Electric Stimulation(음이온 pad)이 생쥐난자의 성숙 및 수정난의 난할에 미치는 영향

배인하,박원,최성미,김문규,Bae, In-Ha,Park, Won,Choi, Sung-Mi,Kim, Moon-Kyoo 대한생식의학회 1996 Clinical and Experimental Reproductive Medicine Vol.23 No.3

In the present study, mouse follicular oocytes and 2-cell embryos(late -zygote stage embryos included) were cultured on the electric pad for electric stimulation in the culture incubator. In addition, follicular oocytes and embryos were tested for maturation and development under higher temperature condition($39^{\circ}C$).Mouse follicular oocyte maturation were not affected by anion electric stimulation and there is no significant difference in GBVD and MI between the control and experiment group after 4hr culture. In the embryo culture, it was found that more morula and blastocyst were found in the electric stimulation group rather than the control(96hr). This may seem to be caused with cytoplasmic $Ca^{2+}$ transient rise by electric stimulation(anion pad). On the other hand higher temperature incubation ($39^{\circ}C$) on the anion pad caused all the embryos degenerated within $12h{\sim}24hr$ culture. This was quite different from large animal embryos(bovine, pig, sheep), in which beneficial effect of high temperature incubation for oocyte maturation and embryo development were found.

'협동적 쓰기' 교수가 초등 작문장애 학생의 쓰기표현력에 미치는 효과

배성미(Sung-mi, Bae),박현숙(Hyun-Sook, Park) 한국언어청각임상학회 2002 Communication Sciences and Disorders Vol.7 No.2

최근의 쓰기교수는 쓰기기술의 습득에만 치중하는것이 아니라 다른 구성원과의 역동적인 상호작용을 통해 쓰기에 필요한 전략들을 직접 수행하고 내면화하는 과정을 강조하고 있다. 이에 본 연구는 협동적 쓰기 교수가 초등 작문장애학생의 쓰기표현력에 미치는 영향을 알아보고자 하였다. 이를 위해 서울 시내의 초등학교 5-6학년 작문장애 아동 20명을 대상으로 15회기에 걸쳐 실험집단에게는 협동적 쓰기 교수를, 그리고 통제집단에게는 전통적인 쓰기 교수를 실시하였다. 두 집단에게 동일한 주제로 글을 쓰는 사전, 사후 검사를 실시하여 공분산 분석을 한 결과, 실험집단이 글의 내용, 글의 길이, 글의 정확도(철자, 띄어쓰기, 문장부호, 문법사용)에 있어서 유의하게 향상되었다. 이러한 결과는 작문하기에 협동적 쓰기 교수를 활용할 경우, 작문장애 학생의 쓰기표현력을 향상시킬 수 있을 뿐만 아니라 쓰기에 쉽게 친숙해질 수 있도록 유도하는 이점을 기대해 볼 수 있음을 시사한다. The collaborative writing is a method by which a student shares the actual process of composition with his/ her writing partner (s), and they alternate turns to complete the composition. A teacher , another student , or a group of student can be writing partner (s), and a teacher was chosen as the writing partner in this study. The purpose of this study was to test the effect s of the writing instruction by the collaborative writing on written expression ability in elementary student s with composition disabilities. For this purpose, 20 elementary student s with composition difficulties were selected (8 from 5th grade and 12 from 6th grade) to be divided into two groups, an experimental and a control. The two groups were trained for 7 weeks (15 40 - minutes sessions) through the stages of choosing a title, planning, writing, and revising their writing product s. In the stage of writing, the experimental group wrote the product collaboratively with a teacher and the control group wrote it individually. The written expression ability was evaluated by measuring story content s, story length, and story correctness using pre- and post - test . ANCOVA was used to analyze the collected data utilizing the pretest scores as covariates. The result s obtained from this study are summarized as follows : (1) A significant difference was found between the experimental and the control groups in story content s, showing significantly higher performance in the former group; (2) A significant difference was found between the two groups in story length, showing significantly longer performance in the experimental group; and (3) The experimental group showed significantly higher performance in story correctness, that is, spelling, spacing words, punctuation, and grammar (in total). In terms of grammar , however , significant differences were found between the two groups in modifier and word order , while no significant differences were found in auxiliary words, subject -predicate concord, tense, and conjunction. In conclusion, these result s imply that the written expression ability of student s with composition disabilities could be enhanced by providing them with composition instruction through the collaborative writing.

원발성 무월경 여성에서 관찰된 Pseudoisodicentric X 염색체

박상희(Sang-Hee Park),심성한(Sung Han Shim),진미욱(Mi-Uk Chin),강수진(Su Jin Kang),배성미(Sung-Mi Bae),손수민(Soo-Min Sohn),차동현(Dong-Hyun Cha),윤태기(Tae Ki Yoon),조정현(Jung-Hyun Cho) 대한의학유전학회 2008 대한의학유전학회지 Vol.5 No.1

24세의 무월경을 주소로 내원한 여성에게서 세포유전학적 검사를 시행하였다. GTG-분염법 결과, 환자의 핵형이 46,X,der(X)로 관찰되어 LSI Kallmann(KAL) 형광소식자[probes for Xp22.3 (KAL)과 CEP(X) for control]로 FISH 분석을 시행하였다. 비정상 X 염색체에서는 KAL (Xp22.3)에 대한 형광이 보이지 않았고, CEP(X)에 대한 형광이 두 개씩 관찰되었다. 간기세포 FISH 분석 결과, CEP(X) 형광소식자에 대해 분석한 세포의 90%에서 세 개의 형광이, 10%의 세포에서 하나의 형광이 관찰되어 두가지 cell line이 혼재되어 있는 모자이시즘을 확인하였다. 이들 결과들을 통해 환자의 핵형이 45,X/46,X,psu idic(X)(p22.1)이며, 이는 Xqter→Xp22.1 부분은 중복되어 있고, Xpter→Xp22.1 부분은 결실된 상태로 터너 증후군의 변형된 형태임을 판명하였다. Idic(X)와 낮은 비율의 모자이시즘을 확인하는데 CEP(X) 형광소식자로 FISH를 시행하는 것이 유용하였다. A 24-year-old female with primary amenorrhea was referred for a chromosome study. The karyotype of the patient was 46,X,der(X) under initial GTG-banding analysis. Fluorescence in situ hybridization (FISH) analysis with an LSI Kallmann (KAL) region probe [probes for Xp22.3(KAL) and CEP(X) for control] was carried out. The abnormal chromosome was KAL- and CEP(X)×2. In addition, interphase FISH analysis revealed the patient to be mosaic for two different cell lines: 90% of cells had three signals and 10% of the cells had only one signal for CEP(X). Based on these results, the karyotype of the patient was 45,X/46,X,psu idic(X)(p22.1), which is partial trisomy for Xqter→Xp22.1 and partial monosomy for Xpter→Xp22.1. This karyotype was considered a variant of Turner syndrome. In summary, Idic(X) and low-level mosaicism was successfully characterized by FISH analysis with a CEP(X) probe.

국제다각화가 재무분석가의 이익예측활동에 미치는 영향

김명인(Myung In Kim),배성미(Seong Mi Bae),윤금상(Kum Sang Yoon) 한국경영학회 2012 經營學硏究 Vol.41 No.4

This study investigates the effect of international diversification of Korean corporations on analysts` forecasting activities, specifically focusing on earnings forecast accuracy, optimism and dispersion. Prior research indicates that analysts suffer from the complexity and difficulty in forecasting earnings of internationally diversified firms due to differences in political, economic, and cultural environment. It also reports that analysts` forecast for firms with high uncertainty tends to be optimistically biased. Thus, this study tests the hypothesis that analysts` forecast becomes less accurate, and optimism and dispersion among analysts increase with the degree of diversification. The sample for the empirical test includes 2,371 firm-years for firms listed in the Korean Stock Exchange or KOSDAQ for the period of 2000-2010 and the analysts` earnings forecast data provided by FN Data Guide Pro database. When we use the analysts` forecast of annual earnings-per-share (EPS) within the twelve month period up to the earnings announcement (i.e., from the end of March in the current year to the end of March in the following year), the empirical results show that, consistent with the expectation, analysts` forecast accuracy decreases significantly while optimism and dispersion among analysts increase significantly with the degree of diversification. The result represents that international diversification of Korean firms increases the complexity and difficulties of analysts` forecasting activities, suggesting that international diversification should be considered as one of the significant factors determining analysts` forecasting activities. On the other hand, when the data within one month up to the earnings announcement is used, we find that the above mentioned effects decreased significantly. Consistent with Richardson et al. (2004), this evidence suggests that financial analysts walk down their earnings forecasts, issuing initial optimistic forecasts, followed by more pessimistic forecasts immediately before the earnings announcement. This allows prediction error to be reduced. This study documents the effect of international diversification of Korean corporations on analysts` forecasting activities. The findings in this study provide several valuable implications to regulators, researchers and investors. First, when investors or users of accounting information use analysts` earnings forecasts as a proxy for the valuation of internationally diversified firms, they should consider the analysts` earnings forecasts may be less accurate and more optimistically biased. Second, Regulators need to mandate Geographic or Country Business Segment Report with the current Business Segment Report disclosure practice. We expect that this disclosure practices will improve analyst` earnings forecasting attributes for the internationally diversified firms. Also, it will provide useful information for investors when they invest in those firms. The improved disclosure practice will enable researchers to study the effect of international diversification of Korean corporations in more detail, and ultimately will contribute to increase transparency in accounting for such firms.