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배성진(Sung Jin Bae),안원석(Won Suk An),박건욱(Geun Wook Park),박희승(Hee Seung Park),김구(Gu Kim),김동수(Dong Su Kim),김광동(Kwang Dong Kim),정재열(Jae Youl Jung),장광열(Kwang Yul Chang),김선택(Sun Tack Kim),김성은(Seong Eun Kim),김 대한내과학회 1997 대한내과학회지 Vol.52 No.5
N/A Objective .We aimed to compare efficacy of treatment between steroid therapy and steroid-chlorambucil combination therapy in patients with adult-onset idiopathic membranous glomerulonephritis (MN). Methods: A series of 31 biopsy-proved idiopathic MN patients was analyzed retrospectively to estimate effect of treatment with steroid and/or cytotoxic agent. All patients (male 15, female 16, mean age of 37 years old) presented a full-blown nephrotic syndrome (proteinuria >3.0gm/day, serum albumin <3.0mg/dL, edema) at the initiation of treat- ment and were observed for at least 6 months (mean follow up period: 28±23 months). Clinical and laboratory information were obtained at the time of presentation and at last follow up. Each patient was assigned to one of the following protacols. 1) Steroid therapy prednisolone 40 or 60mg/day (single dose) for 16 weeks. 2) Steroid-Chlorambucil combination therapy: for 6 months with three cycles of methylprednisolone pulse therapy (lgm 1V for 3 days), prednisolone 0.5mg/kg/day for 27 days, then chlorambucil 0.2mg/kg/day for 28 days. 3. Cyclophosphamide 2mg/kg/day for 28 days. Results: 1) Final status in total 31 cases irrespective of therapeutic modality were complete remission in 5 (16%) cases, partial remission in 9 (29%) cases, no response in 12 (41%) cases, spontaneous complete re- mission in 1 cases, and spontaneous partial remission in 1 case. 2) After initial steroid therapy (in 25 cases), We observed no response in 17 (68%) case, partial remission in 3 (12%) cases, complete remission in 3 (12%) cases, and spontaneous partial remission in 2 (8%) cases. 3) The combination therapy (steroid and chlorambucil) tried in 10 cases results in 5 (50%) cases of partial remission, 2 (20%) cases of complete remission, 1 (10%) case of spontaneous partial remission, and 2 (20%) cases of no response. 4) During follow up period, renal functional deterioration was absent in any case and final albumin levels were significantly increased (p<0.05). Conclusion: Steroid-chlorambucil combination pro- toco1 is considered to be a more effective treatment with higher rate of overall remission compared to steroid therapy. Idiopathic MN itself seems to have a relatively benign course when considering that renal function was preserved in all cases without progression to chronic renal failure and that a few cases of spontaneous remission could be observed. For the limitation in number of cases and duration of follow up in this study, it needs prospective controlled study of more larger scale with long-term follow up to get a more reliable results.
후드캡을 이용한 대장내시경 검사의 유용성 일반 대장내시경 검사와의 비교 연구
최성원 ( Sung Won Choi ),박희승 ( Hee Seung Park ),이재승 ( Jae Seung Lee ),황상연 ( Sang Yon Hwang ),곽성동 ( Sung Dong Kwak ),최성호 ( Seong Ho Choi ) 대한장연구학회 2012 Intestinal Research Vol.10 No.3
Background/Aims: A few studies showed that hood-cap assisted colonoscopy (CAC) had improved cecal intubation rate and cecal intubation time but did not help in finding colon polyps in comparison with conventional colonoscopy (CC). However, other studies have shown different results. Therefore, we investigated the efficacy of CAC for the cecal intubation time and polyp detection rate. Methods: Patients for colonoscopy in Busan St. Mary`s Medical Center were enrolled to this randomized controlled trial between July 2010 and September 2010. The evaluated outcomes were polyp detection rate, adenoma detection rate, and cecal intubation time in all patients, in difficult cases (history of previous abdominal or pelvic surgery, obesity, old age), and in the expert and non-expert groups. Results: A total of 260 patients enrolled in this study were randomly allocated to the CAC group (n=130), or CC group (n=130). The overall cecal intubation time was shorter in the CAC group (5.7±3.4 min vs. 7.8±5.7 min, P<0.001). The polyp detection rate was higher in the CAC group (58.4% vs. 43%, P=0.008). The cecal intubation time in the expert and non-expert groups were shorter in the CAC group (expert: 4.1±2.2 min vs. 5.5±2.0 min, P=0.001; non-expert: 6.7±3.7 min vs. 9.4±5.9 min, P=0.001). Conclusions: The use of CAC improved the detection rate of colon polyps and shortened the cecal intubation time for both the expert and non-expert groups. (Intest Res 2012;10:280-288)
수량 및 과방중 조절에 따른 ‘거봉’ 포도의 품질 및 생육 비교
심성보(Sung-Bo Shim),권용희(Yong-Hee Kwon),홍윤표(Yoon-Pyo Hong),박희승(Hee-Seung Park) 한국원예학회 2007 원예과학기술지 Vol.25 No.4
‘거봉’ 포도 재배에서 착과량이 과실 품질에 미치는 영향을 알아보기 위하여 생산량을 10a당 다(약 2,500㎏) 와 소(약 1,800㎏)로 구분하여 과실 품질을 비교하였으며, 또한 과방중에 따른 과실 품질을 비교하기 위하여 각 수량 처리별로 강(약 350g), 중(약 500g), 약(약 700g)으로 구분하여 적과처리를 하였다. 과실 수확은 만개 90일에 농촌진흥청 원예연구소 포도연구센터의 칼라차트를 이용하여 착색도 8 이상의 과실을 선발하여 1차 수확하였고, 만개 108일에 남은 과실을 모두 수확하였다. 10a당 생산량을 달리 했을 경우 적과 처리를 같게 하더라도 생산량을 적게 했을 때 과립중, 종경, 횡경이 큰 것으로 조사되었다. 과실의 당도는 강하게 적과 하였을 경우에는 10a당 생산량에 따라 차이가 거의 없었으나 적과 정도를 중간 정도나 약하게 했을 때는 생산량을 적게 했을 떄 더 높았으며, 산도는 생산량이나 적과 정도에 따라 차이가 없었다. 열과 발생률은 10a당 생산량이 많을 때 현저히 높았으며, 1차 수확률은 수량을 약 1,800㎏으로 조절했을 때 2,500㎏을 생산할 때보다 2배 이상 많이 수확할 수 있었다. 가지 등숙도 또한 수량을 적게 했을 때 현저히 높은 것으로 조사되었다. 전체적으로 10a당 수량을 적게 하고 강하게 적과하는 것이 품질과 열과 발생, 착색도 등 모든면에서 우수하였다. To find out proper crop load in ‘Kyoho’ grapevine, crop load was adjusted as heavy (about 2,500 ㎏ㆍ10 a⁻¹) and light (about 1,800 ㎏ㆍ10 a⁻¹) degrees, and cluster thinning was achieved by three degrees, light (about 700 g/cluster), medium (about 500 g/cluster), and strong (350 g/cluster). At 90 days after full bloom (DAFB), clusters with over than 8 coloring degree, which was measured by the color chart developed by National Horticultural Research Institute, RDA, Korea, were harvested. Then, the rest was harvested at 108 DAFB. All berry clusters produced larger berries in the vines with light crop load. The berry cluster with strong berry thinning did not show any difference in soluble solids content regardless of the difference in crop load. However, the berry clusters with medium and light berry thinning had higher soluble solids in the vines with light crop load. There were no differences in titratable acidity according to treatments. Heavy cropping delayed berry ripening with more frequent berry cracking. Light cropping showed more even berry ripening with higher fruit quality.