눈썹 아래에 발생한 연골모양땀관종

박정열(Jungyul Park),최희영(Hee-Young Choi) 대한안과학회 2021 대한안과학회지 Vol.62 No.7

목적: 저자들은 눈썹 아래 발생한 연골모양땀관종 1예를 경험하였기에 이를 보고하고자 한다. 증례요약: 57세 여성이 내원 25년 전에 발생한 눈썹 아래 종괴를 주소로 내원하였다. 타병원에서 4회의 피부 절개를 통한 절제술 이후 모두 2개월째 재발한 이 종괴는 가려움을 동반하였으며, 피곤하면 커지는 경향을 보인다고 호소하였다. 압통이나 궤양은 없었으며, 종괴 중앙부의 눈썹 소실이 관찰되었다. 종괴 부위 피부는 표면이 매끈하며, 표재성 혈관으로 붉게 보였다. 촉진상 둥글고 결절성의 움직이지 않는 양상의 명확한 경계의 종괴였다. 초음파검사상 둥근 고해상의 결절 사이에 일부 불규칙한 모양의 저반향 소견이 관찰되었고, 안와자기공명영상에서 T2 강조영상에서 고신호강도를 보였다. 종괴를 완전절제한 후 실시한 조직검사상 연골모양의 기질 내 내강의 크기가 다양한 관모양 구조물들이 관찰되었으며, 이를 바탕으로 연골모양땀관종으로 확진되었다. 2년의 경과 관찰 동안 재발은 없었다. 결론: 눈꺼풀이나 눈썹 아래에 발생하는 연골모양땀관종은 드물지만 악성종양과의 감별 및 치료를 위해 완전절제가 필요하며, 불완전하게 제거되거나 제거 중 피막이 파열된 경우 재발 혹은 악성 변화를 보일 수 있어 주의를 필요로 한다. Purpose: Chondroid syringoma of the skin is a rare subcutaneous tumor and localization in the eyelid and orbital region that has rarely been described. We report a case of chondroid syringoma that involved the sub-brow region and was accompanied by hair loss. Case summary: A 57-year-old women presented with a mass on the lateral side of the left sub-brow region which was observed 25 years earlier. The mass, which recurred 2 months after surgery at another hospital through a skin incision was accompanied by an itching sensation. The mass was not tender or ulcerated but was reddish with superficial blood vessels and had a smooth surface with hair loss at the site of the mass. The mass showed high signal intensity on a T2-weighted magnetic resonance image and a round echogenic nodule with an irregular hypoechoic portion was observed on ultrasonography. A full-thickness excision including the adjacent normal tissue of the sub-brow mass and direct closure were subsequently performed. The pathological diagnosis was chondroid syringoma which was revealed as numerous tubular structures with various lumens in a collagenous stroma. Mucinous and fibrous findings were also observed. No recurrence was detected during the first 2 years after surgery. Conclusions: Chondroid syringoma in the eyelid and sub-brow region is uncommon. Complete resection is required to differentiate it from a malignancy and reduce the possibility of recurrence. Incomplete resection or capsular rupture during removal of the tumor could induce recurrence or a malignant change in the tumor.

갑상샘눈병증 환자에서 사용한 피하 토실리주맙의 효과

박정열(Jungyul Park),최희영(Hee-young Choi) 대한안과학회 2021 대한안과학회지 Vol.62 No.11

목적: 고식적인 치료에도 반응하지 않는 갑상샘눈병증 환자 2명에서 피하 토실리주맙 주사치료를 시행하여 효과를 보고하고자 한다. 증례요약: (증례 1) 52세 남성이 3개월 전 시작된 갑상샘눈병증으로 내원하였으며 임상활성도는 5점으로 측정되었다. 고용량부신피질호르몬 주사요법 및 methotrexate 경구요법에도 증상의 호전을 보이지 않아 2주 간격 4회의 피하 토실리주맙 주사치료를 시행하였다. 치료 2주 후 임상활동도 점수는 0점으로 감소하였으며 6개월 이상의 경과 관찰에서 재발은 없었다. (증례 2) 내원 3개월 전 갑상샘항진증이 진단된 37세 여성이 충혈과 눈꺼풀 발적을 주소로 내원하였다. 임상활성도는 4점, 갑상샘자극항체는 475%였다. 고용량부신피질호르몬 주사요법과 methotrexate 경구요법에도 호전이 없어 2주 간격 4회의 피하 토실리주맙 주사치료를 시행하였다. 주사치료 후 임상활성도 점수는 1점으로 감소하였으며 6개월의 경과 관찰에서 재발은 없었다. 결론: 고용량의 부신피질호르몬 주사치료와 면역억제제치료에도 반응하지 않는 갑상샘눈병증에서 피하 토실리주맙 주사치료는 간편하며 효과적으로 증상을 조절할 수 있는 치료의 선택이 될 수 있다. Purpose: To demonstrate the efficacy of subcutaneous tocilizumab (TCZ-SC) treatment for recalcitrant thyroid eye disease (TED) refractory to intravenous methylprednisolone (MP) and oral methotrexate (MTX). Case summary: (Case 1) A 52-year-old man, smoker, with hyperthyroidism presented with a 3-months history of TED. The initial clinical activity score (CAS) was 5 (total score of 7). High-dose intravenous MP and oral MTX failed to improve the symptoms. He was treated with four doses of 162 mg TCZ-SC at an interval of 2 weeks. Pre-treatment laboratory test results were within normal limits. CAS was reduced to 2 weeks after the final injection, and there were no recurrences during the 6-month follow-up. (Case 2) A 37-year-old woman, non-smoker, with a 3-months history of hyperthyroidism presented with conjunctival injection and upper eyelid erythema. The initial CAS was 4, and thyroid-stimulating immunoglobulin level was raised (475% of normal). The symptoms did not improve with 7.5 g intravenous MP and oral MTX. The patient was treated with 162 mg TCZ-SC. Pre-treatment laboratory test results were within normal limits. CAS was reduced to 1 after the final injection, and there were no recurrences during the 6-months follow-up. Conclusions: TCZ-SC improves symptoms of corticosteroid-resistant TED, and may be a reasonable option in recalcitrant TED cases. However, further studies are required to justify the use of TCZ-SC for TED.

전단유동으로 제어되는 세포부착분자의 경사도생성

박정열(Jungyul Park),김덕호(Deok-Ho Kim),Andre Levchenko 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5

This paper describes a simple, versatile method of generating gradients of cell adhesion molecules and of a mechanical force induced by varying shear flow speeds using microtluidic channel with triangular cross-section. This fabricated microchannel allows varying shear flow speeds in microchannel by just dispensing fluids using a mcrosyringe pump, which makes the different cell adhesion molecule be deposited. We model this phenomenon with analytical mathematical model, analyze with computational fluid dynamics (CFD), and verify it by observing intensity of FN-rhodamine deposition in microchanel. We demonstrate the assessment of cell migration to fibronectin (FN) coated substrates as a function of varying FN concentration in microchannels due to varying shear flow speeds. Using this device, we will demonstrate that FN gradients could induce haptotaxis of CHO cells, while not affecting the overall rate of cell migration. Cells in the higher FN concentrations are more likely to diverge around its area of high FN concentration, while cells in the less FN concentration areas migrate with a direction towards the higher FN concentration. Compared to previous microtludic chip related to generation of gradients, this device can be also used to investigate how cell migration responds to the interactions between haptotaxis and mechanotaxis, which mimic the real in vivo circumstance

Analysis and control of adhesion for efficient transfer printing

박정열(Jungyul Park),김민석(Min Sock Kim),이탁건(Tahk Guhn Lee),최범규(Bumkyoo Choi) 한국생산제조학회 2011 한국생산제조시스템학회 학술발표대회 논문집 Vol.2011 No.4

The adhesion-based transfer printing process allows the devices to be fabricated through low temperature process, which is important for realizing flexible electronics with high mobility. Therefore, comprehensive understanding about adhesion between the solid object and the surface of elastomeric stamp (generally, polydimethylsiloxane (PDMS) is used) and the optimal strategy to control adhesion can support the effective and high yield transfer. In this paper, a novel adhesive force measurement system is developed to measure dynamic adhesive forces from the surface on the flexible stamp. The thermodynamic work of adhesion at the moment of debonding of a tip of sensor from the flexible stamp is modeled and used for developing the adhesion control strategy. The measurement results show that the work of adhesion is strongly dependent on the peel-off velocity of tip, while the indentation force has only minor effects on it. The effect of Young’s modulus of elastomeric stamp is also investigated using the model of work of adhesion based on the relation between the adhesive force and peel-off velocity. The elastomeric stamp with low Young’s modulus is preferred for efficient transfer printing.

Lycurgus cup 효과를 모사한 plasmon resonance imaging 반사/투과 모드의 기계적 제어 기술 개발

박규빈(Gyubin Park),기석호(Seokho Ki),신지원(Jiwon Shin),박정열(jungyul Park) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11

유연 기판의 표면처리 및 점착 특성에 관한 연구

박진호(Jeanho Park),이혜진(Hye-Jin Lee),이낙규(Nak-Kyu Lee),박정열(Jungyul Park) 한국소성가공학회 2011 한국소성가공학회 학술대회 논문집 Vol.2011 No.5

Lycurgus cup 효과를 모사한 plasmon resonance imaging 반사/투과 모드의 기계적 제어 기술 개발

박규빈(Gyubin Park),기석호(Seokho Ki),신지원(Jiwon Shin),박정열(jungyul Park) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11

PET (polyethylene terephthalate) 박막 위의 마이크로 모세관 현상을 이용한 다중벽 탄소나노튜브 패턴 형성 및 변위 측정에 관한 연구

이탁건(Tahk-guhn Lee),박정열(Jungyul Park) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10

Multi-walled carbon nanotubes (MWCNT) were patterned on polyethylene terephthalate (PET) film using capillarity-driven fluidic force through polydimethylsiloxane (PDMS) microchannel mold. The micropatterned MWCNTs with highly ordered direction were applied as a flexible strain-gauge sensor, which is realized with simple fabrication process. It shows a novel sensitivity, compared to the previous carbon nanotube (CNT) based strain-gauge sensor, because of its highly ordered pattern.

미세 유체 내 동전기 현상에 의해 향상된 광촉매 반응

왕총(Cong Wang),박정열(Jungyul Park) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.11

광결정 기반의 휘발성 유기 화합물 검지 박막 센서

장형관(Hyung-Kwan Chang),박정열(Jungyul Park) 대한기계학회 2016 大韓機械學會論文集B Vol.40 No.3

휘발성 유기화합물과 같은 환경유해물질의 조기 검지는 인체 및 환경보호를 위한 중요성을 가진다. 그러나 기존의 모니터링 기술은 많은 시간과 값비싼 장비를 필요로 하고 있다. 본 논문에서는, 무전원으로 작동가능하며, 휴대가 용이하고 빠른 응답속도를 가지는 광결정 기반의 VOC 검출용 박막센서를 제안하였다. 휘발성 유기 화합물은 Polydimethylsiloxane(PDMS)를 팽창시키는 능력을 가지고 있어, 제안된 센서에 휘발성 유기 화합물이 노출되면 PDMS 가 팽창함에 따라 광결정의 구조변화를 가져오므로 색이 변하게 된다. 이러한 원리에 기초하여 휘발성 유기 화합물에 노출되었을 때 가시광선 영역의 정량적 색변화를 통해 검출할 수 있는 환경센서를 구현하였다. 제안된 센서는 수 초 이내의 빠른 반응속도를 보이며, 기체 상태의 휘발성 유기 화합물에도 색 변화를 일으키는 것을 성공적으로 확인하였다. Early detection of toxic gases, such as volatile organic compounds (VOCs), is important for safety and environmental protection. However, the conventional detection methods require long-term measurement times and expensive equipment. In this study, we propose a thin-film-type chemical sensor for VOCs, which consists of selfassembled monosize nanoparticles for 3-D photonic crystal structures and polydimthylsiloxane (PDMS) film. It is operated without any external power source, is truly portable, and has a fast response time. The structure color of the sensor changes when it is exposed to VOCs, because VOCs induce a swelling of the PDMS. Therefore, using this principle of color change, we can create a thin-film sensor for immediate detection of various types of VOCs. The proposed device evidences that a fast response time of just seconds, along with a clear color change, are successfully observed when the sensor is exposed to gas-phase VOCs.