골격성 III급 부정교합 환자에서 양악 수술후 연조직 변화에 대한 연구

박홍주,최홍란,유선열,Park, Hong-Ju,Choi, Hong-Ran,Ryu, Sun-Youl 대한악안면성형재건외과학회 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.4

The purpose of this study was to assess the soft tissue changes using twenty skeletal class III malocclusion patients who treated with bimaxillary surgery for the correction of dentofacial deformities. Patients were divided into two groups. One was impaction and advancement of maxilla with mandibular set-back (Group 1), the other was downward and advancement of maxilla with mandibular set-back (Group 2). Preoperative and postoperative one year cephalometric data were analyzed and compared. Results obtained were as follows: 1. The ratio of horizontal changes of soft tissue to hard tissue at Nt to ANS, Ls to UI, Li to LI, sPog to Pog were 1:0.60, 1:0.79, 1:0.47, 1:0.63 in group 1 respectively, and 1:0.59, 1:0.48, 1:0.83, 1:1.09 in group 2 respectively. Soft tissue changes were highly predictable at the upper lip, lower lip, and chin area. 2. The ratio of vertical changes of soft tissue to hard tissue at Nt to ANS, Li to LI were 1:0.72, 1:0.06 in group 1, and others showed no statistically significant difference. 3. The ratio of horizontal changes of Ls to hard tissue movements at LI(h) was 1:-0.82 in group 1 and at UI(h), LI(h) were 1:0.48, 1:0.01 in group 2. These ratios of group 1 were greater than those of group 2. 4. The direction of horizontal change of Li was the same as that of hard tissue change. The ratio of horizontal changes of Li to LI was 1:0.47 in group 1 and others showed no statistically significant difference. 5. The changes of upper lip thickness and length were -1.6mm, -1.4mm in group 1, and -1mm, -2.7mm in group 2. 6. The ratios of thickness of upper lip to ANS, UI, LI were 1:-0.83, 1:-0.37, 1:0.11 in group 1. There was similar trend in group 2, and there were no statistically significant difference. These results suggest that prediction of changes in soft tissue of upper lip, lower lip, and chin were 79%, 47%, and 63% in group 1, and 48%, 83%, and 109% in group 2. There was a tendency to decrease in thickness and increase in length of the upper lip.

발치 후 즉시 매식된 서로 다른 두종의 RBM표면 처리된 임플란트에 대한 다기관 후향적 임상연구

박홍주,국민석,김수관,김영균,조용석,최갑림,오영학,오희균,Park, Hong-Ju,Kook, Min-Suk,Kim, Su-Gwan,Kim, Young-Kyun,Cho, Yong-Seok,Choi, Gab-Lim,Oh, Young-Hak,Oh, Hee-Kyun 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.3

Purpose. This multicenter retrospective study was performed to evaluate the survival and success rates of immediate placement of USII and SSII Osstem implant (Osstem implant Co, Korea) on the maxillary and mandibular anterior and premolar areas. Materials and methods. Dental records were obtained in 37 patients who were treated with immediate implantation on the maxillary and mandibular anterior and premolar areas in 6 different clinics. The 98 implants were evaluated both clinically and radiographically using predefined success criteria. Results. There was no failed implant in all patients. The mean follow up period was 24.7 months (ranged from 12 to 58 months), and 25.1 months (ranged from 16 to 35 months) in USII and SSII implants, respectively. The crestal bone loss was 3 mm in 3 USII implants during 41 months, and in 1 SSII implant during 22 months. The overall success rate was 94.2% and 97.7% in USII and SSII implants, respectively. The age, gender, diameter, or length of implants, and type of surgery were not influenced to the success rate of immediate implantation. Conclusion. These results suggest that USII and SSII Osstem implant can be used successfully in immediate implantation on the maxillary and mandibular anterior and premolar areas.

가토에서 하악골신장술시 신장부에 대한 가골압축의 효과

박홍주,안진석,국민석,오희균,유선열,조진형,Park, Hong-Ju,An, Jin-Suk,Kook, Min-Suk,Oh, Hee-Kyun,Ryu, Sun-Youl,Cho, Jin-Hyoung 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.1

Purpose: To evaluate the effect of compression on the distracted area in new bone formation during mandibular distraction osteogenesis in rabbits. Materials and method: Sixteen rabbits, weighing approximately 2 Kg, and the prefabricated distraction device were used. With the rabbits under general anesthesia, we performed vertical osteotomies between the anterior and posterior mandibular teeth and then placed the distraction device. After a 5 -day latency period, the mandible was distracted to a length of 10.0 mm at a rate of 1 mm/day and then immediately compressed 4 mm in the experimental group (n=8). In the control group (n=8), the mandible was distracted to a length of 6.0 mm at a rate of 1 mm/day. Rabbits in the control group were killed at 2 and 8 weeks during the consolidation period. The specimens were evaluated with light microscope after H & E stain. Histomorphometric analysis was done at 8 week specimens. Results: All experimental animals showed mandibular elongation on the macroscopical and radiographic evaluations. At 2 week, immature bone formation was observed from the surface of the host bone margins with collagen fibers arranged parallel to the direction of distraction in the control group; in the experimental group, immature bone formation was observed adjacent to the host bone, and the collagen fibers were not arranged uniformly. At 8 week, spindle-shaped new bone formation was seen in the direction of distraction in distracted area of the control group, while in the experimental group, the newly formed bone was arranged in a multidirectional manner, like the pattern of trabeculae. In the histomorphometric analysis of 8 weeks, the area of bone deposition was $2.12{\pm}\;0.75\;inch^2$ in the experimental group and $0.87{\pm}0.51\;inch^2$ in the control group (p<0.01). The bone deposition ratio was $29.60{\pm}10.50%$ in the experimental group and $12.10{\pm}7.17%$ in the control group (p<0.01). Conclusion: These results suggest that compression after over-distraction during the mandibular distraction osteogenesis is an effective method of increasing the amount of newly formed bone in distracted area.

하악과두에서 발생한 악성 골육종 환자에서 외과적 절제 후 유리장골이식을 이용한 재건

박홍주,유민기,국민석,오희균,Park, Hong-Ju,Yu, Min-Gi,Kook, Min-Suk,Oh, Hee-Kyun 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.4

하악골에서 고분화 골육종은 매우 드물게 보고되고 있으며 조직검사상 전형적인 골육종과는 달리 다형성(pleomorphism)을 보이지 않기 때문에 양성종양으로 오진(under-diagnosis) 되기 쉽다. 그러나 정확한 환자의 진단은 적절한 치료와 환자의 예후에 영향을 큰 영향을 미친다. 그러므로 조기에 정확한 진단을 위하여는 의심되는 여러 부위에서 조직검사를 시행하고 임상소견과 방사선소견 등을 병리의사와 공유하여야 한다. 이에 초기에 진단이 어려웠던 하악골에 발생된 고분화 골육종을 경험하여 환자의 사회적 기능적 회복을 위한 수술을 시행하여 바람직한 결과를 얻었기에 문헌고찰과 함께 보고하는 바이다. Osteosarcoma of the jaw is a rare malignant bone tumor which usually leads to a poor prognosis. It commonly occurs in young patients, especially in male. The tumor can involve mandible or maxilla with same frequency. The swelling in the involved area and facial deformity are common clinical findings. The pain and sensory changes are also complained by the patients. Although radical surgery plays an important role in the management of this tumor, the adjuvant chemotherapy or radiotherapy is used to enhance local control and to prevent distant metastases. We treated a 22-year-old male patient who had osteosarcoma in the left condylar region. The radical surgery which consisted of hemimandibulectomy and total parotidectomy, was done and an immediate mandibular reconstruction was performed with a vascularized free iliac osteomuscular flap. The obtained results, both esthetic and functional, were satisfactory. The patient was received postoperative chemotherapy. This is a case with reviews of the literatures.

하악골에 발생한 거대 낭종에서 하악지 시상분할골절단술을 이용한 외과적 치료

박홍주,류재영,국민석,오희균,Park, Hong-Ju,Ryu, Jae-Young,Kook, Min-Suk,Oh, Hee-Kyun 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.1

First of all a good surgical access is considered among various approach methods to the cystic lesion. A poor surgical access can lead to a failure of the whole treatment. A sagittal split ramus osteotomy (SSRO) on the large cyst occurring in the mandibular ramus lets us not only reduce operation time, but can additionally contribute to a good visual field. In addition, a merit exists that it lets this operating method provide soft tissue adhesion for proximal and distal segment and decrease post operative necrosis. We experienced three cases of a large cyst on the mandibular angle and ramus. By employing a sagittal splitting of the mandible, it provided good surgical access and operation results without recurrence during a follow-up period. The surgical technique described may be helpful in treating similar large cysts.

한국산 유색감자 색소의 특성 및 안정성에 관한 연구

박홍주(Hong-Ju Park),전태욱(Tae-Woog Jeon),이성현(Sung-Hyeon Lee),조용식(Yong-Sik Cho),조수묵(Soo-Muk Cho),장규섭(Kyu-Seob Chang) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.9

유색 감자(PL-6, PL-28, PL-31과 Jasim)에 함유된 수용성 색소인 anthocyanin의 pH, 당, ascorbic acid, 유기산과 광원에 대한 색소 안정성을 조사하였다. pH는 유색감자의 anthocyanin 색소 안정성에 영향을 주는 것으로 나타났는데, pH가 낮을수록 색도가 높고 안정하였으며 pH가 높아질수록 색소 파괴가 많아지는 경향을 나타내었다. 유색 감자의 anthocyanin 색소에 당 첨가 시 저장 기간동안 점차적으로 색소가 약간 감소하는 것으로 나타났다. Tartaric, citric, succinic acid와 같은 대부분의 유기산은 anthocyanin 색소의 안정성을 개선시킨 반면 malic, malonic acid는 색소의 안정성을 감소시켰다. 유기산 중 하나인 ascorbic acid만을 첨가했을 때 anthocyanin 색소 안정성은 계속 감소하였으나 thiourea를 함께 사용한 경우 anthocyanin 색소의 안정성 유지에 효과가 있었다. 암실, 형광 그리고 햇빛에 대한 유색감자 anthocyanin 색소의 안정성은 점차 감소하며 빛으로부터 색소를 차단함으로서 색소분해를 최소화할 수 있을 것으로 판단된다. Effects of pH, sugar, ascorbic acid, organic acids and light sources on the stability of anthocyanin pigment extracted from Korean purple-fleshed potatoes (PL-6, PL-28, PL-31 and Jasim) were studied. The pH had remarkable influence on the color stability of anthocyanin pigment. With increasing pH, the color gradually fades as colorless pseudobases are formed. In acidic pH, anthocyanin was stable, but with increasing pH the color gradually changed to colorless. The addition of sugar decrease in color stability of the pigment during storage period. The most of organic acids, such as a tartaric, citric and succinic acids, were found to improve the stability of the pigment, while malic and malonic acid reduced the stability of the pigment. The addition of ascorbic acid considerable decreased in anthocyanin pigment stability, but the effect was not decreased by adding thiourea. The effect of light sources such as a darkroom, a fluorescent light, and sunlight, reduced gradually the stability of anthocyanin pigment. Therefore the pigment degradation could be minimized by shielding the light from the pigment.

채취 시기 및 부위가 다른 표고버섯의 급여가 당뇨 마우스 뇌조직의 신경전달물질 및 지질과산화물 수준에 미치는 영향

박홍주(Hong-Ju Park),김대익(Dea-Ik Kim),이성현(Sung-Hyeon Lee),이영민(Young-Min Lee),정현진(Hyun-Jin Jeong),조수묵(Soo-Muk Cho),전혜경(Hye-Kyung Chun),Hyun S. Lillehoj 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.8

국민생활 수준의 향상과 의학기술의 발달로 인하여 평균수명이 증가하였지만 이에 반해 성인병, 암, 치매 등 질병 유병율은 점차적으로 증가하는 실정이다. 특히 당뇨와 치매는 고령화 현상에 따른 노인 인구의 증가에 따라 그 심각성이 더욱 크다. 또한 문경에서는 품질이 낮은 향신 표고버섯의 대 부위를 분말화하여 조미료로 이용함으로써 표고버섯의 활용 및 부가가치를 높이고 있으나, 표고버섯의 채취시기 및 부위별 생리활성에 대한 연구는 미흡한 실정이다. 이에 따라 본 연구에서는 KK 당뇨마우스를 이용하여 대조군과 표고버섯 품질(동고, 향신) 및 부위별(갓, 대) 분말을 섭취한 4종의 실험군을 8주간 사육한 다음 치매관련 뇌조직 신경전달 물질(neurotransmitter) 및 그 관련효소를 조사하고 활성산소에 의한 산화적 스트레스로 지질과산화(lipid peroxide)를 평가하였다. 그 결과 뇌의 가장 중요한 신경전달물질인 아세틸콜린 함량은 표고버섯 향신갓 부분을 섭취한 실험군 HSC에서 약 12%의 유의적인 증가효과를 보였으며, 아세틸콜린 분해효소인 AChE 효소의 저해활성은 동고갓 부분을 섭취한 DGC 실험군에서 약 10%의 유의적인 아세틸콜린에스테라아제 활성 저해효과를 보였으며, 향신갓 부분를 섭취한 HSC 실험군에서도 저해되는 경향을 보였다. 카테콜아민계 신경전달물질의 파괴에 관계하는 MAO-B효소의 저해활성은 향신갓 부위 첨가 식이 HSC에서 약 12%의 유의적인 활성 저해효과를 보였으며, 지질과산화는 동고갓 부위를 섭취한 실험군 DGC에서 약 10%의 유의적인 지질과산화 감소효과를 보였다. 따라서 표고버섯은 대 부분보다는 갓 부분이 채취시기 및 품질에 상관없이 당뇨모델 마우스 뇌조직의 AChE 효소의 활성을 저해하여 ACh의 농도를 높일 뿐만 아니라 MAO-B효소와 활성산소에 의한 산화적 스트레스를 효과적으로 억제하여 신경전달물질을 잘 보존하여 인지능력 개선에 도움이 될 것으로 생각된다. 그러나 표고버섯의 급여기간 및 첨가수준을 달리한 계속적인 연구가 계속되어야 할 것으로 생각되며, 이러한 결과를 근거로 한 표고버섯 소재의 다양한 제품 개발과 부가가치 향상이 가능할 것으로 기대된다. This study was designed to investigate the supplementary effects of Lentinus edodes which were harvested at different time period and part on acetylcholine content and its related enzyme activities in the brain of diabetic mouse model (KK mouse). We fed mice with standard diet (Control diet; CON) or 4 different kinds of experimental diets (DGC: on time harvested, cap of Dong Go; DGS: on time harvested, stipe of Dong Go; HSC: late harvested, cap of Hyang Sin; HSS: late harvested, stipe of Hyang Sin) to KK mouse for 8 weeks. Neurotransmitter such as acetylcholine contents, acetylcholinesterase activities, monoamine oxidase-B ac-tivities and lipid peroxide contents in the brain were measured. The results showed that acetylcholine content was significantly higher in DGC and HSC groups than CON group. The activities of acetylcholinesterase and monoamine oxidase-B enzyme were significantly inhibited in the brain of DGC and HSC groups compared with CON group. Lipid peroxide content was lower in DGC group than CON group. These results suggested that the cap of Lentinus edodes which were harvested on time and late time contain increased acetylcholine content and decreased acetylcholinesterase activities, monoamine oxidase-B activities and lipid peroxide contents. Thus the cap of Lentinus edodes which were harvested at different time periods may play an effective role in enhancing cognitive function.

서금요법 자가관리 프로그램이 대학생의 알레르기비염에 미치는 효과

박홍주 ( Park Hong Ju ),김남희 ( Kim Nam Hee ) 경희대학교 동서간호학연구소 2019 동서간호학연구지 Vol.25 No.2

Purpose: This study investigated the effects of the Seogeum therapy among college students with allergic rhinitis. Method: A non-equivalent control group pretest-posttest non-synchronized design was used. Intervention of Seogeum therapy has been performed from March 2 through March 31, 2017. Sixty college students diagnosed with allergic rhinitis from two different colleges in B and K cities were assigned to the experimental and control group. Data analysis were conducted using descriptive statistics, chi-square test, Fisher’s exact test, and t-test. Results: There were significant differences in nose itching (t=4.89, p<.001), sneezing (t=6.26, p<.001), watery rhinorrhea (t= 4.09, p<.001), nasal congestion (t=2.36, p=.022), the percent of eosinophil (t=2.01, p=.049), perceived stress (t=2.05, p=.045), and allergic rhinitis related quality of life (t=4.33, p<.001) between the two groups. However, there were no significant differences in the percent of IgE (t=0.60, p=.553) and level of cortisol (t=0.53, p=.598). Conclusion: The results of this study indicates that the self-management of Seogeum therapy improved physical and psychological status of the college students with allergic rhinitis which ultimately improved their quality of life.

구내신연장치를 이용한 치조골증대술 후 임프란트 매식 - 치험 5 예

박홍주(Hong Ju Park),송종운(Jong Woon Song),박충열(Choong Youl Park),오희균(Hee Kyun Oh),유선열(Sun Youl Ryu),이용욱(Yong Uk Lee),김영운(Young Woon Kim) 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Successful alveolar ridge augmentation by distraction osteogenesis method has been reported previously. There are several types of devices for alveolar ridge augmentation. In this paper, a new intraoral distraction device was used on the severe atrophic mandible in order to distract an alveolar ridge vertically in 5 patients. Mean amount of distracted alveolar ridge was 7.4mm (5~9.5mm). Dental implants were placed in the distracted alveolar bone and good osseointegration was obtained in all patients. Mean follow up period is 2years 6months (7months~4years 9months). No complications, such as infection or resorption was observed in all patients. Alveolar ridge augmentation by gradual distraction seems to be a safe, simple and reliable procedure.

골격성 3 급 부정교합 환자에서 양악 수술후 연조직 변화에 대한 연구

박홍주(Hong Ju Park),최홍란(Hong Ran Choi),유선열(Sun Youl Ryu) 대한악안면성형재건외과학회 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.4

The purpose of this study was to assess the soft tissue changes using twenty skeletal class III malocclusion patients who treated with bimaxillary surgery for the correction of dentofacial deformities. Patients were divided into two groups. One was impaction and advancement of maxilla with mandibular set-back (Group 1), the other was downward and advancement of maxilla with mandibular set-back (Group 2). Preoperative and postoperative one year cephalometric data were analyzed and compared. Results obtained were as follows: 1. The ratio of horizontal changes of soft tissue to hard tissue at Nt to ANS, Ls to UI, Li to LI, sPog to Pog were 1:0.60, 1:0.79, 1:0.47, 1:0.63 in group 1 respectively, and 1:0.59, 1:0.48, 1:0.83, 1:1.09 in group 2 respectively. Soft tissue changes were highly predictable at the upper lip, lower lip, and chin area. 2. The ratio of vertical changes of soft tissue to hard tissue at Nt to ANS, Li to LI were 1:0.72, 1:0.06 in group 1, and others showed no statistically significant difference. 3. The ratio of horizontal changes of Ls to hard tissue movements at LI(h) was 1:-0.82 in group 1 and at UI(h), LI(h) were 1:0.48, 1:0.01 in group 2. These ratios of group 1 were greater than those of group 2. 4. The direction of horizontal change of Li was the same as that of hard tissue change. The ratio of horizontal changes of Li to LI was 1:0.47 in group 1 and others showed no statistically significant difference. 5. The changes of upper lip thickness and length were -1.6mm, -1.4mm in group 1, and -1mm, -2.7mm in group 2. 6. The ratios of thickness of upper lip to ANS, UI, LI were 1:-0.83, 1:-0.37, 1:0.11 in group 1. There was similar trend in group 2, and there were no statistically significant difference. These results suggest that prediction of changes in soft tissue of upper lip, lower lip, and chin were 79%, 47%, and 63% in group 1, and 48%, 83%, and 109% in group 2. There was a tendency to decrease in thickness and increase in length of the upper lip.