.8% (n=5); no change or worse in 25.0% (n=6) of subjects. The mean ulcerative colitis disease activity index (UCDAI) scores decreased from 7.09±1.81 to 1.45±1.29 in patients with a remission (p<0.001). The mean endoscopic scores had also significantly decreased from 1.91±0.54 to 0.63±0.50 in patients with a remission (p<0.001). The concentrations of colonic cytokines did not change significantly during treatment in patients with a remission. Conclusions: Our study demonstrated that VSL#3 is effective in achieving clinical responses and remissions in patients with mild-to moderately active UC, further supporting the potential role in UC therapy. (Korean J Gastroenterol 2012;60:94-101)
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