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진단적 대장 내시경 시행 후 발생한 공기후복막, 종격동기종, 기흉, 피하공기증
이희성 ( Hee Sung Lee ),박환희 ( Hwan Hee Park ),김주석 ( Ju Seok Kim ),강선형 ( Sun Hyung Kang ),문희석 ( Hee Seok Moon ),성재규 ( Jae Kyu Sung ),이병석 ( Byung Seok Lee ),정현용 ( Hyun Yong Jeong ) 대한소화기학회 2017 대한소화기학회지 Vol.70 No.3
Colonoscopy is a commonly performed endoscopic procedure. Although it is generally considered to be safe, serious complications, such as colorectal perforation, can occur. Most colonic perforations are intraperitoneal and cause pneumoperitoneum with acute abdominal pain as the initial symptom. However, extraperitoneal perforations with pneumoretroperitoneum may happen, albeit rarely, with atypical initial symptoms. We report a rare case of rectosigmoid perforation occurring after diagnostic colonoscopy that developed into pneumoretroperitoneum, pneumomediastinum, pneumothorax, and subcutaneous emphysema, with a change in voice and neck swelling as the initial symptoms. The patient was successfully treated with endoscopic closure of the perforation and conservative management. (Korean J Gastroenterol 2017;70:145-149)
전통 누룩으로부터 분리된 Killer Toxin 생산 균주 Pichia anomala K15의 특성
정희경,박치덕,이기동,박승춘,박환희,홍주헌,Jung, Hee-Kyoung,Park, Chi-Duck,Lee, Gee-Dong,Park, Seung-Chun,Park, Hwan-Hee,Hong, Joo-Heon 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.8
본 연구에서는 발효식품의 저장기간을 연장하거나 이상발효를 방지하기 위해 미생물 유래의 천연 항균성 물질인 killer toxin 생산 균주인 K3, K5, K11, K12, K15를 전통누룩으로부터 분리하였다. 분리된 killer toxin 생산 균주 중 식중독의 원인균인 Salmonella Typhimurium 및 장염비브리오의 원인균인 Vibrio parahaemolyticus의 생육을 저해하며, killer toxin 활성이 가장 우수한 K15를 최종 선발하고 이를 Biolog사 동정시스템과 ITS영역의 염기서열 homology를 조사하여 동정한 결과, Pichia anomala에 99% 상동성을 나타내어 Pichia anomala K15로 명명하였다. P. anomala K15가 생산하는 killer toxin은 단백질 분해효소에 의해 불활성화 되므로 인체에서 단백질 분해효소에 의해 쉽게 분해가 가능한 안전한 항균물질임을 확인할 수 있었다. 또한 p. anomala K15는 에탄올 내성은 약하나 고농도의 당에서 저항성이 크므로 주조 발효초기 환경에서의 이상발효를 방지할 수 있을 것으로 사료되어진다. In this study, killer yeasts were isolated from traditional Nuruk to improve storage and suppress contaminant in food industry. Among killer yeasts, yeast K15 showed strong killer toxin activity and inhibited growth of Salmonella Typhimurium and Vibrio parahaemolyticus. Killer yeast K15 was identified with Pichia anomala by the Microlog TM 4.0 identification system and homology of the ITS sequence. Killer toxin generated from P. anomala K15 was inactivated by pronase E and suggested to be a protein. Therefore killer toxin of P. anomala K15 was thought to be safe in human such as bacteriocin. P. anomala K15 was sufficient for growth in 50% glucose and could be used to prevent contaminant in initial stages of alcohol beverage fermentation.
고지방식이로 유도한 지방간 마우스에서 기장 첨가식이가 지방간 및 인슐린 저항성에 미치는 영향
박미영(Mi-Young Park),장환희(Hwan-Hee Jang),이진영(Jin-Young Lee),이영민(Young-Min Lee),김재현(Jae-Hyun Kim),박재학(Jae-Hak Park),박동식(Dong-Sik Park) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.4
비알코올성 지방간은 인슐린저항성을 근간으로 하는 대사증후군의 원인으로 생각되고 있으며 최근 그 발병율이 증가하고 있다. 본 연구진은 기장 열수추출물을 식이에 첨가하여 고지방식에 의해 인위적으로 지방간을 유도한 마우스에게 섭취시킨 후 혈청 내 생물학적 수치와 간조직 검사를 통하여 비알코올성 지방간 억제 효과를 검토하였다. 그 결과, 식이섭취량은 차이가 없었으나 간조직 무게가 1% 및 2% 기장 열수추출물 첨가식이군에서 유의적으로 감소하였고(p<0.05) 간조직 내 지방 축적이 유의적으로 감소하였음을 확인하였다. 또한 기장 열수추출물 첨가식이군의 경우 고지방식 대조군에 비해 혈청 중성지방 및 총 콜레스테롤이 감소하였고(p<0.05), HDL과 HDL-/총 콜레스테롤의 비율이 유의적으로 증가하여(p<0.05) 혈액의 지질 조성이 개선되었음을 알 수 있었다. HOMA-IR 및 포도당 내성 검사 결과 2% 기장 열수추출물 첨가군의 경우 이들 모두 유의적으로 감소하여 고지방식에 의한 인슐린 저항성 및 당흡수 부전을 기장열수추출물이 완화시켰다(p<0.05). 한편 간조직에서 지방산 대사와 관련된 인자들의 유전자 발현을 측정한 결과 지방산 합성에 관여하는 L-FABP와 SCD1은 2% 기장 열수추출물 섭취군에서 유의적으로 감소하였고(p<0.05) 지방산 산화와 관련된 PPARα는 1% 및 2% 기장 열수추출물 섭취군에서 모두 유의적으로 증가하였다(p<0.05). 이상의 혈청 및 조직의 생물학적 수치와 간조직 검사 결과를 미루어 볼 때 기장 열수추출물 첨가 식이는 고지방식이에 의해 유도된 마우스의 비알코올성 지방간 치유 혹은 예방에 긍정적으로 기여할 수 있음을 시사해 준다. The dietary intake of whole grains is known to reduce the incidence of chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer. In our previous study, hog millet (HM, Panicum miliaceum L.) water extract showed the highest anti-lipogenic activity among nine cereal types in 3T3-L1 cells. In this study, the effect of hog millet water extract on hepatic steatosis and lipid metabolism in mice fed a high fat diet was investigated. Mice were fed a normal-fat diet (ND), high-fat diet (HFD) or HFD containing 1% or 2% (w/w) HM for 7 weeks. Body weight and food intake were monitored during the study period. Insulin resistance by homeostasis model assessment (HOMA-IR), fasting lipid profile, hepatic fatty acid metabolism-related gene expression determined, and intraperitoneal glucose tolerance test (IGTT) were performed at the study"s end. The results indicated that 1% and 2% HM diets effectively decreased liver weights, blood TG and T-cholesterol levels (p<0.05), while the HDL-cholesterol level was increased (p<0.05) compared to HFD-induced steatotsis mice. Hepatic lipogenic-related gene (PPARα, L-FABP, and SCD1) expressions decreased, whereas lipolysis-related gene (CPT1) expression increased in animals fed the 2% PME diet (p<0.05). In addition, mice fed 1% or 2% HM diet had markedly decreased IGTT and HOMA-IR, compared to the those of the HFD-induced hepatic steatosis control group (p<0.05). These results indicated that HM inhibited hepatic lipid accumulation by regulating fatty acid metabolism, and suggested that HM is useful in the chemoprevention or treatment of high fat-induced hepatic steatosis and hepatic steatosis-related disorders including hyperlipidemia, glucose sensitivity, and insulin resistance.
남서해역에서 양식되는 방사무늬김(Porphyra yezoensis Ueda)의 Diving-PAM에 의한 광합성 특성
김정배 ( Jeong Bae Kim ),이원찬 ( Won Chan Lee ),김형철 ( Hyung Chul Kim ),최희구 ( Hee Gu Choi ),박정임 ( Jung Im Park ),조윤식 ( Yoon Sik Cho ),박환희 ( Hwan Hee Park ) 한국환경생물학회 2012 환경생물 : 환경생물학회지 Vol.30 No.3
The morphological characteristics, carbon and nitrogen concentrations, stable isotope values and photosynthetic rates of Porphyra yezoensis were studied at the main purple lavers production areas on southwestern coast of Korea. The morphological characteristics of leaf length, leaf width and weight of Porphyra blades were between 11.6~16.3 (average 13.8) cm, 4.6~6.3 (average 5.4) cm, 1.1~2.6 (average 1.86) g DW m-2, respectively. Photosynthetic pigment of Chl a concentration of Porphyra blades was between 2.18~17.77 (average 9.65) mg DW Chl a m-2. Carbon and nitrogen concentrations of Porphyra blades was between 201~317 (average 240) mg DW g-1, 39.8~50.0 (average 43.5) mg DW g-1 and C/N ratio 5.0~6.7 (average 5.5). The range of average δ13C and δ15N values of Porphyra blades was between - 25.6 to - 24.0 (average - 24.7)‰ for δ13C, and 1.3 to 4.1 (average 2.1)‰ for δ15N. Photosynthetic characteristics of seaweeds measured by pulse amplitude modulation (PAM) fluorometry was used as an indicator of photosynthetic activity. We use Diving-PAM fluorometry to examine photosynthetic rates of the seaweeds Porphyra yezoensis at each station. Maximum quantum yield of Porphyra blades was between 0.46~ 0.55 (average 0.52), the variance of the effective PS II maximum quantum yield of the station was broadly similar. Maximum relative electron transport rate (rETRmax) of Porphyra blades was between 4.71~5.84 (average 5.33) μmol electrons m-2 s-1, the changes of maximum relative electron transport rate (rETRmax) of Porphyra yezoensis were similar to those of PS II maximum quantum yield. Photosynthetic efficiency (α) was between 0.027~0.045 (average 0.036). Minimum saturating irradiance (Ek) range was 139~180 (average 156) μmol photons m-2 s-1. Minimum saturating irradiance (Ek) made a difference by station within the area on southwestern coast. Carbon and nitrogen concentrations and photosynthetic rates of Porphyra blades production areas on southwestern coast were broadly similar. The photosynthetic characteristics showed low photosynthetic rates because the low maximum quantum yields and low maximum relative electron transport rate.